TWAS
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Traits
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Traits
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Leg fat-free mass (right)
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chr19:49,354,522-51,004,754
Best TWAS P=1.61e-08 · Best GWAS P=5.5e-07 conditioned to 0.655
49.4M
49.6M
49.8M
50M
50.2M
50.4M
50.6M
50.8M
51M
0
1
2
3
4
5
6
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Esophagus Mucosa
AP2A1
0.18
0.09
enet
8
0.13
7.7e-09
-4.5
-5.6
1.6e-08
0.85
0.02
0.97
TRUE
5
The Cancer Genome Atlas
Colon Adenocarcinoma
SNRNP70
0.05
0.02
lasso
3
0.02
2.9e-02
4.4
-5.5
3.9e-08
0.08
0.01
0.61
TRUE
3
GTEx
Nerve Tibial
AP2A1
0.16
0.05
lasso
4
0.07
1.3e-05
-4.4
-5.6
2.5e-08
0.84
0.01
0.97
FALSE
4
The Cancer Genome Atlas
Breast Invasive Carcinoma
LIN7B
0.02
0.00
enet
7
0.02
5.1e-05
4.5
-5.4
5.3e-08
0.05
0.01
0.88
FALSE
1
GTEx
Colon Sigmoid
PRR12
0.20
0.01
lasso
8
0.00
4.9e-01
3.4
5.2
1.7e-07
-0.28
0.03
0.17
FALSE