[Hub]/) : Traits : Leg fat mass (right) :

chr9:14,857,740-16,758,776

Best TWAS P=4.39e-23 · Best GWAS P=2.71e-19 conditioned to 0.424

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Artery Aorta CCDC171 0.18 0.05 lasso 5 0.08 2.2e-05 -4.1 -5.7 9.4e-09 0.30 0.33 0.07 FALSE
2 GTEx Artery Tibial CCDC171 0.10 0.09 enet 9 0.12 7.2e-10 4.9 -6.1 1.2e-09 0.57 0.84 0.16 FALSE
3 GTEx Brain Caudate basal ganglia CCDC171 0.30 0.18 lasso 4 0.23 2.4e-07 8.0 -8.7 3.0e-18 0.92 0.08 0.92 FALSE
4 GTEx Brain Cerebellar Hemisphere CCDC171 0.46 0.19 lasso 7 0.23 1.3e-06 -8.7 -9.9 4.4e-23 0.87 0.15 0.82 TRUE
5 GTEx Brain Cerebellum CCDC171 0.46 0.22 lasso 7 0.15 3.4e-05 -8.7 -9.1 8.0e-20 0.95 0.05 0.94 FALSE
6 GTEx Brain Cortex CCDC171 0.26 0.15 lasso 2 0.16 2.8e-05 -7.1 -8.1 5.3e-16 0.89 0.11 0.84 FALSE
7 GTEx Brain Frontal Cortex BA9 CCDC171 0.27 0.18 enet 10 0.19 8.3e-06 8.2 -8.2 3.2e-16 0.81 0.09 0.84 FALSE
8 GTEx Brain Hypothalamus CCDC171 0.32 0.17 enet 6 0.09 4.0e-03 -8.7 -7.4 1.8e-13 0.90 0.09 0.70 FALSE
9 GTEx Breast Mammary Tissue CCDC171 0.21 0.01 lasso 5 0.03 1.5e-02 7.4 -5.3 1.3e-07 0.52 0.36 0.21 FALSE
10 GTEx Lung CCDC171 0.13 0.03 enet 9 0.01 5.0e-02 5.4 -7.2 7.4e-13 0.65 0.40 0.37 FALSE
11 GTEx Nerve Tibial CCDC171 0.25 0.16 lasso 6 0.14 2.1e-10 -8.6 -8.6 9.5e-18 0.95 0.12 0.88 FALSE
12 GTEx Ovary CCDC171 0.21 0.19 lasso 4 0.16 7.7e-05 7.7 7.4 1.4e-13 -0.82 0.15 0.55 FALSE
13 GTEx Pituitary CCDC171 0.28 0.16 enet 29 0.12 5.2e-04 8.0 -8.4 3.6e-17 0.87 0.23 0.69 FALSE
14 GTEx Skin Not Sun Exposed Suprapubic CCDC171 0.20 0.04 enet 45 0.06 4.9e-04 8.2 -5.6 1.9e-08 0.37 0.66 0.23 FALSE
15 GTEx Skin Sun Exposed Lower leg CCDC171 0.14 0.09 enet 13 0.12 1.9e-10 7.7 -6.4 1.9e-10 0.61 0.95 0.05 FALSE
16 METSIM Adipose CCDC171 0.03 0.00 blup 828 0.01 4.0e-02 8.2 -7.4 1.4e-13 0.77 0.20 0.59 FALSE
17 ROSMAP Brain Pre-frontal Cortex CCDC171 0.14 0.11 enet 21 0.11 8.3e-14 8.3 -8.2 2.1e-16 0.80 0.73 0.27 FALSE
18 The Cancer Genome Atlas Soft Tissue Sarcoma C9orf93 0.06 0.05 lasso 3 0.03 5.3e-03 7.4 -6.5 7.9e-11 0.67 0.12 0.31 FALSE