TWAS hub - C9orf93

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Cervical Squamous Cell Carcinoma	0.2550	0.1270	9.6e-03	0.051	0.015	0.018	NA	0.045	1.6e-03	5.7e-02	4.1e-02	NA	3.0e-03
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0434	0.0218	1.0e-03	0.029	0.032	0.025	NA	0.028	2.9e-04	1.6e-04	6.8e-04	NA	3.8e-04
3	TCGA	Brain Lower Grade Glioma	0.0644	0.0364	6.2e-05	0.027	0.040	0.046	NA	0.045	3.9e-04	2.0e-05	4.9e-06	NA	7.1e-06
4	TCGA	Lung Adenocarcinoma	0.0471	0.0288	4.7e-03	0.006	0.020	0.001	NA	0.008	5.6e-02	1.8e-03	2.0e-01	NA	3.8e-02
5	TCGA	Prostate Adenocarcinoma	0.0617	0.0326	1.4e-03	0.020	0.024	0.022	NA	0.011	3.1e-03	1.2e-03	2.2e-03	NA	2.1e-02
6	TCGA	Soft Tissue Sarcoma	0.0650	0.0400	3.7e-03	0.046	0.030	0.023	NA	0.032	1.0e-03	6.9e-03	1.6e-02	NA	5.3e-03
7	TCGA	Thyroid Carcinoma	0.0910	0.0370	5.9e-07	0.064	0.080	0.068	NA	0.077	8.0e-07	3.1e-08	3.6e-07	NA	5.9e-08

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Number of live births	5.1	7.2	15.4	-1.7	-1.9	-3.9	-2.5	-2.8	-3.2	-2.0
Ever had stillbirth, spontaneous miscarriage or termination	5.0	5.3	10.0	-1.8	-3.2	-2.0	-2.4	-2.1	-0.1	-3.1
Depression (self-reported)	4.9	5.9	8.9	-1.6	-2.3	-2.5	-3.0	-2.4	-3.0	-1.9
Fasting Glucose	4.0	4.8	7.7	1.6	2.3	2.3	2.1	2.8	1.5	2.5
Major Depression (MDD)	3.6	4.4	8.0	-1.0	-1.9	-2.8	-2.0	-2.0	-2.5	-1.8
Leg fat percentage (left)	3.4	12.2	54.9	1.8	3.3	-3.2	0.4	-0.7	-7.4	2.4
Cholesterol lowering medication	3.3	4.8	7.6	-1.5	-1.7	-2.7	-2.8	-2.0	-2.7	-1.5
Leg fat percentage (right)	3.2	11.7	55.2	1.5	2.9	-3.4	0.2	-0.9	-7.4	1.9
Headache pain in last month	3.0	5.2	6.5	-2.4	-2.0	-2.5	-2.6	-1.7	-2.4	-2.1
Chronic bronchitis/emphysema (father)	2.8	3.2	6.0	-1.1	-1.3	-1.7	-2.1	-2.3	-2.4	-1.1
Blood clot in the leg (DVT)	2.8	3.6	6.2	-2.2	-2.1	-1.2	-1.9	-2.0	-0.9	-2.5
Body fat percentage	2.8	11.0	51.8	1.4	2.7	-3.4	-0.3	-1.0	-7.2	1.9
High cholesterol (Self-reported)	2.8	4.9	6.8	-2.1	-1.6	-2.3	-2.6	-2.1	-2.6	-2.0
Sensitivity / hurt feelings	2.7	4.7	7.7	2.0	2.6	1.5	1.9	2.8	0.9	2.7
Arm fat percentage (right)	2.6	10.4	49.4	1.0	2.3	-3.5	-0.7	-1.4	-7.0	1.5
Arm fat percentage (left)	2.6	10.4	49.0	1.3	2.5	-3.4	-0.6	-1.2	-7.0	1.7
Financial situation satisfaction	2.6	3.2	11.4	0.1	-0.2	-2.9	-1.0	-1.2	-3.4	0.1
HDL Cholesterol	2.5	4.2	7.6	-2.8	-2.7	-0.5	-1.9	-2.0	0.3	-2.5
Ever used hormone-replacement therapy (HRT)	2.5	3.1	5.1	-1.7	-1.1	-1.6	-1.7	-2.3	-2.2	-1.5
Townsend deprivation index at recruitment	2.5	3.5	9.7	3.1	1.5	1.7	1.3	2.1	0.2	1.9
Diverticular disease/diverticulitis (self-reported)	2.5	3.0	5.2	-0.8	-2.3	-1.2	-2.0	-1.7	-1.6	-2.1
Trunk fat percentage	2.4	9.7	44.6	1.4	2.6	-3.2	-0.3	-0.9	-6.7	1.9
Medication: Paracetamol	2.4	3.7	12.1	-0.4	-1.0	-2.1	-2.1	-1.7	-3.5	-0.9
Irritability	2.4	4.1	6.6	1.7	1.5	2.6	1.2	2.3	2.1	2.4
Myopia	2.4	3.5	11.5	0.4	-0.1	2.8	1.3	1.8	3.4	0.3
Body Mass Index (BMI) (2010)	2.3	3.2	7.7	1.6	2.8	-0.7	1.7	0.8	-2.0	2.1
Taking other prescription medications	2.3	3.6	9.2	-0.5	-1.1	-3.0	-1.7	-1.6	-2.8	-0.9
Long-standing illness, disability or infirmity	2.3	3.6	14.6	0.0	0.2	-2.8	-1.1	-1.1	-3.8	0.0
Maternal smoking around birth	2.2	3.2	14.1	-0.5	-0.3	-2.2	-0.7	-1.4	-3.8	-0.6
Body mass index (BMI)	2.2	9.2	43.2	0.1	1.3	-3.6	-1.1	-2.2	-6.6	0.5
Leg fat mass (right)	2.2	8.5	42.2	0.5	1.5	-3.3	-0.9	-1.7	-6.5	0.7
Arm fat mass (left)	2.2	8.9	42.3	0.3	1.3	-3.5	-1.3	-2.0	-6.5	0.6
Leg fat mass (left)	2.2	8.5	42.6	0.5	1.6	-3.2	-0.9	-1.7	-6.5	0.8
Sitting height	2.1	14.8	25.6	-4.4	-5.1	1.9	-3.2	-2.6	3.7	-4.9
Arm fat mass (right)	2.1	8.5	40.1	0.1	1.4	-3.4	-1.1	-1.9	-6.3	0.7
Deep venous thrombosis (DVT) (self-reported)	2.1	2.7	4.6	-1.7	-1.7	-1.2	-1.6	-1.8	-1.1	-2.1
Financial difficulties in last 2 years	2.0	2.7	5.6	-1.0	-1.1	-2.0	-1.9	-1.6	-2.4	-0.8
Whole body fat mass	2.0	8.3	40.4	0.4	1.6	-3.3	-1.0	-1.7	-6.4	0.8
Risk taking	2.0	2.9	9.0	0.4	-0.2	-2.7	-1.7	-1.0	-3.0	-0.5
BMI	1.8	10.7	52.7	0.3	1.6	-3.4	-1.3	-2.2	-7.3	1.0
Respiratory disease	1.8	4.0	10.0	-1.2	-0.7	-3.1	-1.5	-1.7	-3.2	-1.0
Trunk fat mass	1.8	7.9	38.6	0.6	1.8	-3.0	-0.9	-1.4	-6.2	1.0
Forced vital capacity (FVC)	1.8	7.1	24.1	-1.4	-2.7	3.5	-0.9	0.5	4.9	-1.8
Breastfed as a baby	1.8	2.3	7.3	-0.3	-1.0	-2.7	-0.7	-0.9	-2.5	-0.6
Number of full brothers	1.8	2.3	4.2	0.8	1.8	1.5	1.6	1.3	1.2	2.0
Ovarian Cancer	1.7	2.2	4.0	-1.7	-2.0	-1.1	-1.8	-1.2	-0.3	-1.6
Prostate Cancer	1.7	2.4	4.0	-1.6	-1.6	-0.7	-1.5	-1.9	-1.2	-2.0
Number of treatments/medications taken	1.7	3.1	7.0	-1.4	-0.8	-2.4	-1.7	-1.7	-2.6	-0.5
Bilateral oophorectomy (both ovaries removed)	1.7	2.0	6.7	0.4	1.7	-1.3	0.8	0.2	-2.6	1.3
Forced vital capacity (FVC), Best measure	1.7	6.2	16.1	-2.4	-3.0	2.2	-1.1	-0.6	4.0	-2.5
Pulse wave peak to peak time	1.7	2.0	6.6	-0.9	0.1	2.6	-0.0	1.0	2.2	0.7
Ever taken oral contraceptive pill	1.7	1.9	3.3	-1.7	-1.8	0.1	-1.3	-1.5	0.4	-1.8
Current tobacco smoking	1.6	2.6	5.3	-1.7	-0.8	-1.8	-1.6	-1.7	-2.3	-0.7
High blood pressure (mother)	1.6	2.3	5.5	1.1	1.0	2.4	1.8	1.2	1.5	1.2
Waist circumference	1.6	6.0	27.7	-0.2	0.3	-2.9	-1.3	-2.1	-5.3	-0.4
Worrier / anxious feelings	1.6	3.1	5.7	1.7	0.4	2.2	0.3	2.4	2.3	1.6
Medication: Paracetamol	1.6	2.6	7.5	-0.9	-1.1	-1.7	-1.8	-1.4	-2.7	-0.7
Eye problems/disorders: Cataract	1.6	1.9	2.8	1.1	1.2	1.6	1.3	1.3	1.2	1.7
Breast cancer (self-reported)	1.6	1.9	2.7	1.0	1.6	1.5	1.4	1.6	0.7	1.7
Alzheimer’s Disease (in mother)	1.5	1.8	4.7	-1.0	-2.1	0.1	-2.2	-0.8	0.1	-1.2
LDL Cholesterol	1.5	2.3	4.7	1.7	1.9	0.8	1.3	1.6	0.2	2.2
Supplements: Zinc	1.5	1.6	2.6	1.4	0.6	1.6	0.6	1.5	1.6	0.9
Pulse wave Arterial Stiffness index	1.5	1.8	5.9	0.8	-0.3	-2.4	-0.0	-1.0	-2.0	-0.8
Tense / ‘highly strung’	1.5	2.5	6.1	2.5	1.0	1.1	1.1	2.1	1.0	1.6
Qualifications: College or University degree	1.5	4.8	9.1	-2.5	-3.0	-0.4	-1.8	-2.1	1.0	-3.0
Medication for pain relief, constipation, heartburn	1.5	2.6	8.7	0.6	0.8	2.0	1.3	1.3	3.0	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	3.5	1.4	1.2	1.9	0.7	1.7	1.0	1.1
Rheumatoid Arthritis	1.4	1.9	3.8	2.0	1.4	-1.3	0.8	0.9	-1.6	1.4
Triglycerides	1.4	2.2	3.6	1.7	1.9	-0.0	1.8	1.6	-0.2	1.9
Lung FEV1/FVC ratio	1.4	6.9	26.0	0.3	1.7	-4.1	-0.2	-1.5	-5.1	0.6
Chronotype (morning person)	1.4	3.3	10.8	-0.8	-0.2	-3.0	-0.7	-1.3	-3.3	-0.6
Medication: Simvastatin	1.4	2.0	3.6	-0.9	-1.4	-1.4	-1.9	-1.2	-1.6	-1.5
Gout (self-reported)	1.4	1.9	3.5	-1.1	-1.5	-1.7	-1.2	-1.2	-1.0	-1.9
Wheeze or whistling in the chest in last year	1.4	2.5	10.6	-0.4	1.0	-2.2	-0.7	-0.6	-3.3	0.6
Medication: Allopurinol	1.4	1.8	3.3	-1.2	-1.3	-1.8	-1.4	-1.1	-1.1	-1.4
Commuting to job workplace: Car/motor vehicle	1.4	1.6	3.1	-1.6	-0.0	-1.4	0.6	-1.2	-1.8	-1.1
Wears glasses or contact lenses	1.4	1.6	4.0	-0.9	-2.0	-0.6	-2.0	-0.8	-0.1	-1.3
Medication: Bendroflumethiazide	1.4	2.2	5.0	-2.2	-1.5	-0.7	-1.5	-1.6	-0.3	-1.6
Type 2 Diabetes (T2D) (2012)	1.3	1.5	4.6	-0.6	-0.5	-1.6	-0.8	-1.4	-2.1	-0.4
Ulcerative Colitis	1.3	1.9	3.1	1.3	1.1	1.2	1.5	1.7	1.0	1.6
Supplements: Glucosamine	1.3	1.7	4.4	-0.4	-2.1	0.3	-1.8	-0.7	1.1	-1.5
Hip circumference	1.3	5.7	27.1	-0.3	0.7	-2.5	-1.3	-2.1	-5.2	-0.0
Prospective memory result	1.3	1.6	6.7	-0.4	1.0	-1.5	0.5	-0.5	-2.6	0.8
Glaucoma (self-reported)	1.3	1.5	4.4	0.3	1.7	0.3	2.1	0.9	0.7	1.4
Chest pain or discomfort	1.3	1.8	3.0	-1.7	-1.1	-0.9	-1.0	-1.6	-1.4	-1.6
Mineral and other dietary supplements	1.3	1.7	4.5	0.2	1.9	-1.2	1.1	-0.0	-2.1	1.1
Osteoarthritis (self-reported)	1.3	1.7	6.3	1.3	0.6	-1.9	0.1	-0.1	-2.5	0.3
Pain type(s) experienced in last month: Hip pain	1.3	1.6	8.1	0.4	1.0	-1.3	0.2	-0.2	-2.9	0.5
Unable to work because of sickness or disability	1.3	1.7	7.1	-0.5	-0.6	-1.3	-1.2	-1.0	-2.7	-0.5
Commuting to job workplace: Cycle	1.3	1.6	4.4	0.7	0.2	2.1	1.0	1.2	1.8	0.6
Neuroticism (Nagel 2018)	1.2	2.7	5.4	1.7	0.9	2.3	0.6	2.2	1.6	1.4
Neuroticism (2016)	1.2	1.7	4.0	1.0	0.2	2.0	0.3	1.7	1.6	0.9
Medication: Metformin	1.2	1.7	2.4	-1.3	-1.3	-1.2	-1.2	-1.5	-1.2	-1.5
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	5.1	2.3	0.8	0.2	0.2	1.5	0.3	1.6
Weight	1.2	6.0	24.1	-0.9	-0.0	-2.7	-1.7	-2.4	-4.9	-0.7
Chronic bronchitis/emphysema (mother)	1.2	1.4	3.4	1.8	1.4	0.3	1.2	0.9	-0.5	1.3
Exposure to tobacco smoke outside home	1.2	1.5	3.4	1.8	1.4	-0.4	0.9	1.1	-1.0	1.4
Medication: Omeprazole	1.2	1.4	6.0	0.5	0.0	-1.4	-0.5	-1.1	-2.4	-0.4
Age at last live birth	1.2	1.7	3.8	-1.6	-1.9	-0.6	-0.8	-1.0	0.3	-1.9
Mood swings	1.2	2.2	4.3	1.8	1.3	1.7	0.6	2.1	0.7	1.7
Medication: Aspirin	1.2	1.6	4.5	-0.9	-0.1	-2.0	-0.6	-1.3	-2.1	-0.1
Eye problems/disorders: Glaucoma	1.2	1.4	4.1	0.6	1.7	0.4	2.0	0.8	0.3	1.3
Ever smoked	1.2	2.1	6.4	0.5	-0.0	2.5	-0.1	1.1	2.5	0.5
Average weekly beer plus cider intake	1.2	1.7	4.7	-0.3	-0.5	-1.8	-1.0	-1.4	-2.2	-0.9
Alzheimer’s Disease (including proxy)	1.1	1.6	4.0	-0.7	-2.0	-1.2	-1.6	-0.8	0.1	-1.4
HbA1C	1.1	1.2	3.0	1.7	1.0	-0.8	0.7	0.6	-1.6	0.5
Schizophrenia (2014)	1.1	2.5	8.6	2.9	0.6	1.3	0.8	1.8	1.1	1.3
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	6.4	0.8	-0.4	-1.4	-1.7	-0.3	-2.5	0.1
Forced expiratory volume in 1-second (FEV1)	1.1	3.7	14.3	-0.9	-1.3	2.7	-0.2	0.7	3.8	-0.9
Medication: Ibuprofen	1.1	1.3	6.5	-0.3	-0.0	-1.3	-0.3	-0.5	-2.5	-0.4
Medication: Aspirin	1.1	1.5	3.3	-1.1	-0.3	-1.8	-0.6	-1.4	-1.8	-0.4
Supplements: Vitamin C	1.1	1.3	4.1	0.9	0.6	2.0	0.3	1.1	1.4	0.8
Smoking status: Current	1.1	1.8	3.0	-1.5	-0.8	-1.4	-1.4	-1.6	-1.7	-0.7
Average weekly champagne plus white wine intake	1.1	1.5	3.0	0.1	1.4	1.2	1.7	0.7	1.6	1.0
Supplements: Fish oil (including cod liver oil)	1.1	1.4	4.0	-0.5	-1.1	1.9	-0.9	0.4	2.0	-0.3
Diabetes (mother)	1.0	1.3	1.9	0.6	1.1	1.4	1.0	1.3	1.0	1.4
Stomach or abdominal pain in last month	1.0	1.2	3.2	-1.2	-1.8	0.2	-1.4	-0.6	0.3	-1.2
Qualifications: None of the above	1.0	2.1	7.2	1.5	1.2	-0.9	-0.6	0.1	-2.7	1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	3.2	0.5	-0.8	-1.6	-1.8	-0.8	-1.7	-0.5
Comparative body size at age 10	1.0	2.7	6.7	0.7	1.3	2.6	1.2	1.6	1.9	1.5
Age at first live birth	1.0	1.7	4.1	-1.0	-1.5	1.6	-0.2	0.2	2.0	-1.3
Heart disease (mother)	1.0	1.2	2.4	-0.8	-1.2	-0.7	-1.1	-0.9	-1.6	-1.1
Had major operations	1.0	1.2	2.5	1.2	1.1	-1.1	0.9	0.5	-1.6	0.7
Handedness (chirality/laterality): Left-handed	1.0	1.2	1.9	1.4	0.5	1.2	0.8	1.3	1.2	0.9
Tinnitus: Yes, now most or all of the time	1.0	1.2	3.8	1.0	0.6	2.0	0.2	1.2	0.6	1.1
Commuting to job workplace: Public transport	1.0	1.2	3.5	0.4	0.3	1.8	0.3	0.9	1.9	0.8
Pain experienced in last month	1.0	1.6	5.5	0.3	0.4	1.9	0.6	0.7	2.4	1.0
Pack years of smoking	1.0	1.5	5.2	1.8	0.6	-0.8	-0.4	0.4	-2.3	0.6
Arm predicted mass (left)	1.0	4.9	8.3	-2.2	-1.6	-2.0	-1.9	-2.9	-2.7	-2.1
Bipolar Disorder or Schizophrenia	0.9	2.3	5.8	2.4	0.6	1.3	0.9	1.9	1.4	1.2
Diabetes (father)	0.9	1.1	4.1	-2.0	-0.4	-0.3	-0.1	-1.3	-0.5	-1.2
Pack years adult smoking proportion	0.9	1.4	6.0	1.3	0.2	-1.0	-0.9	0.1	-2.4	0.2
Pain all over the body in last month	0.9	1.0	2.9	1.7	0.5	-1.0	0.4	-0.0	-1.5	0.2
Medication: Ramipril	0.9	1.2	2.3	-1.5	-0.8	-1.0	-1.0	-1.1	-1.2	-1.0
Noisy workplace	0.9	1.1	3.0	1.1	1.2	-0.0	0.8	0.8	-0.7	1.7
Qualifications: O levels/GCSEs or equivalent	0.9	1.5	6.4	-0.1	-1.0	1.2	-0.1	0.7	2.5	-0.9
Number of full sisters	0.9	1.1	4.8	0.8	0.8	-0.8	-0.3	0.3	-2.2	0.7
Arm fat-free mass (left)	0.9	4.4	7.8	-2.1	-1.5	-1.8	-1.8	-2.8	-2.5	-2.0
Ulcerative Colitis (UC)	0.8	1.5	2.4	1.3	0.9	1.3	1.3	1.5	0.7	1.3
Coronary Artery Disease (CAD)	0.8	0.9	3.7	-0.1	-0.4	-1.9	-0.3	-0.9	-1.0	-0.9
Lung FVC	0.8	3.8	14.8	-0.6	-1.4	2.9	-0.1	0.6	3.9	-0.9
Hearing difficulty/problems: Yes	0.8	1.2	2.7	-1.6	-0.6	-1.1	-1.0	-1.4	-1.0	-0.6
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	2.2	-0.2	-1.1	-0.9	-0.9	-1.1	-1.5	-1.1
Angina	0.8	1.1	3.5	-0.8	0.1	-1.5	-0.3	-1.0	-1.9	-0.5
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.7	0.6	0.7	0.5	0.9	1.3	1.3	1.1
Trunk fat-free mass	0.8	4.8	7.7	-2.6	-2.4	-1.1	-2.0	-2.7	-0.8	-2.8
Trunk predicted mass	0.8	4.7	7.5	-2.6	-2.4	-1.1	-2.1	-2.6	-0.8	-2.7
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	3.0	1.5	0.3	1.3	-0.5	1.2	1.7	1.4
Worry too long after embarrassment	0.8	1.3	3.1	0.6	0.2	1.8	1.0	1.3	1.6	0.3
Health satisfaction	0.8	1.1	2.3	-0.4	-0.9	-1.2	-0.9	-0.9	-1.5	-1.1
Eye problems/disorders: None of the above	0.8	0.9	2.8	-0.7	-1.2	-0.6	-0.8	-0.6	0.3	-1.7
Migraine (self-reported)	0.8	1.0	3.5	-0.1	-0.6	-0.7	-1.0	-0.9	-1.9	-0.8
Arm predicted mass (right)	0.8	4.3	7.5	-2.0	-1.8	-1.6	-2.1	-2.7	-2.0	-2.1
Overall health rating	0.8	1.6	4.1	0.3	-1.2	-1.6	-1.3	-0.7	-2.0	-1.1
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	3.1	-1.1	-0.6	1.3	0.0	-0.2	1.8	-0.6
Smoking status: Previous	0.8	1.2	3.9	0.3	-0.2	1.8	-0.5	0.9	2.0	0.2
Whole body water mass	0.8	4.7	7.7	-2.3	-2.1	-1.4	-2.2	-2.8	-1.6	-2.4
Alcohol drinker status: Never	0.8	0.9	2.3	-1.5	-1.2	-0.6	-0.7	-0.4	0.5	-1.2
Basal metabolic rate	0.8	4.5	7.3	-2.0	-1.5	-1.8	-2.1	-2.7	-2.5	-2.0
Diastolic blood pressure, automated reading	0.8	2.4	4.1	2.0	2.0	-0.8	1.7	0.6	-1.7	1.6
Medication: Omeprazole (e.g. Zanprol)	0.8	0.9	4.4	1.0	0.2	-0.9	0.2	-0.5	-2.1	-0.2
Heart disease (siblings)	0.8	1.0	4.1	0.1	0.4	-1.6	-0.2	-0.3	-2.0	0.3
Bipolar Disorder (2018)	0.7	1.1	2.8	0.9	0.3	1.3	0.8	1.3	1.7	0.3
Intelligence (Savage-Jansen 2018)	0.7	2.2	9.7	1.1	-0.9	1.6	0.4	0.7	3.1	-0.7
Schizophrenia (2018)	0.7	1.5	5.8	2.4	0.4	0.6	0.4	1.5	0.5	1.2
Worry (Nagel 2018)	0.7	1.5	3.3	1.1	-0.5	1.8	-0.3	1.6	1.8	0.3
Neuroticism	0.7	1.6	4.0	1.3	0.7	1.4	0.2	2.0	1.1	1.4
Average weekly spirits intake	0.7	0.9	2.5	0.9	1.2	0.4	0.0	1.3	0.3	1.6
Average weekly fortified wine intake	0.7	0.8	2.3	1.5	0.7	0.5	0.7	0.9	0.5	1.0
Past tobacco smoking	0.7	1.3	4.3	-0.2	0.3	-2.0	0.4	-0.8	-2.1	-0.2
Alcohol usually taken with meals	0.7	1.2	3.8	0.5	0.3	1.4	0.9	0.9	2.0	0.8
Heart attack	0.7	0.9	2.0	-0.4	-0.7	-1.1	-0.9	-1.0	-1.4	-0.6
Fluid intelligence score	0.7	1.4	3.3	-0.6	-1.7	-0.6	-1.0	-1.4	0.2	-1.8
Illnesses of mother	0.7	0.9	3.2	-1.8	-0.2	-1.0	-0.3	-0.7	1.0	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	7.3	-1.2	-1.5	1.6	-0.3	-0.1	2.7	-1.4
Birth weight of first child	0.7	1.3	3.0	-0.2	-1.4	-0.6	-1.7	-0.8	-1.2	-1.2
Arm fat-free mass (right)	0.7	3.8	6.5	-2.0	-1.6	-1.6	-1.8	-2.5	-2.0	-2.0
Medication: Blood pressure	0.7	1.3	2.2	0.9	1.4	0.7	1.5	1.4	0.7	1.3
Angina (self-reported)	0.7	1.0	2.9	-0.7	-0.1	-1.4	-0.5	-0.9	-1.7	-0.5
Pulse rate, automated reading	0.7	2.1	5.7	0.5	-0.8	-1.9	-1.1	-1.1	-2.4	-1.5
Whole body fat-free mass	0.7	4.2	6.9	-2.2	-2.0	-1.3	-2.1	-2.6	-1.5	-2.4
Asthma (self-reported)	0.7	1.3	4.5	-0.5	-0.3	-2.1	-0.6	-0.8	-1.8	-0.4
Illnesses of father: High blood pressure	0.7	0.9	2.9	-1.7	-0.0	0.2	0.9	-0.3	1.1	-1.0
Basal cell carcinoma (self-reported)	0.7	0.8	3.6	0.3	0.6	-0.9	0.8	-0.1	-1.9	0.4
Breast Cancer	0.6	1.5	3.0	-1.6	-1.7	-0.4	-0.4	-1.3	0.1	-1.7
Bipolar Disorder (2011)	0.6	0.5	1.5	0.8	0.3	0.6	0.5	0.8	1.2	0.6
Primary Biliary Cirrhosis	0.6	0.8	1.3	0.9	1.0	-0.1	1.2	1.0	0.9	0.9
Smoking Status	0.6	1.4	3.8	-1.4	-1.2	0.1	-1.9	-1.2	-0.4	-1.0
Systolic blood pressure, automated reading	0.6	1.7	6.3	0.9	1.2	-1.6	0.7	-0.3	-2.5	0.9
Medication: Co-codamol	0.6	0.7	2.9	1.1	0.2	-0.6	-0.2	-0.0	-1.7	0.3
Leg fat-free mass (left)	0.6	3.1	4.9	-1.6	-1.4	-1.2	-1.9	-2.2	-1.9	-1.7
Leg predicted mass (left)	0.6	3.2	5.1	-1.5	-1.4	-1.4	-2.0	-2.3	-2.1	-1.7
Nervous feelings	0.6	1.1	3.5	0.6	-0.0	1.6	0.2	1.1	1.9	0.4
Had menopause	0.6	0.7	1.5	-0.1	-0.7	-1.0	-0.8	-1.2	-1.0	-0.5
Alcohol intake versus 10 years previously	0.6	0.9	2.3	-1.0	-1.5	0.3	-0.8	-0.7	0.0	-1.3
Qualifications: A levels/AS levels or equivalent	0.6	1.3	5.8	-0.2	-0.4	1.7	0.0	0.6	2.4	-0.5
Asthma	0.6	1.2	4.0	-0.6	-0.3	-2.0	-0.7	-0.8	-1.6	-0.4
Medication: Lansoprazole	0.6	0.6	1.5	-0.6	-0.4	-0.9	-0.4	-1.1	-1.2	-0.5
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	2.6	-0.8	-1.3	-0.2	-1.6	-0.9	-0.3	-1.1
High blood pressure (siblings)	0.6	0.9	1.3	-1.1	-0.8	-1.1	-1.0	-0.9	-0.9	-0.7
Friendships satisfaction	0.6	0.7	2.2	-0.2	-1.5	0.1	-1.3	0.1	0.7	-0.5
Medication for cholesterol	0.6	0.9	1.5	1.2	0.9	1.2	1.1	1.0	0.4	0.8
Mother’s age at death	0.6	0.8	1.8	0.3	-1.0	1.3	-0.9	0.1	1.2	-0.0
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.7	-0.3	-0.7	-1.1	-0.8	-1.1	-1.3	-0.6
Depressed Affect (Nagel 2018)	0.5	1.0	2.2	0.9	0.7	1.5	0.2	1.5	0.5	1.0
Verbal and Numeric Reasoning (VNR)	0.5	1.1	3.1	-0.3	-1.8	-0.3	-0.4	-0.5	1.4	-1.5
Ever had hysterectomy (womb removed)	0.5	0.5	1.8	-0.3	0.7	-0.8	0.5	-0.5	-1.4	0.5
Qualifications: CSEs or equivalent	0.5	0.7	1.8	-0.7	1.4	0.4	1.2	0.6	0.5	0.6
Medication: Levothyroxine sodium	0.5	0.8	3.0	1.1	-0.5	0.2	-1.7	0.1	0.7	0.7
Impedance of leg (left)	0.5	2.5	4.3	1.3	1.8	1.2	1.8	2.1	0.8	1.7
Had other major operations	0.5	0.7	1.7	-1.3	-0.4	0.9	-0.4	-0.5	1.2	-0.4
Illnesses of siblings	0.5	0.7	1.7	-0.7	-0.5	1.0	0.2	-0.3	1.3	-1.0
Time employed in main current job	0.5	0.6	2.2	-0.4	-0.1	1.5	0.5	0.1	0.9	-0.7
Father’s age at death	0.5	0.7	1.6	-0.3	-1.3	0.5	-0.2	-0.2	1.3	-1.0
Happiness	0.5	0.6	1.7	1.3	0.6	-0.5	-0.1	0.6	-0.7	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	1.9	1.4	0.5	0.4	0.7	0.9	0.2	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	3.3	-0.3	0.2	-0.9	0.1	0.0	-1.8	-0.0
Lung cancer (father)	0.5	0.6	1.7	0.2	-0.0	-1.1	-0.6	-0.8	-1.3	0.2
Standing height	0.5	4.8	8.1	-2.3	-2.8	1.3	-1.7	-1.0	2.6	-2.8
Loud music exposure frequency	0.5	0.6	1.7	0.0	-0.9	-0.2	-1.3	-0.5	-0.7	-0.8
Emphysema/chronic bronchitis	0.5	0.6	2.5	0.9	0.2	-0.4	-0.8	-0.1	-1.6	0.2
Leg fat-free mass (right)	0.5	2.7	4.8	-1.6	-1.3	-1.1	-1.9	-2.2	-1.6	-1.6
Diabetes diagnosed by doctor	0.5	0.9	2.3	-0.9	-0.1	-1.5	-0.6	-1.1	-1.2	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.5	0.9	2.7	1.6	0.6	0.9	0.7	1.1	0.0	0.7
Leg predicted mass (right)	0.5	2.6	4.5	-1.5	-1.3	-1.0	-1.9	-2.1	-1.5	-1.5
Hearing aid user	0.5	0.6	1.9	-0.5	1.4	0.8	0.8	-0.1	-0.0	0.9
Medication: Blood pressure	0.5	1.0	1.7	-1.2	-0.1	-1.2	-0.8	-1.3	-1.3	-0.2
Vascular/heart problems diagnosed by doctor	0.5	1.4	3.5	-0.3	-1.5	1.4	-0.8	0.2	1.9	-1.1
Impedance of whole body	0.5	2.6	5.4	1.5	1.5	1.5	1.4	2.3	1.4	1.6
Alzheimer’s Disease (in father)	0.4	0.4	1.0	-0.3	-0.9	-0.9	-0.2	-0.6	-0.2	-1.0
Age at First Birth	0.4	0.6	1.3	0.5	0.7	1.0	1.1	0.7	0.8	0.4
Crohns Disease (2012)	0.4	0.6	1.8	1.3	-0.1	0.5	0.6	1.2	0.2	0.5
Mean Putamen Volume	0.4	0.4	1.2	0.4	0.1	-0.1	0.6	1.1	0.9	0.6
Lupus	0.4	0.6	2.2	1.5	0.0	-0.3	-0.1	0.0	-1.3	0.5
Blood Red Count	0.4	3.6	6.6	-2.4	-2.3	-1.1	-1.6	-1.8	-0.5	-2.6
Hair Pigment	0.4	12.5	24.7	-2.0	-3.9	-3.4	-5.0	-3.5	-3.1	-3.1
Severe depression (siblings)	0.4	0.4	0.7	-0.8	-0.7	-0.7	-0.6	-0.6	-0.0	-0.8
Impedance of leg (right)	0.4	1.8	3.6	1.0	1.3	1.1	1.7	1.9	1.0	1.1
Fed-up feelings	0.4	0.8	2.1	0.3	1.1	1.4	0.6	1.0	0.1	1.0
High blood pressure	0.4	1.1	3.0	0.2	1.7	-0.6	0.8	-0.1	-1.3	1.3
Multivitamins +/- minerals	0.4	0.5	0.9	-0.9	-0.9	-0.6	-0.4	-0.2	0.9	-0.8
Mouth/teeth dental problems	0.4	0.7	2.2	-1.5	-0.6	-0.6	-0.5	-0.7	-0.2	-1.0
Falls in the last year	0.4	0.5	2.5	-0.1	0.9	0.1	0.6	-0.4	-1.6	0.1
Impedance of arm (left)	0.4	1.9	3.9	1.3	1.2	1.3	0.7	2.0	1.3	1.4
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.3	0.9	0.6	-0.2	-0.5	-0.2	-1.1	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.8	0.5	0.0	-0.5	-1.1	-0.3	-1.3	0.4
Neck or shoulder pain in last month	0.4	0.6	2.1	-0.5	0.3	-1.3	-0.0	-0.2	-1.5	-0.4
Medication: Seretide 50 evohaler	0.4	0.4	1.2	0.2	-0.5	-0.7	-0.7	-0.1	-1.1	-0.8
Alcohol intake frequency.	0.4	0.9	2.0	-1.4	-1.2	0.8	-0.8	-0.2	0.9	-0.8
Suffer from ‘nerves’	0.4	0.6	1.8	0.7	-0.2	1.0	-0.3	0.8	1.3	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.0	-0.8	-0.3	-1.0	-0.3	-0.7	-0.3	-1.0
Hypertension (Self-reported)	0.4	1.0	3.2	-0.6	0.9	-1.2	0.0	-0.9	-1.8	0.4
Average weekly red wine intake	0.4	0.5	0.9	0.5	0.7	0.8	-0.1	0.8	0.9	0.9
Ever had bowel cancer screening	0.4	0.5	2.5	-0.4	-0.0	0.5	0.2	0.5	1.6	0.4
Commuting to job workplace: Walk	0.4	0.4	1.5	1.2	0.3	-0.3	0.2	0.8	0.4	0.8
Osteoporosis (self-reported)	0.4	0.6	1.1	1.1	1.0	0.8	0.5	0.5	-0.2	0.6
Number of operations (self-reported)	0.4	0.6	1.6	0.3	0.8	-1.0	0.7	-0.3	-1.3	0.2
Ever had prostate specific antigen (PSA) test	0.4	0.5	0.9	0.6	0.6	1.0	0.9	0.7	0.6	0.5
Fractured/broken bones in last 5 years	0.4	0.5	1.1	1.0	0.9	-0.4	0.5	0.8	-0.4	0.8
Ever depressed for a whole week	0.4	0.5	1.7	1.3	0.5	0.3	0.2	0.7	0.6	0.5
Depression (Nagel 2018)	0.3	0.4	1.3	0.6	-0.2	0.1	-0.9	0.3	-1.2	0.3
Blood Eosinophil Count	0.3	2.0	5.4	-1.4	0.0	-1.4	-0.3	-2.0	-2.3	-0.7
Height	0.3	4.9	9.9	-2.0	-3.1	1.1	-1.7	-0.6	2.5	-3.1
Systolic Blood Pressure	0.3	1.7	3.4	1.2	1.8	-0.6	1.7	0.9	-0.4	1.8
Cardiovascular Disease	0.3	1.1	3.0	-0.6	1.3	-1.2	0.5	-0.4	-1.7	1.0
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.7	0.8	-0.0	0.3	-0.8	0.1	-0.8	0.6
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.1	-0.2	-0.0	-0.7	0.0	-0.5	-1.1	0.0
Vitamin and mineral supplements	0.3	0.4	0.9	0.5	0.9	-0.3	0.7	0.1	-0.8	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.7	0.3	0.2	0.0	-1.0	0.0	-1.3	0.6
Medication: Atenolol	0.3	0.4	0.8	-0.9	0.6	-0.7	0.8	-0.6	-0.3	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.9	0.8	0.2	-1.4	0.1	-0.3	-1.4	-0.3
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.0	0.6	1.0	-0.1	-0.0	0.2	-0.1	1.0
Neuroticism score	0.3	0.7	1.7	1.0	0.2	0.8	-0.3	1.3	0.7	1.0
Impedance of arm (right)	0.3	1.6	3.5	1.1	1.0	1.2	0.8	1.9	1.3	1.2
Length of working week for main job	0.3	0.4	1.4	0.4	0.7	0.3	1.2	0.5	0.0	0.3
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.5	-1.2	0.3	0.3	0.5	0.0	0.7	0.0
Birth weight	0.3	0.7	1.7	-0.7	-0.3	-1.0	-0.3	-0.8	-1.0	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.8	0.9	0.3	0.1	0.5	0.8	0.6	0.3
Shortness of breath walking on level ground	0.3	0.4	1.2	1.1	0.3	0.0	-0.0	0.4	-0.9	0.5
Comparative height size at age 10	0.3	1.7	4.3	-1.5	-1.3	1.3	-0.5	-0.0	2.1	-1.4
Family relationship satisfaction	0.3	0.4	1.0	0.2	-1.0	-0.3	-0.7	-0.3	-0.7	-0.7
Knee pain experienced in last month	0.3	0.4	1.0	-0.9	0.7	0.2	0.6	-0.5	-1.0	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.7	0.4	0.8	0.8	0.6	0.1	0.1	0.8
Illnesses of father: Heart disease	0.3	0.4	0.8	-0.1	0.9	0.5	0.7	0.6	0.3	0.9
Loneliness, isolation	0.3	0.4	0.9	0.9	0.1	-0.1	-0.3	0.5	-0.9	0.8
Back pain experienced in last month	0.3	0.5	1.1	-0.8	-0.9	0.1	-0.6	-0.4	-0.4	-1.0
Miserableness	0.3	0.5	0.9	0.9	0.5	0.9	-0.1	0.9	0.0	0.8
Guilty feelings	0.3	0.4	1.2	-0.4	-0.4	-0.6	-1.1	-0.6	-0.9	-0.1
Blood White Count	0.2	1.8	5.3	1.3	1.4	0.1	-0.1	0.9	-2.3	1.7
Hypothyroidism (self reported)	0.2	0.4	0.7	0.7	0.2	0.6	-0.8	0.4	0.6	0.9
Tanning	0.2	2.8	6.7	1.4	1.4	2.6	1.4	1.9	1.4	1.1
Medication for hormone replacement therapy	0.2	0.3	0.6	-0.7	-0.7	-0.4	0.1	-0.2	0.5	-0.8
Relative age voice broke	0.2	0.3	0.8	-0.5	-0.4	0.7	-0.9	0.1	0.6	-0.4
Age when periods started (menarche)	0.2	0.5	1.6	-0.4	-0.2	-1.0	-0.9	-0.3	-1.3	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.4	0.6	0.2	-1.2	0.1	-0.3	-1.1	-0.2
Serious illness, injury or assault to yourself	0.2	0.2	0.9	0.9	0.4	-0.0	0.1	0.6	-0.5	0.3
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.8	0.6	0.6	0.4	-0.1	0.9	0.7	0.9
Number of incorrect matches in round	0.2	0.3	0.9	0.1	0.1	-0.7	-0.2	-0.8	-1.0	0.5
Hair/balding pattern: Pattern 2	0.2	0.3	1.0	0.5	0.3	-0.0	-0.1	0.8	0.3	1.0
Allergy	0.2	0.4	1.3	0.3	0.3	0.7	1.2	0.2	0.6	0.0
Pulse rate	0.2	0.3	0.9	0.4	-0.1	-0.5	0.2	-0.3	-1.0	-0.9
Mouth/teeth dental problems: Dentures	0.2	0.4	0.8	0.7	-0.0	-0.4	-0.8	-0.2	-0.9	0.7
Medication: Cholesterol lowering	0.2	0.4	0.6	0.7	0.8	-0.4	0.5	0.3	-0.8	0.5
Peak expiratory flow (PEF)	0.2	0.5	1.4	-0.9	-0.2	1.2	-0.2	0.1	1.0	-0.2
Pulse wave reflection index	0.2	0.2	1.0	0.7	-0.2	-1.0	-0.3	0.1	-0.3	0.1
Number of children fathered	0.2	0.2	0.9	-0.3	0.7	-0.1	0.9	0.1	0.0	0.2
Leg pain on walking	0.2	0.2	0.9	0.3	0.1	-0.4	0.6	0.1	-1.0	-0.3
Illnesses of siblings: Diabetes	0.2	0.2	0.5	0.3	0.3	0.2	0.4	0.7	-0.4	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	2.0	-1.0	-0.4	0.4	0.1	0.4	1.4	-0.4
Qualifications: nursing, teaching	0.2	0.4	0.8	-0.8	-0.2	0.2	0.8	-0.3	0.6	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.7	0.5	-0.4	-0.3	-0.8	-0.3	-0.8	-0.1
Illnesses of father: None of the above (group 1)	0.2	0.3	1.0	1.0	0.3	0.5	0.4	0.5	0.2	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.9	0.8	0.3	0.5	0.6	0.4	1.0	0.3
Number of self-reported non-cancer illnesses	0.2	0.4	0.8	0.2	-0.0	-0.9	-0.8	-0.4	-0.9	0.4
Medication: Lisinopril	0.2	0.3	0.7	-0.2	0.4	0.9	0.5	-0.0	0.7	0.3
Alcohol drinker status: Previous	0.2	0.2	0.7	0.4	-0.3	0.4	-0.8	-0.3	-0.1	0.0
Schizophrenia vs Biploar Disorder	0.1	0.1	0.6	0.8	-0.0	-0.1	0.1	0.1	-0.1	0.1
Crohns Disease (2017)	0.1	0.3	0.7	-0.0	-0.7	-0.1	-0.5	-0.5	-0.8	-0.8
Irritable Bowel Disease (IBD)	0.1	0.3	0.7	0.8	0.1	0.8	0.6	0.7	0.0	0.3
Reaction Time	0.1	0.2	0.7	0.3	-0.3	0.8	-0.5	0.2	0.2	0.1
Heel T-Score	0.1	1.1	2.4	-0.1	-0.7	-1.4	-0.9	-1.0	-1.6	-1.0
Allergy or Eczema	0.1	0.3	1.8	-0.2	-0.6	-0.1	-1.4	-0.0	0.2	-0.1
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.4	-0.4	0.6	-0.4	-0.1	-0.4	-0.6	0.5
Hand grip strength (left)	0.1	0.1	0.4	0.0	0.3	0.2	-0.5	0.6	0.1	0.5
Relative age of first facial hair	0.1	0.3	0.8	-0.6	-0.4	0.9	-0.5	0.0	0.6	-0.3
Hand grip strength (right)	0.1	0.2	1.2	-0.2	-0.2	0.3	-1.1	0.3	-0.2	0.2
Hearing difficulty/problems with background noise	0.1	0.1	0.3	-0.3	0.1	0.1	-0.3	0.0	-0.2	0.6
Diabetes (self-reported)	0.1	0.1	0.3	-0.3	0.3	-0.6	0.2	-0.2	-0.0	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.5	0.5	0.5	0.5	0.4	0.1	-0.7	0.1
Hair/balding pattern: Pattern 3	0.1	0.2	0.5	0.6	-0.7	-0.5	0.1	-0.2	0.1	-0.4
Exposure to tobacco smoke at home	0.1	0.2	0.6	0.5	0.3	0.8	0.1	0.3	-0.1	-0.0
Hair/balding pattern: Pattern 4	0.1	0.1	0.4	0.2	-0.1	0.6	-0.2	0.3	0.6	-0.1
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.3	-0.5	0.3	-0.1	0.3	-0.1	-0.2	-0.2
Medication: Amlodipine	0.1	0.1	0.3	0.4	0.3	-0.5	0.2	0.5	-0.2	0.3
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.3	-0.1	-0.4	-0.6	-0.3	-0.4	-0.3	-0.0
Mean time to correctly identify matches	0.1	0.1	0.3	0.5	-0.3	0.4	-0.4	0.3	0.3	0.3
Medication: Gliclazide	0.1	0.2	0.3	-0.1	0.5	0.5	0.5	0.2	-0.0	0.6
Medication: Atorvastatin	0.1	0.2	0.7	-0.3	0.2	-0.8	0.0	-0.2	-0.4	-0.0
Supplements: Calcium	0.1	0.1	0.3	0.5	-0.0	-0.0	-0.1	0.0	-0.2	-0.5
Blood Platelet Count	0.0	0.2	0.8	0.9	0.3	0.0	0.0	0.3	-0.7	0.4
Waist Hip Ratio (WHR)	0.0	0.2	0.6	-0.0	0.2	0.3	0.8	0.5	0.5	0.1
Age started oral contraceptive pill	0.0	0.0	0.2	0.4	-0.0	0.2	-0.2	-0.1	-0.1	0.2

Hub : Genes

C9orf93

Models

Trait associations