[Hub]/) : Traits : Leg fat mass (right) :

chr17:65,123,352-66,885,526

Best TWAS P=4.03e-18 · Best GWAS P=1.61e-18 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous LINC00674 0.12 0.13 enet 6 0.14 9.9e-12 7.3 7.3 3.1e-13 0.79 0.96 0.04 FALSE
2 GTEx Adipose Subcutaneous SH3GL1P3 0.08 0.06 lasso 5 0.04 2.5e-04 7.3 7.2 5.4e-13 0.80 0.06 0.91 FALSE
3 GTEx Adipose Subcutaneous RP11-147L13.8 0.28 0.09 enet 27 0.23 9.7e-19 4.6 5.2 2.4e-07 0.46 1.00 0.00 FALSE
4 GTEx Adipose Visceral Omentum LINC00674 0.29 0.03 enet 40 0.03 6.9e-03 7.7 5.2 1.7e-07 0.63 0.07 0.54 FALSE
5 GTEx Artery Aorta LINC00674 0.12 0.00 lasso 5 0.01 1.5e-01 4.6 5.6 1.7e-08 0.58 0.08 0.33 FALSE
6 GTEx Brain Cerebellum BPTF 0.22 -0.01 lasso 10 -0.01 6.9e-01 7.3 -7.5 6.6e-14 -0.85 0.04 0.48 FALSE
7 GTEx Brain Cortex C17orf58 0.34 0.09 lasso 6 0.13 2.4e-04 8.6 8.2 2.0e-16 0.95 0.03 0.95 FALSE
8 GTEx Cells Transformed fibroblasts LINC00674 0.30 0.31 enet 10 0.32 1.5e-24 7.3 7.9 3.8e-15 0.86 1.00 0.00 FALSE
9 GTEx Cells Transformed fibroblasts LRRC37A16P 0.50 0.46 lasso 8 0.47 1.1e-38 7.3 7.5 6.2e-14 0.84 1.00 0.00 FALSE
10 GTEx Cells Transformed fibroblasts SH3GL1P3 0.26 0.31 lasso 7 0.31 1.5e-23 7.3 8.1 8.0e-16 0.90 0.99 0.01 FALSE
11 GTEx Colon Sigmoid LINC00674 0.42 0.09 lasso 8 0.12 5.5e-05 7.7 7.2 5.0e-13 0.80 0.14 0.67 FALSE
12 GTEx Esophagus Mucosa LRRC37A16P 0.11 0.06 enet 13 0.08 7.5e-06 6.0 -5.9 3.9e-09 -0.67 0.14 0.80 FALSE
13 GTEx Esophagus Muscularis LINC00674 0.11 0.04 lasso 6 0.07 7.9e-05 4.6 7.2 7.6e-13 0.77 0.17 0.80 FALSE
14 GTEx Esophagus Muscularis LRRC37A16P 0.12 0.03 enet 21 0.02 3.2e-02 8.5 5.3 1.4e-07 0.64 0.02 0.79 FALSE
15 GTEx Heart Atrial Appendage LINC00674 0.14 0.08 lasso 17 0.09 1.1e-04 4.6 6.8 9.9e-12 0.73 0.06 0.87 FALSE
16 GTEx Lung LINC00674 0.14 0.03 enet 22 0.08 2.1e-06 8.6 6.9 4.4e-12 0.80 0.11 0.89 FALSE
17 GTEx Muscle Skeletal LRRC37A16P 0.14 0.04 lasso 5 0.08 3.3e-08 4.6 -5.7 1.3e-08 -0.59 0.99 0.00 FALSE
18 GTEx Nerve Tibial LINC00674 0.09 0.01 enet 13 0.03 2.2e-03 4.6 5.7 1.1e-08 0.65 0.20 0.25 FALSE
19 GTEx Nerve Tibial LRRC37A16P 0.09 0.08 lasso 4 0.06 2.7e-05 7.3 7.4 9.4e-14 0.84 0.11 0.78 FALSE
20 GTEx Skin Sun Exposed Lower leg BPTF 0.10 0.01 enet 14 0.03 2.7e-03 7.2 -6.7 2.9e-11 -0.69 0.05 0.80 FALSE
21 GTEx Spleen C17orf58 0.30 -0.01 lasso 8 -0.01 4.6e-01 4.4 6.5 6.1e-11 0.81 0.03 0.35 FALSE
22 GTEx Stomach RP11-147L13.8 0.23 -0.01 enet 9 0.01 8.1e-02 3.4 6.5 9.8e-11 0.57 0.04 0.18 FALSE
23 GTEx Thyroid LINC00674 0.09 0.10 enet 16 0.12 4.0e-09 4.6 5.2 2.1e-07 0.61 0.58 0.38 FALSE
24 GTEx Thyroid SH3GL1P3 0.08 0.00 lasso 3 0.00 2.8e-01 4.6 5.3 1.1e-07 0.56 0.05 0.44 FALSE
25 YFS Blood KPNA2 0.01 0.01 blup 312 0.01 2.8e-04 7.7 -8.4 4.3e-17 -0.86 0.05 0.93 FALSE
26 The Cancer Genome Atlas Thyroid Carcinoma C17orf58 0.02 0.02 lasso 2 0.01 1.8e-02 8.7 8.7 4.0e-18 1.00 0.00 0.76 TRUE