Best TWAS P=6.6e-09 · Best GWAS P=6.63e-09 conditioned to 0.0969
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | NOP14 | 0.12 | 0.06 | enet | 11 | 0.09 | 2.9e-07 | -3.6 | 5.6 | 1.7e-08 | 0.17 | 0.71 | 0.21 | FALSE |
| 2 | GTEx | Colon Transverse | GRK4 | 0.27 | 0.25 | enet | 18 | 0.25 | 2.4e-12 | -4.3 | 5.2 | 2.3e-07 | 0.15 | 0.53 | 0.46 | FALSE |
| 3 | GTEx | Whole Blood | HTT | 0.10 | 0.00 | enet | 15 | 0.03 | 1.4e-03 | 5.8 | 5.8 | 6.6e-09 | 0.60 | 0.01 | 0.93 | TRUE |
| 4 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | RNF4 | 0.14 | 0.02 | blup | 47 | 0.07 | 3.1e-04 | 3.0 | 5.3 | 1.0e-07 | 0.19 | 0.00 | 0.02 | TRUE |
| 5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C4orf44 | 0.03 | 0.02 | blup | 42 | 0.02 | 8.0e-04 | -4.4 | 5.2 | 1.5e-07 | 0.48 | 0.29 | 0.18 | FALSE |
| 6 | The Cancer Genome Atlas | Lung Adenocarcinoma | C4orf44 | 0.03 | 0.04 | lasso | 4 | 0.05 | 2.9e-06 | -4.5 | 5.3 | 1.0e-07 | 0.48 | 0.42 | 0.50 | FALSE |