[Hub]/) : Traits : Leg fat-free mass (right) : ← →

chr12:109,231,851-113,517,494

Best TWAS P=1.19e-10 · Best GWAS P=1.1e-16 conditioned to 0.201

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
3	GTEx	Artery Tibial	HECTD4	0.05	0.02	lasso	3	0.01	3.1e-02	-7.3	-6.4	1.2e-10	0.85	0.02	0.92	TRUE
13	NTR	Blood	ALDH2	0.06	0.01	blup	222	0.02	4.3e-08	4.4	6.1	8.8e-10	-0.60	0.38	0.62	TRUE
17	The Cancer Genome Atlas	Prostate Adenocarcinoma	CUX2	0.08	0.01	blup	95	0.02	1.3e-03	4.4	5.9	2.8e-09	-0.16	0.02	0.85	TRUE
14	NTR	Blood	UBE3B	0.09	0.05	lasso	8	0.08	1.0e-25	5.0	5.8	8.1e-09	0.02	0.02	0.98	TRUE
2	GTEx	Artery Tibial	VPS29	0.05	0.03	lasso	3	0.02	5.9e-03	5.6	5.6	2.7e-08	-0.07	0.01	0.96	TRUE
18	The Cancer Genome Atlas	Prostate Adenocarcinoma	MMAB	0.06	0.06	blup	57	0.06	5.4e-07	-4.7	-5.6	1.7e-08	-0.03	0.11	0.88	FALSE
8	GTEx	Colon Sigmoid	KCTD10	0.25	0.16	lasso	8	0.15	6.2e-06	5.1	-5.4	6.8e-08	-0.03	0.09	0.88	FALSE
12	GTEx	Thyroid	VPS29	0.07	0.01	lasso	5	0.01	8.9e-02	4.7	5.4	7.1e-08	-0.06	0.01	0.89	FALSE
1	GTEx	Adrenal Gland	PPTC7	0.13	-0.01	lasso	6	0.00	3.4e-01	4.6	5.3	1.0e-07	-0.19	0.04	0.10	FALSE
10	GTEx	Muscle Skeletal	VPS29	0.06	0.06	lasso	3	0.05	4.3e-06	5.6	5.3	1.0e-07	-0.04	0.00	1.00	FALSE
6	GTEx	Breast Mammary Tissue (Female)	VPS29	0.10	-0.01	lasso	2	0.02	1.0e-01	-3.9	5.3	1.2e-07	-0.24	0.02	0.33	FALSE
4	GTEx	Brain Cerebellar Hemisphere	MMAB	0.31	0.27	lasso	3	0.24	6.6e-07	5.3	-5.3	1.3e-07	-0.06	0.02	0.98	FALSE
5	GTEx	Brain Nucleus accumbens basal ganglia	MMAB	0.40	0.24	enet	16	0.28	2.5e-08	4.5	-5.3	1.4e-07	-0.01	0.06	0.83	FALSE
16	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MMAB	0.04	0.02	blup	53	0.02	5.2e-03	5.1	-5.2	1.9e-07	-0.05	0.01	0.57	FALSE
15	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	KCTD10	0.06	0.00	lasso	3	0.00	1.4e-01	5.0	-5.2	2.0e-07	-0.05	0.00	0.66	FALSE
9	GTEx	Colon Transverse	MMAB	0.08	0.07	lasso	2	0.05	1.7e-03	5.1	-5.2	2.4e-07	-0.04	0.09	0.77	FALSE
7	GTEx	Cells Transformed fibroblasts	VPS29	0.09	0.13	lasso	3	0.13	9.8e-10	5.6	5.2	2.6e-07	-0.03	0.00	1.00	FALSE
11	GTEx	Skin Not Sun Exposed Suprapubic	VPS29	0.06	0.01	lasso	3	0.01	6.9e-02	4.6	5.1	2.7e-07	-0.01	0.04	0.61	FALSE