Best TWAS P=2.6e-08 · Best GWAS P=1.38e-11 conditioned to 0.000125
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | TPM2 | 0.13 | 0.06 | lasso | 4 | 0.09 | 1.7e-11 | -5.1 | -5.3 | 1.2e-07 | -0.49 | 0.94 | 0.06 | FALSE |
| 2 | GTEx | Artery Aorta | SPAG8 | 0.11 | 0.10 | lasso | 7 | 0.06 | 2.0e-04 | 5.2 | -5.4 | 6.3e-08 | -0.86 | 0.02 | 0.97 | FALSE |
| 3 | GTEx | Liver | NPR2 | 0.18 | 0.04 | lasso | 3 | 0.02 | 1.1e-01 | 5.3 | -5.3 | 1.1e-07 | -0.88 | 0.03 | 0.79 | FALSE |
| 4 | GTEx | Thyroid | RP11-112J3.16 | 0.26 | 0.13 | lasso | 7 | 0.13 | 1.9e-10 | 5.2 | -5.6 | 2.6e-08 | -0.83 | 0.41 | 0.59 | TRUE |
| 5 | The Cancer Genome Atlas | Colon Adenocarcinoma | C9orf128 | 0.07 | 0.03 | blup | 50 | 0.06 | 2.3e-04 | 4.8 | -5.3 | 1.3e-07 | -0.85 | 0.02 | 0.91 | FALSE |