Best TWAS P=3.36e-09 · Best GWAS P=6.63e-08 conditioned to 0.0421
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Caudate basal ganglia | SEMA6C | 0.35 | 0.22 | lasso | 2 | 0.17 | 1.1e-05 | 4.1 | 5.2 | 1.7e-07 | 0.82 | 0.14 | 0.56 | FALSE |
| 2 | GTEx | Brain Cerebellar Hemisphere | ECM1 | 0.27 | 0.09 | lasso | 6 | 0.04 | 3.2e-02 | 4.7 | 5.4 | 5.7e-08 | 0.19 | 0.02 | 0.94 | FALSE |
| 3 | GTEx | Brain Cerebellum | ECM1 | 0.34 | 0.21 | lasso | 6 | 0.19 | 3.2e-06 | 5.1 | 5.6 | 2.2e-08 | 0.18 | 0.01 | 0.98 | FALSE |
| 4 | GTEx | Breast Mammary Tissue (Female) | MRPS21 | 0.18 | 0.09 | lasso | 6 | 0.12 | 1.9e-04 | 5.0 | 5.2 | 1.8e-07 | 0.12 | 0.02 | 0.89 | FALSE |
| 5 | GTEx | Skin Not Sun Exposed Suprapubic | GABPB2 | 0.12 | 0.02 | enet | 10 | 0.04 | 2.7e-03 | 4.8 | 5.3 | 1.3e-07 | 0.85 | 0.02 | 0.95 | FALSE |
| 6 | METSIM | Adipose | BNIPL | 0.05 | 0.01 | blup | 313 | 0.03 | 9.7e-05 | 3.5 | 5.7 | 1.5e-08 | 0.60 | 0.15 | 0.76 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | BNIPL | 0.03 | 0.02 | blup | 35 | 0.02 | 6.4e-03 | 4.3 | 5.9 | 3.4e-09 | 0.82 | 0.01 | 0.60 | TRUE |
| 8 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | RPRD2 | 0.14 | 0.13 | enet | 8 | 0.13 | 1.5e-04 | 5.0 | 5.5 | 5.2e-08 | -0.11 | 0.00 | 0.74 | TRUE |