[Hub]/) : Traits : Leg fat-free mass (right) :

chr6:129,638,583-132,080,991

Best TWAS P=3.86e-45 · Best GWAS P=2.73e-41 conditioned to 0.0546

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous L3MBTL3 0.20 0.08 lasso 4 0.09 1.1e-07 13.1 13.8 4.3e-43 0.89 0.08 0.92 FALSE
2 GTEx Adipose Visceral Omentum L3MBTL3 0.14 0.12 lasso 2 0.15 2.8e-08 13.1 13.8 1.5e-43 0.90 0.02 0.98 FALSE
3 GTEx Breast Mammary Tissue L3MBTL3 0.31 0.25 lasso 7 0.23 2.8e-12 13.1 13.6 2.1e-42 0.89 0.01 0.99 FALSE
4 GTEx Breast Mammary Tissue RP11-73O6.3 0.27 0.22 lasso 9 0.22 1.5e-11 13.1 13.5 1.4e-41 0.85 0.06 0.94 FALSE
5 GTEx Breast Mammary Tissue (Male) L3MBTL3 0.31 0.24 lasso 6 0.23 5.5e-06 13.1 13.7 7.8e-43 0.91 0.01 0.96 FALSE
6 GTEx Breast Mammary Tissue (Male) RP11-73O6.3 0.33 0.17 lasso 4 0.12 1.3e-03 13.1 12.6 1.8e-36 0.84 0.03 0.81 FALSE
7 GTEx Breast Mammary Tissue (Female) L3MBTL3 0.30 0.13 lasso 5 0.14 4.5e-05 9.5 13.3 2.3e-40 0.86 0.01 0.97 FALSE
8 GTEx Breast Mammary Tissue (Female) RP11-73O6.3 0.29 0.08 lasso 5 0.10 5.7e-04 11.6 13.5 2.8e-41 0.85 0.02 0.95 FALSE
9 GTEx Cells EBV-transformed lymphocytes L3MBTL3 0.28 0.08 lasso 10 0.03 4.4e-02 13.1 12.6 2.1e-36 0.86 0.02 0.90 FALSE
10 GTEx Colon Transverse L3MBTL3 0.27 0.13 lasso 8 0.20 8.0e-10 13.1 13.7 5.8e-43 0.87 0.01 0.99 FALSE
11 GTEx Colon Transverse RP11-73O6.3 0.19 0.09 lasso 2 0.06 1.2e-03 13.1 13.5 1.2e-41 0.88 0.01 0.97 FALSE
12 GTEx Esophagus Mucosa L3MBTL3 0.26 0.18 lasso 2 0.23 2.7e-15 11.6 13.3 1.7e-40 0.82 0.29 0.71 FALSE
13 GTEx Lung L3MBTL3 0.37 0.34 lasso 4 0.38 4.1e-30 13.1 13.9 6.0e-44 0.89 0.09 0.91 FALSE
14 GTEx Lung RP11-73O6.3 0.15 0.08 lasso 5 0.12 2.2e-09 13.1 13.8 1.9e-43 0.91 0.02 0.98 FALSE
15 GTEx Nerve Tibial L3MBTL3 0.30 0.23 lasso 4 0.22 2.3e-15 13.1 13.7 1.4e-42 0.87 0.15 0.85 FALSE
16 GTEx Pancreas L3MBTL3 0.32 0.17 lasso 4 0.23 4.4e-10 13.1 13.7 5.3e-43 0.88 0.04 0.96 FALSE
17 GTEx Pituitary L3MBTL3 0.45 0.31 lasso 8 0.29 5.1e-08 9.5 11.7 2.2e-31 0.74 0.14 0.84 FALSE
18 GTEx Pituitary RP11-73O6.3 0.48 0.07 lasso 7 0.16 8.2e-05 9.5 9.6 1.1e-21 0.62 0.14 0.68 FALSE
19 GTEx Prostate L3MBTL3 0.35 0.27 lasso 5 0.17 5.9e-05 13.1 13.4 1.1e-40 0.87 0.02 0.91 FALSE
20 GTEx Skin Not Sun Exposed Suprapubic L3MBTL3 0.26 0.12 lasso 4 0.12 4.0e-07 10.5 13.0 7.5e-39 0.79 0.10 0.89 FALSE
21 GTEx Skin Sun Exposed Lower leg L3MBTL3 0.25 0.25 lasso 9 0.24 1.4e-19 13.1 13.4 8.4e-41 0.86 0.13 0.87 FALSE
22 GTEx Small Intestine Terminal Ileum L3MBTL3 0.37 0.20 lasso 4 0.17 1.3e-04 13.1 13.7 1.1e-42 0.86 0.01 0.93 FALSE
23 GTEx Spleen L3MBTL3 0.64 0.34 enet 14 0.48 6.4e-14 11.6 13.8 4.9e-43 0.88 0.02 0.98 FALSE
24 GTEx Spleen RP11-73O6.3 0.45 0.43 enet 21 0.42 7.7e-12 11.6 12.6 1.5e-36 0.80 0.13 0.86 FALSE
25 GTEx Stomach L3MBTL3 0.36 0.18 enet 27 0.20 1.1e-09 13.3 12.5 9.2e-36 0.85 0.01 0.99 FALSE
26 GTEx Stomach RP11-73O6.3 0.21 0.12 lasso 6 0.06 5.9e-04 13.3 13.4 3.9e-41 0.89 0.01 0.95 FALSE
27 GTEx Testis L3MBTL3 0.41 0.22 lasso 8 0.30 9.2e-14 13.1 12.4 2.5e-35 0.78 0.04 0.96 FALSE
28 GTEx Thyroid L3MBTL3 0.40 0.39 enet 9 0.43 2.8e-35 13.1 14.1 3.9e-45 0.90 0.15 0.85 TRUE
29 GTEx Thyroid RP11-73O6.3 0.18 0.15 lasso 3 0.20 2.3e-15 12.4 13.8 2.1e-43 0.91 0.05 0.95 FALSE
30 GTEx Whole Blood L3MBTL3 0.22 0.20 lasso 9 0.20 5.1e-18 13.1 13.6 6.4e-42 0.86 0.14 0.86 FALSE
31 GTEx Whole Blood RP11-73O6.3 0.15 0.06 lasso 8 0.04 1.1e-04 13.1 13.5 2.2e-41 0.85 0.04 0.91 FALSE
32 METSIM Adipose L3MBTL3 0.13 0.12 enet 22 0.12 4.8e-18 11.6 10.6 2.9e-26 0.68 0.92 0.08 FALSE
33 ROSMAP Brain Pre-frontal Cortex EPB41L2 0.12 0.12 blup 522 0.10 6.5e-13 2.8 5.1 2.7e-07 -0.01 0.80 0.01 TRUE
34 ROSMAP Brain Pre-frontal Cortex L3MBTL3 0.14 0.07 blup 609 0.08 3.8e-10 13.1 10.4 3.0e-25 0.67 0.07 0.93 FALSE
35 YFS Blood L3MBTL3 0.28 0.22 blup 614 0.27 1.2e-88 11.6 10.8 2.3e-27 0.67 1.00 0.00 FALSE
36 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma L3MBTL3 0.05 0.00 blup 114 0.01 1.0e-02 8.9 5.9 3.5e-09 0.51 0.02 0.30 FALSE
37 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma L3MBTL3 0.06 0.01 blup 114 0.04 4.0e-03 11.6 10.7 8.1e-27 0.78 0.07 0.50 FALSE