Hub : Genes

NPR2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.2286	0.0704	2.3e-04	0.061	NA	0.034	NA	0.078	3.1e-03	NA	2.2e-02	NA	9.4e-04
2	GTEx	Artery Tibial	0.1511	0.0464	3.9e-05	0.034	NA	0.127	NA	0.124	1.0e-03	NA	3.6e-10	NA	6.4e-10
3	GTEx	Heart Left Ventricle	0.1347	0.0575	7.3e-03	-0.005	NA	-0.002	NA	0.000	7.5e-01	NA	4.2e-01	NA	3.1e-01
4	GTEx	Liver	0.1760	0.0740	6.2e-03	0.038	NA	-0.003	NA	0.017	3.1e-02	NA	4.1e-01	NA	1.1e-01
5	GTEx	Nerve Tibial	0.1331	0.0447	4.4e-04	0.030	NA	0.066	NA	0.079	3.4e-03	NA	2.0e-05	NA	3.1e-06
6	GTEx	Thyroid	0.0900	0.0340	1.4e-03	0.066	NA	0.053	NA	0.037	9.4e-06	NA	6.9e-05	NA	7.0e-04
7	TCGA	Prostate Adenocarcinoma	0.0665	0.0578	6.4e-03	0.006	0.003	0.008	NA	0.009	6.2e-02	0.13	4.3e-02	NA	3.5e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	2.8	4.5	7.8	-1.7	-2.8	2.0	1.1	-2.6	-2.5	-1.5
Bipolar Disorder or Schizophrenia	1.5	3.8	6.0	-2.4	-2.1	1.4	1.0	-2.5	-2.3	-1.5
Depressed Affect (Nagel 2018)	0.4	0.9	2.9	-0.7	-1.3	-0.1	0.6	-0.7	-1.7	0.4
Depression (Nagel 2018)	2.3	3.5	8.8	-1.9	-1.7	0.9	1.8	-3.0	-1.8	-1.5
Intelligence (Savage-Jansen 2018)	1.3	3.9	7.0	2.0	-1.0	-2.6	2.2	1.7	2.6	-0.9
Neuroticism (Nagel 2018)	1.0	2.4	4.5	-0.8	-2.1	0.0	1.5	-1.8	-2.0	-1.5
Schizophrenia (2018)	0.4	0.8	3.0	-1.7	-0.4	0.1	0.4	-1.0	-0.9	-0.7
Schizophrenia vs Biploar Disorder	0.7	0.9	1.8	0.4	1.3	-1.1	0.2	1.1	1.0	0.9
Worry (Nagel 2018)	1.4	2.9	7.2	-0.9	-2.7	-0.0	1.5	-2.0	-1.1	-2.2
Alzheimer’s Disease (in mother)	0.7	0.9	3.8	-0.4	-0.9	1.2	1.9	-0.1	-0.1	-0.2
Alzheimer’s Disease (in father)	2.4	2.6	5.0	1.9	1.5	-1.5	-1.4	1.7	2.2	0.6
Alzheimer’s Disease (including proxy)	0.1	0.2	0.7	-0.2	-0.3	0.4	0.8	0.3	0.3	-0.2
Crohns Disease (2017)	0.3	0.6	1.9	0.2	0.4	-1.4	-1.2	-0.2	0.0	0.8
Irritable Bowel Disease (IBD)	0.1	0.3	1.3	0.5	-0.1	-1.1	-0.8	-0.2	0.0	-0.0
Ulcerative Colitis (UC)	0.2	0.3	0.8	0.9	0.3	-0.8	-0.5	0.3	0.6	-0.1
Major Depression (MDD)	0.7	0.8	2.6	-0.6	-1.0	-0.9	-0.6	-1.6	-0.4	-0.3
Reaction Time	0.1	0.1	0.3	0.1	-0.3	-0.1	-0.6	0.3	0.5	0.1
Verbal and Numeric Reasoning (VNR)	0.8	2.0	5.5	0.4	-1.6	-1.4	2.3	0.7	1.4	-1.1
Breast Cancer	1.1	2.6	5.2	2.3	0.9	-0.4	-1.3	2.3	1.1	2.0
Ovarian Cancer	1.0	1.3	6.0	0.2	0.7	-0.2	-0.9	1.5	2.5	0.2
Prostate Cancer	0.1	0.1	0.4	-0.1	-0.4	-0.6	-0.6	0.2	0.2	-0.0
Age at First Birth	2.7	3.9	10.0	-1.7	-2.1	1.3	1.0	-2.3	-3.2	-1.7
Bipolar Disorder (2011)	0.6	0.5	1.8	0.2	-1.4	0.3	-0.2	-0.8	-0.9	-0.5
Body Mass Index (BMI) (2010)	1.5	2.1	4.7	1.3	2.0	-0.2	-2.2	1.0	1.4	1.2
Coronary Artery Disease (CAD)	1.3	1.5	5.2	-1.3	-0.4	0.4	2.3	-1.3	0.0	-1.4
Crohns Disease (2012)	0.4	0.7	1.6	0.1	-0.1	-0.9	-1.3	-0.1	0.7	1.2
Mean Putamen Volume	0.3	0.3	0.8	-0.9	0.5	-0.1	-0.7	-0.7	0.3	0.4
Fasting Glucose	1.0	1.2	3.2	1.8	0.4	-1.1	-0.9	1.2	1.1	0.5
HbA1C	4.7	5.2	12.2	-2.4	-3.5	1.3	1.3	-2.2	-2.0	-2.6
HDL Cholesterol	0.1	0.2	0.4	-0.2	-0.3	-0.1	0.2	-0.6	-0.5	0.7
LDL Cholesterol	1.0	1.6	2.8	-1.6	0.1	-1.4	1.7	-1.2	-0.4	-1.6
Lupus	1.2	1.8	5.5	-1.3	0.1	0.6	2.3	-1.3	-0.4	-1.9
Neuroticism (2016)	1.4	2.1	5.4	-0.2	-2.3	0.4	0.4	-1.6	-1.1	-2.2
Primary Biliary Cirrhosis	0.8	1.1	2.1	0.2	-1.3	-1.4	1.5	0.3	0.3	-1.4
Rheumatoid Arthritis	0.7	1.0	3.6	0.4	0.9	0.5	-0.5	1.2	0.9	1.9
Schizophrenia (2014)	0.4	0.9	1.8	-1.3	-1.2	0.2	0.6	-1.1	-0.9	-0.6
Triglycerides	0.7	1.1	3.9	-1.6	2.0	0.7	-0.4	-0.4	-0.3	-0.4
Type 2 Diabetes (T2D) (2012)	1.2	1.4	4.0	1.5	0.3	-1.3	-2.0	0.6	0.6	0.9
Ulcerative Colitis	0.2	0.3	1.1	0.5	-0.7	-1.0	0.3	0.1	-0.1	-0.7
Blood Eosinophil Count	0.7	5.2	9.5	2.5	1.1	-3.1	-2.9	1.9	2.2	1.6
Blood Platelet Count	3.2	37.6	47.1	6.5	6.3	-5.4	-5.7	6.9	6.8	5.0
Blood Red Count	0.3	2.9	8.7	-1.1	3.0	2.5	-0.8	-0.3	0.3	1.8
Blood White Count	3.4	25.1	45.0	4.8	5.9	-2.7	-6.7	4.8	4.2	5.0
Heel T-Score	2.0	15.5	38.1	-3.1	-5.0	0.2	6.2	-3.4	-2.8	-4.1
BMI	1.6	9.4	20.7	3.4	4.5	-1.6	-3.4	2.2	2.7	2.7
Height	1.8	34.4	65.4	-6.1	-3.4	7.7	-8.1	-6.3	-5.0	1.5
Waist Hip Ratio (WHR)	1.9	8.7	21.0	-2.3	-2.8	-0.5	3.7	-2.3	-2.7	-4.6
Systolic Blood Pressure	0.7	3.3	7.1	-0.3	-1.7	0.5	2.2	-1.9	-2.7	-2.1
Smoking Status	0.7	1.7	3.9	-1.3	-0.3	1.7	1.8	0.1	-2.0	0.6
Allergy or Eczema	0.3	0.7	1.6	-0.7	0.5	0.3	1.2	-0.5	-0.9	-1.3
Cardiovascular Disease	1.0	3.3	11.8	0.5	-3.4	-0.5	1.7	-0.8	-2.5	-1.1
Hypothyroidism (self reported)	0.2	0.5	1.7	0.2	0.1	-0.1	-1.3	0.5	0.3	1.1
Respiratory disease	0.5	1.0	3.9	-0.7	0.4	1.5	-0.2	-0.7	-2.0	0.3
Type 2 Diabetes (T2D) (2018)	1.6	2.9	5.5	1.5	2.0	-1.4	-1.8	1.6	2.3	1.0
Lung FEV1/FVC ratio	0.6	2.9	6.4	-2.3	-0.0	2.5	2.0	-1.5	-1.0	-1.0
Lung FVC	0.1	0.4	0.7	0.8	-0.6	-0.2	-0.5	0.7	0.5	0.5
Neuroticism	0.9	2.1	5.3	-0.8	-2.3	-0.3	1.7	-1.5	-1.6	-1.1
Chronotype (morning person)	0.7	1.7	3.0	-1.1	1.5	1.7	-1.2	-0.0	1.2	1.5
Hair Pigment	0.0	0.6	1.6	0.2	0.5	-0.5	1.2	0.7	1.3	-0.0
Tanning	0.1	1.4	2.5	-1.3	-0.9	0.6	1.6	-1.4	0.1	-1.6
Hand grip strength (left)	3.1	8.1	14.4	-3.8	-2.1	3.0	1.0	-2.9	-3.8	-2.4
Number of treatments/medications taken	0.7	1.3	5.0	-0.0	-2.2	-0.3	0.8	-0.9	-1.5	-0.7
Average weekly spirits intake	0.3	0.3	1.6	-0.1	-0.0	-1.3	0.3	0.0	-0.6	-0.5
Sensitivity / hurt feelings	1.7	2.8	6.6	-1.5	-2.0	0.6	0.9	-2.1	-2.6	-1.3
Frequency of depressed mood in last 2 weeks	2.2	3.1	6.6	-0.6	-2.6	-1.3	2.2	-1.8	-1.7	-1.5
Hearing difficulty/problems: Yes	0.5	0.7	2.4	1.1	0.9	0.3	-1.6	0.3	-0.2	0.7
Relative age of first facial hair	0.9	1.8	6.0	-0.8	-1.3	-1.3	2.4	-0.7	-0.4	-1.5
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.8	0.9	-0.7	0.8	-0.7	-0.8	-1.3	0.3
Ever used hormone-replacement therapy (HRT)	0.4	0.6	1.0	0.6	-0.9	0.2	-1.0	-0.0	0.9	0.8
Ever had hysterectomy (womb removed)	0.3	0.3	0.7	0.8	-0.3	0.8	0.0	0.1	0.8	-0.1
Systolic blood pressure, automated reading	0.3	1.0	2.1	-0.2	1.0	1.0	0.8	-1.5	-1.4	-0.6
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	0.7	-0.7	-0.6	0.8	0.2	-0.4	-0.8	-0.4
Angina	2.1	2.7	3.7	-1.5	-1.9	0.3	1.8	-1.8	-1.8	-1.9
Medication for hormone replacement therapy	1.0	1.1	3.3	-0.6	-1.0	1.8	-0.6	-1.1	-1.0	0.7
Vitamin and mineral supplements	0.1	0.2	1.1	0.0	-0.2	-1.1	0.1	-0.3	-0.3	0.2
Supplements: Zinc	0.6	0.6	1.4	1.2	-0.7	-0.9	0.7	0.3	-0.3	-0.9
Medication: Co-codamol	0.9	1.1	2.5	0.6	1.3	-0.3	-1.6	1.2	0.1	1.3
Medication: Metformin	3.2	4.6	14.4	1.1	2.6	1.3	-3.8	1.4	0.8	2.3
Diabetes (father)	0.5	0.6	1.6	-0.3	0.1	-1.3	-0.3	-1.2	0.2	-1.0
Diabetes (mother)	1.6	2.0	7.0	2.1	1.0	-2.6	-0.6	0.6	1.1	0.1
Severe depression (siblings)	0.5	0.6	1.7	-0.7	-1.0	1.3	0.1	-0.7	-0.5	0.0
Pack years adult smoking proportion	0.5	0.7	2.8	-1.1	0.6	1.7	-0.1	-0.0	0.6	0.7
Impedance of leg (right)	0.6	2.7	7.4	-0.1	-1.7	-1.1	2.7	-0.2	0.4	-2.7
Leg fat-free mass (left)	1.5	8.2	32.6	-1.1	1.1	2.9	-5.7	-2.1	-1.7	2.5
Trunk fat percentage	1.0	3.9	10.3	1.5	3.2	-0.9	-3.2	0.6	0.9	1.7
Hand grip strength (right)	3.3	9.0	17.3	-3.7	-2.7	2.6	1.3	-2.9	-4.2	-2.9
Townsend deprivation index at recruitment	1.2	1.6	3.7	-1.3	-0.9	-0.3	1.2	-1.9	-0.9	-1.8
Current tobacco smoking	1.4	2.3	6.9	-1.3	-0.8	2.4	0.7	-0.4	-2.6	0.7
Average weekly fortified wine intake	0.8	0.9	3.0	0.5	0.1	-1.7	0.9	0.4	0.7	-1.4
Maternal smoking around birth	0.1	0.1	0.4	-0.2	0.6	-0.2	-0.2	-0.4	0.3	-0.1
Fed-up feelings	1.0	1.8	4.7	-0.2	-2.2	-1.5	0.5	-0.9	-2.1	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	2.0	2.6	7.9	-1.4	-0.9	0.3	1.9	-2.8	-1.2	-1.7
Relative age voice broke	1.7	2.6	7.8	1.6	0.6	-2.8	0.3	1.1	2.4	0.1
Taking other prescription medications	0.3	0.5	1.4	1.0	0.2	-1.2	-0.7	0.4	0.6	0.4
Age when periods started (menarche)	0.7	1.7	3.9	1.3	1.3	-1.7	0.4	1.1	2.0	0.4
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.8	-0.1	0.5	0.8	-0.9	-0.3	0.5	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	3.1	7.0	10.0	-3.2	-3.0	2.0	2.5	-2.6	-2.9	-2.1
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	2.1	0.4	-0.9	-0.5	-0.5	-1.4	-0.4	-0.9
Qualifications: CSEs or equivalent	0.9	1.2	5.5	0.7	-0.5	0.2	-2.3	-0.0	-0.8	1.2
Serious illness, injury or assault to yourself	1.3	1.6	5.0	-0.4	-0.9	-1.1	2.2	-1.1	-0.5	-1.4
High blood pressure	0.3	1.0	2.5	1.6	-1.0	-0.5	1.3	0.5	-1.0	-0.1
Hayfever, allergic rhinitis or eczema	0.9	1.9	5.4	-1.1	-0.8	1.4	1.0	-1.4	-2.3	-1.2
Multivitamins +/- minerals	0.1	0.1	0.3	0.2	0.2	0.3	0.1	0.6	-0.3	0.3
Stomach or abdominal pain in last month	1.1	1.4	3.9	2.0	0.5	-1.6	-0.9	0.7	1.2	0.3
Supplements: Glucosamine	1.0	1.4	2.7	1.4	0.7	-1.7	0.3	1.6	1.2	0.4
Diverticular disease/diverticulitis (self-reported)	2.2	2.6	5.3	-1.5	-0.2	1.3	-2.0	-2.3	-2.2	-0.1
Medication: Atenolol	0.2	0.3	1.3	0.2	-0.5	-0.5	1.1	0.6	-0.2	0.1
Medication: Levothyroxine sodium	0.5	0.8	3.6	0.4	0.6	-0.1	-1.9	0.3	0.1	1.0
Sitting height	1.0	7.3	19.2	-1.5	-1.5	3.7	-4.4	-2.9	-1.6	1.5
Chronic bronchitis/emphysema (father)	0.3	0.4	0.6	0.8	0.6	-0.2	-0.6	0.7	0.1	0.8
High blood pressure (mother)	0.1	0.1	0.2	0.5	0.2	0.4	0.2	-0.3	-0.3	0.3
Body mass index (BMI)	1.0	4.1	11.8	1.8	3.4	-1.1	-2.4	1.3	1.1	1.9
Impedance of leg (left)	0.8	3.9	11.7	-0.4	-1.8	-0.9	3.4	-0.5	-0.0	-3.3
Leg predicted mass (left)	1.5	8.2	32.0	-1.2	1.1	2.9	-5.7	-2.2	-1.7	2.5
Trunk fat mass	1.1	4.6	19.1	1.2	2.8	-0.2	-4.4	-0.1	0.5	1.9
Waist circumference	0.6	2.0	8.6	0.7	2.1	-0.2	-2.9	-0.4	-0.4	0.4
Number of incorrect matches in round	0.4	0.7	2.1	0.2	1.0	0.8	-0.7	-0.2	0.6	1.4
Past tobacco smoking	0.7	1.4	6.8	-0.1	1.2	0.9	-2.6	-0.4	-0.0	0.6
Alcohol usually taken with meals	2.6	4.2	8.2	2.7	0.6	-2.7	-0.5	2.3	2.9	0.8
Nervous feelings	1.5	2.8	6.0	-0.9	-2.4	-0.2	1.5	-2.0	-0.9	-2.5
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	3.1	-0.4	-1.8	0.1	1.4	-1.2	-1.3	-0.6
Hearing difficulty/problems with background noise	0.7	1.2	4.6	-0.2	-0.5	1.0	0.1	-2.1	-0.6	-1.4
Hair/balding pattern: Pattern 2	1.6	2.1	5.8	1.3	-0.1	-2.4	1.9	0.2	0.1	-1.8
Had menopause	0.7	0.9	3.0	0.9	1.7	-0.4	-0.4	0.7	0.1	1.3
Had other major operations	0.7	0.8	2.2	0.5	-1.0	-0.8	1.5	0.6	0.1	-1.2
Forced vital capacity (FVC)	1.3	5.0	9.0	-2.5	-2.0	2.6	-2.3	-3.0	-1.9	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	1.8	4.2	5.6	-2.1	-2.3	1.9	1.8	-2.1	-2.4	-1.5
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	2.0	-0.5	-0.8	-0.1	0.8	-1.2	-1.4	-0.9
Qualifications: None of the above	0.7	1.4	3.4	-1.8	0.3	1.3	-0.6	-1.5	-1.4	-0.3
Financial difficulties in last 2 years	0.3	0.5	1.0	0.2	-0.8	0.1	-0.2	-1.0	-1.0	-0.7
Mouth/teeth dental problems	0.4	0.6	2.0	-0.6	0.1	-0.4	1.4	0.7	-0.0	-1.2
Heart attack	1.7	2.2	7.6	-1.0	-1.5	0.3	2.8	-0.2	-0.8	-2.0
Allergy	0.2	0.6	2.3	-0.0	-0.0	-1.2	-0.0	0.4	1.5	-0.1
Pain all over the body in last month	2.7	2.9	6.2	-1.7	-2.3	0.9	1.1	-1.9	-2.5	-0.9
Diabetes (self-reported)	1.9	3.0	7.9	0.7	2.6	0.7	-2.8	1.1	1.0	1.7
Hayfever/allergic rhinitis (self-reported)	5.1	6.7	11.0	-2.5	-1.4	2.4	2.4	-3.0	-2.6	-3.3
Medication: Ramipril	1.4	1.8	4.9	-1.1	-2.0	-0.2	2.2	0.3	-1.2	-0.9
Medication: Simvastatin	0.1	0.2	0.5	0.4	-0.6	-0.4	-0.7	-0.2	-0.3	0.2
Fluid intelligence score	1.5	3.2	5.9	2.0	-0.7	-2.2	1.9	2.4	1.8	0.2
Illnesses of siblings	0.4	0.5	1.7	-1.0	-1.3	0.4	0.7	-0.4	-0.3	-0.6
Neuroticism score	1.9	3.9	11.2	-1.2	-3.4	0.3	1.5	-2.4	-1.9	-1.7
Weight	1.1	5.2	25.5	-0.1	2.0	1.3	-5.0	-1.3	-0.7	1.8
Impedance of arm (right)	0.3	1.3	3.1	1.4	-0.2	-1.0	-1.3	0.8	1.8	0.6
Arm fat percentage (right)	2.5	9.8	18.1	3.4	4.3	-2.2	-3.5	2.5	2.7	2.8
Trunk fat-free mass	1.4	8.2	25.4	-1.8	-0.4	3.4	-5.0	-3.1	-2.4	1.4
Hip circumference	2.1	8.9	35.6	1.8	3.4	0.3	-6.0	0.5	1.2	3.1
Time employed in main current job	0.6	0.7	3.4	-0.2	-1.9	0.2	0.3	-0.6	-0.8	-0.7
Alcohol intake versus 10 years previously	0.2	0.4	1.0	1.0	-0.4	-0.3	0.6	0.5	0.7	-0.6
Father’s age at death	0.3	0.4	0.8	0.2	-0.8	-0.7	-0.5	-0.6	-0.2	-0.9
Worrier / anxious feelings	0.5	1.0	2.4	-0.8	-1.5	0.4	1.0	-1.2	-0.4	-1.0
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.2	2.9	-0.8	-0.5	1.3	-1.0	-1.4	-1.7	-0.3
Falls in the last year	1.5	2.1	4.8	-0.8	-0.3	0.2	1.1	-2.2	-1.9	-2.0
Hair/balding pattern: Pattern 3	1.2	1.8	5.9	-2.4	0.3	0.9	1.3	-0.8	-1.7	-0.7
Number of live births	0.9	1.3	5.3	-0.2	2.3	0.1	0.0	1.3	1.4	0.5
Forced expiratory volume in 1-second (FEV1)	1.2	4.1	7.7	-2.2	-2.3	2.2	-1.6	-2.8	-1.5	-0.7
Pulse rate	0.7	1.1	3.0	0.4	0.2	-0.5	1.3	1.3	1.7	1.1
Happiness	0.8	0.9	2.0	-1.1	-0.2	1.2	-0.8	-1.4	-1.0	0.2
Noisy workplace	0.2	0.2	0.9	0.1	-0.3	0.2	0.4	-0.5	0.2	-0.9
Qualifications: A levels/AS levels or equivalent	1.2	2.7	7.6	2.8	-0.1	-1.2	-0.6	1.5	2.5	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.4	1.2	-0.2	-0.7	0.9	1.2	0.3	0.1
Mouth/teeth dental problems: Dentures	1.8	3.1	9.0	-0.2	2.3	1.7	-3.0	-0.5	-0.8	1.8
Asthma	1.1	2.2	6.5	-0.6	0.6	2.6	-1.4	-0.9	-2.0	1.2
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.5	0.4	-1.2	0.6	-0.1	-0.0	-0.8	0.3
Medication: Cholesterol lowering	1.2	1.9	5.2	-1.6	-0.7	1.5	-0.6	-1.2	-2.3	0.8
Depression (self-reported)	3.8	4.6	9.7	-0.8	-2.9	0.5	1.9	-3.1	-1.0	-2.9
Medication: Lansoprazole	0.1	0.2	0.6	0.1	0.2	0.4	-0.3	0.8	-0.4	0.2
Prospective memory result	0.2	0.2	0.5	-0.3	-0.6	0.7	0.4	-0.4	-0.7	-0.0
Lung cancer (father)	0.3	0.4	1.4	-0.8	-0.2	0.6	-0.4	0.2	-1.2	0.0
Illnesses of mother	0.3	0.4	1.4	-1.0	-0.2	0.6	-1.2	-0.5	-0.2	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.2	5.5	-2.1	-2.3	1.4	-1.3	-2.4	-1.5	-0.9
Pulse wave Arterial Stiffness index	1.0	1.2	4.2	-1.1	-1.0	-0.3	-0.7	-1.2	-2.1	0.1
Impedance of arm (left)	0.1	0.4	0.9	0.7	-0.5	-0.6	-0.8	0.2	1.0	0.2
Arm fat mass (right)	1.3	5.4	17.3	1.7	3.3	-0.5	-4.2	0.7	1.0	2.3
Trunk predicted mass	1.4	8.2	25.8	-1.8	-0.4	3.4	-5.1	-3.1	-2.3	1.4
Standing height	2.0	20.3	37.3	-4.2	-2.8	5.5	-6.1	-5.8	-3.9	0.0
Length of working week for main job	0.3	0.4	1.3	1.2	-0.7	0.2	-0.7	0.1	-0.1	0.1
Exposure to tobacco smoke at home	0.4	0.4	2.0	0.6	-0.3	-1.4	0.2	0.2	0.4	-0.4
Breastfed as a baby	1.5	1.8	4.5	1.5	0.6	-0.9	-1.4	1.2	1.3	2.1
Tense / ‘highly strung’	2.7	4.5	8.5	-1.7	-2.9	2.7	0.3	-2.5	-2.5	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	3.5	0.3	-1.0	-0.7	1.4	-1.1	-1.0	-1.9
Hair/balding pattern: Pattern 4	0.4	0.9	2.6	-0.4	-1.6	0.2	1.0	-1.2	-0.6	-0.8
Birth weight of first child	1.6	2.9	6.6	-2.1	-1.2	2.6	-1.4	-1.5	-1.9	-0.1
Peak expiratory flow (PEF)	2.5	5.7	11.9	-2.9	-3.5	1.4	1.1	-2.6	-2.4	-2.1
Pulse wave reflection index	0.6	0.8	3.3	-0.6	0.0	-0.3	-1.0	-0.7	-1.8	0.4
Ever highly irritable/argumentative for 2 days	1.5	1.8	4.1	-1.0	-1.9	0.8	0.0	-2.0	-1.3	-1.2
Loud music exposure frequency	0.9	1.0	1.7	-0.6	-1.3	0.7	-0.3	-1.2	-1.3	1.1
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.9	0.9	-0.4	-0.6	0.5	0.3	0.2	-0.7
Mouth/teeth dental problems: Bleeding gums	0.4	0.6	1.9	0.6	-0.7	-1.4	0.6	-0.6	0.8	-0.1
Blood clot in the leg (DVT)	0.4	0.5	1.9	0.5	0.2	-0.6	0.8	-0.3	0.6	-1.4
Medication: Paracetamol	0.1	0.2	0.5	-0.3	-0.7	-0.1	-0.1	0.3	-0.1	0.6
Headache pain in last month	1.8	3.1	9.8	2.2	0.3	-3.1	-0.6	1.6	1.7	1.0
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	3.2	0.2	1.8	0.6	-1.2	0.2	1.2	-0.1
Glaucoma (self-reported)	1.4	1.7	3.1	-0.7	1.2	1.7	-1.8	-0.3	0.9	1.7
Gout (self-reported)	4.0	5.5	12.2	-3.3	-1.3	3.5	-0.5	-2.8	-2.3	-0.8
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	3.8	0.2	0.0	-0.2	-2.0	0.3	-0.2	0.8
Medication: Amlodipine	0.6	0.8	1.8	1.3	0.1	-1.1	1.2	1.0	0.0	0.2
Medication: Ventolin 100micrograms inhaler	0.2	0.3	1.2	0.5	0.4	0.2	0.1	-0.3	-0.6	-1.1
Birth weight	0.9	1.9	5.5	-1.6	-0.8	2.3	0.0	-1.2	-1.8	-0.3
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.5	0.3	1.2	-0.2	-0.3	1.1	0.6	1.0
High blood pressure (siblings)	0.5	0.7	2.1	0.6	-0.3	-1.4	1.3	-0.0	-0.4	-0.7
Forced vital capacity (FVC), Best measure	1.0	3.7	6.1	-2.0	-1.8	1.8	-2.5	-2.5	-1.7	-0.5
Body fat percentage	1.2	4.7	12.2	2.1	3.5	-1.5	-2.8	1.3	1.5	1.6
Leg fat percentage (right)	1.7	6.3	13.8	3.0	3.7	-2.6	-1.5	2.3	2.1	1.5
Arm fat-free mass (right)	1.5	7.8	14.2	-2.5	-0.4	3.4	-3.8	-3.5	-3.1	0.5
Exposure to tobacco smoke outside home	0.3	0.4	1.3	0.8	0.0	-1.1	0.7	0.5	-0.5	-0.2
Comparative body size at age 10	0.2	0.4	1.7	0.6	0.0	-1.3	0.4	0.7	0.5	0.2
Number of full brothers	0.4	0.5	1.9	-0.3	0.0	0.6	-0.1	-0.2	-1.4	1.2
Worry too long after embarrassment	1.3	2.1	4.5	-0.7	-2.1	0.7	1.3	-1.7	-0.7	-2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	2.2	-0.3	-0.7	-1.5	0.9	-1.4	-0.2	-1.2
Wheeze or whistling in the chest in last year	0.3	0.5	2.1	1.0	-0.1	0.1	-0.2	0.2	-1.5	0.8
Number of children fathered	1.1	1.2	4.6	-1.0	0.5	0.9	-0.7	0.4	-1.1	2.1
Reason for reducing amount of alcohol drunk: Health precaution	1.9	2.2	5.3	0.8	1.9	-2.0	0.3	1.1	2.3	0.7
Age at first live birth	0.7	1.3	2.5	-1.0	-1.6	0.0	1.3	-0.4	-1.0	-1.6
Pulse wave peak to peak time	0.8	0.9	3.3	1.0	1.0	0.6	-0.0	0.9	1.8	0.3
Health satisfaction	1.1	1.4	2.6	-1.1	-1.6	1.1	0.3	-1.3	-1.6	0.3
Shortness of breath walking on level ground	0.3	0.4	1.5	-0.1	0.7	1.2	-0.3	0.7	-0.4	0.1
Qualifications: College or University degree	1.0	3.2	8.1	1.9	-0.3	-2.8	1.5	0.3	2.8	-1.0
Eye problems/disorders: None of the above	0.2	0.2	0.7	-0.1	0.1	-0.7	-0.1	0.1	-0.9	0.5
Mouth/teeth dental problems: Loose teeth	4.7	5.6	12.3	-2.9	-0.9	2.4	1.3	-3.5	-2.5	-1.9
Emphysema/chronic bronchitis	3.9	4.4	7.8	2.6	2.6	-2.3	-0.8	2.8	1.5	1.3
Medication for pain relief, constipation, heartburn	0.5	0.9	2.1	0.4	1.4	-0.7	-1.0	0.4	1.3	0.7
Neck or shoulder pain in last month	0.2	0.3	1.3	0.1	-0.6	0.1	-1.1	-0.4	-0.5	0.0
Medication: Blood pressure	0.7	1.2	3.1	0.9	-1.2	-1.8	1.6	0.3	-0.7	-0.2
Angina (self-reported)	2.0	2.6	4.1	-1.5	-2.0	0.4	1.5	-1.8	-1.9	-1.6
Migraine (self-reported)	1.2	1.5	2.2	1.3	0.5	-1.2	-1.5	1.1	1.1	1.5
Medication: Ibuprofen	0.7	0.8	3.0	0.1	-1.7	0.4	0.1	-0.6	-1.4	-0.2
Medication: Allopurinol	2.6	3.4	8.2	-2.3	-0.9	2.9	-1.3	-2.2	-1.6	-0.8
Medication: Omeprazole	0.2	0.2	0.4	0.3	-0.2	-0.6	-0.7	0.3	0.5	-0.3
Medication: Seretide 50 evohaler	1.4	1.6	3.7	-1.7	0.1	1.9	-0.1	0.4	-1.7	1.3
Mean time to correctly identify matches	0.5	0.9	1.9	1.0	0.6	-1.1	-0.2	1.2	1.4	0.7
Heart disease (mother)	0.4	0.5	2.5	0.3	-0.5	-0.7	1.6	0.3	-0.0	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.8	0.4	0.2	0.9	0.8	0.4	-0.8	0.5
Whole body fat mass	1.1	4.4	15.8	1.3	3.0	-0.3	-4.0	0.3	0.6	1.9
Leg fat mass (right)	1.1	4.2	11.2	1.7	3.1	-0.5	-3.4	0.8	0.7	1.9
Arm predicted mass (right)	1.5	7.9	15.5	-2.5	-0.2	3.5	-3.9	-3.5	-3.0	0.5
Pulse rate, automated reading	0.9	3.1	10.3	1.4	1.6	-0.4	-0.3	1.7	3.2	1.8
Alcohol intake frequency.	0.5	1.1	4.4	0.6	-0.0	-0.5	-2.1	-0.3	-1.5	0.6
Comparative height size at age 10	3.0	16.7	23.0	-4.5	-3.3	4.8	-4.6	-4.7	-4.4	0.3
Number of full sisters	0.5	0.6	2.9	-0.5	-0.2	-0.9	1.7	0.3	-0.1	-0.7
Suffer from ‘nerves’	2.1	3.3	6.7	-1.2	-2.6	0.7	1.4	-2.4	-1.3	-2.3
Overall health rating	1.0	2.2	5.0	-1.2	-1.7	1.2	0.3	-2.2	-2.1	-0.6
Chest pain or discomfort	1.0	1.5	4.8	0.0	0.1	1.5	-0.9	-0.8	-2.2	1.4
Had major operations	0.9	1.0	3.8	0.5	0.5	0.7	-2.0	0.8	-0.4	1.3
Age at last live birth	0.7	0.9	1.9	-1.2	-1.3	0.1	1.0	-0.4	-0.7	-1.4
Family relationship satisfaction	1.8	2.2	4.8	-1.8	-1.4	0.7	0.7	-2.2	-1.4	-1.5
Leg pain on walking	0.2	0.3	1.4	0.2	-1.2	0.2	0.6	0.0	0.3	-0.3
Qualifications: NVQ or HND or HNC or equivalent	2.2	2.7	4.8	1.6	1.6	-1.1	-1.3	2.2	1.2	2.1
Commuting to job workplace: Car/motor vehicle	0.8	1.0	2.8	0.8	1.6	-0.6	0.1	1.7	0.4	0.6
Illness, injury, bereavement, stress in last 2 years	1.2	1.4	3.4	-0.7	1.5	1.2	-1.8	0.4	-0.8	1.3
Medication: Aspirin	0.9	1.2	3.9	-0.2	-0.8	0.1	1.7	-0.7	-0.8	-2.0
Supplements: Vitamin C	2.4	2.9	6.2	-2.5	-0.3	2.1	0.5	-2.0	-1.9	-1.3
Knee pain experienced in last month	0.2	0.3	0.7	0.6	0.6	-0.5	0.2	0.9	-0.0	0.3
Hypertension (Self-reported)	0.4	1.0	1.9	1.4	-1.1	-0.6	1.4	0.2	-1.2	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.6	0.1	0.7	-0.1	-0.0	0.5	0.8	0.1
Illnesses of father: Heart disease	0.4	0.6	1.4	-0.9	-0.6	1.0	1.2	-0.4	-0.7	-0.2
Illnesses of siblings: Diabetes	2.1	2.6	7.8	1.3	1.8	-0.0	-2.8	1.2	0.2	2.0
Smoking status: Previous	0.5	0.7	3.3	-0.1	-0.5	-0.8	1.8	0.4	0.4	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	2.8	5.9	11.6	-1.7	-2.7	3.3	-1.6	-3.4	-2.1	-1.0
Whole body fat-free mass	1.4	8.2	26.5	-1.8	0.1	3.3	-5.1	-2.9	-2.4	1.6
Leg fat-free mass (right)	1.5	7.9	28.2	-1.4	0.8	3.1	-5.3	-2.4	-2.0	2.3
Arm fat percentage (left)	2.0	7.8	15.6	3.0	4.0	-1.9	-3.3	2.0	2.2	2.5
Average weekly red wine intake	0.3	0.5	2.0	0.3	-1.4	0.0	0.5	-0.6	-0.2	-0.8
Handedness (chirality/laterality): Left-handed	0.9	1.1	2.5	-0.3	1.0	-0.7	0.9	-0.5	1.6	-1.6
Mood swings	0.2	0.4	1.9	-0.3	-0.5	-0.3	-0.0	-0.6	-1.4	0.7
Loneliness, isolation	1.4	1.9	3.2	-0.7	-1.7	-0.1	1.4	-1.6	-1.5	-1.8
Long-standing illness, disability or infirmity	0.4	0.6	2.2	0.7	-1.5	-0.1	-0.4	-0.3	-1.3	0.1
Ever had bowel cancer screening	1.0	1.1	2.2	-1.5	0.5	1.1	0.6	-1.3	-0.5	-1.3
Diabetes diagnosed by doctor	1.6	2.7	7.5	0.9	2.4	-0.3	-2.7	1.1	1.1	1.4
Ever had stillbirth, spontaneous miscarriage or termination	2.5	2.6	6.2	1.7	0.8	-2.3	0.5	2.5	1.2	1.2
Friendships satisfaction	0.2	0.2	0.6	-0.5	-0.0	-0.1	-0.1	-0.8	0.7	-0.5
Qualifications: nursing, teaching	0.6	1.0	3.8	2.0	0.6	-0.7	-0.6	0.5	0.9	0.8
Commuting to job workplace: Walk	1.1	1.2	4.1	0.3	-0.4	0.9	-1.8	0.3	-0.2	2.0
Eye problems/disorders: Cataract	0.2	0.3	1.2	0.2	0.1	0.2	1.1	0.2	-0.0	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	5.5	0.1	-2.3	-1.4	1.1	-0.4	0.3	-1.1
Medication for cholesterol	0.5	0.7	1.9	-1.2	1.4	-0.3	-0.3	-0.3	0.9	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	5.0	-1.6	-0.3	0.2	0.7	-1.0	-2.2	-0.8
Back pain experienced in last month	0.4	0.6	2.0	0.6	0.2	0.6	-1.4	-0.7	-1.1	0.2
Mineral and other dietary supplements	0.2	0.3	0.7	-0.3	0.1	0.8	-0.4	-0.0	0.6	0.7
Breast cancer (self-reported)	0.8	0.9	2.1	0.5	1.4	-0.5	-0.9	1.2	0.7	1.1
Asthma (self-reported)	1.0	2.0	6.0	-0.6	0.5	2.4	-1.3	-0.8	-1.9	1.2
Osteoporosis (self-reported)	0.8	0.9	2.0	1.4	1.1	-1.3	0.7	1.0	0.3	0.1
Osteoarthritis (self-reported)	2.8	3.6	9.0	-2.3	-1.3	1.6	0.9	-2.1	-3.0	-1.0
Medication: Aspirin	1.0	1.3	3.8	-0.3	-0.4	0.1	1.8	-0.8	-1.0	-2.0
Medication: Gliclazide	0.6	0.7	2.7	-0.8	1.1	0.4	-1.6	-0.5	-0.2	-0.1
Illnesses of father: None of the above (group 1)	0.2	0.2	0.6	-0.3	0.5	0.8	-0.5	-0.2	0.4	-0.6
Smoking status: Current	1.2	2.0	6.2	-1.0	-0.4	2.3	0.4	-0.2	-2.5	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.5	1.5	-0.3	-0.0	0.4	-1.2	0.7	-0.2	1.2
Whole body water mass	1.4	8.0	27.4	-1.7	0.1	3.2	-5.2	-2.8	-2.2	1.7
Leg predicted mass (right)	1.5	8.0	28.4	-1.4	0.8	3.1	-5.3	-2.4	-2.1	2.2
Arm fat mass (left)	1.3	5.5	16.9	1.8	3.3	-0.6	-4.1	0.8	1.1	2.2
Number of self-reported non-cancer illnesses	0.8	1.3	3.6	-0.1	-1.9	0.1	0.5	-1.5	-1.6	-0.8
Average weekly champagne plus white wine intake	0.4	0.6	2.7	0.1	0.6	-0.2	0.2	0.9	1.7	0.5
Miserableness	1.1	1.9	4.7	-0.5	-2.2	-0.5	1.5	-1.5	-1.5	-1.2
Guilty feelings	2.3	3.5	8.6	-1.5	-2.3	-0.1	2.9	-1.4	-0.8	-2.4
Wears glasses or contact lenses	1.3	1.5	3.3	1.4	1.8	-1.4	-0.9	1.4	0.6	0.5
Ever taken oral contraceptive pill	0.8	0.9	1.8	0.9	0.7	-1.4	0.3	1.3	1.1	-0.3
Hearing aid user	0.6	0.6	2.3	-0.2	0.9	0.9	-1.5	-0.4	-0.5	0.2
Mother’s age at death	2.3	2.9	8.9	0.6	2.2	0.6	-3.0	0.5	0.6	2.2
Financial situation satisfaction	0.4	0.5	1.1	-0.7	-1.0	0.2	-0.4	-1.1	-0.3	-0.8
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.3	-0.4	0.6	1.2	-0.7	-0.4	-0.6	0.6
Commuting to job workplace: Public transport	0.7	0.9	3.0	0.9	0.6	-0.7	-1.7	0.4	0.9	0.6
Eye problems/disorders: Glaucoma	1.1	1.3	2.5	0.4	1.5	0.3	-1.0	1.0	1.5	1.6
Medication: Blood pressure	0.8	1.5	5.6	2.4	0.1	-0.7	0.7	1.8	0.2	0.7
Pain type(s) experienced in last month: Hip pain	0.9	1.1	3.0	1.7	-0.3	-1.1	0.6	1.7	0.2	0.4
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.6	-0.2	-0.4	1.3	-0.5	-1.0	-1.2	-0.4
High cholesterol (Self-reported)	0.3	0.5	1.4	-0.3	-1.2	-0.1	0.6	-0.2	-1.2	0.2
Medication: Bendroflumethiazide	0.4	0.7	1.5	1.2	-0.3	-0.6	1.2	1.0	-0.3	0.4
Medication: Paracetamol	0.2	0.2	0.5	-0.7	-0.7	0.1	0.0	0.0	-0.6	0.5
Medication: Lisinopril	0.4	0.5	1.1	1.0	0.7	-0.8	1.0	0.7	0.0	0.2
Medication: Atorvastatin	0.6	0.8	3.0	-1.2	-0.2	1.7	0.6	-0.3	-0.6	0.4
Illnesses of father: High blood pressure	1.2	1.5	3.6	1.5	-0.2	-1.9	1.9	1.1	-0.4	-0.1
Alcohol drinker status: Never	0.8	1.0	4.2	-0.3	-0.5	-1.2	0.1	-0.7	-2.0	-0.5
Ever smoked	1.6	2.8	11.4	0.4	-2.1	-1.4	3.4	1.1	0.1	-0.4
Basal metabolic rate	1.3	7.4	27.7	-1.4	0.6	2.9	-5.3	-2.5	-2.0	1.8
Leg fat percentage (left)	1.8	6.5	15.1	3.1	3.9	-2.8	-1.3	2.4	2.1	1.3
Arm fat-free mass (left)	1.3	6.6	15.4	-2.1	-0.0	3.3	-3.9	-3.1	-2.4	0.6
Number of operations (self-reported)	0.2	0.3	1.3	0.1	-0.3	0.6	-0.3	-0.1	-1.2	-0.3
Average weekly beer plus cider intake	1.2	1.7	4.8	-0.9	2.2	1.9	0.4	0.5	-1.2	0.6
Irritability	2.9	4.9	14.6	-1.7	-2.9	0.6	0.7	-2.5	-3.8	-1.1
Risk taking	1.0	1.5	4.8	-0.4	-1.4	0.1	1.2	-1.3	-0.4	-2.2
Ever had prostate specific antigen (PSA) test	0.8	1.0	2.8	-0.2	1.7	-1.3	0.6	0.7	1.0	0.6
Fractured/broken bones in last 5 years	3.2	4.2	7.7	-2.0	-1.8	2.0	1.1	-2.8	-1.4	-2.6
Age started oral contraceptive pill	1.7	2.1	4.9	2.1	1.1	-1.4	0.2	1.4	2.2	0.0
Diastolic blood pressure, automated reading	0.4	1.1	4.1	0.3	0.0	0.8	2.0	-1.2	-1.2	-0.4
Ever depressed for a whole week	1.5	1.8	4.7	-0.7	-0.8	-0.1	1.4	-2.0	-0.9	-2.2
Unable to work because of sickness or disability	1.3	1.7	4.3	-1.5	-1.4	0.4	0.2	-1.4	-2.1	-0.8
Commuting to job workplace: Cycle	0.4	0.5	1.7	1.3	-0.1	-0.2	-0.4	-0.0	1.2	-0.2
Myopia	0.3	0.4	1.4	0.2	0.5	-0.2	-1.1	-0.2	0.3	1.2
Vascular/heart problems diagnosed by doctor	0.5	1.3	4.7	-1.1	0.9	0.3	-2.2	-0.4	1.3	0.6
Cholesterol lowering medication	0.5	0.7	1.8	-0.1	-1.3	-0.5	0.7	-0.9	-0.0	-1.3
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.5	0.4	0.8	-1.2	-0.5	0.8	1.2	0.4
Pain experienced in last month	0.3	0.6	1.5	-0.6	0.6	1.2	-0.9	-0.7	-0.6	0.3
Supplements: Calcium	0.4	0.5	1.3	-0.6	-0.4	0.2	0.7	-0.2	-1.1	-0.9
Basal cell carcinoma (self-reported)	0.9	1.1	3.0	-0.4	-0.3	-1.3	1.7	-0.5	-0.6	-1.5
Heart attack/myocardial infarction (self-reported)	2.1	2.7	8.9	-0.9	-1.8	0.1	3.0	-0.3	-0.9	-2.2
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	2.1	0.7	0.3	-1.0	0.8	0.1	0.9	-1.4
Heart disease (siblings)	0.4	0.5	1.8	-0.4	0.2	1.3	-0.4	-0.3	-1.0	0.4
Alcohol drinker status: Previous	0.4	0.5	1.1	0.1	-1.0	0.7	-0.9	0.8	-0.2	0.6
Pack years of smoking	0.5	0.7	1.6	-0.9	1.0	1.3	0.1	0.3	1.0	0.5
Impedance of whole body	0.2	0.8	2.5	-0.1	-1.2	-0.5	1.1	-0.5	0.3	-1.6
Leg fat mass (left)	1.1	4.2	11.4	1.8	3.4	-0.7	-3.1	0.9	0.7	1.8
Arm predicted mass (left)	1.2	6.3	17.7	-1.7	0.2	3.1	-4.2	-2.6	-2.2	1.1