Hub : Genes

BPTF

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.084	0.030	0.0011	0.036	0.033	0.015	0.037	0.027	3.1e-05	6.1e-05	0.0050	2.5e-05	0.00029
2	GTEx	Brain Cerebellum	0.224	0.104	0.0099	-0.006	NA	-0.010	NA	-0.008	5.5e-01	NA	0.8600	NA	0.69000
3	GTEx	Skin Sun Exposed Lower leg	0.104	0.037	0.0008	0.010	NA	0.026	NA	0.025	4.8e-02	NA	0.0027	NA	0.00320

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Trunk fat mass	13.4	57.6	87.4	-4.0	-9.3	-8.3
Trunk fat percentage	12.9	51.8	76.9	-3.4	-8.8	-8.2
Whole body fat mass	12.1	50.5	76.3	-4.0	-8.7	-7.7
Waist circumference	11.9	43.4	67.7	-3.7	-8.2	-7.0
Body fat percentage	11.7	46.1	68.6	-3.3	-8.3	-7.7
Leg fat mass (left)	10.4	40.8	60.4	-3.8	-7.8	-6.9
Arm fat mass (right)	10.1	41.4	60.7	-4.1	-7.8	-6.8
Leg fat mass (right)	9.9	38.4	56.2	-3.8	-7.5	-6.7
Arm fat mass (left)	9.9	40.8	61.2	-3.9	-7.8	-6.8
Blood Eosinophil Count	9.5	73.1	106.1	-4.0	-10.3	-9.9
Weight	9.4	46.2	71.6	-4.6	-8.5	-6.8
Arm fat percentage (left)	9.2	36.7	54.6	-3.5	-7.4	-6.6
Fractured/broken bones in last 5 years	9.1	11.8	17.5	-1.6	-4.2	-3.9
Arm fat percentage (right)	8.9	34.9	50.2	-3.3	-7.1	-6.6
Leg fat percentage (left)	8.6	31.3	46.6	-2.9	-6.8	-6.2
Taking other prescription medications	8.3	12.8	13.7	-3.4	-3.7	-3.7
Leg fat percentage (right)	8.2	29.6	44.1	-3.0	-6.6	-6.0
Loneliness, isolation	8.0	11.0	13.7	-3.7	-3.7	-2.4
Wheeze or whistling in the chest in last year	7.7	13.7	21.8	-1.4	-4.2	-4.7
Hip circumference	7.4	32.0	51.4	-3.7	-7.2	-5.6
Medication: Omeprazole	7.4	8.9	13.9	-3.7	-2.6	-2.5
Health satisfaction	7.3	9.5	12.8	-2.1	-3.3	-3.6
Overall health rating	7.3	15.7	20.3	-2.9	-4.3	-4.5
Medication: Metformin	7.0	9.8	10.5	-3.2	-3.2	-2.9
Number of treatments/medications taken	6.8	12.2	20.4	-2.5	-3.2	-4.5
Family relationship satisfaction	6.4	7.9	11.3	-1.4	-3.4	-3.2
Myopia	6.3	9.1	10.6	3.0	3.2	2.8
Medication: Omeprazole (e.g. Zanprol)	6.2	7.5	11.8	-3.4	-2.6	-2.0
Body mass index (BMI)	6.1	26.1	38.1	-3.8	-6.2	-5.1
Smoking status: Current	6.1	9.7	12.8	-3.1	-3.6	-2.6
Ever used hormone-replacement therapy (HRT)	6.0	7.6	12.2	-1.5	-2.9	-3.5
Townsend deprivation index at recruitment	5.9	8.3	17.0	-0.7	-2.7	-4.1
Current tobacco smoking	5.9	9.6	12.3	-2.9	-3.5	-2.8
BMI	5.8	33.7	49.1	-3.4	-7.0	-6.3
Lung FEV1/FVC ratio	5.8	29.3	42.8	-3.9	-6.5	-5.5
Fed-up feelings	5.7	10.3	17.3	-4.2	-2.8	-2.4
Frequency of tiredness / lethargy in last 2 weeks	5.7	9.3	10.4	-3.0	-3.2	-2.9
Long-standing illness, disability or infirmity	5.7	8.8	10.8	-2.5	-3.3	-3.0
Alcohol drinker status: Previous	5.6	6.3	8.2	-1.8	-2.8	-2.9
Exposure to tobacco smoke outside home	5.4	7.2	7.7	-2.6	-2.7	-2.8
High blood pressure (siblings)	5.3	7.7	13.4	-2.2	-3.7	-2.2
Financial situation satisfaction	5.3	6.5	6.8	-2.6	-2.5	-2.5
Eye problems/disorders: Glaucoma	5.3	6.3	13.8	-3.7	-0.5	-2.2
Loud music exposure frequency	5.1	5.6	7.2	-2.7	-2.6	-1.6
Type 2 Diabetes (T2D) (2012)	5.0	5.8	8.0	-2.0	-2.3	-2.8
Serious illness, injury or assault to yourself	4.9	6.0	10.9	-0.6	-2.6	-3.3
Medication: Gliclazide	4.9	5.5	10.0	-1.4	-3.2	-2.1
Multivitamins +/- minerals	4.8	6.1	10.1	-1.5	-3.2	-2.4
Back pain experienced in last month	4.8	6.9	12.8	-3.6	-2.7	-0.9
Age at last live birth	4.7	6.7	7.6	2.6	2.4	2.8
Pain experienced in last month	4.5	7.4	10.2	1.5	3.1	3.2
Body Mass Index (BMI) (2010)	4.4	6.0	10.2	-3.2	-2.0	-2.0
Triglycerides	4.4	7.2	10.9	-2.5	-3.3	-2.1
Type 2 Diabetes (T2D) (2018)	4.4	8.1	9.6	-3.1	-2.9	-2.5
Hearing aid user	4.4	5.0	6.8	1.3	2.6	2.6
Basal metabolic rate	4.4	24.4	38.4	-4.0	-6.2	-4.4
Illnesses of father: High blood pressure	4.3	5.3	6.4	1.9	2.5	2.5
Leg fat-free mass (left)	4.2	22.0	33.8	-4.0	-5.8	-4.0
Age at first live birth	4.2	7.4	8.0	2.8	2.6	2.8
Leg predicted mass (left)	4.1	21.6	33.2	-4.0	-5.8	-3.9
Eye problems/disorders: None of the above	4.1	4.7	7.7	2.8	1.2	2.2
Medication for pain relief, constipation, heartburn	4.1	7.1	9.2	1.7	3.0	3.0
Medication for hormone replacement therapy	4.0	4.5	5.8	-2.1	-2.4	-1.8
Number of self-reported non-cancer illnesses	4.0	6.9	9.5	-2.1	-2.6	-3.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.9	4.5	6.5	-2.3	-2.6	-1.4
Ever depressed for a whole week	3.9	4.9	8.1	-1.4	-2.9	-2.1
Ulcerative Colitis (UC)	3.8	7.2	9.9	1.7	3.0	3.2
Arm fat-free mass (left)	3.8	19.2	30.0	-3.6	-5.5	-3.9
Alzheimer’s Disease (in mother)	3.7	4.3	6.8	2.6	2.2	1.1
Leg fat-free mass (right)	3.7	19.6	30.6	-3.9	-5.5	-3.7
Age at First Birth	3.6	5.3	7.8	1.5	2.8	2.4
Frequency of unenthusiasm / disinterest in last 2 weeks	3.6	4.8	7.1	-1.7	-2.7	-2.1
Illnesses of siblings	3.6	5.1	8.3	1.8	2.9	1.9
Shortness of breath walking on level ground	3.6	4.2	5.4	-1.4	-2.3	-2.3
Leg predicted mass (right)	3.6	19.3	30.0	-3.8	-5.5	-3.7
Eye problems/disorders: Diabetes related eye disease	3.5	3.9	6.1	-2.5	-2.0	-1.3
Maternal smoking around birth	3.5	5.1	7.2	-1.2	-2.6	-2.7
Alcohol usually taken with meals	3.5	5.6	11.0	1.1	3.3	2.1
Glaucoma (self-reported)	3.5	4.1	6.9	-2.6	-0.5	-2.3
Arm predicted mass (right)	3.5	17.7	28.6	-3.6	-5.3	-3.4
Average weekly fortified wine intake	3.4	4.0	5.7	1.8	2.4	1.8
Ever had stillbirth, spontaneous miscarriage or termination	3.4	3.7	5.1	-1.6	-2.2	-1.9
Medication: Atorvastatin	3.4	4.2	7.1	-2.1	-1.1	-2.7
Arm predicted mass (left)	3.4	17.5	27.8	-3.5	-5.3	-3.5
Alzheimer’s Disease (including proxy)	3.2	4.6	6.2	2.5	2.2	1.7
Prospective memory result	3.2	4.0	6.4	-0.3	-2.5	-2.3
Arm fat-free mass (right)	3.2	16.2	26.2	-3.4	-5.1	-3.3
Diabetes diagnosed by doctor	3.2	5.2	5.3	-2.3	-2.3	-2.3
Comparative height size at age 10	3.1	17.3	25.1	-3.1	-5.0	-4.2
Whole body fat-free mass	3.1	17.6	27.8	-3.6	-5.3	-3.4
Vitamin and mineral supplements	3.0	4.1	7.1	0.5	2.7	2.2
Hand grip strength (right)	3.0	8.2	15.0	0.4	3.1	3.9
Whole body water mass	3.0	17.1	27.8	-3.5	-5.3	-3.4
Cholesterol lowering medication	3.0	4.5	6.1	-1.3	-2.4	-2.5
Heart disease (siblings)	3.0	3.6	6.5	-2.5	-1.9	-0.9
HbA1C	2.9	3.2	7.7	-0.8	-2.8	-1.2
Ever highly irritable/argumentative for 2 days	2.9	3.5	4.7	-2.2	-2.1	-1.2
Coronary Artery Disease (CAD)	2.8	3.3	5.9	-1.5	-2.4	-1.4
Medication: Co-codamol	2.8	3.3	6.6	-1.8	-2.6	0.1
Bilateral oophorectomy (both ovaries removed)	2.8	3.2	4.7	-2.2	-1.5	-1.7
Frequency of tenseness / restlessness in last 2 weeks	2.8	4.3	5.3	-2.2	-2.3	-1.7
Neck or shoulder pain in last month	2.8	3.9	4.2	-2.1	-1.9	-1.9
Pack years of smoking	2.8	4.2	4.8	-1.7	-2.2	-2.2
Serious illness, injury or assault of a close relative in last 2 years	2.7	3.1	5.7	-1.5	1.2	2.4
Number of children fathered	2.7	3.0	5.5	0.1	1.9	2.4
Unable to work because of sickness or disability	2.7	3.5	4.0	-1.7	-2.0	-1.9
Systolic Blood Pressure	2.6	13.0	18.4	1.6	4.2	4.3
Hand grip strength (left)	2.6	6.8	11.3	0.0	3.0	3.4
Diabetes (self-reported)	2.6	4.0	4.6	-1.7	-2.1	-2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	2.6	3.4	5.7	1.4	-1.6	-2.4
Depressed Affect (Nagel 2018)	2.5	5.3	7.4	-2.7	-2.2	-1.9
Ever unenthusiastic/disinterested for a whole week	2.5	3.0	4.9	-1.5	-2.2	-1.4
Headache pain in last month	2.5	4.2	10.3	-1.0	-1.2	-3.2
Friendships satisfaction	2.5	3.1	4.2	-1.8	-1.4	-2.0
Major Depression (MDD)	2.4	2.9	5.3	0.1	-2.3	-1.8
Neuroticism	2.4	5.8	10.7	-0.8	-3.3	-2.5
Eye problems/disorders: Cataract	2.4	2.8	8.1	-2.9	-0.1	-0.5
Pain type(s) experienced in last month: Hip pain	2.4	3.0	4.7	-2.2	-1.9	-0.8
Father’s age at death	2.3	3.0	7.3	-2.7	0.2	1.3
Pack years adult smoking proportion	2.2	3.4	3.7	-1.7	-1.9	-1.9
Bipolar Disorder or Schizophrenia	2.1	5.2	13.8	3.7	-0.0	-1.4
Height	2.1	41.4	66.9	-2.5	-8.2	-7.1
Qualifications: CSEs or equivalent	2.1	2.8	3.8	1.9	1.1	1.9
Trunk fat-free mass	2.1	12.0	19.5	-3.1	-4.4	-2.6
Happiness	2.1	2.5	3.0	-1.3	-1.7	-1.7
Medication: Amlodipine	2.1	2.9	4.1	0.9	2.0	2.0
Birth weight	2.1	4.5	5.2	-2.0	-2.3	-2.1
Leg pain on walking	2.1	2.6	5.1	0.3	-1.6	-2.3
LDL Cholesterol	2.0	3.2	5.0	-2.2	-1.9	-1.0
Had menopause	2.0	2.5	4.1	0.7	-2.0	-1.8
Trunk predicted mass	2.0	11.4	18.1	-3.1	-4.3	-2.6
Irritability	2.0	3.4	7.9	-2.8	-1.4	-0.6
Depression (Nagel 2018)	1.9	2.9	4.0	-1.1	-2.0	-1.9
Lung FVC	1.9	9.6	14.2	1.5	3.5	3.8
Number of incorrect matches in round	1.9	3.2	6.0	-1.5	-1.1	-2.4
Hayfever/allergic rhinitis (self-reported)	1.9	2.5	4.4	-0.4	-1.7	-2.1
Qualifications: A levels/AS levels or equivalent	1.9	4.1	8.7	0.0	1.9	3.0
Standing height	1.9	18.8	32.4	-2.1	-5.7	-4.4
Irritable Bowel Disease (IBD)	1.8	4.2	6.0	0.9	2.4	2.4
Average weekly spirits intake	1.8	2.2	4.5	-2.1	-1.3	-0.6
Relative age of first facial hair	1.8	3.7	5.5	2.3	2.3	0.6
Medication: Allopurinol	1.8	2.4	5.1	-0.7	-2.2	-1.2
Guilty feelings	1.8	2.7	4.2	-1.7	-2.1	-1.0
Mother’s age at death	1.8	2.3	3.9	0.6	2.0	1.6
HDL Cholesterol	1.7	2.8	4.4	2.1	1.9	0.7
Sensitivity / hurt feelings	1.7	2.9	5.1	-1.3	-2.3	-1.4
Relative age voice broke	1.7	2.7	4.3	2.1	1.9	-0.3
Falls in the last year	1.7	2.3	3.9	-0.6	-1.6	-2.0
Qualifications: O levels/GCSEs or equivalent	1.7	2.7	6.0	-1.1	1.0	2.5
Knee pain experienced in last month	1.7	2.6	5.4	-0.4	-2.3	-1.5
Asthma (self-reported)	1.7	3.3	5.8	-1.6	-1.3	-2.4
Supplements: Fish oil (including cod liver oil)	1.7	2.2	4.3	2.1	1.5	0.2
Rheumatoid Arthritis	1.6	2.2	6.0	2.4	0.2	-0.8
Allergy or Eczema	1.6	4.2	6.7	-1.9	-2.6	-1.6
Severe depression (siblings)	1.6	1.8	2.6	1.6	-1.0	-1.4
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	2.8	-1.7	0.9	1.2
Pulse rate	1.6	2.8	4.2	-1.4	-2.0	-1.4
Gout (self-reported)	1.6	2.2	4.3	-0.8	-2.1	-1.3
Qualifications: College or University degree	1.6	5.0	8.5	2.9	1.6	2.0
Medication: Seretide 50 evohaler	1.6	1.8	2.6	-1.3	-1.6	-1.0
Illnesses of siblings: Diabetes	1.6	2.0	2.5	-1.6	-1.6	-1.1
Risk taking	1.6	2.3	4.7	-0.8	-2.2	-1.3
Neuroticism (Nagel 2018)	1.5	3.6	4.6	-2.1	-2.0	-1.5
Schizophrenia (2018)	1.5	3.0	8.4	2.9	-0.0	-0.8
Schizophrenia (2014)	1.5	3.3	9.1	3.0	-0.1	-1.0
Other serious medical condition/disability diagnosed by doctor	1.5	1.9	2.8	-0.9	-1.5	-1.7
Hayfever, allergic rhinitis or eczema	1.5	3.2	5.3	-1.4	-2.3	-1.5
Mouth/teeth dental problems: Loose teeth	1.5	1.8	4.2	0.0	-2.0	-1.0
Commuting to job workplace: Walk	1.5	1.6	3.4	0.7	1.9	0.9
Medication for cholesterol	1.5	2.2	3.6	0.7	1.6	1.9
Mineral and other dietary supplements	1.5	2.0	4.8	-2.2	-0.2	1.1
Medication: Paracetamol	1.5	2.4	3.9	-1.4	-1.2	-2.0
Bipolar Disorder (2018)	1.4	2.1	5.1	2.3	-0.0	-1.1
Reaction Time	1.4	2.7	5.6	1.3	-0.8	-2.4
Heel T-Score	1.4	10.9	15.3	2.3	3.9	3.5
Exposure to tobacco smoke at home	1.4	1.6	3.9	0.7	-0.6	-2.0
Medication: Ibuprofen	1.4	1.7	3.1	-1.1	-1.7	-0.8
Mean time to correctly identify matches	1.4	2.6	6.6	-0.2	-1.1	-2.6
Miserableness	1.4	2.5	6.2	-2.5	-1.0	-0.6
Number of operations (self-reported)	1.4	2.0	3.0	-1.2	-1.3	-1.7
Ovarian Cancer	1.3	1.7	2.9	-1.7	-1.4	-0.5
Respiratory disease	1.3	2.9	7.4	0.8	-0.7	-2.7
Hearing difficulty/problems: Yes	1.3	2.0	3.1	0.5	1.8	1.7
Chronic bronchitis/emphysema (father)	1.3	1.5	2.9	-1.7	-1.2	-0.1
Allergy	1.3	3.1	4.4	1.1	2.1	1.9
Asthma	1.3	2.5	4.2	-1.4	-1.2	-2.1
Blood clot in the leg (DVT)	1.3	1.7	1.9	-1.2	-1.4	-1.3
Emphysema/chronic bronchitis	1.3	1.5	2.8	1.7	1.1	-0.7
Angina (self-reported)	1.3	1.7	4.1	-0.3	-0.9	-2.0
Wears glasses or contact lenses	1.3	1.5	3.9	-0.7	-0.1	-2.0
Age started oral contraceptive pill	1.3	1.7	4.9	2.2	0.4	-0.1
Hypothyroidism (self reported)	1.2	2.7	4.9	0.3	-1.7	-2.2
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	2.7	-0.7	-1.6	-1.2
Medication: Ventolin 100micrograms inhaler	1.2	1.5	2.9	-1.7	-0.6	-1.2
Pulse rate, automated reading	1.2	3.8	5.8	-1.3	-2.4	-2.0
Mood swings	1.2	2.1	4.1	-2.0	-0.9	-1.2
High cholesterol (Self-reported)	1.2	2.2	4.7	-2.2	-1.1	-0.8
Neuroticism score	1.1	2.4	3.4	-1.8	-1.7	-1.0
Time employed in main current job	1.1	1.2	2.6	-1.6	-0.7	-0.8
Depression (self-reported)	1.1	1.3	1.7	1.2	-1.3	-0.8
Breastfed as a baby	1.1	1.3	1.9	-0.7	1.4	1.3
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	3.3	1.8	-0.2	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	3.4	-0.3	-0.7	-1.8
Prostate Cancer	1.0	1.4	2.5	-1.6	0.8	1.0
Mean Putamen Volume	1.0	1.1	2.2	-1.0	1.5	0.3
Frequency of depressed mood in last 2 weeks	1.0	1.4	2.4	-0.7	-1.6	-1.2
Angina	1.0	1.4	3.7	-0.1	-0.6	-1.9
Had other major operations	1.0	1.2	3.3	-0.3	-0.4	-1.8
Medication: Simvastatin	1.0	1.4	1.8	-1.2	-1.0	-1.3
Lung cancer (father)	1.0	1.2	2.2	-1.1	-1.5	-0.5
Comparative body size at age 10	1.0	2.7	5.1	-1.2	-2.3	-1.3
Medication: Bendroflumethiazide	1.0	1.5	2.1	-1.3	-0.7	-1.5
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	1.6	-1.1	-1.3	-1.0
Neuroticism (2016)	0.9	1.3	2.3	-1.0	-0.7	-1.5
Primary Biliary Cirrhosis	0.9	1.3	2.0	1.4	-0.5	-1.3
Waist Hip Ratio (WHR)	0.9	3.9	5.9	0.6	-2.4	-2.3
Ever had hysterectomy (womb removed)	0.9	1.1	2.5	-0.4	-0.7	-1.6
Qualifications: None of the above	0.9	1.9	2.9	-0.7	-1.7	-1.5
Financial difficulties in last 2 years	0.9	1.2	2.1	0.2	-1.4	-1.2
Pulse wave reflection index	0.9	1.1	2.1	1.2	1.4	0.1
Number of full brothers	0.9	1.2	2.4	1.6	-0.7	-0.8
Heart disease (mother)	0.9	1.1	3.3	-1.8	-0.2	0.2
Handedness (chirality/laterality): Left-handed	0.9	1.1	1.2	1.1	1.1	1.1
Medication: Aspirin	0.9	1.2	2.3	-1.5	-0.7	-0.9
Alzheimer’s Disease (in father)	0.8	0.9	1.0	1.0	0.9	1.0
Chronotype (morning person)	0.8	1.9	3.7	1.3	-0.5	-1.9
Diabetes (father)	0.8	1.0	2.0	-1.0	0.1	1.4
Sitting height	0.8	5.9	12.0	-1.6	-3.5	-1.7
Impedance of leg (left)	0.8	4.1	10.6	3.2	1.1	-0.8
Forced vital capacity (FVC), Best measure	0.8	3.1	5.5	1.4	1.3	2.4
Medication: Aspirin	0.8	1.1	1.6	-1.3	-0.6	-1.1
Illnesses of father: None of the above (group 1)	0.8	1.0	2.7	1.6	-0.2	-0.3
Medication: Lisinopril	0.8	1.0	2.9	-0.0	0.1	1.7
Impedance of leg (right)	0.7	3.6	8.5	2.9	1.4	-0.3
Mouth/teeth dental problems	0.7	1.0	2.5	-0.6	0.4	1.6
Heart attack	0.7	0.9	2.1	-0.8	-0.1	-1.4
Impedance of arm (right)	0.7	3.4	7.8	2.8	0.0	-1.5
Hair/balding pattern: Pattern 3	0.7	1.1	2.3	0.7	0.7	1.5
Mouth/teeth dental problems: Dentures	0.7	1.2	2.4	-0.7	-0.9	-1.5
Illnesses of mother	0.7	0.9	1.6	-0.1	-1.3	-1.1
Medication: Paracetamol	0.7	1.2	1.8	-1.1	-0.8	-1.4
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.7	-0.8	-1.3	-0.1
Illnesses of father: Heart disease	0.7	1.0	2.0	-1.4	-0.3	-0.9
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.2	-1.5	-0.4	0.4
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.0	-0.8	-0.1	-1.4
Lupus	0.6	0.8	2.1	0.3	1.4	-0.6
Blood White Count	0.6	4.3	7.5	0.3	-2.7	-2.3
Smoking Status	0.6	1.5	3.2	-0.6	-1.8	-1.0
Systolic blood pressure, automated reading	0.6	1.8	3.0	0.9	1.2	1.7
Age when periods started (menarche)	0.6	1.4	2.4	1.0	1.5	0.9
Pain all over the body in last month	0.6	0.6	1.7	-0.3	0.1	-1.3
Length of working week for main job	0.6	0.6	0.9	0.8	-0.9	-0.6
Worry too long after embarrassment	0.6	1.0	2.5	0.3	-0.6	-1.6
Suffer from ‘nerves’	0.6	1.0	1.2	-0.9	-1.1	-0.9
Ever had bowel cancer screening	0.6	0.7	1.6	0.7	0.2	-1.3
Intelligence (Savage-Jansen 2018)	0.5	1.4	3.2	-0.3	1.0	1.8
Supplements: Glucosamine	0.5	0.7	1.3	1.2	0.6	-0.5
Medication: Atenolol	0.5	0.6	1.3	-0.5	0.6	1.1
High blood pressure (mother)	0.5	0.8	1.3	0.1	1.0	1.2
Hearing difficulty/problems with background noise	0.5	0.9	2.4	0.4	1.5	-0.2
Hair/balding pattern: Pattern 2	0.5	0.6	1.3	-0.7	-0.0	-1.1
Fluid intelligence score	0.5	1.1	3.2	-0.3	0.2	1.8
Number of live births	0.5	0.7	1.6	-0.1	-0.6	1.3
Impedance of arm (left)	0.5	2.4	4.3	2.1	-0.4	-1.7
Birth weight of first child	0.5	1.0	1.6	-1.3	1.1	0.1
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.2	0.1	-0.9	-1.5
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.5	-1.2	-0.4	0.1
Medication: Blood pressure	0.5	0.8	2.2	-1.5	0.3	0.4
Chest pain or discomfort	0.5	0.7	1.8	-0.4	-1.3	-0.2
Osteoporosis (self-reported)	0.5	0.6	1.5	-1.2	-0.6	-0.3
Osteoarthritis (self-reported)	0.5	0.7	1.0	1.0	-0.8	-0.7
Impedance of whole body	0.5	2.3	5.3	2.3	0.2	-1.3
Schizophrenia vs Biploar Disorder	0.4	0.6	1.0	0.5	-1.0	-0.6
Breast Cancer	0.4	0.9	1.5	-1.1	-0.1	1.2
Blood Platelet Count	0.4	4.7	8.9	1.7	3.0	1.5
Tanning	0.4	5.3	5.9	-2.1	-2.4	-2.4
Supplements: Zinc	0.4	0.4	1.3	1.1	-0.1	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	1.7	0.4	1.0	1.3
Forced vital capacity (FVC)	0.4	1.6	3.1	0.6	1.2	1.8
Medication: Ramipril	0.4	0.5	1.1	-1.0	-0.3	-0.7
Medication: Cholesterol lowering	0.4	0.7	1.9	-1.4	-0.1	-0.3
Medication: Lansoprazole	0.4	0.5	1.1	-1.1	-0.5	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	2.7	0.8	0.4	1.6
Number of full sisters	0.4	0.4	0.7	0.0	-0.8	-0.8
Had major operations	0.4	0.4	1.0	1.0	-0.4	-0.4
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.3	1.1	-0.1	0.3
Smoking status: Previous	0.4	0.6	1.5	0.4	1.2	0.3
Ever smoked	0.4	0.7	1.1	-0.5	-0.8	-1.0
Average weekly beer plus cider intake	0.4	0.6	1.0	-0.6	-0.6	-1.0
Supplements: Calcium	0.4	0.5	0.8	-0.1	-0.8	-0.9
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.1	-0.5	0.9	1.1
Fasting Glucose	0.3	0.4	0.6	0.8	-0.0	0.8
Past tobacco smoking	0.3	0.5	1.1	0.4	0.5	1.0
Nervous feelings	0.3	0.5	0.8	0.5	0.9	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	0.9	0.4	1.0	0.9
Pulse wave Arterial Stiffness index	0.3	0.4	1.0	0.1	-1.0	0.3
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.3	1.1	-0.1	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.1	-1.0	-0.3	0.0
Breast cancer (self-reported)	0.3	0.4	0.7	0.4	0.6	-0.8
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.7	-0.5	-0.3	-0.8
Worry (Nagel 2018)	0.2	0.4	0.7	0.4	0.8	0.7
Crohns Disease (2012)	0.2	0.3	0.8	-0.3	0.9	-0.1
Hair Pigment	0.2	4.8	8.4	-0.3	-2.4	-2.9
Medication: Levothyroxine sodium	0.2	0.3	0.9	-0.1	0.1	-1.0
Alcohol intake versus 10 years previously	0.2	0.3	0.8	-0.1	-0.4	-0.9
Worrier / anxious feelings	0.2	0.5	1.0	-0.2	1.0	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.6	-0.1	-0.4	-0.8
Peak expiratory flow (PEF)	0.2	0.6	1.5	0.4	-0.0	1.2
Pulse wave peak to peak time	0.2	0.2	0.4	-0.2	0.7	-0.4
Migraine (self-reported)	0.2	0.3	0.8	-0.9	0.2	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.5	0.3	-0.2	-0.7
Supplements: Vitamin C	0.2	0.3	0.5	0.5	0.2	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.8	0.7	-0.9	0.0
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	0.7	0.8	0.2	-0.6
Average weekly champagne plus white wine intake	0.2	0.3	0.5	-0.7	-0.1	-0.5
Ever taken oral contraceptive pill	0.2	0.2	0.6	0.2	-0.8	0.2
Medication: Blood pressure	0.2	0.5	0.7	0.8	-0.2	-0.8
Diastolic blood pressure, automated reading	0.2	0.7	2.0	-1.4	-0.2	0.4
Commuting to job workplace: Cycle	0.2	0.2	0.5	0.0	-0.4	-0.7
Crohns Disease (2017)	0.1	0.3	0.5	-0.1	0.6	0.7
Ulcerative Colitis	0.1	0.1	0.3	0.1	0.6	0.2
Blood Red Count	0.1	0.9	2.1	0.7	0.3	-1.4
Cardiovascular Disease	0.1	0.3	0.8	-0.9	-0.0	0.1
High blood pressure	0.1	0.1	0.3	-0.4	0.5	-0.2
Stomach or abdominal pain in last month	0.1	0.1	0.1	-0.3	0.3	0.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.7	-0.0	-0.0	0.8
Noisy workplace	0.1	0.1	0.1	-0.3	-0.3	-0.3
Hair/balding pattern: Pattern 4	0.1	0.3	0.6	0.8	0.3	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.1	-0.4	0.2	0.0
Average weekly red wine intake	0.1	0.2	0.4	0.0	0.4	-0.6
Qualifications: nursing, teaching	0.1	0.2	0.5	0.7	-0.1	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.5	0.2	0.7	0.5
Commuting to job workplace: Public transport	0.1	0.1	0.2	-0.2	0.4	0.2
Alcohol drinker status: Never	0.1	0.2	0.2	-0.5	-0.5	-0.2
Vascular/heart problems diagnosed by doctor	0.1	0.4	0.6	0.8	-0.6	0.5
Basal cell carcinoma (self-reported)	0.1	0.1	0.3	0.3	-0.2	-0.5
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Diabetes (mother)	0.0	0.0	0.1	-0.1	-0.0	-0.3
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.1	0.1	-0.2	-0.0
Tense / ‘highly strung’	0.0	0.0	0.0	-0.2	0.1	-0.2
Alcohol intake frequency.	0.0	0.1	0.1	-0.3	-0.2	-0.3
Hypertension (Self-reported)	0.0	0.1	0.3	-0.2	0.5	0.1