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chr17:41,946,180-43,913,030

Best TWAS P=1.45e-14 · Best GWAS P=7.85e-15 conditioned to 0.573

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
21	GTEx	Thyroid	ACBD4	0.20	0.16	enet	23	0.15	1.2e-11	-6.1	-7.7	1.5e-14	0.51	0.98	0.02	TRUE
10	GTEx	Breast Mammary Tissue	KANSL1	0.31	0.00	enet	9	0.11	2.6e-06	4.2	-5.9	3.2e-09	0.08	0.00	0.02	TRUE
5	GTEx	Artery Coronary	NMT1	0.13	0.06	enet	7	0.11	1.5e-04	4.5	-5.8	9.0e-09	0.53	0.12	0.28	TRUE
2	GTEx	Adipose Subcutaneous	ACBD4	0.10	0.06	enet	8	0.06	1.8e-05	-6.2	-7.1	1.5e-12	0.52	0.54	0.34	FALSE
32	The Cancer Genome Atlas	Thyroid Carcinoma	HEXIM1	0.05	0.05	blup	47	0.04	8.5e-05	-7.8	7.0	3.2e-12	-0.84	0.00	1.00	FALSE
19	GTEx	Skin Sun Exposed Lower leg	ACBD4	0.06	0.05	lasso	4	0.02	3.8e-03	5.4	-6.8	7.3e-12	0.33	0.19	0.07	FALSE
18	GTEx	Nerve Tibial	ACBD4	0.21	0.10	lasso	5	0.11	4.2e-08	-5.5	-6.8	1.2e-11	0.47	0.92	0.07	FALSE
7	GTEx	Artery Tibial	ACBD4	0.10	0.09	lasso	2	0.08	4.8e-07	-6.3	-6.3	3.0e-10	0.58	0.80	0.13	FALSE
4	GTEx	Artery Aorta	DCAKD	0.22	0.16	enet	26	0.19	1.1e-10	-3.0	5.9	2.9e-09	-0.46	0.92	0.06	FALSE
27	The Cancer Genome Atlas	Brain Lower Grade Glioma	ACBD4	0.08	0.04	enet	9	0.04	6.9e-06	-6.1	-5.8	6.6e-09	0.50	0.94	0.02	FALSE
33	The Cancer Genome Atlas	Thyroid Carcinoma	PLCD3	0.24	0.16	lasso	5	0.20	2.8e-19	5.2	5.8	8.3e-09	-0.15	1.00	0.00	FALSE
30	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	NMT1	0.23	0.08	blup	82	0.12	1.1e-05	3.4	-5.6	1.7e-08	0.55	0.05	0.90	FALSE
24	YFS	Blood	NMT1	0.02	0.01	lasso	6	0.01	5.0e-03	5.4	-5.6	2.6e-08	0.37	0.28	0.03	FALSE
13	GTEx	Esophagus Gastroesophageal Junction	NMT1	0.24	0.21	lasso	4	0.22	2.8e-08	3.4	-5.5	2.8e-08	0.54	0.45	0.51	FALSE
11	GTEx	Breast Mammary Tissue (Female)	FZD2	0.10	0.08	lasso	2	0.05	1.1e-02	5.2	5.5	3.4e-08	-0.07	0.04	0.13	FALSE
22	METSIM	Adipose	C17orf104	0.05	0.02	bslmm	404	0.04	4.2e-06	5.0	-5.5	3.5e-08	0.11	0.91	0.00	FALSE
15	GTEx	Esophagus Mucosa	ACBD4	0.14	0.10	lasso	4	0.10	4.5e-07	5.2	-5.5	3.6e-08	0.13	0.60	0.08	FALSE
20	GTEx	Stomach	DCAKD	0.29	0.17	enet	25	0.20	9.4e-10	-3.0	5.5	3.8e-08	-0.48	0.59	0.40	FALSE
26	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	DCAKD	0.07	0.07	lasso	4	0.07	1.4e-08	-4.4	5.5	4.2e-08	-0.56	0.19	0.76	FALSE
17	GTEx	Muscle Skeletal	PLCD3	0.18	0.10	enet	8	0.10	1.7e-10	5.2	5.4	5.8e-08	-0.12	1.00	0.00	FALSE
23	YFS	Blood	HEXIM2	0.02	0.01	bslmm	279	0.01	1.0e-05	4.5	-5.4	6.6e-08	0.61	0.10	0.90	FALSE
9	GTEx	Brain Cerebellum	ACBD4	0.40	0.06	lasso	8	0.17	1.0e-05	5.4	-5.4	8.4e-08	0.27	0.09	0.15	FALSE
25	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	LOC644172	0.19	-0.01	blup	81	0.03	1.3e-02	1.9	5.3	9.5e-08	-0.47	0.02	0.55	FALSE
3	GTEx	Adrenal Gland	PLEKHM1	0.21	0.00	enet	20	0.08	1.0e-03	3.6	5.3	9.9e-08	-0.13	0.08	0.14	FALSE
28	The Cancer Genome Atlas	Brain Lower Grade Glioma	LOC644172	0.04	0.00	enet	15	0.02	4.0e-03	-7.8	5.3	1.1e-07	-0.60	0.00	0.74	FALSE
29	The Cancer Genome Atlas	Lung Adenocarcinoma	NMT1	0.04	0.00	blup	81	0.01	1.9e-02	-3.4	-5.3	1.3e-07	0.27	0.03	0.70	FALSE
8	GTEx	Brain Cerebellum	ADAM11	0.17	0.19	enet	8	0.18	4.4e-06	3.8	5.3	1.4e-07	-0.13	0.48	0.03	FALSE
14	GTEx	Esophagus Mucosa	ADAM11	0.19	0.14	lasso	4	0.12	1.2e-08	5.2	5.3	1.4e-07	-0.07	0.99	0.00	FALSE
16	GTEx	Esophagus Muscularis	KANSL1	0.41	0.11	enet	8	0.15	1.3e-09	4.2	-5.2	2.2e-07	0.05	0.00	0.83	FALSE
31	The Cancer Genome Atlas	Prostate Adenocarcinoma	ACBD4	0.04	0.01	enet	7	0.03	2.2e-04	3.6	-5.2	2.2e-07	0.44	0.09	0.14	FALSE
12	GTEx	Cells Transformed fibroblasts	PLCD3	0.23	0.04	lasso	5	0.08	1.3e-06	2.2	5.2	2.5e-07	-0.48	0.94	0.01	FALSE
1	GTEx	Adipose Subcutaneous	DCAKD	0.21	0.09	lasso	6	0.14	6.1e-12	4.9	5.1	2.8e-07	-0.35	1.00	0.00	FALSE
6	GTEx	Artery Tibial	KANSL1	0.31	0.07	lasso	6	0.07	1.7e-06	4.2	-5.1	2.9e-07	-0.01	0.00	0.83	FALSE