[Hub]/) : Traits : Leg fat mass (right) :

chr7:73,425,238-75,842,792

Best TWAS P=3.9e-16 · Best GWAS P=2.07e-15 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex POM121C 0.08 0.05 lasso 2 0.04 1.1e-05 -7.9 -7.8 6.5e-15 0.99 0.00 1.00 FALSE
2 CommonMind Brain Pre-frontal Cortex STAG3L1 0.23 0.14 enet 13 0.17 1.0e-19 -7.9 -7.4 1.9e-13 0.91 0.00 1.00 FALSE
3 GTEx Adipose Subcutaneous PMS2P3 0.15 0.12 lasso 3 0.10 9.8e-09 -7.0 -7.2 6.6e-13 0.96 0.00 1.00 FALSE
4 GTEx Adipose Subcutaneous POM121C 0.20 0.11 enet 18 0.12 1.2e-09 -7.9 -6.9 4.8e-12 0.80 0.00 1.00 FALSE
5 GTEx Adipose Subcutaneous TRIM73 0.20 0.12 enet 26 0.12 2.0e-10 -7.9 -6.6 4.4e-11 0.82 0.00 1.00 FALSE
6 GTEx Adipose Subcutaneous STAG3L1 0.30 0.24 enet 24 0.27 2.4e-22 -7.9 -7.7 1.3e-14 0.92 0.00 1.00 FALSE
7 GTEx Adipose Visceral Omentum POM121C 0.16 0.10 lasso 5 0.12 7.2e-07 5.0 -6.3 2.3e-10 0.80 0.02 0.98 FALSE
8 GTEx Adipose Visceral Omentum TRIM73 0.17 0.19 lasso 3 0.22 1.4e-11 -7.0 -6.2 7.6e-10 0.92 0.00 1.00 FALSE
9 GTEx Adipose Visceral Omentum STAG3L1 0.20 0.19 lasso 3 0.17 2.3e-09 -7.9 -7.9 3.5e-15 1.00 0.00 1.00 FALSE
10 GTEx Artery Aorta STAG3L1 0.18 0.03 lasso 4 0.08 3.9e-05 -7.9 -7.7 1.2e-14 1.00 0.00 1.00 FALSE
11 GTEx Artery Coronary STAG3L1 0.28 0.13 lasso 4 0.17 1.8e-06 -7.1 -7.3 3.2e-13 0.86 0.01 0.99 FALSE
12 GTEx Artery Tibial POM121C 0.12 0.10 lasso 1 0.10 6.8e-08 -7.9 -7.9 2.1e-15 1.00 0.00 1.00 FALSE
13 GTEx Artery Tibial TRIM73 0.10 0.00 lasso 7 0.02 5.5e-03 -7.9 -5.2 1.7e-07 0.82 0.00 0.96 FALSE
14 GTEx Artery Tibial STAG3L1 0.25 0.19 lasso 4 0.19 8.3e-15 -7.9 -8.0 1.7e-15 1.00 0.00 1.00 FALSE
15 GTEx Brain Cerebellar Hemisphere POM121C 0.33 0.32 lasso 3 0.30 1.4e-08 -7.9 -7.8 4.8e-15 1.00 0.00 1.00 FALSE
16 GTEx Brain Cerebellar Hemisphere TRIM73 0.35 0.28 enet 25 0.25 3.6e-07 -7.9 -6.3 3.6e-10 0.84 0.00 1.00 FALSE
17 GTEx Brain Cerebellum POM121C 0.30 0.15 lasso 8 0.08 2.4e-03 -7.9 -7.0 2.9e-12 0.90 0.00 0.97 FALSE
18 GTEx Brain Frontal Cortex BA9 POM121C 0.43 0.16 enet 24 0.17 3.4e-05 -7.9 -5.6 2.0e-08 0.81 0.00 0.98 FALSE
19 GTEx Brain Hippocampus PMS2P5 0.37 0.03 enet 12 0.05 2.9e-02 4.3 -5.2 1.6e-07 0.13 0.01 0.36 TRUE
20 GTEx Brain Nucleus accumbens basal ganglia TRIM73 0.34 0.16 enet 11 0.29 1.5e-08 5.0 -6.4 1.3e-10 0.82 0.00 1.00 FALSE
21 GTEx Brain Nucleus accumbens basal ganglia STAG3L1 0.29 0.09 enet 13 0.18 1.9e-05 -7.9 -6.3 3.9e-10 0.79 0.00 0.97 FALSE
22 GTEx Brain Putamen basal ganglia PMS2P3 0.37 0.13 lasso 6 0.18 6.0e-05 -7.1 -6.1 1.3e-09 0.73 0.01 0.85 FALSE
23 GTEx Breast Mammary Tissue PMS2P3 0.19 0.14 lasso 4 0.19 3.5e-10 -7.0 -6.8 1.0e-11 0.88 0.00 1.00 FALSE
24 GTEx Breast Mammary Tissue STAG3L1 0.16 0.15 lasso 2 0.14 8.7e-08 -7.9 -7.9 3.5e-15 0.98 0.00 1.00 FALSE
25 GTEx Breast Mammary Tissue (Female) PMS2P3 0.31 0.05 enet 8 0.10 6.2e-04 -7.1 -5.3 8.8e-08 0.69 0.02 0.79 FALSE
26 GTEx Breast Mammary Tissue (Female) POM121C 0.17 -0.01 lasso 3 0.02 6.3e-02 -7.9 -7.1 1.1e-12 0.90 0.01 0.63 FALSE
27 GTEx Breast Mammary Tissue (Female) STAG3L1 0.04 0.12 lasso 1 0.04 2.9e-02 -7.9 -7.9 2.1e-15 1.00 0.00 0.96 FALSE
28 GTEx Cells EBV-transformed lymphocytes STAG3L1 0.43 0.21 enet 21 0.23 3.8e-08 -7.9 -7.6 2.7e-14 0.86 0.00 1.00 FALSE
29 GTEx Cells Transformed fibroblasts PMS2P3 0.23 0.15 lasso 6 0.15 1.4e-11 -7.0 -7.2 6.8e-13 0.94 0.00 1.00 FALSE
30 GTEx Cells Transformed fibroblasts POM121C 0.15 0.06 lasso 5 0.07 1.2e-05 -7.9 -8.0 1.2e-15 0.99 0.00 1.00 FALSE
31 GTEx Cells Transformed fibroblasts STAG3L1 0.22 0.17 lasso 4 0.18 2.6e-13 -7.9 -7.9 3.6e-15 0.96 0.00 1.00 FALSE
32 GTEx Colon Sigmoid STAG3L1 0.30 0.18 lasso 4 0.18 8.5e-07 -7.9 -7.5 4.9e-14 0.97 0.00 1.00 FALSE
33 GTEx Colon Transverse STAG3L1 0.22 0.18 lasso 1 0.16 4.0e-08 -7.9 -7.9 2.1e-15 1.00 0.00 1.00 FALSE
34 GTEx Esophagus Gastroesophageal Junction STAG3L1 0.36 0.16 lasso 5 0.16 1.7e-06 -7.9 -7.1 1.0e-12 0.93 0.00 1.00 FALSE
35 GTEx Esophagus Mucosa PMS2P3 0.14 0.15 lasso 2 0.14 9.7e-10 -7.9 -8.1 6.2e-16 1.00 0.00 1.00 FALSE
36 GTEx Esophagus Mucosa POM121C 0.13 0.10 lasso 1 0.07 1.0e-05 -7.9 -7.9 2.1e-15 1.00 0.00 1.00 FALSE
37 GTEx Esophagus Mucosa STAG3L1 0.19 0.19 lasso 1 0.18 2.4e-12 -7.9 -7.9 2.1e-15 1.00 0.00 1.00 FALSE
38 GTEx Esophagus Muscularis TRIM73 0.12 0.07 lasso 2 0.05 3.5e-04 -7.0 -6.9 4.1e-12 0.96 0.00 0.98 FALSE
39 GTEx Esophagus Muscularis STAG3L1 0.30 0.15 lasso 4 0.16 4.3e-10 -7.9 -7.3 2.4e-13 0.94 0.00 1.00 FALSE
40 GTEx Heart Atrial Appendage STAG3L1 0.14 0.04 enet 12 0.04 5.0e-03 -7.0 -6.8 1.5e-11 0.76 0.00 0.95 FALSE
41 GTEx Heart Left Ventricle POM121C 0.13 0.12 lasso 1 0.09 2.2e-05 -7.9 -7.9 2.1e-15 1.00 0.00 1.00 FALSE
42 GTEx Lung POM121C 0.13 0.10 lasso 3 0.10 7.8e-08 -7.9 -7.9 2.0e-15 0.98 0.00 1.00 FALSE
43 GTEx Lung TRIM73 0.14 0.03 enet 8 0.06 2.9e-05 -7.0 -6.2 4.8e-10 0.79 0.00 0.99 FALSE
44 GTEx Lung STAG3L1 0.28 0.12 enet 35 0.16 3.3e-12 -7.9 -7.1 1.3e-12 0.79 0.00 1.00 FALSE
45 GTEx Muscle Skeletal PMS2P3 0.07 0.07 lasso 2 0.06 3.8e-06 -7.9 -7.9 2.4e-15 1.00 0.00 1.00 FALSE
46 GTEx Muscle Skeletal TRIM73 0.08 0.05 enet 11 0.06 3.4e-06 -7.9 -7.4 1.8e-13 0.88 0.00 1.00 FALSE
47 GTEx Muscle Skeletal STAG3L1 0.16 0.10 enet 24 0.10 3.7e-10 -7.9 -6.5 8.1e-11 0.85 0.00 1.00 FALSE
48 GTEx Nerve Tibial PMS2P5 0.16 0.04 enet 34 0.08 3.5e-06 3.4 -5.2 2.2e-07 0.22 0.02 0.94 FALSE
49 GTEx Nerve Tibial PMS2P3 0.29 0.13 enet 4 0.18 1.1e-12 -7.1 -6.6 4.1e-11 0.87 0.03 0.97 FALSE
50 GTEx Nerve Tibial POM121C 0.22 0.14 lasso 5 0.14 6.9e-10 -7.9 -7.9 2.7e-15 0.97 0.00 1.00 FALSE
51 GTEx Nerve Tibial STAG3L2 0.36 0.09 enet 13 0.24 9.5e-17 3.4 -5.6 1.9e-08 0.25 0.02 0.96 FALSE
52 GTEx Nerve Tibial TRIM73 0.19 0.20 enet 6 0.20 6.3e-14 -7.9 -6.9 4.3e-12 0.96 0.00 1.00 FALSE
53 GTEx Nerve Tibial STAG3L1 0.37 0.21 enet 34 0.22 1.2e-15 -7.9 -6.0 2.0e-09 0.83 0.00 1.00 FALSE
54 GTEx Skin Not Sun Exposed Suprapubic PMS2P3 0.26 0.19 lasso 3 0.17 1.3e-09 -7.9 -7.7 1.0e-14 0.99 0.00 1.00 FALSE
55 GTEx Skin Not Sun Exposed Suprapubic STAG3L1 0.13 0.19 lasso 1 0.18 2.6e-10 -7.9 -7.9 2.1e-15 1.00 0.00 1.00 FALSE
56 GTEx Skin Sun Exposed Lower leg PMS2P3 0.38 0.30 lasso 3 0.29 1.9e-24 -7.9 -8.0 1.4e-15 1.00 0.00 1.00 FALSE
57 GTEx Skin Sun Exposed Lower leg STAG3L2 0.15 0.05 enet 8 0.08 2.8e-07 3.4 -5.3 1.3e-07 0.24 0.15 0.45 FALSE
58 GTEx Skin Sun Exposed Lower leg TRIM73 0.13 0.08 enet 10 0.14 1.6e-11 -7.0 -5.6 2.3e-08 0.85 0.01 0.99 FALSE
59 GTEx Skin Sun Exposed Lower leg STAG3L1 0.27 0.15 lasso 5 0.15 1.3e-12 -7.9 -8.0 1.6e-15 0.98 0.00 1.00 FALSE
60 GTEx Stomach PMS2P3 0.16 0.07 lasso 5 0.09 3.7e-05 -7.1 -7.3 3.2e-13 0.91 0.00 0.99 FALSE
61 GTEx Stomach TRIM73 0.23 0.09 lasso 5 0.09 3.2e-05 -7.9 -7.6 4.1e-14 0.96 0.00 0.99 FALSE
62 GTEx Stomach STAG3L1 0.35 0.20 lasso 5 0.18 4.2e-09 -7.1 -7.1 8.7e-13 0.86 0.01 0.99 FALSE
63 GTEx Testis TRIM73 0.20 0.21 lasso 2 0.19 6.2e-09 -7.9 -7.9 3.2e-15 1.00 0.00 1.00 FALSE
64 GTEx Testis STAG3L1 0.24 0.24 enet 14 0.27 1.4e-12 -7.9 -7.3 4.1e-13 0.88 0.00 1.00 FALSE
65 GTEx Thyroid POM121C 0.14 0.08 lasso 3 0.07 3.4e-06 -7.9 -7.8 7.8e-15 0.96 0.00 1.00 FALSE
66 GTEx Thyroid TRIM73 0.21 0.17 lasso 4 0.18 1.6e-13 -7.9 -7.1 1.3e-12 0.97 0.00 1.00 FALSE
67 GTEx Thyroid STAG3L1 0.36 0.24 enet 17 0.27 8.0e-21 -7.9 -7.3 2.6e-13 0.92 0.00 1.00 FALSE
68 GTEx Whole Blood STAG3L1 0.08 0.06 lasso 3 0.07 2.8e-07 -7.9 -7.9 2.2e-15 1.00 0.00 1.00 FALSE
69 METSIM Adipose NCF1 0.05 0.03 blup 130 0.04 3.9e-07 4.5 5.8 8.2e-09 -0.22 0.02 0.97 FALSE
70 METSIM Adipose POM121C 0.11 0.08 lasso 1 0.08 1.6e-11 -7.9 -7.9 2.1e-15 1.00 0.00 1.00 FALSE
71 METSIM Adipose TRIM73 0.11 0.11 lasso 5 0.12 8.6e-18 -7.0 -6.8 7.6e-12 0.95 0.01 0.99 FALSE
72 ROSMAP Brain Pre-frontal Cortex PMS2P3 0.05 0.04 lasso 1 0.03 4.6e-05 -7.9 -7.9 2.1e-15 1.00 0.00 1.00 FALSE
73 ROSMAP Brain Pre-frontal Cortex POM121C 0.36 0.26 lasso 7 0.27 2.8e-34 -7.9 -7.9 2.6e-15 0.99 0.00 1.00 FALSE
74 ROSMAP Brain Pre-frontal Cortex PMS2P2 0.17 0.08 enet 8 0.08 6.0e-10 -7.9 -7.3 2.6e-13 0.90 0.00 1.00 FALSE
75 ROSMAP Brain Pre-frontal Cortex STAG3L1 0.46 0.32 lasso 4 0.32 2.2e-42 -7.9 -7.9 2.0e-15 1.00 0.00 1.00 FALSE
76 ROSMAP Brain Pre-frontal Cortex GTF2IP1 0.09 0.06 lasso 3 0.05 1.7e-07 -7.9 -7.9 1.9e-15 1.00 0.00 1.00 FALSE
77 The Cancer Genome Atlas Breast Invasive Carcinoma POM121C 0.04 0.04 lasso 2 0.03 1.2e-07 -7.9 -7.9 2.8e-15 1.00 0.00 1.00 FALSE
78 The Cancer Genome Atlas Pancreatic Adenocarcinoma POM121C 0.07 0.02 enet 3 0.04 5.8e-03 -7.9 -6.2 6.1e-10 0.85 0.00 0.67 FALSE
79 The Cancer Genome Atlas Thyroid Carcinoma POM121C 0.08 0.07 lasso 3 0.07 3.6e-07 -7.9 -7.9 2.0e-15 0.99 0.00 1.00 FALSE
80 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma PMS2L3 0.23 0.14 lasso 2 0.14 1.3e-04 -7.9 -8.1 3.9e-16 0.98 0.00 0.92 TRUE