[Hub]/) : Traits : Leg fat-free mass (right) : ← →

chr6:129,638,583-132,080,991

Best TWAS P=3.86e-45 · Best GWAS P=2.73e-41 conditioned to 0.0546

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
28	GTEx	Thyroid	L3MBTL3	0.40	0.39	enet	9	0.43	2.8e-35	13.1	14.1	3.9e-45	0.90	0.15	0.85	TRUE
33	ROSMAP	Brain Pre-frontal Cortex	EPB41L2	0.12	0.12	blup	522	0.10	6.5e-13	2.8	5.1	2.7e-07	-0.01	0.80	0.01	TRUE
13	GTEx	Lung	L3MBTL3	0.37	0.34	lasso	4	0.38	4.1e-30	13.1	13.9	6.0e-44	0.89	0.09	0.91	FALSE
2	GTEx	Adipose Visceral Omentum	L3MBTL3	0.14	0.12	lasso	2	0.15	2.8e-08	13.1	13.8	1.5e-43	0.90	0.02	0.98	FALSE
14	GTEx	Lung	RP11-73O6.3	0.15	0.08	lasso	5	0.12	2.2e-09	13.1	13.8	1.9e-43	0.91	0.02	0.98	FALSE
29	GTEx	Thyroid	RP11-73O6.3	0.18	0.15	lasso	3	0.20	2.3e-15	12.4	13.8	2.1e-43	0.91	0.05	0.95	FALSE
1	GTEx	Adipose Subcutaneous	L3MBTL3	0.20	0.08	lasso	4	0.09	1.1e-07	13.1	13.8	4.3e-43	0.89	0.08	0.92	FALSE
23	GTEx	Spleen	L3MBTL3	0.64	0.34	enet	14	0.48	6.4e-14	11.6	13.8	4.9e-43	0.88	0.02	0.98	FALSE
16	GTEx	Pancreas	L3MBTL3	0.32	0.17	lasso	4	0.23	4.4e-10	13.1	13.7	5.3e-43	0.88	0.04	0.96	FALSE
10	GTEx	Colon Transverse	L3MBTL3	0.27	0.13	lasso	8	0.20	8.0e-10	13.1	13.7	5.8e-43	0.87	0.01	0.99	FALSE
5	GTEx	Breast Mammary Tissue (Male)	L3MBTL3	0.31	0.24	lasso	6	0.23	5.5e-06	13.1	13.7	7.8e-43	0.91	0.01	0.96	FALSE
22	GTEx	Small Intestine Terminal Ileum	L3MBTL3	0.37	0.20	lasso	4	0.17	1.3e-04	13.1	13.7	1.1e-42	0.86	0.01	0.93	FALSE
15	GTEx	Nerve Tibial	L3MBTL3	0.30	0.23	lasso	4	0.22	2.3e-15	13.1	13.7	1.4e-42	0.87	0.15	0.85	FALSE
3	GTEx	Breast Mammary Tissue	L3MBTL3	0.31	0.25	lasso	7	0.23	2.8e-12	13.1	13.6	2.1e-42	0.89	0.01	0.99	FALSE
30	GTEx	Whole Blood	L3MBTL3	0.22	0.20	lasso	9	0.20	5.1e-18	13.1	13.6	6.4e-42	0.86	0.14	0.86	FALSE
11	GTEx	Colon Transverse	RP11-73O6.3	0.19	0.09	lasso	2	0.06	1.2e-03	13.1	13.5	1.2e-41	0.88	0.01	0.97	FALSE
4	GTEx	Breast Mammary Tissue	RP11-73O6.3	0.27	0.22	lasso	9	0.22	1.5e-11	13.1	13.5	1.4e-41	0.85	0.06	0.94	FALSE
31	GTEx	Whole Blood	RP11-73O6.3	0.15	0.06	lasso	8	0.04	1.1e-04	13.1	13.5	2.2e-41	0.85	0.04	0.91	FALSE
8	GTEx	Breast Mammary Tissue (Female)	RP11-73O6.3	0.29	0.08	lasso	5	0.10	5.7e-04	11.6	13.5	2.8e-41	0.85	0.02	0.95	FALSE
26	GTEx	Stomach	RP11-73O6.3	0.21	0.12	lasso	6	0.06	5.9e-04	13.3	13.4	3.9e-41	0.89	0.01	0.95	FALSE
21	GTEx	Skin Sun Exposed Lower leg	L3MBTL3	0.25	0.25	lasso	9	0.24	1.4e-19	13.1	13.4	8.4e-41	0.86	0.13	0.87	FALSE
19	GTEx	Prostate	L3MBTL3	0.35	0.27	lasso	5	0.17	5.9e-05	13.1	13.4	1.1e-40	0.87	0.02	0.91	FALSE
12	GTEx	Esophagus Mucosa	L3MBTL3	0.26	0.18	lasso	2	0.23	2.7e-15	11.6	13.3	1.7e-40	0.82	0.29	0.71	FALSE
7	GTEx	Breast Mammary Tissue (Female)	L3MBTL3	0.30	0.13	lasso	5	0.14	4.5e-05	9.5	13.3	2.3e-40	0.86	0.01	0.97	FALSE
20	GTEx	Skin Not Sun Exposed Suprapubic	L3MBTL3	0.26	0.12	lasso	4	0.12	4.0e-07	10.5	13.0	7.5e-39	0.79	0.10	0.89	FALSE
24	GTEx	Spleen	RP11-73O6.3	0.45	0.43	enet	21	0.42	7.7e-12	11.6	12.6	1.5e-36	0.80	0.13	0.86	FALSE
6	GTEx	Breast Mammary Tissue (Male)	RP11-73O6.3	0.33	0.17	lasso	4	0.12	1.3e-03	13.1	12.6	1.8e-36	0.84	0.03	0.81	FALSE
9	GTEx	Cells EBV-transformed lymphocytes	L3MBTL3	0.28	0.08	lasso	10	0.03	4.4e-02	13.1	12.6	2.1e-36	0.86	0.02	0.90	FALSE
25	GTEx	Stomach	L3MBTL3	0.36	0.18	enet	27	0.20	1.1e-09	13.3	12.5	9.2e-36	0.85	0.01	0.99	FALSE
27	GTEx	Testis	L3MBTL3	0.41	0.22	lasso	8	0.30	9.2e-14	13.1	12.4	2.5e-35	0.78	0.04	0.96	FALSE
17	GTEx	Pituitary	L3MBTL3	0.45	0.31	lasso	8	0.29	5.1e-08	9.5	11.7	2.2e-31	0.74	0.14	0.84	FALSE
35	YFS	Blood	L3MBTL3	0.28	0.22	blup	614	0.27	1.2e-88	11.6	10.8	2.3e-27	0.67	1.00	0.00	FALSE
37	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	L3MBTL3	0.06	0.01	blup	114	0.04	4.0e-03	11.6	10.7	8.1e-27	0.78	0.07	0.50	FALSE
32	METSIM	Adipose	L3MBTL3	0.13	0.12	enet	22	0.12	4.8e-18	11.6	10.6	2.9e-26	0.68	0.92	0.08	FALSE
34	ROSMAP	Brain Pre-frontal Cortex	L3MBTL3	0.14	0.07	blup	609	0.08	3.8e-10	13.1	10.4	3.0e-25	0.67	0.07	0.93	FALSE
18	GTEx	Pituitary	RP11-73O6.3	0.48	0.07	lasso	7	0.16	8.2e-05	9.5	9.6	1.1e-21	0.62	0.14	0.68	FALSE
36	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	L3MBTL3	0.05	0.00	blup	114	0.01	1.0e-02	8.9	5.9	3.5e-09	0.51	0.02	0.30	FALSE