Best TWAS P=5.74e-10 · Best GWAS P=9.93e-11 conditioned to 0.000161
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | DHX36 | 0.05 | 0.06 | blup | 357 | 0.05 | 1.3e-06 | -4.7 | -5.8 | 5.6e-09 | 0.58 | 0.94 | 0.06 | FALSE |
| 2 | GTEx | Ovary | ARHGEF26 | 0.14 | 0.03 | enet | 15 | 0.06 | 1.4e-02 | 5.3 | 6.2 | 5.7e-10 | -0.53 | 0.10 | 0.31 | TRUE |
| 3 | GTEx | Pancreas | ARHGEF26 | 0.26 | 0.26 | lasso | 5 | 0.28 | 3.2e-12 | -4.3 | 5.4 | 8.4e-08 | -0.62 | 0.97 | 0.03 | FALSE |
| 4 | GTEx | Spleen | DHX36 | 0.39 | 0.09 | enet | 21 | 0.34 | 2.1e-09 | -3.6 | -5.8 | 6.9e-09 | 0.58 | 0.67 | 0.25 | FALSE |
| 5 | GTEx | Thyroid | ARHGEF26 | 0.09 | 0.07 | enet | 17 | 0.08 | 1.9e-06 | -4.4 | 5.8 | 7.8e-09 | -0.62 | 0.19 | 0.79 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SGEF | 0.04 | 0.04 | enet | 12 | 0.04 | 1.1e-05 | -4.6 | 5.7 | 1.1e-08 | -0.63 | 0.11 | 0.86 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DHX36 | 0.11 | 0.09 | enet | 11 | 0.10 | 6.4e-12 | -4.7 | -5.2 | 2.1e-07 | 0.37 | 0.83 | 0.16 | FALSE |