Hub : Genes

LRRC37A16P

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.0970 0.0450 0.00410 0.098 NA 0.137 NA 0.093 2.1e-08 NA 2.9e-11 NA 4.7e-08
2 GTEx Cells Transformed fibroblasts 0.4960 0.0580 0.00000 0.458 NA 0.461 NA 0.466 6.9e-38 NA 3.5e-38 NA 1.1e-38
3 GTEx Colon Sigmoid 0.2540 0.0820 0.00270 -0.008 NA 0.038 NA -0.008 9.0e-01 NA 1.7e-02 NA 8.9e-01
4 GTEx Esophagus Mucosa 0.1110 0.0390 0.00030 0.056 NA 0.077 NA 0.071 1.2e-04 NA 7.5e-06 NA 1.6e-05
5 GTEx Esophagus Muscularis 0.1160 0.0560 0.00900 0.031 NA 0.017 NA 0.012 5.5e-03 NA 3.2e-02 NA 5.7e-02
6 GTEx Muscle Skeletal 0.1374 0.0433 0.00026 0.040 NA 0.063 NA 0.079 8.3e-05 NA 8.4e-07 NA 3.3e-08
7 GTEx Nerve Tibial 0.0854 0.0377 0.00480 0.076 NA 0.048 NA 0.064 5.0e-06 NA 2.5e-04 NA 2.7e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.5 0.8 2.3 -1.4 -0.5 -0.1 0.8 -1.5 0.3 -0.5
Bipolar Disorder or Schizophrenia 0.2 0.4 2.0 -0.8 0.1 1.4 0.4 -0.3 -0.3 0.2
Depressed Affect (Nagel 2018) 2.3 4.7 9.9 2.1 3.1 0.4 -1.6 1.9 -1.6 3.1
Depression (Nagel 2018) 3.3 5.0 8.5 1.8 2.9 1.1 -2.0 2.5 -2.0 2.9
Intelligence (Savage-Jansen 2018) 0.3 0.8 1.5 -1.2 -1.0 -1.1 -0.5 -0.6 -0.1 -1.1
Neuroticism (Nagel 2018) 1.3 3.2 6.7 1.2 2.6 -0.0 -1.7 1.0 -1.9 2.5
Schizophrenia (2018) 0.3 0.7 3.3 -0.0 0.4 1.8 -0.1 0.6 -0.7 0.5
Schizophrenia vs Biploar Disorder 1.9 2.5 7.4 0.1 0.9 1.3 -1.7 1.8 -2.7 1.1
Worry (Nagel 2018) 0.3 0.6 2.2 -0.8 -0.5 -1.5 0.2 -1.0 0.4 -0.5
Alzheimer’s Disease (in mother) 1.6 1.9 3.6 -1.2 -1.4 0.1 1.7 -0.5 1.9 -1.7
Alzheimer’s Disease (in father) 0.6 0.6 1.5 -0.2 -1.0 0.5 0.9 -0.2 1.2 -1.0
Alzheimer’s Disease (including proxy) 2.3 3.3 5.2 -1.7 -2.1 0.3 2.2 -0.9 2.2 -2.3
Crohns Disease (2017) 0.2 0.4 1.5 0.1 -0.3 -1.2 -1.1 -0.4 0.1 -0.3
Irritable Bowel Disease (IBD) 1.7 4.0 6.9 -2.4 -2.5 -2.4 -0.3 -1.8 0.3 -2.6
Ulcerative Colitis (UC) 3.9 7.4 14.3 -3.3 -3.6 -2.5 0.8 -2.2 1.1 -3.8
Major Depression (MDD) 2.6 3.1 5.5 2.3 2.1 1.3 -1.5 1.9 -0.7 2.1
Reaction Time 2.8 5.2 9.7 2.1 3.0 2.6 -0.8 2.3 -1.2 3.1
Verbal and Numeric Reasoning (VNR) 0.1 0.3 1.0 -0.5 -0.5 -1.0 -0.1 -0.5 0.2 -0.5
Breast Cancer 0.2 0.5 0.9 -0.7 -0.7 0.0 0.5 -1.0 0.7 -0.7
Ovarian Cancer 0.6 0.7 1.8 0.4 0.5 0.7 -1.4 0.4 -1.3 0.6
Prostate Cancer 0.6 0.8 2.5 -1.1 -0.8 0.2 0.2 -1.6 -0.2 -1.0
Age at First Birth 3.7 5.3 9.5 -2.5 -3.1 -0.8 2.3 -2.0 1.7 -3.0
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 2.5 3.5 6.3 1.6 2.5 0.5 -2.2 1.3 -1.6 2.5
Coronary Artery Disease (CAD) 1.4 1.7 4.2 1.4 2.0 1.2 -0.8 0.3 -0.2 2.0
Crohns Disease (2012) 0.2 0.4 1.3 -0.3 -0.3 -0.9 -0.7 -1.1 -0.1 -0.2
Mean Putamen Volume 0.9 1.1 2.1 -1.0 -1.3 -1.0 -0.6 -1.4 -0.5 -1.2
Fasting Glucose 0.3 0.4 1.6 -0.3 -0.3 -1.3 0.5 -0.3 0.7 -0.3
HbA1C 1.7 1.8 5.1 0.0 1.5 -0.5 -1.7 -0.0 -2.3 1.5
HDL Cholesterol 0.7 1.1 2.2 -0.4 -1.4 -0.2 1.1 -0.7 1.4 -1.5
LDL Cholesterol 3.4 5.4 7.6 2.3 2.5 2.6 -1.9 2.3 -1.7 2.7
Lupus 0.4 0.6 1.6 -1.3 -0.9 0.3 0.2 -0.6 0.0 -1.1
Neuroticism (2016) 0.3 0.5 1.0 0.1 0.9 0.5 -0.4 0.4 -0.9 1.0
Primary Biliary Cirrhosis 0.1 0.2 0.9 0.0 0.5 0.1 0.0 0.9 -0.0 0.5
Rheumatoid Arthritis 0.7 1.0 3.3 0.3 -0.7 0.2 1.2 0.9 1.8 -0.7
Schizophrenia (2014) 0.5 1.1 3.8 -1.2 0.0 1.0 -1.2 0.0 -1.9 0.2
Triglycerides 5.0 8.2 14.7 2.0 3.7 -0.8 -3.3 2.5 -2.6 3.8
Type 2 Diabetes (T2D) (2012) 6.0 6.9 19.1 -0.3 2.5 -0.7 -3.8 1.0 -4.4 2.6
Ulcerative Colitis 0.8 1.2 2.8 -1.7 -1.0 -0.8 -1.2 -0.5 -1.1 -1.2
Blood Eosinophil Count 11.2 86.3 144.0 8.4 11.9 4.7 -8.4 9.5 -8.0 12.0
Blood Platelet Count 0.8 9.6 21.3 -3.6 -3.2 -3.5 0.3 -4.6 -0.6 -3.2
Blood Red Count 0.0 0.4 0.9 0.9 0.3 -0.1 0.9 -0.3 1.0 0.4
Blood White Count 0.3 2.0 3.9 0.6 2.0 -1.0 -1.4 -0.6 -1.6 1.9
Heel T-Score 0.9 7.2 13.5 -1.5 -3.6 -0.4 2.6 -1.3 3.7 -3.6
BMI 4.6 26.8 47.3 4.3 6.8 0.3 -5.8 4.2 -4.8 6.9
Height 2.4 45.6 90.6 6.9 7.3 7.8 -2.3 9.5 -2.7 7.3
Waist Hip Ratio (WHR) 1.1 4.9 9.5 1.2 2.9 0.5 -1.8 2.2 -2.6 3.1
Systolic Blood Pressure 3.0 15.0 23.7 -4.1 -4.8 -3.1 2.2 -4.8 2.0 -4.9
Smoking Status 1.1 2.6 5.2 2.1 2.2 0.6 -1.1 1.4 -0.1 2.3
Allergy or Eczema 1.3 3.4 5.2 1.2 2.1 0.6 -2.2 1.8 -2.1 2.3
Cardiovascular Disease 0.3 1.0 2.9 -0.5 0.7 -0.4 -1.7 -0.6 -1.6 0.6
Hypothyroidism (self reported) 0.6 1.3 4.2 1.0 1.1 1.2 0.0 2.0 -0.0 1.2
Respiratory disease 1.2 2.7 7.3 2.2 1.7 0.6 0.3 2.7 0.4 1.7
Type 2 Diabetes (T2D) (2018) 3.8 7.2 12.9 1.3 3.1 0.1 -3.0 2.3 -3.6 3.4
Lung FEV1/FVC ratio 7.7 39.3 63.0 5.5 7.9 5.0 -6.0 5.0 -5.8 7.9
Lung FVC 2.3 11.8 24.4 -3.2 -4.0 -2.0 2.3 -4.9 2.4 -4.2
Neuroticism 2.6 6.2 11.9 2.1 3.5 1.4 -2.2 2.4 -1.9 3.4
Chronotype (morning person) 0.8 1.9 4.3 0.2 1.5 0.4 -1.8 1.0 -2.1 1.5
Hair Pigment 0.3 8.2 15.8 3.3 4.0 0.6 -2.1 2.7 -1.6 4.0
Tanning 0.2 1.9 6.4 0.0 1.3 0.2 -1.8 0.3 -2.5 1.3
Hand grip strength (left) 3.6 9.6 20.7 -2.6 -3.6 -1.5 2.4 -4.5 2.1 -3.8
Number of treatments/medications taken 7.6 13.6 24.9 3.2 5.0 0.8 -3.9 3.0 -3.4 4.9
Average weekly spirits intake 0.7 0.8 2.4 0.6 1.0 -0.4 -1.6 -0.1 -1.0 1.0
Sensitivity / hurt feelings 2.1 3.7 5.9 0.8 2.4 1.7 -2.1 1.0 -2.4 2.3
Frequency of depressed mood in last 2 weeks 1.5 2.2 4.8 0.9 1.9 1.2 -0.6 2.2 -0.7 1.9
Hearing difficulty/problems: Yes 1.7 2.6 4.6 -1.2 -2.1 -0.5 1.9 -1.1 1.7 -2.0
Relative age of first facial hair 0.9 1.8 3.3 -1.2 -1.8 -0.5 1.7 -0.1 1.2 -1.7
Other serious medical condition/disability diagnosed by doctor 1.2 1.5 4.3 -0.5 1.4 0.8 -1.3 -0.4 -2.1 1.3
Ever used hormone-replacement therapy (HRT) 6.8 8.6 14.4 2.8 3.8 1.8 -2.5 3.4 -1.8 3.8
Ever had hysterectomy (womb removed) 1.6 1.8 5.7 1.5 1.6 -0.3 -0.3 2.4 0.4 1.3
Systolic blood pressure, automated reading 0.7 2.2 4.0 -1.3 -1.9 -0.8 1.0 -1.8 0.9 -2.0
Eye problems/disorders: Diabetes related eye disease 2.0 2.2 5.8 0.0 1.3 -0.8 -2.0 0.9 -2.4 1.6
Angina 1.8 2.3 3.8 1.7 1.9 0.6 -1.5 1.6 -1.2 1.9
Medication for hormone replacement therapy 3.7 4.1 7.9 1.7 2.8 1.3 -1.6 2.1 -1.5 2.7
Vitamin and mineral supplements 3.5 4.8 9.3 -1.3 -2.6 0.3 2.7 -1.4 3.1 -2.6
Supplements: Zinc 0.9 0.9 2.8 0.1 -0.1 1.1 -1.0 1.3 -1.7 -0.1
Medication: Co-codamol 1.3 1.6 2.3 1.0 1.5 1.3 -1.4 0.8 -1.2 1.4
Medication: Metformin 4.6 6.5 9.9 1.7 3.0 -0.0 -3.1 2.3 -2.9 3.1
Diabetes (father) 0.7 0.9 1.5 -1.2 -1.0 -1.1 -0.7 -0.8 -0.6 -1.0
Diabetes (mother) 0.7 0.9 3.3 -0.6 0.5 -0.9 -1.0 0.2 -1.8 0.6
Severe depression (siblings) 0.2 0.3 0.7 -0.7 -0.2 0.5 0.9 -0.3 -0.3 -0.1
Pack years adult smoking proportion 1.7 2.6 6.5 -0.5 0.9 -1.8 -2.5 -0.6 -2.4 1.1
Impedance of leg (right) 0.1 0.6 3.2 -0.2 -0.3 1.8 0.6 0.6 -0.7 -0.2
Leg fat-free mass (left) 2.7 14.6 23.8 3.9 4.9 1.6 -3.1 4.6 -2.4 4.8
Trunk fat percentage 12.3 49.2 80.9 5.8 9.0 3.2 -6.7 7.0 -6.7 9.0
Hand grip strength (right) 3.8 10.3 17.5 -3.2 -4.0 -2.4 2.2 -3.6 2.2 -4.2
Townsend deprivation index at recruitment 3.6 5.1 10.5 1.6 3.0 0.8 -1.9 2.5 -1.8 3.2
Current tobacco smoking 5.6 9.2 16.5 2.5 4.0 0.9 -3.5 2.3 -2.7 4.1
Average weekly fortified wine intake 1.3 1.5 3.9 -0.4 -1.4 -0.2 1.6 -0.4 2.0 -1.4
Maternal smoking around birth 1.8 2.6 5.2 2.0 2.3 0.2 -0.4 2.0 0.0 2.2
Fed-up feelings 3.9 7.2 11.4 1.9 3.4 0.7 -2.7 3.0 -2.7 3.3
Frequency of unenthusiasm / disinterest in last 2 weeks 5.0 6.6 10.4 1.5 3.2 1.1 -2.8 2.6 -2.8 3.1
Relative age voice broke 0.3 0.5 2.0 -0.4 -0.4 -0.2 1.4 0.1 1.0 -0.4
Taking other prescription medications 7.6 11.8 18.9 2.8 4.3 1.4 -3.4 4.0 -2.6 4.3
Age when periods started (menarche) 0.6 1.5 2.5 -1.4 -1.4 -0.5 1.6 -1.3 1.0 -1.2
Bilateral oophorectomy (both ovaries removed) 3.3 3.8 8.4 2.2 2.6 0.1 -0.8 2.9 0.1 2.4
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 2.4 0.1 -0.9 -0.0 0.9 0.1 1.5 -0.9
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.9 -0.9 -0.5 -0.0 0.2 0.0 -0.9 -0.3
Qualifications: CSEs or equivalent 2.1 2.8 4.7 -2.2 -2.1 -1.1 1.5 -1.5 0.3 -2.1
Serious illness, injury or assault to yourself 3.1 3.8 11.6 -0.2 1.9 0.7 -2.2 1.3 -3.4 2.1
High blood pressure 0.3 0.9 2.2 -0.9 0.2 -1.5 -0.9 -0.5 -1.4 0.1
Hayfever, allergic rhinitis or eczema 2.0 4.3 6.7 1.3 2.3 0.8 -2.2 2.6 -2.3 2.4
Multivitamins +/- minerals 4.4 5.6 10.4 1.2 2.9 -1.0 -3.0 1.1 -3.2 2.8
Stomach or abdominal pain in last month 1.8 2.2 6.4 -1.3 0.3 -1.4 -2.2 -0.6 -2.5 0.1
Supplements: Glucosamine 0.4 0.5 1.6 0.4 -0.2 0.1 1.2 0.5 1.3 -0.5
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.5 -0.4 -0.6 -0.5 0.7 -0.3 0.1 -0.6
Medication: Atenolol 0.2 0.3 1.1 -0.8 -0.0 -0.5 -1.0 -0.2 -0.2 -0.1
Medication: Levothyroxine sodium 0.1 0.1 0.5 -0.2 0.1 -0.7 -0.2 0.4 -0.1 0.2
Sitting height 1.0 7.1 14.6 3.8 2.9 2.6 0.0 3.5 0.7 2.7
Chronic bronchitis/emphysema (father) 0.8 0.9 1.8 -0.0 0.6 -1.0 -0.8 1.3 -1.4 0.7
High blood pressure (mother) 2.5 3.6 7.1 -2.7 -2.1 -1.7 0.4 -2.4 -0.2 -2.2
Body mass index (BMI) 4.6 19.4 33.5 3.4 5.8 0.5 -4.9 3.6 -4.5 5.7
Impedance of leg (left) 0.1 0.4 1.9 -0.2 -0.3 1.4 0.7 0.5 -0.6 -0.2
Leg predicted mass (left) 2.7 14.5 23.8 3.9 4.9 1.7 -3.1 4.6 -2.4 4.8
Trunk fat mass 12.1 52.1 86.5 6.3 9.3 3.3 -6.7 7.4 -6.5 9.3
Waist circumference 9.4 34.5 58.6 4.7 7.7 1.9 -5.6 5.7 -5.8 7.6
Number of incorrect matches in round 2.2 3.6 6.9 1.9 2.6 0.8 -2.2 0.2 -1.8 2.5
Past tobacco smoking 0.1 0.2 0.6 -0.6 -0.7 0.2 0.0 0.5 -0.3 -0.5
Alcohol usually taken with meals 3.3 5.4 8.7 -2.4 -3.0 -1.2 2.0 -2.6 1.6 -2.8
Nervous feelings 0.2 0.3 0.8 -0.0 -0.3 0.6 0.9 -0.5 0.7 -0.4
Frequency of tenseness / restlessness in last 2 weeks 3.4 5.3 8.4 1.4 2.9 1.2 -2.4 2.8 -2.0 2.8
Hearing difficulty/problems with background noise 0.3 0.6 1.2 -0.1 -0.9 -0.3 1.1 -0.4 1.1 -0.7
Hair/balding pattern: Pattern 2 0.1 0.2 0.9 -0.2 -0.1 0.1 -0.4 -0.3 -0.9 -0.0
Had menopause 1.6 2.0 3.4 1.0 1.8 -0.2 -1.6 1.1 -1.6 1.7
Had other major operations 2.2 2.7 5.0 2.2 2.1 0.9 -0.6 2.0 -0.4 2.0
Forced vital capacity (FVC) 0.5 2.1 5.3 0.2 -1.3 0.9 1.9 -0.9 2.3 -1.3
Heel bone mineral density (BMD) T-score, automated (right) 0.4 0.9 3.1 0.2 -0.8 0.3 1.2 0.5 1.8 -0.8
Ever unenthusiastic/disinterested for a whole week 2.8 3.4 6.9 1.9 2.6 1.6 -0.3 1.9 -0.4 2.6
Qualifications: None of the above 0.9 1.9 3.4 1.8 1.8 1.2 -0.1 1.4 0.2 1.8
Financial difficulties in last 2 years 0.3 0.4 0.9 0.2 0.9 0.9 0.2 0.7 -0.2 0.9
Mouth/teeth dental problems 0.5 0.8 1.2 -0.9 -1.1 -1.1 0.6 0.5 0.9 -1.1
Heart attack 0.9 1.1 2.5 1.0 1.3 1.6 -0.7 0.7 -0.4 1.1
Allergy 1.5 3.6 7.3 -1.4 -2.1 -0.7 1.8 -2.7 1.8 -2.1
Pain all over the body in last month 0.7 0.7 2.2 1.5 1.0 0.1 -0.2 0.9 0.3 1.0
Diabetes (self-reported) 2.6 3.9 6.8 1.2 2.4 -0.4 -1.6 2.4 -2.3 2.6
Hayfever/allergic rhinitis (self-reported) 2.8 3.7 6.4 2.5 2.5 1.1 -1.4 1.7 -1.3 2.5
Medication: Ramipril 1.1 1.4 2.7 -1.4 0.0 -1.3 -1.5 -0.9 -1.6 -0.1
Medication: Simvastatin 1.1 1.6 3.2 0.7 1.8 -0.1 -1.3 1.4 -1.0 1.8
Fluid intelligence score 0.1 0.3 1.0 -0.4 -0.5 -0.3 -0.6 -1.0 -0.2 -0.4
Illnesses of siblings 2.3 3.3 8.8 -0.3 -2.0 0.3 2.5 -0.4 3.0 -1.9
Neuroticism score 1.1 2.3 5.3 0.5 2.3 0.4 -1.5 0.8 -1.8 2.1
Weight 7.4 36.3 59.8 5.7 7.7 3.0 -5.2 6.5 -4.9 7.7
Impedance of arm (right) 0.4 2.0 6.7 0.2 0.5 2.6 0.4 2.4 -0.8 0.7
Arm fat percentage (right) 7.9 31.1 52.9 4.5 7.3 1.8 -5.6 5.3 -5.5 7.2
Trunk fat-free mass 1.3 7.7 14.1 3.3 3.3 2.0 -1.4 3.8 -1.1 3.2
Hip circumference 5.1 21.9 35.5 3.9 6.0 1.9 -4.5 4.8 -4.7 5.8
Time employed in main current job 0.8 0.9 1.6 0.9 1.1 -1.3 -1.0 0.7 -0.6 1.0
Alcohol intake versus 10 years previously 0.7 1.1 1.9 0.5 1.3 0.3 -1.4 1.0 -1.3 1.2
Father’s age at death 1.6 2.2 4.8 -2.2 -1.4 -0.9 -0.3 -2.1 -0.9 -1.5
Worrier / anxious feelings 0.4 0.7 2.2 -1.0 -0.3 -1.3 0.2 -1.5 -0.0 -0.5
Frequency of tiredness / lethargy in last 2 weeks 4.3 7.1 11.5 1.1 3.4 -2.3 -3.4 1.6 -2.8 3.1
Falls in the last year 2.8 3.7 6.6 1.1 2.6 0.9 -2.2 1.4 -2.0 2.6
Hair/balding pattern: Pattern 3 1.2 1.7 4.0 -2.0 -1.6 -0.6 0.8 -1.2 0.1 -1.6
Number of live births 0.5 0.7 1.6 -0.9 -1.2 -0.2 0.4 -1.0 0.3 -1.3
Forced expiratory volume in 1-second (FEV1) 0.1 0.5 2.2 0.6 -0.1 1.5 0.6 -0.2 0.7 -0.1
Pulse rate 3.1 5.2 14.0 1.0 1.9 -0.1 -3.7 1.0 -3.5 2.1
Happiness 2.6 3.1 5.7 1.7 2.3 1.4 -0.8 2.0 -1.1 2.4
Noisy workplace 0.1 0.1 0.2 0.4 0.1 -0.4 -0.5 -0.1 -0.1 0.1
Qualifications: A levels/AS levels or equivalent 3.0 6.6 14.5 -3.0 -2.9 -2.1 0.8 -3.8 0.6 -2.9
Serious illness, injury or assault of a close relative in last 2 years 4.5 5.2 8.5 -2.8 -2.2 -2.8 1.1 -2.9 1.2 -2.2
Mouth/teeth dental problems: Dentures 0.5 0.9 2.6 -0.2 0.8 0.0 -1.3 -0.6 -1.6 0.8
Asthma 1.6 3.2 7.8 2.8 2.0 0.9 0.2 2.4 0.3 2.0
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 1.1 0.5 1.1 0.1 -0.9 -0.5 -0.9 1.0
Medication: Cholesterol lowering 1.1 1.7 3.2 0.6 1.6 0.9 -1.8 1.2 -1.2 1.6
Depression (self-reported) 0.5 0.6 1.5 0.5 0.4 0.3 0.8 1.2 1.1 0.3
Medication: Lansoprazole 0.4 0.4 1.2 -0.4 0.0 -1.1 -0.8 0.9 -0.5 0.1
Prospective memory result 7.7 9.5 13.9 3.5 3.6 3.4 -1.6 3.7 -0.9 3.6
Lung cancer (father) 0.4 0.5 1.1 1.0 1.1 0.2 -0.3 -0.1 -0.5 0.9
Illnesses of mother 2.1 2.6 5.8 1.9 1.6 1.7 -0.5 2.4 -0.4 1.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.0 5.0 0.6 -0.5 2.2 0.7 -0.3 0.8 -0.5
Pulse wave Arterial Stiffness index 0.8 1.0 2.0 0.6 1.1 0.9 -0.9 0.6 -1.4 1.1
Impedance of arm (left) 0.6 2.8 8.9 0.8 1.1 2.5 -0.1 3.0 -0.9 1.3
Arm fat mass (right) 8.3 34.1 57.2 4.9 7.6 2.1 -5.8 5.7 -5.6 7.5
Trunk predicted mass 1.3 7.5 13.8 3.3 3.2 2.0 -1.4 3.7 -1.1 3.1
Standing height 2.4 23.3 47.6 5.4 5.0 5.7 -1.3 6.9 -1.4 5.0
Length of working week for main job 1.3 1.4 4.1 0.9 1.5 0.4 -0.6 2.0 -0.5 1.5
Exposure to tobacco smoke at home 1.9 2.1 4.2 1.6 2.0 1.1 -0.2 1.7 0.2 2.0
Breastfed as a baby 2.7 3.3 7.5 -2.7 -2.2 -1.1 -0.2 -2.0 -1.0 -2.2
Tense / ‘highly strung’ 0.5 0.8 2.4 -0.2 0.9 1.5 -0.7 -0.1 -1.0 0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 2.3 0.2 0.5 -0.2 1.5 0.1 0.6 0.5
Hair/balding pattern: Pattern 4 0.3 0.8 2.2 1.1 0.1 0.5 1.1 0.7 1.5 0.1
Birth weight of first child 0.3 0.6 1.5 0.2 -0.5 -0.4 1.1 -0.9 1.2 -0.4
Peak expiratory flow (PEF) 0.2 0.4 1.1 -0.6 -0.6 -0.0 0.4 -1.1 0.1 -0.8
Pulse wave reflection index 1.5 1.8 5.6 -0.0 -1.1 0.4 2.4 -1.0 1.9 -1.2
Ever highly irritable/argumentative for 2 days 1.3 1.6 2.7 0.6 1.3 0.8 -1.4 1.6 -1.3 1.4
Loud music exposure frequency 2.3 2.5 4.8 0.6 1.4 -1.6 -2.2 1.7 -1.8 1.4
Qualifications: O levels/GCSEs or equivalent 3.0 4.8 9.8 -2.7 -2.3 -2.4 0.2 -3.1 -0.2 -2.3
Mouth/teeth dental problems: Bleeding gums 0.7 0.9 2.2 1.5 0.6 0.7 0.5 1.3 1.0 0.6
Blood clot in the leg (DVT) 1.2 1.6 4.6 -0.5 0.8 1.2 -1.8 0.7 -2.1 0.8
Medication: Paracetamol 1.3 2.2 3.8 0.9 1.7 0.8 -2.0 0.7 -1.9 1.7
Headache pain in last month 3.0 5.1 8.7 1.5 2.9 1.3 -2.3 1.7 -2.6 2.8
Medication for cholesterol, blood pressure or diabetes 1.1 1.8 4.2 -0.8 -1.6 -0.3 2.0 -0.3 1.5 -1.5
Glaucoma (self-reported) 1.1 1.3 2.6 0.5 1.6 0.4 -1.2 0.3 -1.6 1.4
Gout (self-reported) 2.3 3.2 4.4 1.5 1.7 2.1 -2.0 1.9 -1.5 1.8
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 0.8 0.7 0.9 0.1 -0.3 0.8 -0.2 0.9
Medication: Amlodipine 1.0 1.5 3.6 -1.3 -1.1 -1.9 0.1 -1.6 -0.2 -1.1
Medication: Ventolin 100micrograms inhaler 1.0 1.2 3.0 0.6 1.6 -0.6 -0.8 0.9 -1.1 1.7
Birth weight 2.2 4.8 8.8 3.0 2.6 1.2 -0.7 2.9 -0.2 2.8
Chronic bronchitis/emphysema (mother) 0.3 0.3 0.7 0.9 0.5 -0.4 -0.5 0.7 -0.2 0.6
High blood pressure (siblings) 2.8 4.0 6.5 1.3 2.5 1.1 -2.2 1.5 -2.4 2.5
Forced vital capacity (FVC), Best measure 0.7 2.5 4.8 0.5 -1.4 2.1 2.0 -0.4 2.2 -1.4
Body fat percentage 11.2 44.4 74.0 5.6 8.6 2.5 -6.5 6.5 -6.4 8.6
Leg fat percentage (right) 7.7 27.8 46.5 4.1 6.8 1.4 -5.5 4.6 -5.7 6.8
Arm fat-free mass (right) 2.1 10.7 18.6 3.8 4.3 1.1 -2.4 3.8 -1.8 4.2
Exposure to tobacco smoke outside home 3.3 4.4 8.5 2.1 2.9 1.0 -1.6 2.3 -0.9 2.8
Comparative body size at age 10 0.9 2.4 4.6 1.2 2.1 -0.1 -1.8 0.6 -1.6 2.2
Number of full brothers 0.4 0.5 1.1 0.3 0.5 0.8 -0.5 1.1 -0.8 0.7
Worry too long after embarrassment 0.6 1.0 3.4 0.1 1.2 0.5 -0.8 0.3 -1.8 1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 1.0 1.3 2.4 0.3 1.6 1.0 -0.1 1.4 -1.1 1.6
Wheeze or whistling in the chest in last year 6.4 11.5 21.9 3.6 4.5 0.8 -1.7 4.7 -1.1 4.5
Number of children fathered 1.3 1.5 2.5 -0.5 -1.4 -1.5 0.9 -1.6 0.9 -1.4
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.1 2.4 1.5 1.0 1.5 -0.3 0.9 0.1 0.9
Age at first live birth 3.2 5.7 10.6 -2.0 -3.3 -0.0 2.5 -2.0 2.2 -3.2
Pulse wave peak to peak time 0.7 0.8 2.2 -0.3 -0.9 -0.7 1.0 -0.4 1.5 -0.9
Health satisfaction 6.1 8.0 12.3 1.5 3.5 0.6 -3.5 2.1 -3.5 3.5
Shortness of breath walking on level ground 3.0 3.6 6.1 0.7 2.4 0.4 -2.3 1.8 -2.1 2.5
Qualifications: College or University degree 0.2 0.7 2.1 -0.2 -1.0 0.1 1.0 -0.5 1.4 -0.9
Eye problems/disorders: None of the above 2.8 3.2 7.7 -0.3 -1.8 0.8 2.8 -0.2 2.7 -1.9
Mouth/teeth dental problems: Loose teeth 1.0 1.2 2.2 0.7 1.2 0.5 -1.5 -0.8 -1.4 1.2
Emphysema/chronic bronchitis 1.0 1.1 3.1 -1.6 -0.2 -1.8 -0.3 -0.2 -1.3 -0.2
Medication for pain relief, constipation, heartburn 4.2 7.2 13.1 -2.1 -3.6 -1.3 2.9 -2.1 2.7 -3.4
Neck or shoulder pain in last month 6.1 8.7 14.9 1.4 3.2 3.9 -2.8 2.2 -3.2 3.2
Medication: Blood pressure 0.3 0.6 1.2 0.1 0.7 -0.4 -1.1 -0.9 -1.1 0.6
Angina (self-reported) 2.0 2.6 3.8 1.6 1.9 0.6 -1.8 1.7 -1.4 1.9
Migraine (self-reported) 0.4 0.5 0.8 0.7 0.5 0.9 -0.8 0.9 -0.7 0.4
Medication: Ibuprofen 1.0 1.2 2.1 -0.1 0.9 -1.0 -1.5 -1.4 -1.3 0.9
Medication: Allopurinol 2.4 3.2 5.2 2.2 2.2 1.5 -1.7 1.1 -1.2 2.3
Medication: Omeprazole 3.9 4.6 8.2 1.8 2.9 -1.0 -2.6 0.7 -2.2 2.8
Medication: Seretide 50 evohaler 3.4 3.9 6.3 2.1 2.5 1.9 -1.3 2.1 -0.9 2.4
Mean time to correctly identify matches 2.4 4.5 8.5 1.3 2.8 2.3 -1.4 1.3 -2.0 2.9
Heart disease (mother) 0.2 0.2 0.5 0.3 0.7 0.0 -0.7 -0.5 -0.0 0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.2 -0.3 0.2 -0.1 -0.0 0.5 -0.4 0.2
Whole body fat mass 10.8 45.1 75.5 5.8 8.7 2.6 -6.4 6.8 -6.2 8.6
Leg fat mass (right) 8.6 33.2 56.3 4.9 7.5 1.6 -5.9 5.3 -5.7 7.4
Arm predicted mass (right) 2.4 12.3 21.1 4.1 4.6 1.5 -2.5 4.0 -1.9 4.5
Pulse rate, automated reading 2.6 8.4 19.3 1.3 2.6 -0.1 -4.4 1.7 -4.4 3.0
Alcohol intake frequency. 0.4 0.9 4.1 -0.5 0.4 0.3 -1.0 0.7 -2.0 0.5
Comparative height size at age 10 2.9 15.8 25.1 4.1 4.5 3.0 -3.5 5.0 -3.0 4.3
Number of full sisters 0.5 0.6 2.9 0.5 0.3 1.7 0.5 0.5 -0.4 0.5
Suffer from ‘nerves’ 0.6 0.9 2.6 0.6 1.6 -0.2 0.2 1.0 -0.1 1.5
Overall health rating 7.7 16.6 28.8 3.2 5.4 1.3 -4.0 3.9 -4.0 5.4
Chest pain or discomfort 1.1 1.5 2.4 1.2 1.5 0.7 -1.2 1.6 -0.8 1.3
Had major operations 0.6 0.7 1.4 0.8 1.2 0.8 -0.4 0.6 -0.6 1.1
Age at last live birth 5.3 7.6 13.5 -2.5 -3.6 -0.9 3.0 -2.3 2.5 -3.7
Family relationship satisfaction 3.8 4.6 10.5 2.2 3.2 0.3 -1.2 2.1 -1.1 3.2
Leg pain on walking 2.5 3.1 5.2 0.7 2.3 0.3 -2.2 1.7 -1.7 2.2
Qualifications: NVQ or HND or HNC or equivalent 0.8 1.0 1.9 -0.3 -1.1 -1.2 1.4 -0.4 1.0 -1.1
Commuting to job workplace: Car/motor vehicle 0.5 0.5 1.7 -0.2 -0.0 -1.3 -1.0 -1.0 -0.2 -0.2
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.3 0.0 -0.6 0.1 -0.3 0.0 0.1 -0.5
Medication: Aspirin 1.0 1.3 2.9 0.6 1.3 0.7 -1.0 1.7 -1.0 1.2
Supplements: Vitamin C 0.4 0.4 2.0 0.6 0.5 -0.4 0.1 1.4 0.1 0.5
Knee pain experienced in last month 3.8 5.9 12.0 1.5 2.4 2.3 -2.5 3.5 -2.1 2.2
Hypertension (Self-reported) 0.3 0.8 2.2 -0.6 0.5 -1.1 -1.1 -0.5 -1.5 0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.4 -0.2 0.2 0.1 0.0 0.6 -0.0 0.1
Illnesses of father: Heart disease 0.4 0.6 1.3 1.1 1.1 -0.3 -0.5 0.6 0.3 1.0
Illnesses of siblings: Diabetes 0.6 0.8 2.2 0.4 0.9 -0.3 -1.2 0.3 -1.5 0.9
Smoking status: Previous 0.7 1.1 2.2 -0.0 -0.8 -0.5 1.3 -1.3 1.5 -1.0
Forced expiratory volume in 1-second (FEV1), predicted 1.1 2.2 4.8 1.4 0.2 2.2 1.3 2.2 1.5 0.2
Whole body fat-free mass 2.0 11.1 18.1 3.8 4.2 1.9 -2.2 4.3 -1.7 4.1
Leg fat-free mass (right) 2.1 11.3 19.0 3.6 4.4 1.3 -2.5 4.2 -1.9 4.3
Arm fat percentage (left) 8.6 34.3 58.4 4.8 7.6 1.7 -5.8 5.8 -5.6 7.6
Average weekly red wine intake 0.2 0.3 1.5 0.5 0.3 -0.5 -0.4 -1.2 0.3 0.3
Handedness (chirality/laterality): Left-handed 1.1 1.4 4.7 1.1 -0.0 0.5 1.8 -0.5 2.2 -0.0
Mood swings 1.5 2.7 5.9 0.5 2.0 0.8 -2.1 0.4 -2.4 1.9
Loneliness, isolation 6.2 8.6 18.8 2.9 4.2 0.8 -2.0 2.7 -1.9 4.3
Long-standing illness, disability or infirmity 5.1 7.8 14.8 2.6 3.9 0.4 -2.5 2.6 -2.3 3.8
Ever had bowel cancer screening 0.4 0.4 0.9 -0.0 0.5 -1.0 -0.5 0.7 -0.9 0.5
Diabetes diagnosed by doctor 3.4 5.5 8.9 0.9 2.8 -0.7 -2.2 2.7 -2.9 3.0
Ever had stillbirth, spontaneous miscarriage or termination 2.1 2.2 5.1 1.8 2.3 0.4 -0.9 1.2 -0.3 2.2
Friendships satisfaction 0.6 0.8 2.0 0.4 1.4 -0.1 -0.5 0.8 -0.9 1.4
Qualifications: nursing, teaching 1.3 2.0 4.1 -1.9 -1.2 -1.7 -0.1 -2.0 -0.6 -1.3
Commuting to job workplace: Walk 0.4 0.5 1.1 -0.4 -0.9 -0.2 1.1 -0.3 0.6 -0.8
Eye problems/disorders: Cataract 0.5 0.6 1.4 -0.2 0.2 -1.2 -0.9 -1.1 -0.8 0.3
Mouth/teeth dental problems: Mouth ulcers 0.2 0.2 0.9 0.6 0.4 0.9 -0.4 0.1 -0.1 0.4
Medication for cholesterol 2.1 3.2 5.2 -0.7 -2.3 0.5 1.8 -1.9 2.1 -2.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 4.0 4.7 7.9 2.8 2.7 1.7 -2.2 1.9 -0.6 2.5
Back pain experienced in last month 2.0 3.0 5.7 1.2 2.2 -0.2 -2.4 1.3 -1.8 2.0
Mineral and other dietary supplements 0.1 0.1 0.3 -0.2 -0.3 -0.2 -0.6 -0.5 -0.1 -0.3
Breast cancer (self-reported) 0.2 0.2 1.3 0.0 0.0 -1.1 -0.5 -0.3 -0.4 -0.1
Asthma (self-reported) 1.6 3.2 7.0 2.6 2.1 1.1 -0.1 2.4 -0.1 2.1
Osteoporosis (self-reported) 1.1 1.3 3.9 0.8 1.1 -0.1 -2.0 0.2 -1.5 1.1
Osteoarthritis (self-reported) 2.4 3.1 8.2 1.6 1.6 1.5 -1.6 2.9 -1.0 1.6
Medication: Aspirin 0.9 1.2 2.5 0.8 1.2 1.2 -0.9 1.6 -0.9 1.1
Medication: Gliclazide 4.8 5.5 10.7 1.3 3.1 -0.5 -2.2 2.4 -2.3 3.3
Illnesses of father: None of the above (group 1) 0.2 0.2 1.2 -0.2 0.0 0.3 1.1 0.0 0.5 -0.0
Smoking status: Current 6.2 9.8 17.3 2.5 4.1 1.2 -3.6 2.3 -2.8 4.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.3 1.2 -0.0 -0.4 1.1 0.4 -0.4 -0.0 -0.6
Whole body water mass 2.0 11.4 18.6 3.8 4.2 1.9 -2.3 4.3 -1.8 4.1
Leg predicted mass (right) 2.1 11.2 18.7 3.6 4.3 1.4 -2.5 4.2 -1.8 4.2
Arm fat mass (left) 8.4 34.5 58.7 5.0 7.7 1.9 -5.7 5.9 -5.4 7.6
Number of self-reported non-cancer illnesses 4.2 7.3 12.8 2.2 3.6 0.6 -2.7 2.6 -2.5 3.5
Average weekly champagne plus white wine intake 0.3 0.4 0.9 0.3 0.9 0.1 -0.6 0.5 -0.4 1.0
Miserableness 0.5 0.9 1.8 0.9 1.4 0.5 -0.3 1.0 -0.6 1.4
Guilty feelings 1.7 2.6 5.8 1.6 2.4 1.5 -0.6 1.6 -0.6 2.0
Wears glasses or contact lenses 0.1 0.1 0.7 0.1 -0.0 0.0 0.8 -0.4 0.3 -0.0
Ever taken oral contraceptive pill 0.4 0.5 1.5 1.2 0.8 -0.1 -0.1 -0.0 0.6 1.0
Hearing aid user 2.1 2.4 4.8 -1.6 -2.2 -0.1 0.9 -1.9 0.5 -2.2
Mother’s age at death 0.3 0.4 1.1 -0.8 -0.9 0.6 0.1 -0.4 -0.1 -1.0
Financial situation satisfaction 2.7 3.4 8.3 1.3 2.6 -0.9 -1.8 0.8 -1.6 2.9
Tinnitus: Yes, now most or all of the time 1.8 2.1 3.4 1.6 1.5 1.4 -1.4 1.8 -1.2 1.3
Commuting to job workplace: Public transport 0.1 0.1 0.3 -0.5 0.5 -0.2 -0.2 -0.2 -0.4 0.4
Eye problems/disorders: Glaucoma 1.3 1.6 2.9 0.9 1.7 -0.0 -1.3 0.2 -1.7 1.7
Medication: Blood pressure 0.2 0.4 1.5 -0.2 0.2 -1.2 0.1 1.0 -0.4 0.2
Pain type(s) experienced in last month: Hip pain 1.9 2.4 6.5 -0.8 1.4 -0.4 -2.2 1.1 -2.5 1.3
Supplements: Fish oil (including cod liver oil) 0.5 0.6 1.5 -1.2 -0.9 -1.1 0.4 -0.1 -0.2 -0.9
High cholesterol (Self-reported) 1.9 3.3 7.1 0.6 2.1 0.1 -2.7 1.1 -2.5 2.1
Medication: Bendroflumethiazide 0.8 1.3 2.0 0.3 1.1 -1.1 -1.4 1.2 -1.4 1.0
Medication: Paracetamol 2.8 4.4 9.0 1.2 2.3 0.8 -3.0 0.9 -2.9 2.3
Medication: Lisinopril 1.3 1.7 7.0 -1.3 -1.0 -2.7 0.1 -1.0 -0.2 -1.0
Medication: Atorvastatin 5.2 6.5 10.0 1.2 2.8 1.6 -2.5 3.1 -3.2 2.7
Illnesses of father: High blood pressure 2.3 2.9 7.0 -1.6 -2.6 0.1 1.0 -1.1 1.2 -2.6
Alcohol drinker status: Never 1.9 2.3 6.4 0.4 1.2 -0.5 -2.5 0.2 -2.4 1.5
Ever smoked 0.2 0.4 1.5 -0.0 0.6 -1.2 -0.2 -0.8 0.3 0.5
Basal metabolic rate 3.0 16.4 26.6 4.3 5.2 2.1 -3.1 4.9 -2.6 5.1
Leg fat percentage (left) 7.6 27.4 47.5 4.2 6.9 0.9 -5.4 4.6 -5.4 6.8
Arm fat-free mass (left) 2.6 13.2 21.5 3.8 4.6 2.0 -3.0 4.0 -2.7 4.5
Number of operations (self-reported) 1.6 2.4 3.9 1.3 2.0 0.3 -1.7 1.9 -1.1 1.9
Average weekly beer plus cider intake 0.5 0.7 2.4 -0.2 0.0 -1.5 -1.3 -0.0 -1.0 -0.1
Irritability 2.2 3.7 6.2 1.2 2.2 0.8 -2.5 1.5 -2.3 2.2
Risk taking 3.0 4.3 7.1 1.4 2.5 0.9 -2.7 1.4 -2.5 2.5
Ever had prostate specific antigen (PSA) test 0.3 0.4 1.0 -0.5 -0.2 -0.8 -1.0 -0.8 -0.4 0.0
Fractured/broken bones in last 5 years 5.5 7.1 11.6 1.4 3.4 1.2 -2.5 2.6 -3.2 3.4
Age started oral contraceptive pill 0.3 0.3 1.7 0.4 -0.3 1.3 0.3 0.1 -0.0 -0.4
Diastolic blood pressure, automated reading 0.4 1.3 3.4 -0.8 -0.5 -1.7 -1.2 -1.8 -0.6 -0.6
Ever depressed for a whole week 4.8 5.9 12.0 2.4 3.3 2.1 -1.0 2.4 -1.4 3.5
Unable to work because of sickness or disability 2.9 3.7 6.6 0.5 1.9 0.2 -2.5 2.3 -2.6 2.0
Commuting to job workplace: Cycle 2.3 2.8 4.8 1.3 2.0 2.2 -0.8 1.9 -1.1 1.8
Myopia 6.0 8.7 16.3 -3.5 -4.0 -0.0 2.7 -2.5 1.5 -4.0
Vascular/heart problems diagnosed by doctor 0.2 0.6 1.5 0.7 -0.4 1.0 0.9 0.3 1.2 -0.2
Cholesterol lowering medication 2.8 4.1 6.7 1.3 2.5 -0.4 -1.9 2.6 -1.9 2.5
Medication: Omeprazole (e.g. Zanprol) 4.3 5.2 8.8 1.7 3.0 -1.1 -2.9 1.2 -2.4 2.8
Pain experienced in last month 8.3 13.9 20.2 -2.9 -4.5 -3.0 3.6 -4.5 3.1 -4.1
Supplements: Calcium 1.0 1.1 3.4 1.8 1.3 0.4 0.2 0.9 -0.1 1.3
Basal cell carcinoma (self-reported) 0.3 0.4 1.2 0.5 0.6 0.9 -0.1 1.1 0.1 0.5
Heart attack/myocardial infarction (self-reported) 0.9 1.1 2.9 1.0 1.2 1.7 -0.8 0.6 -0.4 1.1
Deep venous thrombosis (DVT) (self-reported) 1.1 1.4 4.6 -0.8 0.5 0.8 -1.9 0.4 -2.1 0.5
Heart disease (siblings) 2.0 2.5 4.6 0.8 2.1 0.1 -2.1 -0.4 -1.8 2.1
Alcohol drinker status: Previous 4.7 5.3 9.6 0.5 2.7 1.3 -2.6 2.0 -3.1 2.7
Pack years of smoking 2.1 3.1 7.7 -0.0 1.3 -1.8 -2.8 -0.3 -2.6 1.5
Impedance of whole body 0.3 1.8 6.1 0.7 0.7 2.5 0.4 2.0 -0.6 0.8
Leg fat mass (left) 8.8 34.3 59.1 5.1 7.7 1.4 -5.9 5.4 -5.5 7.6
Arm predicted mass (left) 2.4 12.1 19.9 3.8 4.5 1.8 -2.8 4.0 -2.5 4.3