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chr6:124,741,508-127,355,237

Best TWAS P=8.7e-27 · Best GWAS P=2.74e-28 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CENPW	0.04	0.06	lasso	10	0.06	2.4e-07	10.73	-10.7	8.7e-27	-0.99	0.02	0.98	TRUE
7	GTEx	Thyroid	HEY2	0.22	0.24	lasso	6	0.23	1.0e-17	-8.69	-8.8	1.2e-18	-0.08	0.01	0.99	TRUE
15	The Cancer Genome Atlas	Brain Lower Grade Glioma	CENPW	0.04	0.06	blup	35	0.05	9.2e-07	10.78	-10.6	2.3e-26	-0.98	0.01	0.99	FALSE
13	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CENPW	0.04	0.05	lasso	5	0.05	2.6e-06	11.00	-10.5	1.0e-25	-0.98	0.01	0.98	FALSE
6	GTEx	Testis	HEY2	0.31	0.17	lasso	5	0.19	7.4e-09	-8.69	-8.7	2.7e-18	-0.08	0.01	0.99	FALSE
2	CommonMind	Brain Pre-frontal Cortex	HEY2	0.15	0.20	lasso	10	0.21	6.7e-25	-8.76	-8.7	4.2e-18	-0.07	0.01	0.99	FALSE
11	METSIM	Adipose	NCOA7	0.05	0.05	enet	5	0.05	1.9e-07	6.79	8.5	2.5e-17	0.24	0.95	0.02	FALSE
17	The Cancer Genome Atlas	Thyroid Carcinoma	HEY2	0.03	0.04	lasso	3	0.02	3.8e-03	7.77	-8.0	1.2e-15	-0.07	0.01	0.98	FALSE
12	ROSMAP	Brain Pre-frontal Cortex	HEY2	0.10	0.12	enet	15	0.13	9.8e-17	8.24	-8.0	1.5e-15	-0.06	0.01	0.99	FALSE
9	METSIM	Adipose	CENPW	0.02	0.02	blup	189	0.01	8.3e-03	10.93	-7.6	2.6e-14	-0.74	0.02	0.79	FALSE
4	GTEx	Esophagus Muscularis	HINT3	0.08	0.00	enet	14	0.00	2.9e-01	8.41	-7.1	1.0e-12	-0.11	0.07	0.04	FALSE
5	GTEx	Pancreas	HEY2	0.28	0.11	lasso	3	0.10	3.5e-05	-6.24	-7.0	2.2e-12	-0.05	0.09	0.90	FALSE
10	METSIM	Adipose	HEY2	0.02	0.04	lasso	1	0.02	1.6e-04	-6.37	-6.4	1.9e-10	-0.05	0.02	0.97	FALSE
16	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	HEY2	0.09	0.06	lasso	8	0.06	2.3e-03	-6.24	-6.2	7.1e-10	-0.03	0.03	0.76	FALSE
3	GTEx	Artery Coronary	TPD52L1	0.31	-0.01	enet	19	0.05	7.0e-03	0.42	-6.1	8.1e-10	-0.15	0.03	0.54	FALSE
8	GTEx	Vagina	CENPW	0.24	-0.01	lasso	8	-0.01	7.9e-01	5.14	5.8	6.3e-09	0.41	0.04	0.07	FALSE
14	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HEY2	0.05	0.05	blup	36	0.05	4.9e-06	-6.24	-5.2	1.6e-07	-0.03	0.17	0.82	FALSE