TWAS hub - NCF1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Gastroesophageal Junction	0.1430	0.0620	4.1e-03	0.008	NA	-0.007	NA	0.010	1.5e-01	NA	6.9e-01	NA	1.3e-01
2	METSIM	Adipose	0.0516	0.0184	2.7e-06	0.028	0.043	0.036	0.042	0.039	3.6e-05	3.9e-07	3.4e-06	5.6e-07	1.6e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Mouth/teeth dental problems	7.4	11.3	20.1	-1.6	-4.5
Age when periods started (menarche)	7.3	17.5	32.1	-1.7	-5.7
Diastolic blood pressure, automated reading	7.0	21.7	43.3	-0.4	6.6
Mouth/teeth dental problems: Dentures	6.9	11.7	17.0	2.5	4.1
BMI	6.5	37.8	65.0	3.3	8.1
Body mass index (BMI)	6.1	25.9	46.5	2.3	6.8
Illnesses of siblings: Diabetes	5.6	6.9	11.6	1.5	3.4
Waist circumference	5.4	19.8	37.6	1.4	6.1
Hypertension (Self-reported)	5.4	15.0	29.3	0.9	5.4
High blood pressure	5.3	14.9	29.1	0.9	5.4
Vascular/heart problems diagnosed by doctor	5.3	14.4	28.1	-0.9	-5.3
Cardiovascular Disease	5.2	17.3	30.8	2.0	5.5
Arm fat percentage (right)	5.2	20.5	38.2	1.7	6.2
High blood pressure (siblings)	5.2	7.5	15.0	-0.1	3.9
Arm fat percentage (left)	5.0	20.0	37.5	1.6	6.1
Number of self-reported non-cancer illnesses	5.0	8.7	16.4	1.0	4.0
Leg fat mass (left)	5.0	19.3	38.0	0.8	6.2
Overall health rating	4.8	10.2	17.9	1.6	4.2
Illnesses of siblings	4.7	6.6	12.9	-0.6	-3.6
Leg fat percentage (left)	4.6	16.8	32.2	1.2	5.7
Arm fat mass (right)	4.5	18.4	34.9	1.3	5.9
Arm fat mass (left)	4.5	18.5	35.2	1.3	5.9
Diabetes (self-reported)	4.3	6.7	10.4	1.7	3.2
Leg fat mass (right)	4.3	16.8	33.2	0.6	5.8
Impedance of leg (right)	4.0	19.6	24.4	-3.8	-4.9
Body fat percentage	4.0	15.7	31.0	0.6	5.6
Number of treatments/medications taken	3.8	6.9	13.1	0.8	3.6
Other serious medical condition/disability diagnosed by doctor	3.8	4.9	5.3	2.1	2.3
Hip circumference	3.8	16.3	30.5	1.4	5.5
Medication for cholesterol, blood pressure or diabetes	3.8	6.4	11.0	-1.3	-3.3
Whole body fat mass	3.8	15.9	31.4	0.7	5.6
Long-standing illness, disability or infirmity	3.8	5.8	10.6	1.0	3.2
Medication: Amlodipine	3.6	5.1	9.3	0.9	3.0
Leg fat percentage (right)	3.6	12.9	25.3	0.7	5.0
Lung FEV1/FVC ratio	3.2	16.0	21.9	4.7	3.2
Systolic blood pressure, automated reading	3.2	9.4	18.8	-0.1	4.3
Trunk fat percentage	3.2	12.7	25.4	0.2	5.0
Mean time to correctly identify matches	3.2	6.0	7.6	2.1	2.8
Diabetes diagnosed by doctor	3.2	5.2	6.9	1.9	2.6
Medication: Lisinopril	3.2	4.1	7.6	0.8	2.7
Impedance of whole body	3.2	16.4	20.7	-3.5	-4.5
Maternal smoking around birth	3.1	4.5	9.0	0.1	3.0
Trunk fat mass	3.1	13.1	26.2	0.1	5.1
Weight	3.1	15.2	30.5	0.1	5.5
Fasting Glucose	3.0	3.6	6.1	1.1	2.5
Impedance of leg (left)	3.0	14.5	17.1	-3.4	-4.1
Qualifications: None of the above	3.0	6.5	12.6	0.6	3.5
Taking other prescription medications	2.9	4.5	9.0	0.3	3.0
Happiness	2.9	3.6	5.9	1.1	2.4
Seen doctor (GP) for nerves, anxiety, tension or depression	2.9	4.5	7.1	-1.4	2.7
Medication: Blood pressure	2.9	5.2	9.9	0.6	3.1
Osteoarthritis (self-reported)	2.9	3.7	6.8	0.8	2.6
Alcohol usually taken with meals	2.7	4.3	7.8	-0.9	-2.8
Illnesses of mother	2.7	3.3	5.1	-1.2	-2.3
Pack years adult smoking proportion	2.6	3.9	7.6	-0.5	2.8
Type 2 Diabetes (T2D) (2018)	2.5	4.7	5.6	2.4	1.9
Ever had hysterectomy (womb removed)	2.5	2.8	5.4	-0.4	2.3
Relative age voice broke	2.5	3.9	4.9	-1.7	-2.2
Mouth/teeth dental problems: Bleeding gums	2.5	3.3	6.5	0.1	2.5
Wheeze or whistling in the chest in last year	2.5	4.4	7.9	-0.9	2.8
Alcohol intake frequency.	2.5	5.9	10.7	1.1	3.3
Age at last live birth	2.5	3.6	6.1	-1.0	-2.5
Body Mass Index (BMI) (2010)	2.4	3.3	4.5	1.5	2.1
Medication: Metformin	2.4	3.4	3.5	1.9	1.8
Qualifications: O levels/GCSEs or equivalent	2.4	3.8	4.3	-2.1	-1.8
Number of live births	2.3	3.2	6.0	-0.7	-2.4
Medication for cholesterol	2.3	3.4	6.7	-0.4	-2.6
High cholesterol (Self-reported)	2.3	4.1	8.2	-0.2	2.9
Major Depression (MDD)	2.2	2.7	5.2	-0.5	2.3
Medication: Blood pressure	2.2	4.1	7.9	0.6	2.8
Medication: Paracetamol	2.2	3.4	6.5	2.6	0.6
HbA1C	2.1	2.4	3.8	-1.0	-1.9
Knee pain experienced in last month	2.1	3.2	4.5	1.4	2.1
Pack years of smoking	2.1	3.1	5.8	-0.6	2.4
Breast Cancer	2.0	4.9	9.5	-0.6	-3.1
Current tobacco smoking	2.0	3.2	3.5	-1.9	1.7
Pulse rate	2.0	3.4	6.0	-2.5	0.9
Lung cancer (father)	2.0	2.3	4.3	0.5	2.1
Medication: Paracetamol	2.0	3.3	6.2	2.5	0.6
Mother’s age at death	2.0	2.5	4.8	-0.4	-2.2
Diabetes (father)	1.9	2.4	2.4	1.6	1.6
Heel bone mineral density (BMD) T-score, automated (right)	1.9	4.3	5.7	-1.7	-2.4
Heart disease (mother)	1.9	2.3	4.2	0.7	2.0
Smoking status: Current	1.9	3.0	3.7	-1.9	1.5
Average weekly fortified wine intake	1.8	2.1	3.2	1.8	-1.0
Stomach or abdominal pain in last month	1.8	2.2	2.4	1.6	1.4
Diverticular disease/diverticulitis (self-reported)	1.8	2.2	4.3	2.1	0.1
Impedance of arm (right)	1.8	8.2	8.7	-2.8	-3.0
Qualifications: A levels/AS levels or equivalent	1.8	3.9	6.8	-1.0	-2.6
Impedance of arm (left)	1.8	8.4	10.7	-2.5	-3.3
Ever taken oral contraceptive pill	1.8	2.0	2.8	-1.7	1.1
Schizophrenia (2018)	1.7	3.5	6.9	0.0	2.6
Supplements: Zinc	1.7	1.8	3.3	-0.6	-1.8
Qualifications: College or University degree	1.7	5.2	7.3	1.8	-2.7
Number of operations (self-reported)	1.7	2.5	3.2	1.8	1.4
Irritable Bowel Disease (IBD)	1.6	3.9	4.0	-2.0	-2.0
Reaction Time	1.6	3.1	4.0	1.5	2.0
Mean Putamen Volume	1.6	1.8	3.1	-0.7	-1.8
Diabetes (mother)	1.6	2.0	2.7	1.2	1.6
Medication: Atenolol	1.6	2.0	2.2	1.5	1.3
Exposure to tobacco smoke outside home	1.6	2.1	2.9	1.2	1.7
Leg fat-free mass (right)	1.6	8.4	16.8	0.1	4.1
Medication: Aspirin	1.6	2.0	3.7	0.6	1.9
Leg predicted mass (right)	1.6	8.4	16.7	0.0	4.1
Miserableness	1.6	2.7	3.8	-1.3	1.9
Medication: Bendroflumethiazide	1.6	2.5	4.9	-0.1	2.2
Ever smoked	1.6	2.8	5.5	2.4	0.4
Age started oral contraceptive pill	1.6	2.0	3.8	0.5	1.9
Myopia	1.6	2.3	4.5	-0.3	-2.1
Worry (Nagel 2018)	1.5	3.2	5.9	-0.6	2.4
Primary Biliary Cirrhosis	1.5	2.1	2.2	-1.5	-1.4
Leg fat-free mass (left)	1.5	7.7	15.4	-0.1	3.9
Leg predicted mass (left)	1.5	8.0	16.1	-0.1	4.0
Depression (self-reported)	1.5	1.8	2.4	-1.5	1.1
Standing height	1.5	15.0	24.2	-4.9	-2.4
Headache pain in last month	1.5	2.6	4.1	2.0	1.0
Medication: Aspirin	1.5	1.9	3.6	0.6	1.9
Fluid intelligence score	1.4	2.9	5.7	-0.1	-2.4
Medication: Cholesterol lowering	1.4	2.2	4.5	0.2	2.1
Medication: Ventolin 100micrograms inhaler	1.4	1.8	3.5	-0.1	-1.9
Eye problems/disorders: None of the above	1.4	1.6	2.1	1.5	-1.0
Medication for pain relief, constipation, heartburn	1.4	2.4	3.0	-1.3	-1.7
Commuting to job workplace: Car/motor vehicle	1.4	1.6	1.8	-1.2	-1.4
Medication: Gliclazide	1.4	1.6	2.9	1.7	0.6
Average weekly beer plus cider intake	1.4	2.0	4.0	-2.0	0.3
Alcohol drinker status: Previous	1.4	1.6	1.8	1.3	1.2
Systolic Blood Pressure	1.3	6.5	13.0	0.1	3.6
Fed-up feelings	1.3	2.4	4.2	-2.0	0.8
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	1.5	1.1	1.2
Nervous feelings	1.3	2.4	3.8	1.0	1.9
Birth weight of first child	1.3	2.3	2.7	1.4	-1.7
Age at first live birth	1.3	2.3	4.2	-0.7	-2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	2.0	-1.4	1.0
Family relationship satisfaction	1.3	1.6	2.3	1.0	1.5
Eye problems/disorders: Cataract	1.3	1.5	2.4	-0.7	1.6
Ovarian Cancer	1.2	1.5	3.0	-0.2	-1.7
Chronotype (morning person)	1.2	2.7	5.1	2.3	-0.5
Hand grip strength (left)	1.2	3.2	4.9	-2.2	-1.2
Hair/balding pattern: Pattern 2	1.2	1.5	2.8	1.7	0.4
Allergy	1.2	2.7	5.3	0.0	-2.3
Medication: Ramipril	1.2	1.6	2.3	0.9	1.5
Peak expiratory flow (PEF)	1.2	2.8	5.5	-2.4	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	3.2	-0.1	1.8
Qualifications: nursing, teaching	1.2	1.9	3.8	0.1	-1.9
Alcohol drinker status: Never	1.2	1.4	2.7	-0.4	1.6
Unable to work because of sickness or disability	1.2	1.5	2.4	0.8	1.6
Cholesterol lowering medication	1.2	1.7	2.4	1.0	1.6
Depressed Affect (Nagel 2018)	1.1	2.4	3.1	-1.8	1.3
Crohns Disease (2017)	1.1	2.3	2.5	-1.6	-1.5
Allergy or Eczema	1.1	2.8	5.4	0.4	2.3
Medication: Co-codamol	1.1	1.3	1.4	-1.1	1.2
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.5	2.8	-1.5	-1.7
Father’s age at death	1.1	1.5	2.4	-0.8	-1.5
Health satisfaction	1.1	1.5	1.5	1.2	1.2
Suffer from ‘nerves’	1.1	1.8	2.3	1.2	1.5
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	2.3	-1.5	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	2.1	0.7	1.4
Supplements: Fish oil (including cod liver oil)	1.1	1.4	2.7	-1.7	0.3
Basal metabolic rate	1.1	6.3	12.2	-0.5	3.5
Intelligence (Savage-Jansen 2018)	1.0	3.1	6.2	0.1	-2.5
Ulcerative Colitis (UC)	1.0	1.8	1.9	-1.4	-1.3
Relative age of first facial hair	1.0	2.1	4.2	-0.4	-2.0
Townsend deprivation index at recruitment	1.0	1.4	2.7	0.4	1.7
Qualifications: CSEs or equivalent	1.0	1.3	2.6	-1.6	0.3
Hayfever, allergic rhinitis or eczema	1.0	2.1	4.2	-0.2	2.1
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	2.7	0.7	1.7
Medication: Simvastatin	1.0	1.5	2.7	0.5	1.6
Neuroticism score	1.0	2.2	3.5	-0.9	1.9
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	2.9	0.5	1.7
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	2.3	1.5	0.0
Mouth/teeth dental problems: Loose teeth	1.0	1.2	1.6	1.3	0.9
Medication: Allopurinol	1.0	1.4	2.3	-1.5	0.6
Chest pain or discomfort	1.0	1.5	2.1	0.9	1.4
Mood swings	1.0	1.8	2.6	-1.6	1.1
Breast cancer (self-reported)	1.0	1.2	1.4	-1.0	-1.2
Lupus	0.9	1.3	2.3	-0.5	1.5
Schizophrenia (2014)	0.9	2.1	4.1	0.0	2.0
Neuroticism	0.9	2.1	2.5	-1.3	1.6
Number of incorrect matches in round	0.9	1.4	2.9	-1.7	0.1
Had other major operations	0.9	1.1	1.1	1.0	1.1
Medication: Lansoprazole	0.9	1.0	2.0	-0.1	1.4
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.2	0.0	1.5
Pulse wave peak to peak time	0.9	1.0	1.1	-1.0	-1.0
Medication: Omeprazole	0.9	1.1	1.8	0.6	1.3
Smoking status: Previous	0.9	1.3	2.4	1.6	-0.4
Arm predicted mass (left)	0.9	4.4	8.6	-0.4	2.9
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	1.3	0.6	1.1
Heart attack	0.8	1.0	1.2	0.9	1.1
Birth weight	0.8	1.7	2.5	-1.0	-1.6
Comparative height size at age 10	0.8	4.4	6.2	-1.6	2.5
Commuting to job workplace: Public transport	0.8	1.0	1.5	1.2	0.7
Arm fat-free mass (left)	0.8	4.1	8.1	-0.2	2.9
Commuting to job workplace: Cycle	0.8	1.0	1.9	1.4	-0.1
Height	0.7	13.1	22.9	-4.8	-1.8
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.0	0.3	1.4
Hand grip strength (right)	0.7	1.9	3.5	-1.9	-0.5
Sitting height	0.7	4.7	7.8	-2.8	-1.3
Forced vital capacity (FVC)	0.7	2.9	5.6	-2.4	-0.4
Pulse wave Arterial Stiffness index	0.7	0.8	0.9	0.9	0.9
Breastfed as a baby	0.7	0.9	0.9	-0.9	-0.9
Pulse rate, automated reading	0.7	2.2	4.4	0.1	2.1
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.6	1.6	-1.2	-1.3
Whole body fat-free mass	0.7	4.1	7.8	-0.5	2.8
Whole body water mass	0.7	4.1	8.1	-0.5	2.8
Fractured/broken bones in last 5 years	0.7	1.0	1.2	-0.8	-1.1
Neuroticism (Nagel 2018)	0.6	1.3	2.0	-0.8	1.4
Prostate Cancer	0.6	0.9	1.0	-0.9	-1.0
Rheumatoid Arthritis	0.6	0.8	1.6	0.3	1.3
Sensitivity / hurt feelings	0.6	1.0	1.7	1.3	-0.6
Past tobacco smoking	0.6	1.2	2.0	-1.4	-0.5
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.2	1.1	0.6
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.0	0.6	1.0
Arm fat-free mass (right)	0.6	3.2	6.4	-0.3	2.5
Worry too long after embarrassment	0.6	0.9	0.9	-1.0	1.0
Arm predicted mass (right)	0.6	3.3	6.6	-0.1	2.6
Had major operations	0.6	0.7	1.3	0.2	-1.1
Illnesses of father: Heart disease	0.6	0.8	1.5	-1.2	0.4
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.3	-1.1	0.3
Ever depressed for a whole week	0.6	0.7	0.8	0.9	0.8
Heart attack/myocardial infarction (self-reported)	0.6	0.7	0.9	0.9	0.7
Blood Eosinophil Count	0.5	3.6	7.1	0.2	-2.7
Blood Red Count	0.5	5.3	8.5	1.4	2.9
Heel T-Score	0.5	3.6	7.0	-0.4	-2.6
Medication for hormone replacement therapy	0.5	0.6	0.8	-0.6	0.9
Exposure to tobacco smoke at home	0.5	0.5	0.7	-0.6	0.8
Medication: Seretide 50 evohaler	0.5	0.6	1.1	0.4	1.1
Loneliness, isolation	0.5	0.6	0.7	-0.7	0.9
Back pain experienced in last month	0.5	0.8	1.2	1.1	0.6
Mineral and other dietary supplements	0.5	0.6	0.8	0.9	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	1.7	-0.7	1.3
Average weekly champagne plus white wine intake	0.5	0.6	1.1	-1.0	-0.5
Wears glasses or contact lenses	0.5	0.6	1.0	-0.2	1.0
Pain type(s) experienced in last month: Hip pain	0.5	0.7	1.2	-1.1	-0.4
Risk taking	0.5	0.7	1.4	-1.2	-0.0
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	0.9	0.5	0.9
Neuroticism (2016)	0.4	0.6	1.2	-1.1	0.0
Hearing difficulty/problems: Yes	0.4	0.6	1.0	-1.0	-0.4
Vitamin and mineral supplements	0.4	0.5	0.6	-0.7	-0.7
High blood pressure (mother)	0.4	0.6	0.9	0.6	0.9
Had menopause	0.4	0.5	0.6	0.7	0.8
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	0.9	-0.9	0.3
Pain all over the body in last month	0.4	0.4	0.7	-0.8	-0.4
Prospective memory result	0.4	0.5	0.9	-0.1	-1.0
Forced vital capacity (FVC), Best measure	0.4	1.4	2.3	-1.5	-0.6
Number of children fathered	0.4	0.5	1.0	-0.1	-1.0
Shortness of breath walking on level ground	0.4	0.5	0.9	0.1	1.0
Neck or shoulder pain in last month	0.4	0.6	1.0	0.4	1.0
Illnesses of father: None of the above (group 1)	0.4	0.5	1.0	0.1	-1.0
Guilty feelings	0.4	0.6	0.8	0.9	0.5
Medication: Atorvastatin	0.4	0.5	0.7	0.5	0.8
Supplements: Calcium	0.4	0.5	0.7	0.8	-0.5
Basal cell carcinoma (self-reported)	0.4	0.4	0.8	0.9	0.3
Alzheimer’s Disease (in mother)	0.3	0.4	0.7	-0.8	-0.1
Verbal and Numeric Reasoning (VNR)	0.3	0.8	1.6	-0.2	-1.3
LDL Cholesterol	0.3	0.5	1.0	1.0	0.0
Ulcerative Colitis	0.3	0.4	0.9	0.0	-0.9
Blood White Count	0.3	2.0	3.2	1.8	0.9
Smoking Status	0.3	0.8	1.0	-0.7	1.0
Lung FVC	0.3	1.4	2.1	0.8	1.4
Trunk fat-free mass	0.3	2.0	2.9	-1.0	1.7
Hair/balding pattern: Pattern 3	0.3	0.4	0.4	0.6	0.6
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	1.7	-1.3	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.6	-0.8	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	0.7	0.2	-0.8
Trunk predicted mass	0.3	1.9	2.9	-1.0	1.7
Blood clot in the leg (DVT)	0.3	0.4	0.5	0.5	-0.7
Gout (self-reported)	0.3	0.4	0.8	-0.1	0.9
Number of full brothers	0.3	0.4	0.7	-0.1	0.8
Supplements: Vitamin C	0.3	0.4	0.7	0.9	0.2
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.6	-0.8	0.1
Friendships satisfaction	0.3	0.3	0.6	-0.2	-0.8
Asthma (self-reported)	0.3	0.6	0.9	-1.0	0.4
Osteoporosis (self-reported)	0.3	0.4	0.5	0.7	0.5
Pain experienced in last month	0.3	0.5	0.7	-0.5	-0.8
Heart disease (siblings)	0.3	0.4	0.8	0.2	0.9
Bipolar Disorder or Schizophrenia	0.2	0.6	1.2	0.0	1.1
Waist Hip Ratio (WHR)	0.2	0.8	1.1	-0.6	-1.1
Respiratory disease	0.2	0.4	0.8	-0.9	0.1
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.5	0.0	0.7
Severe depression (siblings)	0.2	0.3	0.4	-0.6	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.4	-0.6	0.5
Hearing difficulty/problems with background noise	0.2	0.3	0.6	-0.8	-0.3
Time employed in main current job	0.2	0.2	0.3	-0.2	0.6
Asthma	0.2	0.5	0.8	-0.9	0.4
Tense / ‘highly strung’	0.2	0.3	0.5	-0.1	0.7
Hair/balding pattern: Pattern 4	0.2	0.4	0.8	-0.9	-0.3
Pulse wave reflection index	0.2	0.2	0.4	0.6	0.1
Medication: Ibuprofen	0.2	0.2	0.2	0.4	-0.5
Leg pain on walking	0.2	0.3	0.3	0.6	0.4
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.4	0.6	0.4
Average weekly red wine intake	0.2	0.3	0.5	-0.3	-0.7
Ever had bowel cancer screening	0.2	0.2	0.3	0.3	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.4	-0.1	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.2	0.2	0.4	0.4	-0.6
Irritability	0.2	0.3	0.7	-0.8	0.1
Depression (Nagel 2018)	0.1	0.2	0.3	-0.4	0.5
Alzheimer’s Disease (in father)	0.1	0.1	0.1	0.3	-0.4
Age at First Birth	0.1	0.2	0.4	0.0	-0.6
Crohns Disease (2012)	0.1	0.1	0.2	-0.4	0.0
HDL Cholesterol	0.1	0.2	0.3	0.6	0.2
Hair Pigment	0.1	2.0	2.1	-1.4	-1.4
Tanning	0.1	0.9	1.2	0.8	1.1
Average weekly spirits intake	0.1	0.1	0.1	0.4	0.3
Angina	0.1	0.1	0.2	0.4	0.2
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.3	-0.5	-0.0
Multivitamins +/- minerals	0.1	0.2	0.2	-0.5	0.4
Alcohol intake versus 10 years previously	0.1	0.2	0.4	0.1	0.6
Worrier / anxious feelings	0.1	0.1	0.2	-0.4	0.3
Falls in the last year	0.1	0.1	0.2	0.3	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.5	-0.7	0.2
Length of working week for main job	0.1	0.1	0.1	0.4	-0.2
Glaucoma (self-reported)	0.1	0.1	0.1	-0.4	-0.1
Emphysema/chronic bronchitis	0.1	0.1	0.1	-0.3	-0.2
Angina (self-reported)	0.1	0.1	0.2	0.4	0.2
Migraine (self-reported)	0.1	0.1	0.1	0.1	0.3
Number of full sisters	0.1	0.1	0.3	-0.5	0.2
Commuting to job workplace: Walk	0.1	0.1	0.1	-0.4	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.3	0.5	-0.3
Hearing aid user	0.1	0.1	0.1	0.2	-0.3
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.1	0.3	-0.2
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	-0.4	0.3
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.3	0.2	-0.5
Bipolar Disorder (2018)	0.0	0.0	0.0	0.0	0.0
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0
Alzheimer’s Disease (including proxy)	0.0	0.1	0.1	-0.3	-0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0
Triglycerides	0.0	0.0	0.0	-0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0
Blood Platelet Count	0.0	0.5	1.0	1.0	-0.3
Hypothyroidism (self reported)	0.0	0.0	0.0	0.2	0.2
Serious illness, injury or assault to yourself	0.0	0.0	0.1	-0.0	0.2
Supplements: Glucosamine	0.0	0.0	0.0	0.2	-0.2
Medication: Levothyroxine sodium	0.0	0.0	0.0	-0.0	0.0
Chronic bronchitis/emphysema (father)	0.0	0.0	0.0	0.2	0.1
Financial difficulties in last 2 years	0.0	0.1	0.1	0.3	-0.1
Noisy workplace	0.0	0.0	0.0	0.2	0.0
Loud music exposure frequency	0.0	0.0	0.0	0.2	0.2
Hypothyroidism/myxoedema (self-reported)	0.0	0.1	0.1	-0.4	-0.0
Comparative body size at age 10	0.0	0.1	0.1	-0.2	-0.3
Financial situation satisfaction	0.0	0.0	0.0	0.0	0.1
Illnesses of father: High blood pressure	0.0	0.1	0.1	0.1	0.3

Hub : Genes

NCF1

Models

Trait associations