[Hub]/) : Traits : Leg fat mass (right) :

chr1:76,862,305-79,300,939

Best TWAS P=2.09e-12 · Best GWAS P=6.23e-21 conditioned to 8.8e-13

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Artery Coronary PIGK 0.22 0.00 lasso 8 -0.01 9.0e-01 4.9 -5.6 2.4e-08 -0.10 0.08 0.06 TRUE
2 GTEx Cells EBV-transformed lymphocytes NEXN 0.23 0.10 lasso 3 0.08 1.4e-03 -4.8 -5.3 1.1e-07 -0.13 0.21 0.04 FALSE
3 GTEx Lung GIPC2 0.15 0.09 enet 17 0.12 2.5e-09 -4.9 5.9 3.9e-09 0.19 1.00 0.00 FALSE
4 GTEx Nerve Tibial DNAJB4 0.08 0.07 lasso 3 0.07 1.3e-05 -5.6 -5.8 7.4e-09 -0.14 0.82 0.01 FALSE
5 GTEx Pancreas GIPC2 0.41 0.13 enet 29 0.14 1.1e-06 -5.4 5.2 1.6e-07 0.31 0.65 0.10 FALSE
6 GTEx Skin Sun Exposed Lower leg DNAJB4 0.07 0.05 lasso 5 0.05 6.5e-05 -5.6 -5.7 1.5e-08 -0.11 0.60 0.01 FALSE
7 GTEx Spleen GIPC2 0.43 0.07 enet 19 0.22 2.9e-06 -6.1 6.6 5.1e-11 0.22 0.83 0.02 FALSE
8 METSIM Adipose DNAJB4 0.04 0.04 lasso 4 0.03 2.1e-05 -5.5 -6.1 1.4e-09 -0.26 0.70 0.01 FALSE
9 ROSMAP Brain Pre-frontal Cortex DNAJB4 0.08 0.09 lasso 2 0.09 1.3e-11 -5.8 -5.8 4.8e-09 -0.18 1.00 0.00 FALSE
10 The Cancer Genome Atlas Bladder Urothelial Carcinoma DNAJB4 0.05 0.03 lasso 3 0.02 3.3e-03 -5.4 -5.5 4.5e-08 -0.20 0.06 0.80 FALSE
11 The Cancer Genome Atlas Breast Invasive Carcinoma GIPC2 0.02 0.02 lasso 2 0.02 8.3e-05 -5.1 5.2 1.6e-07 0.24 0.56 0.02 FALSE
12 The Cancer Genome Atlas Colon Adenocarcinoma GIPC2 0.04 0.01 blup 65 0.00 2.5e-01 -5.4 7.0 2.1e-12 0.28 0.07 0.06 TRUE
13 The Cancer Genome Atlas Brain Lower Grade Glioma DNAJB4 0.08 0.07 lasso 1 0.06 9.3e-08 -5.4 -5.4 8.2e-08 -0.19 0.03 0.97 FALSE
14 The Cancer Genome Atlas Brain Lower Grade Glioma GIPC2 0.02 0.02 lasso 3 0.02 1.0e-03 -6.1 6.2 6.0e-10 0.22 0.37 0.02 FALSE
15 The Cancer Genome Atlas Lung Adenocarcinoma DNAJB4 0.04 0.04 lasso 2 0.04 1.2e-05 5.8 -5.8 6.3e-09 -0.45 0.00 0.99 FALSE
16 The Cancer Genome Atlas Testicular Germ Cell Tumors DNAJB4 0.24 0.14 lasso 1 0.11 1.1e-04 -5.4 -5.4 8.2e-08 -0.19 0.03 0.76 FALSE
17 The Cancer Genome Atlas Thyroid Carcinoma GIPC2 0.07 0.05 blup 64 0.06 1.5e-06 -4.4 5.6 1.8e-08 0.28 0.67 0.02 FALSE