Best TWAS P=4.39e-23 · Best GWAS P=2.71e-19 conditioned to 0.424
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Aorta | CCDC171 | 0.18 | 0.05 | lasso | 5 | 0.08 | 2.2e-05 | -4.1 | -5.7 | 9.4e-09 | 0.30 | 0.33 | 0.07 | FALSE |
2 | GTEx | Artery Tibial | CCDC171 | 0.10 | 0.09 | enet | 9 | 0.12 | 7.2e-10 | 4.9 | -6.1 | 1.2e-09 | 0.57 | 0.84 | 0.16 | FALSE |
3 | GTEx | Brain Caudate basal ganglia | CCDC171 | 0.30 | 0.18 | lasso | 4 | 0.23 | 2.4e-07 | 8.0 | -8.7 | 3.0e-18 | 0.92 | 0.08 | 0.92 | FALSE |
4 | GTEx | Brain Cerebellar Hemisphere | CCDC171 | 0.46 | 0.19 | lasso | 7 | 0.23 | 1.3e-06 | -8.7 | -9.9 | 4.4e-23 | 0.87 | 0.15 | 0.82 | TRUE |
5 | GTEx | Brain Cerebellum | CCDC171 | 0.46 | 0.22 | lasso | 7 | 0.15 | 3.4e-05 | -8.7 | -9.1 | 8.0e-20 | 0.95 | 0.05 | 0.94 | FALSE |
6 | GTEx | Brain Cortex | CCDC171 | 0.26 | 0.15 | lasso | 2 | 0.16 | 2.8e-05 | -7.1 | -8.1 | 5.3e-16 | 0.89 | 0.11 | 0.84 | FALSE |
7 | GTEx | Brain Frontal Cortex BA9 | CCDC171 | 0.27 | 0.18 | enet | 10 | 0.19 | 8.3e-06 | 8.2 | -8.2 | 3.2e-16 | 0.81 | 0.09 | 0.84 | FALSE |
8 | GTEx | Brain Hypothalamus | CCDC171 | 0.32 | 0.17 | enet | 6 | 0.09 | 4.0e-03 | -8.7 | -7.4 | 1.8e-13 | 0.90 | 0.09 | 0.70 | FALSE |
9 | GTEx | Breast Mammary Tissue | CCDC171 | 0.21 | 0.01 | lasso | 5 | 0.03 | 1.5e-02 | 7.4 | -5.3 | 1.3e-07 | 0.52 | 0.36 | 0.21 | FALSE |
10 | GTEx | Lung | CCDC171 | 0.13 | 0.03 | enet | 9 | 0.01 | 5.0e-02 | 5.4 | -7.2 | 7.4e-13 | 0.65 | 0.40 | 0.37 | FALSE |
11 | GTEx | Nerve Tibial | CCDC171 | 0.25 | 0.16 | lasso | 6 | 0.14 | 2.1e-10 | -8.6 | -8.6 | 9.5e-18 | 0.95 | 0.12 | 0.88 | FALSE |
12 | GTEx | Ovary | CCDC171 | 0.21 | 0.19 | lasso | 4 | 0.16 | 7.7e-05 | 7.7 | 7.4 | 1.4e-13 | -0.82 | 0.15 | 0.55 | FALSE |
13 | GTEx | Pituitary | CCDC171 | 0.28 | 0.16 | enet | 29 | 0.12 | 5.2e-04 | 8.0 | -8.4 | 3.6e-17 | 0.87 | 0.23 | 0.69 | FALSE |
14 | GTEx | Skin Not Sun Exposed Suprapubic | CCDC171 | 0.20 | 0.04 | enet | 45 | 0.06 | 4.9e-04 | 8.2 | -5.6 | 1.9e-08 | 0.37 | 0.66 | 0.23 | FALSE |
15 | GTEx | Skin Sun Exposed Lower leg | CCDC171 | 0.14 | 0.09 | enet | 13 | 0.12 | 1.9e-10 | 7.7 | -6.4 | 1.9e-10 | 0.61 | 0.95 | 0.05 | FALSE |
16 | METSIM | Adipose | CCDC171 | 0.03 | 0.00 | blup | 828 | 0.01 | 4.0e-02 | 8.2 | -7.4 | 1.4e-13 | 0.77 | 0.20 | 0.59 | FALSE |
17 | ROSMAP | Brain Pre-frontal Cortex | CCDC171 | 0.14 | 0.11 | enet | 21 | 0.11 | 8.3e-14 | 8.3 | -8.2 | 2.1e-16 | 0.80 | 0.73 | 0.27 | FALSE |
18 | The Cancer Genome Atlas | Soft Tissue Sarcoma | C9orf93 | 0.06 | 0.05 | lasso | 3 | 0.03 | 5.3e-03 | 7.4 | -6.5 | 7.9e-11 | 0.67 | 0.12 | 0.31 | FALSE |