TWAS hub - LIN7B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0770	0.0240	3.5e-05	0.084	0.040	0.048	0.058	0.078	2.2e-10	1.1e-05	1.5e-06	1.2e-07	8.5e-10
2	GTEx	Heart Atrial Appendage	0.2190	0.0890	4.9e-03	0.045	NA	0.020	NA	0.086	4.3e-03	NA	4.3e-02	NA	1.1e-04
3	GTEx	Muscle Skeletal	0.1125	0.0415	7.1e-04	0.064	NA	0.088	NA	0.110	7.0e-07	NA	6.1e-09	NA	6.9e-11
4	YFS	Blood	0.0498	0.0182	4.4e-04	0.047	0.013	0.048	0.046	0.046	5.0e-15	3.9e-05	1.5e-15	5.7e-15	8.1e-15
5	TCGA	Breast Invasive Carcinoma	0.0227	0.0110	2.8e-04	0.004	0.019	0.020	NA	0.014	3.9e-02	7.1e-05	5.1e-05	NA	4.5e-04
6	TCGA	Head and Neck Squamous Cell Carcinoma	0.0514	0.0269	1.3e-03	0.035	0.014	0.030	NA	0.027	7.5e-05	9.8e-03	2.3e-04	NA	4.6e-04
7	TCGA	Kidney Renal Clear Cell Carcinoma	0.0937	0.0432	5.3e-04	0.027	0.022	0.043	NA	0.043	4.5e-04	1.5e-03	1.1e-05	NA	1.1e-05
8	TCGA	Brain Lower Grade Glioma	0.0591	0.0333	5.3e-03	0.002	0.018	0.026	NA	0.012	1.9e-01	3.2e-03	6.0e-04	NA	1.3e-02
9	TCGA	Lung Adenocarcinoma	0.0322	0.0184	5.0e-03	0.005	0.010	0.016	NA	0.012	6.6e-02	2.2e-02	5.1e-03	NA	1.4e-02
10	TCGA	Pancreatic Adenocarcinoma	0.3430	0.0980	1.4e-05	0.126	0.163	0.177	NA	0.175	6.4e-06	2.3e-07	7.0e-08	NA	8.3e-08
11	TCGA	Prostate Adenocarcinoma	0.1061	0.0406	1.2e-06	0.062	0.063	0.095	NA	0.098	4.9e-07	3.8e-07	3.6e-10	NA	2.2e-10
12	TCGA	Thyroid Carcinoma	0.1120	0.0470	4.2e-05	0.035	0.064	0.077	NA	0.080	2.4e-04	7.7e-07	5.8e-08	NA	3.2e-08

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Maternal smoking around birth	6.0	8.6	12.0	-3.1	-2.9	-3.2	-2.1	-3.5	-2.6	-2.5	-3.2	-3.0	-2.7	-3.0	-3.0
Qualifications: A levels/AS levels or equivalent	5.3	11.7	16.8	3.9	4.0	3.6	2.9	4.1	3.3	3.3	1.9	3.4	2.3	3.7	4.1
Fluid intelligence score	5.1	10.5	14.3	2.3	3.5	3.8	3.5	3.3	3.1	3.8	2.7	2.3	3.1	3.5	3.5
Alcohol drinker status: Previous	4.5	5.2	10.5	0.6	2.3	2.5	3.2	2.5	1.9	2.7	2.1	2.2	2.2	1.8	2.2
Medication: Ventolin 100micrograms inhaler	4.4	5.7	8.0	-2.1	-2.8	-2.3	-2.4	-2.1	-2.5	-2.8	-1.8	-2.2	-1.4	-2.8	-2.8
Qualifications: NVQ or HND or HNC or equivalent	4.4	5.3	8.3	1.4	2.0	2.6	2.2	2.8	1.9	2.3	2.9	2.0	2.6	2.5	2.0
Wears glasses or contact lenses	3.5	4.0	9.9	-1.8	-1.8	-2.0	-1.5	-2.2	-1.2	-1.4	-3.1	-2.8	-1.7	-1.5	-1.9
Arm fat-free mass (left)	3.5	17.5	35.4	-5.4	-3.9	-4.5	-2.7	-6.0	-3.3	-2.9	-3.8	-4.6	-3.4	-4.1	-4.3
Verbal and Numeric Reasoning (VNR)	3.4	8.1	13.3	1.5	3.3	3.2	3.4	2.7	2.6	3.6	2.6	1.9	2.4	3.1	3.2
Arm predicted mass (right)	3.4	17.6	34.9	-5.3	-4.1	-4.6	-3.0	-5.9	-3.3	-3.2	-3.5	-4.4	-3.2	-4.3	-4.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.4	3.9	6.1	-2.1	-2.5	-1.6	-2.4	-1.6	-2.3	-2.1	-0.6	-1.9	-1.5	-2.1	-2.4
Average weekly red wine intake	3.4	5.1	8.1	2.2	2.8	2.1	2.0	1.5	2.4	2.6	2.7	1.8	0.8	2.5	2.7
Arm predicted mass (left)	3.4	17.2	35.4	-5.1	-3.9	-4.6	-2.9	-6.0	-3.1	-3.0	-3.6	-4.6	-3.6	-4.0	-4.2
Shortness of breath walking on level ground	3.3	3.9	6.0	-2.1	-2.2	-2.4	-1.6	-2.2	-1.5	-2.1	-2.0	-1.8	-0.9	-2.4	-2.2
Handedness (chirality/laterality): Left-handed	3.2	3.8	6.8	-0.2	-2.0	-2.2	-2.4	-1.4	-1.5	-2.6	-1.8	-1.8	-2.6	-1.9	-1.9
Whole body fat-free mass	3.0	16.9	32.4	-5.2	-4.0	-4.4	-3.1	-5.7	-3.5	-3.1	-3.1	-4.4	-3.3	-4.2	-4.3
Leg fat-free mass (right)	3.0	16.2	29.6	-5.0	-4.0	-4.4	-3.2	-5.4	-3.3	-3.2	-2.8	-4.2	-3.5	-4.1	-4.3
Whole body water mass	3.0	17.1	33.2	-5.2	-4.1	-4.4	-3.1	-5.8	-3.5	-3.1	-3.2	-4.4	-3.3	-4.2	-4.3
Leg predicted mass (right)	3.0	16.0	29.4	-5.0	-4.0	-4.4	-3.2	-5.4	-3.4	-3.1	-2.7	-4.1	-3.4	-4.1	-4.3
HbA1C	2.9	3.2	6.4	0.3	-1.5	-1.8	-2.3	-2.1	-2.0	-2.5	-1.5	-1.4	-1.2	-2.3	-1.4
Number of treatments/medications taken	2.9	5.3	9.1	-2.5	-2.4	-1.9	-2.0	-2.4	-2.1	-1.9	-3.0	-2.9	-1.3	-2.3	-2.3
Leg fat-free mass (left)	2.9	15.3	28.5	-4.8	-3.9	-4.3	-3.0	-5.3	-3.3	-3.1	-2.8	-4.0	-3.4	-4.0	-4.1
Leg predicted mass (left)	2.9	15.4	28.7	-4.8	-3.9	-4.3	-3.0	-5.4	-3.3	-3.1	-2.8	-4.0	-3.4	-4.0	-4.2
Qualifications: None of the above	2.9	6.3	9.0	-2.1	-2.4	-2.5	-2.6	-3.0	-2.3	-2.4	-2.2	-3.0	-2.4	-2.5	-2.4
Arm fat-free mass (right)	2.9	15.0	31.4	-4.9	-3.7	-4.3	-2.8	-5.6	-3.0	-2.9	-3.2	-4.2	-3.2	-3.9	-4.0
Basal metabolic rate	2.9	16.1	31.9	-5.1	-3.9	-4.3	-2.9	-5.6	-3.3	-3.0	-3.2	-4.3	-3.3	-4.0	-4.2
Qualifications: O levels/GCSEs or equivalent	2.8	4.4	7.1	2.7	2.3	1.8	1.3	2.1	2.4	1.9	2.2	1.8	1.1	2.5	2.4
Triglycerides	2.7	4.4	8.3	-1.4	-2.3	-2.3	-2.9	-2.2	-2.1	-2.4	-1.6	-1.4	-1.4	-2.4	-2.3
Trunk fat-free mass	2.7	15.7	31.2	-5.1	-3.9	-4.2	-2.9	-5.6	-3.5	-3.0	-3.1	-4.2	-2.9	-4.0	-4.2
Trunk predicted mass	2.7	15.3	30.5	-5.0	-3.8	-4.1	-2.8	-5.5	-3.5	-2.9	-3.0	-4.2	-2.9	-3.9	-4.1
Intelligence (Savage-Jansen 2018)	2.6	8.1	14.0	1.6	3.4	3.1	3.2	2.5	2.6	3.7	2.3	1.9	2.5	3.2	3.4
Average weekly fortified wine intake	2.6	3.1	6.6	1.9	2.2	1.7	2.6	2.0	1.6	1.8	-0.0	0.9	0.0	1.8	2.2
Angina	2.4	3.2	7.0	0.7	2.2	2.2	2.7	1.1	1.1	2.6	0.6	1.2	0.9	2.3	2.0
Weight	2.4	12.0	24.1	-4.4	-3.2	-3.8	-2.1	-4.9	-2.2	-2.3	-3.6	-3.9	-3.4	-3.2	-3.4
Angina (self-reported)	2.4	3.2	7.4	0.7	2.2	2.1	2.7	1.2	1.2	2.5	0.6	1.2	1.0	2.2	2.0
Medication for hormone replacement therapy	2.3	2.6	4.1	0.7	1.7	1.8	1.6	1.3	1.6	2.0	1.5	2.0	1.3	1.7	1.7
Lung FVC	2.2	11.0	16.2	-3.9	-3.5	-2.6	-2.8	-3.4	-3.8	-3.2	-3.5	-3.1	-1.2	-4.0	-3.7
Headache pain in last month	2.2	3.8	8.3	-2.5	-2.1	-1.5	-1.5	-1.8	-2.9	-1.6	-1.7	-1.1	-1.9	-1.9	-2.1
Forced vital capacity (FVC), Best measure	2.2	8.0	13.7	-3.3	-3.1	-2.3	-2.6	-3.3	-3.7	-2.8	-1.0	-2.4	-1.8	-3.4	-3.2
Commuting to job workplace: Public transport	2.2	2.6	4.0	1.1	1.9	1.5	1.8	1.4	1.3	1.7	1.3	2.0	1.8	1.4	1.8
Forced vital capacity (FVC)	2.1	8.1	15.8	-3.4	-3.1	-2.1	-2.5	-3.0	-4.0	-2.7	-1.7	-2.5	-1.6	-3.3	-3.2
Birth weight of first child	2.1	3.8	6.2	-1.1	-1.9	-2.5	-1.9	-2.3	-1.8	-2.1	-2.3	-1.0	-2.2	-1.8	-1.9
Medication: Blood pressure	2.1	3.8	11.2	-1.8	-1.1	-1.9	-1.0	-2.6	-1.1	-0.9	-3.3	-2.5	-2.6	-1.3	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.1	4.5	7.1	-2.1	-2.0	-2.1	-2.3	-2.7	-1.8	-2.0	-2.0	-2.1	-1.2	-2.4	-2.2
Neuroticism (2016)	2.0	2.8	4.7	-1.7	-2.1	-1.3	-1.2	-1.2	-1.9	-2.0	-2.0	-0.9	-1.1	-2.2	-2.0
Sensitivity / hurt feelings	2.0	3.4	6.6	-2.5	-1.7	-1.6	-1.4	-2.6	-2.1	-1.4	-1.0	-1.3	-1.8	-2.1	-2.0
Depression (self-reported)	1.9	2.3	7.6	-0.5	1.1	1.8	2.6	1.4	0.3	1.5	0.4	1.7	2.8	0.4	1.0
Severe depression (siblings)	1.8	2.0	4.4	-0.6	-1.3	-1.9	-2.1	-1.8	-0.5	-1.6	-1.2	-0.8	-1.5	-1.5	-1.2
Qualifications: CSEs or equivalent	1.8	2.4	4.8	-0.1	1.4	2.1	2.0	1.6	1.4	2.2	1.2	0.9	1.2	1.8	1.4
Asthma	1.8	3.6	7.6	-2.8	-2.6	-1.5	-1.3	-1.4	-2.6	-1.8	-1.3	-0.8	0.3	-2.0	-2.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.8	5.6	8.3	-2.8	-2.6	-1.9	-2.1	-2.7	-2.9	-2.3	-1.1	-2.2	-1.7	-2.8	-2.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.7	4.3	1.4	1.9	1.7	2.0	1.4	1.3	1.6	2.1	1.5	1.0	1.6	1.8
Irritability	1.8	3.0	8.4	-1.4	-1.1	-2.1	-1.6	-2.9	-0.1	-1.2	-2.1	-2.2	-1.8	-1.7	-1.3
Hip circumference	1.7	7.2	14.3	-3.8	-2.5	-2.9	-1.2	-3.7	-1.5	-1.8	-2.5	-2.8	-2.6	-2.7	-2.7
Ever smoked	1.7	3.0	4.5	0.3	1.8	2.0	2.1	1.4	1.1	2.1	2.0	2.0	1.8	1.6	1.7
Respiratory disease	1.6	3.6	6.6	-2.6	-2.5	-1.8	-1.3	-1.7	-2.3	-1.9	-1.4	-0.6	0.6	-2.1	-2.5
Forced expiratory volume in 1-second (FEV1)	1.6	5.4	9.8	-2.7	-2.5	-1.9	-2.0	-2.6	-3.1	-2.2	-1.4	-2.1	-1.6	-2.7	-2.5
Medication: Amlodipine	1.6	2.2	5.3	-1.6	-1.2	-1.6	-1.1	-1.8	-0.8	-0.8	-2.1	-2.3	-1.5	-1.0	-1.2
Mean time to correctly identify matches	1.6	3.0	12.4	-1.9	-1.6	-1.2	-0.4	-1.1	-1.1	-1.2	-3.5	-2.3	0.2	-1.9	-1.7
Leg fat mass (right)	1.6	6.3	15.4	-3.3	-2.1	-2.9	-1.2	-3.9	-1.2	-1.3	-3.1	-2.7	-2.6	-2.1	-2.2
Asthma (self-reported)	1.6	3.1	6.6	-2.6	-2.4	-1.3	-1.2	-1.3	-2.4	-1.7	-1.2	-0.6	0.6	-1.9	-2.5
Fractured/broken bones in last 5 years	1.6	2.0	4.8	-0.1	1.2	1.7	2.2	2.2	0.5	1.6	1.6	1.2	1.2	1.1	1.1
Basal cell carcinoma (self-reported)	1.6	1.9	3.4	-1.0	-1.8	-1.5	-1.2	-0.6	-1.3	-1.8	-1.4	-1.3	-0.7	-1.8	-1.6
Leg fat mass (left)	1.6	6.3	15.1	-3.3	-2.0	-2.9	-1.1	-3.9	-1.1	-1.2	-3.0	-2.8	-2.8	-2.1	-2.2
Allergy or Eczema	1.5	4.0	5.9	-2.4	-2.3	-1.7	-1.5	-2.2	-2.4	-1.6	-2.4	-1.9	-1.2	-1.7	-2.3
Trunk fat mass	1.5	6.2	10.8	-2.7	-2.1	-2.6	-1.3	-3.2	-1.1	-1.6	-3.1	-3.3	-3.3	-2.2	-2.1
Whole body fat mass	1.5	6.3	12.2	-3.0	-2.0	-2.7	-1.2	-3.5	-1.1	-1.4	-3.1	-3.2	-3.0	-2.1	-2.2
Illnesses of father: None of the above (group 1)	1.5	1.9	5.2	1.9	1.0	1.4	0.4	1.6	0.2	0.6	0.5	2.3	2.3	0.8	1.1
Medication: Paracetamol	1.5	2.4	4.8	-2.2	-1.7	-1.2	-0.8	-2.0	-1.9	-1.2	-0.7	-1.7	-1.1	-1.6	-1.7
Fasting Glucose	1.4	1.6	2.8	0.7	1.7	0.9	1.3	0.9	1.6	1.6	1.1	1.6	-0.0	1.3	1.5
Height	1.4	26.8	35.6	-4.8	-5.6	-5.2	-5.0	-6.0	-4.8	-5.3	-3.3	-5.3	-4.8	-5.9	-5.5
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	2.3	-1.3	-1.3	-1.5	-0.8	-1.3	-0.5	-1.2	-1.2	-1.5	-0.9	-1.5	-1.3
Stomach or abdominal pain in last month	1.4	1.7	2.7	-1.3	-1.4	-1.3	-0.9	-1.4	-1.1	-1.4	-1.6	-1.5	-0.5	-1.6	-1.4
Financial difficulties in last 2 years	1.4	1.9	3.6	0.3	1.6	1.8	1.8	0.8	1.2	1.9	1.2	1.5	0.7	1.4	1.5
Prospective memory result	1.4	1.7	4.4	-0.9	-1.4	-1.3	-0.9	-1.2	-0.9	-1.8	-1.2	-0.8	-1.2	-2.1	-1.4
Number of children fathered	1.4	1.6	2.2	-0.5	-1.3	-1.5	-1.5	-1.5	-1.3	-1.5	-1.3	-1.0	-1.3	-1.1	-1.3
Ever had bowel cancer screening	1.4	1.6	3.8	-1.1	-1.4	-1.2	-1.6	-1.4	-0.9	-1.2	-0.4	-1.9	-0.7	-1.0	-1.5
Impedance of whole body	1.4	7.3	19.1	3.9	2.3	3.2	1.7	4.4	1.6	1.3	2.7	2.8	1.9	2.2	2.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.7	6.2	-0.3	1.5	1.3	2.5	0.8	1.3	1.6	0.9	1.1	1.2	0.7	1.1
Hair/balding pattern: Pattern 3	1.3	1.9	5.2	2.3	1.4	0.7	1.0	1.5	2.2	0.7	0.9	1.2	0.5	1.2	1.5
Standing height	1.3	13.3	17.8	-4.0	-4.1	-3.3	-3.1	-4.1	-4.2	-3.6	-1.5	-3.8	-2.8	-4.2	-4.0
Medication: Lisinopril	1.3	1.7	2.8	0.5	1.5	1.1	1.4	0.9	1.4	1.7	1.3	1.4	1.2	1.5	1.4
Lupus	1.2	1.9	3.8	-1.7	-1.5	-1.2	-0.4	-1.5	-0.8	-1.3	-1.5	-2.0	-0.5	-1.6	-1.6
Waist circumference	1.2	4.5	10.1	-3.2	-1.9	-2.3	-1.0	-3.0	-1.0	-1.1	-2.7	-2.1	-2.0	-1.9	-2.1
Noisy workplace	1.2	1.5	6.6	-1.0	-0.6	-1.7	-0.4	-1.9	-0.1	-0.4	-0.9	-1.0	-2.6	-0.4	-0.7
Impedance of arm (left)	1.2	5.4	16.2	3.6	1.7	2.9	1.1	4.0	1.2	0.8	2.9	1.9	1.3	1.8	2.1
Arm fat mass (right)	1.2	5.1	11.4	-2.9	-1.7	-2.4	-0.8	-3.4	-0.9	-0.9	-2.9	-2.8	-2.8	-1.7	-1.9
Medication: Paracetamol	1.2	1.9	3.6	-1.9	-1.8	-0.9	-0.6	-1.4	-1.4	-1.5	-0.9	-1.5	-0.6	-1.6	-1.8
Chronic bronchitis/emphysema (mother)	1.2	1.5	2.8	-0.4	-1.1	-1.3	-1.7	-1.6	-1.1	-1.1	-1.5	-0.9	-1.5	-0.6	-1.1
Mouth/teeth dental problems: Loose teeth	1.2	1.4	2.2	-0.9	-0.9	-1.2	-1.5	-1.4	-1.1	-1.3	-1.3	-0.6	-1.4	-1.4	-1.1
Medication: Omeprazole	1.2	1.4	2.9	-1.1	-1.3	-1.0	-1.1	-0.9	-1.1	-1.4	-1.0	-1.3	-0.4	-1.7	-1.3
Leg pain on walking	1.2	1.5	4.3	-0.9	-1.0	-1.4	-0.4	-1.4	0.1	-0.9	-1.9	-2.1	-0.8	-1.1	-1.0
Supplements: Vitamin C	1.2	1.4	2.6	-1.6	-1.4	-1.3	-0.8	-1.0	-1.6	-1.1	-1.2	-0.6	0.1	-1.3	-1.4
Arm fat mass (left)	1.2	4.8	10.7	-2.8	-1.6	-2.3	-0.9	-3.3	-0.7	-1.0	-2.7	-2.8	-2.8	-1.7	-1.8
Heart attack/myocardial infarction (self-reported)	1.2	1.6	4.0	-1.6	-1.3	-1.1	-0.9	-1.3	-1.0	-0.9	-2.0	-0.9	0.3	-1.3	-1.5
Pack years of smoking	1.2	1.7	8.0	-0.7	-0.5	-1.8	-0.5	-1.4	0.1	-0.3	-1.2	-2.1	-2.8	-0.3	-0.6
Relative age of first facial hair	1.1	2.3	12.0	-3.5	-1.1	-0.2	0.3	-1.9	-2.4	0.0	-0.0	-0.5	0.1	-1.3	-1.5
Impedance of leg (right)	1.1	5.2	10.9	3.2	2.0	2.6	1.8	3.3	1.2	1.2	1.7	2.8	2.3	1.9	2.2
Heart attack	1.1	1.4	3.3	-1.5	-1.3	-1.1	-0.8	-1.2	-1.1	-0.9	-1.8	-0.7	0.4	-1.2	-1.4
Medication: Simvastatin	1.1	1.5	6.4	-2.5	-1.2	-0.3	0.0	-1.3	-1.6	-0.4	-1.1	-1.2	-0.2	-1.3	-1.4
Exposure to tobacco smoke outside home	1.1	1.4	4.2	1.9	1.3	0.8	0.9	1.0	2.0	0.9	0.4	0.3	0.6	1.3	1.4
Mother’s age at death	1.1	1.3	5.0	0.2	0.3	1.4	0.7	2.2	0.4	0.9	1.1	1.1	1.9	1.1	0.5
Average weekly beer plus cider intake	1.1	1.6	3.5	1.1	1.1	1.7	1.0	1.6	0.6	0.9	1.1	1.6	1.9	0.8	1.1
Cholesterol lowering medication	1.1	1.7	3.4	-1.9	-1.6	-0.8	-0.9	-0.9	-1.6	-1.0	-0.9	-1.8	-0.4	-1.3	-1.6
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	3.9	-1.0	-1.0	-0.9	-0.7	-1.3	-0.5	-1.3	-1.1	-2.0	-0.4	-1.7	-1.0
Sitting height	1.0	7.0	10.1	-3.2	-2.9	-2.3	-1.4	-2.5	-3.1	-2.5	-2.3	-3.0	-1.9	-3.1	-2.9
Body mass index (BMI)	1.0	4.3	10.5	-2.7	-1.5	-2.4	-0.8	-3.2	-0.4	-0.7	-3.0	-2.3	-2.3	-1.4	-1.7
Falls in the last year	1.0	1.3	3.0	0.5	1.3	1.1	1.5	1.4	1.7	1.3	-0.6	0.4	0.9	1.1	1.1
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	4.5	1.5	0.9	1.0	0.4	1.5	1.0	0.5	2.1	1.9	1.6	0.9	0.9
Number of full brothers	1.0	1.2	3.7	1.9	0.9	0.7	-0.1	1.0	1.4	0.4	1.2	1.4	1.0	1.1	1.1
Medication for pain relief, constipation, heartburn	1.0	1.7	3.9	1.5	1.4	0.7	0.5	1.6	0.9	1.1	1.8	2.0	0.1	1.4	1.4
Comparative height size at age 10	1.0	5.7	8.7	-2.5	-3.0	-2.1	-2.2	-2.1	-2.1	-2.6	-2.0	-2.9	-1.2	-2.7	-2.9
Illness, injury, bereavement, stress in last 2 years	1.0	1.3	2.3	-0.9	-0.9	-1.3	-0.8	-1.3	-1.2	-1.1	-0.8	-1.2	-1.5	-1.3	-1.0
Osteoarthritis (self-reported)	1.0	1.3	6.2	-0.6	-0.4	-0.8	-0.6	-1.5	0.2	-0.2	-0.7	-2.5	-2.2	-0.1	-0.4
Alcohol drinker status: Never	1.0	1.2	2.6	-1.2	-0.8	-1.3	-0.5	-1.4	-0.6	-0.7	-1.1	-1.4	-1.6	-1.3	-0.7
Neuroticism (Nagel 2018)	0.9	2.1	4.8	-1.7	-0.9	-1.2	-0.9	-2.1	-1.2	-0.7	-1.0	-2.0	-2.2	-1.0	-1.3
Reaction Time	0.9	1.7	6.5	-1.7	-1.1	-1.0	-0.1	-1.0	-1.1	-0.7	-2.5	-1.7	0.0	-1.4	-1.3
Age at First Birth	0.9	1.3	2.5	-1.6	-1.1	-1.0	-0.5	-1.2	-1.4	-0.8	-1.1	-1.2	-1.1	-1.2	-1.2
Ever had hysterectomy (womb removed)	0.9	1.0	5.1	-0.8	-0.0	-0.4	0.3	-1.2	-0.2	0.1	0.4	-2.0	-2.3	-0.3	-0.2
Systolic blood pressure, automated reading	0.9	2.7	9.5	2.3	1.7	0.1	0.4	0.6	3.1	1.3	-0.8	-1.4	-1.5	1.8	2.0
Hand grip strength (right)	0.9	2.5	4.5	-1.6	-1.7	-1.8	-1.8	-2.1	-1.7	-1.6	-0.7	-1.3	-0.8	-1.7	-1.7
Supplements: Glucosamine	0.9	1.2	3.2	-0.3	-1.3	-1.2	-1.8	-1.0	-0.5	-1.4	-1.3	-0.6	0.1	-1.1	-1.2
Impedance of leg (left)	0.9	4.2	9.6	2.7	1.8	2.4	1.6	3.1	1.2	1.2	1.5	2.5	1.9	1.7	2.0
Hair/balding pattern: Pattern 2	0.9	1.1	2.5	-1.4	-1.2	-0.4	-0.5	-0.3	-1.0	-1.1	-1.6	-0.7	-0.5	-1.4	-1.3
Allergy	0.9	2.0	6.3	2.5	1.7	0.5	0.2	1.0	2.1	0.7	1.3	1.5	-0.5	1.0	1.8
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	1.8	0.3	0.9	1.2	0.8	1.1	1.0	1.3	1.1	1.3	1.1	1.3	1.0
Pain experienced in last month	0.9	1.5	4.6	2.1	1.0	0.6	-0.3	1.1	1.4	0.6	1.4	1.5	-0.1	1.4	1.3
Prostate Cancer	0.8	1.2	5.5	0.4	0.6	1.4	0.5	1.4	0.7	0.5	-0.7	1.4	2.4	0.6	0.5
Trunk fat percentage	0.8	3.4	8.5	-1.6	-1.3	-1.8	-0.8	-2.1	-0.4	-1.1	-2.7	-2.6	-2.9	-1.5	-1.3
Relative age voice broke	0.8	1.2	4.0	-1.9	-0.6	-0.5	-0.4	-2.0	-1.8	0.1	0.1	-1.0	-0.4	-0.6	-0.8
Taking other prescription medications	0.8	1.3	5.2	-1.9	-1.1	-0.7	-0.1	-1.0	-0.3	-0.5	-0.9	-2.3	-0.3	-1.2	-1.0
Medication: Atenolol	0.8	0.9	2.9	-0.4	1.2	1.2	1.7	0.1	0.8	1.7	-0.3	-0.2	0.1	0.8	1.0
Hearing difficulty/problems with background noise	0.8	1.2	5.7	-2.4	-0.8	-0.2	0.7	-1.3	-1.1	-0.0	-1.2	-1.0	-0.5	-1.0	-1.1
Mouth/teeth dental problems	0.8	1.2	5.1	0.9	0.3	0.7	0.9	1.4	0.1	0.3	1.5	2.3	1.6	0.7	0.5
Impedance of arm (right)	0.8	3.9	13.0	3.0	1.3	2.5	0.9	3.6	0.5	0.6	2.3	1.7	1.1	1.5	1.7
Tense / ‘highly strung’	0.8	1.4	2.6	0.6	1.6	0.9	0.8	-0.9	1.4	1.6	1.4	-0.3	-0.7	1.3	1.4
Hair/balding pattern: Pattern 4	0.8	2.0	4.4	1.2	1.7	1.8	1.1	1.0	1.5	1.6	0.7	0.5	2.1	1.3	1.7
Peak expiratory flow (PEF)	0.8	1.8	3.2	-1.3	-1.4	-1.0	-1.1	-1.8	-1.1	-1.3	-0.8	-1.5	-1.3	-1.7	-1.2
Gout (self-reported)	0.8	1.1	2.4	-0.4	-1.1	-1.4	-0.7	-1.0	-0.1	-1.1	-0.9	-1.5	-1.2	-0.9	-1.0
Qualifications: College or University degree	0.8	2.6	5.3	0.6	1.5	1.6	1.9	1.8	0.3	1.7	1.4	2.2	2.3	1.4	1.4
Knee pain experienced in last month	0.8	1.3	2.2	-1.5	-1.2	-1.2	-0.6	-1.5	-1.1	-0.8	-1.0	-1.4	-0.9	-1.0	-1.3
Long-standing illness, disability or infirmity	0.8	1.2	3.5	-1.9	-0.3	0.1	1.6	-0.1	-0.0	0.2	-1.8	-1.2	1.5	-0.9	-0.4
Qualifications: nursing, teaching	0.8	1.3	5.0	2.2	1.0	0.2	-0.2	1.2	1.0	0.3	1.2	1.6	0.4	1.2	1.2
Smoking status: Current	0.8	1.2	1.9	0.6	1.2	1.3	1.1	0.9	1.3	1.1	1.0	1.4	1.4	0.8	1.1
Hearing aid user	0.8	0.9	7.1	-0.2	0.1	-0.7	-0.2	-1.2	0.3	0.0	0.1	-1.0	-2.7	-0.3	0.1
Medication: Atorvastatin	0.8	1.0	1.8	-0.9	-1.3	-1.0	-0.7	-0.5	-0.8	-1.2	-1.2	-1.1	-0.2	-1.3	-1.3
Depressed Affect (Nagel 2018)	0.7	1.5	4.6	-2.1	-0.5	-0.7	0.4	-1.7	-1.5	-0.1	-0.6	-1.6	-1.8	-0.8	-1.0
Major Depression (MDD)	0.7	0.9	6.4	-0.3	0.3	0.4	0.8	0.5	0.8	0.7	0.1	1.3	2.5	0.3	0.2
Primary Biliary Cirrhosis	0.7	1.0	2.2	0.6	1.1	1.1	1.4	1.5	0.5	1.1	0.0	1.0	0.7	1.2	1.1
Systolic Blood Pressure	0.7	3.5	9.5	1.7	2.5	0.8	1.4	1.2	3.1	2.5	-0.4	-0.3	-0.8	2.5	2.4
Neuroticism	0.7	1.7	4.4	-1.6	-0.5	-0.9	-0.0	-2.0	-0.8	-0.5	-1.5	-2.1	-2.0	-1.0	-1.0
Medication: Metformin	0.7	1.0	4.3	-1.0	0.2	0.5	1.0	1.0	0.0	1.1	0.4	2.1	1.8	0.6	0.2
Pack years adult smoking proportion	0.7	1.0	5.8	-0.5	-0.1	-1.3	-0.1	-1.0	0.4	0.0	-0.6	-1.6	-2.4	0.0	-0.3
Current tobacco smoking	0.7	1.1	1.7	0.4	1.1	1.1	1.1	0.9	1.3	1.1	0.9	1.3	1.1	0.8	1.0
Chronic bronchitis/emphysema (father)	0.7	0.8	1.3	-1.1	-1.0	-0.9	-0.9	-0.8	-0.6	-0.8	-1.1	-0.9	-0.5	-1.0	-1.0
Number of incorrect matches in round	0.7	1.2	5.6	-0.1	-0.8	-1.5	-1.1	-1.3	-0.7	-1.1	-0.7	-0.2	-2.4	-0.7	-0.7
Alcohol intake versus 10 years previously	0.7	1.0	6.8	-0.3	-0.0	0.8	1.4	1.3	0.4	0.6	-0.3	0.0	2.6	0.6	-0.0
Pulse rate	0.7	1.2	2.6	-1.0	-0.8	-1.1	-0.9	-1.1	-0.5	-1.2	-1.4	-0.9	-0.7	-1.6	-1.0
Mouth/teeth dental problems: Dentures	0.7	1.1	6.0	-1.7	0.1	-0.4	0.1	-1.5	0.2	0.8	-0.5	-2.4	-1.0	-0.0	-0.2
Body fat percentage	0.7	2.8	7.2	-1.8	-1.1	-1.7	-0.4	-2.1	-0.2	-0.7	-2.7	-2.2	-2.5	-1.1	-1.1
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.9	1.0	0.9	0.7	0.2	0.5	0.7	0.9	1.4	1.1	-0.3	1.2	1.0
Friendships satisfaction	0.7	0.9	2.4	0.6	1.1	0.9	0.6	0.8	1.5	0.8	0.2	1.5	1.0	0.8	0.9
Commuting to job workplace: Walk	0.7	0.7	2.0	1.4	1.0	0.7	0.9	1.3	0.7	0.6	-0.1	0.0	0.3	1.0	1.0
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	3.4	-0.2	-1.0	-1.1	-1.8	-1.3	-0.5	-1.2	-1.2	-0.3	-1.4	-0.9	-0.9
Medication: Gliclazide	0.7	0.8	3.6	0.2	0.6	0.8	0.9	1.1	0.6	0.4	-0.5	1.9	1.5	0.1	0.5
Number of self-reported non-cancer illnesses	0.7	1.2	3.6	-1.9	-1.0	-0.6	-0.3	-1.2	-1.0	-0.4	-1.5	-1.3	-0.9	-1.0	-1.0
Pain type(s) experienced in last month: Hip pain	0.7	0.8	4.7	0.0	0.1	-0.3	0.8	-0.1	0.3	0.0	-2.2	-1.8	-1.0	0.2	-0.0
Medication: Bendroflumethiazide	0.7	1.1	3.6	-0.5	-0.6	-0.8	-0.9	-1.1	0.0	-0.3	-1.5	-1.9	-1.9	-0.2	-0.5
Leg fat percentage (left)	0.7	2.5	7.3	-2.1	-0.9	-1.7	-0.1	-2.5	0.1	-0.2	-2.7	-1.7	-1.8	-0.9	-1.0
Unable to work because of sickness or disability	0.7	0.9	4.6	0.2	-0.9	-1.2	-0.9	-0.5	-0.1	-1.4	-2.1	0.2	-0.2	-0.9	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	2.1	-0.8	-1.0	-0.7	-0.9	-0.7	-0.8	-1.2	-1.0	-0.9	-0.2	-1.5	-1.0
Alzheimer’s Disease (in mother)	0.6	0.7	1.4	0.7	1.2	0.8	0.8	0.3	1.1	1.1	0.7	0.3	-0.1	1.0	1.1
Alzheimer’s Disease (in father)	0.6	0.7	1.5	-0.8	-0.9	-0.7	-0.7	-1.2	-1.2	-0.8	0.4	0.1	-0.2	-0.9	-1.0
Crohns Disease (2017)	0.6	1.3	5.2	-2.3	-1.0	-0.5	0.1	-0.9	-1.9	-0.2	-0.7	-1.0	-0.8	-1.1	-1.2
BMI	0.6	3.4	10.9	-3.3	-0.7	-1.8	0.3	-3.1	-0.5	0.5	-1.8	-2.3	-2.4	-0.7	-1.1
Hand grip strength (left)	0.6	1.6	3.1	-1.5	-1.3	-1.4	-1.2	-1.8	-1.4	-1.1	-0.7	-1.1	-0.4	-1.2	-1.4
Average weekly spirits intake	0.6	0.7	1.7	0.3	1.2	0.3	1.1	-0.4	0.5	1.3	0.5	-0.3	-1.0	1.1	1.0
Medication: Co-codamol	0.6	0.7	2.2	-1.5	-0.5	-0.3	0.2	-0.5	-1.0	-0.4	-1.1	-0.9	0.1	-1.3	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	2.1	-0.1	1.3	1.3	1.5	0.5	0.4	1.4	1.1	1.2	0.5	0.7	1.1
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	3.6	-1.9	-0.8	-0.3	0.2	-0.4	-0.6	-0.2	-1.0	-0.4	0.7	-0.7	-1.0
Arm fat percentage (right)	0.6	2.2	5.9	-1.7	-0.8	-1.4	-0.1	-1.9	-0.1	-0.3	-2.4	-2.0	-2.4	-0.8	-0.9
Worrier / anxious feelings	0.6	1.1	5.1	-0.6	-0.8	-0.6	-0.5	-0.8	-0.4	-0.9	-1.2	-1.5	-2.3	-0.7	-0.8
Length of working week for main job	0.6	0.6	2.3	-0.5	0.9	0.5	1.5	-0.6	0.1	1.0	0.4	-0.8	-1.2	0.2	0.6
Exposure to tobacco smoke at home	0.6	0.7	4.2	0.1	0.3	0.6	0.9	1.0	0.0	0.1	-1.2	0.5	2.0	-0.2	0.2
Breastfed as a baby	0.6	0.8	3.3	1.8	0.4	-0.1	-0.9	0.8	1.2	-0.4	0.3	1.5	-0.3	0.4	0.6
Glaucoma (self-reported)	0.6	0.7	1.8	-0.4	-0.4	-1.3	-1.3	-1.3	0.3	-0.6	-0.3	-0.3	-1.3	-0.7	-0.4
Leg fat percentage (right)	0.6	2.1	7.6	-1.8	-0.8	-1.6	-0.0	-2.3	0.1	-0.2	-2.8	-1.5	-1.4	-0.8	-0.9
Health satisfaction	0.6	0.7	1.6	-1.3	-0.9	-0.3	-0.5	-0.4	-0.7	-0.7	-1.2	-1.0	0.7	-1.1	-0.9
Family relationship satisfaction	0.6	0.8	3.6	0.1	0.5	1.3	0.4	1.1	0.8	0.6	0.5	0.6	1.9	0.5	0.4
Medication: Aspirin	0.6	0.7	3.2	-0.0	0.6	0.4	0.6	-0.3	1.1	0.9	-1.2	-1.8	0.7	0.6	0.5
Number of operations (self-reported)	0.6	0.8	4.6	-0.5	-0.4	-0.4	0.4	-0.5	-0.5	-0.8	-1.1	-2.1	-1.1	-1.0	-0.5
Age started oral contraceptive pill	0.6	0.8	2.3	-1.1	-0.7	-1.1	-0.5	-1.2	-0.6	-0.3	-0.7	-1.5	-0.9	-0.5	-0.7
Schizophrenia vs Biploar Disorder	0.5	0.6	2.6	0.5	0.3	1.0	0.1	0.9	-0.5	0.1	0.0	1.6	1.6	0.1	0.4
Worry (Nagel 2018)	0.5	1.0	3.6	-0.5	-0.4	-0.6	-0.8	-1.4	-0.5	-0.4	-0.9	-1.9	-1.8	-0.4	-0.6
Mean Putamen Volume	0.5	0.6	1.5	1.2	0.2	0.2	-0.1	0.6	-0.8	-0.2	1.2	1.2	1.0	0.4	0.4
LDL Cholesterol	0.5	0.9	3.6	0.4	-0.7	-0.9	-1.9	-0.7	-0.8	-1.1	-0.9	-0.5	-1.1	-0.4	-0.6
Schizophrenia (2014)	0.5	1.2	4.5	1.9	-0.3	-0.1	-2.1	0.4	-0.2	-1.1	-0.5	1.8	1.0	-0.0	-0.0
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.9	-0.4	0.7	0.7	1.0	0.3	0.4	0.8	1.4	1.4	0.8	0.2	0.5
Ever used hormone-replacement therapy (HRT)	0.5	0.6	2.2	-0.5	-0.2	-0.8	-0.3	-0.9	0.7	-0.1	-1.3	-1.5	-1.2	-0.3	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	3.4	0.5	1.2	0.7	1.6	0.7	1.8	1.5	-0.4	0.3	0.3	1.5	1.2
Had menopause	0.5	0.6	2.1	-0.8	-0.7	-0.9	-0.2	-0.7	-0.1	-0.7	-0.9	-1.4	-0.8	-0.8	-0.8
Happiness	0.5	0.7	3.3	-1.1	0.2	0.9	0.8	0.5	-0.0	0.7	0.6	0.8	1.8	0.0	0.0
Medication: Cholesterol lowering	0.5	0.7	2.5	-1.2	-0.6	-0.3	0.2	-0.8	-0.7	-0.3	-1.6	-1.3	-0.4	-0.8	-0.6
Pulse wave Arterial Stiffness index	0.5	0.6	3.5	-0.2	-0.2	-0.7	-0.6	-0.8	0.6	-0.3	-1.9	-0.9	-0.6	-0.5	-0.2
Loud music exposure frequency	0.5	0.6	1.8	-0.2	0.6	1.2	1.0	1.0	-0.0	0.9	0.2	-0.1	1.3	0.6	0.6
Blood clot in the leg (DVT)	0.5	0.6	2.0	0.7	0.3	1.1	0.8	1.4	0.5	0.3	0.0	0.0	1.3	0.7	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.3	-0.3	-1.0	-0.5	-0.8	-0.2	-1.1	-1.1	0.0	-0.7	0.3	-0.9	-0.9
Medication: Ibuprofen	0.5	0.6	1.4	1.2	1.0	0.7	0.3	0.2	0.8	0.9	-0.5	-0.0	-0.0	1.2	1.1
Medication: Seretide 50 evohaler	0.5	0.6	2.1	-0.9	-0.8	-0.2	-0.2	0.0	-0.3	-1.0	-0.3	0.0	1.3	-1.5	-0.9
Pulse rate, automated reading	0.5	1.6	4.1	-1.9	-1.0	-1.1	-0.7	-1.6	-0.2	-0.9	-2.0	-0.5	-0.0	-1.7	-1.3
Number of full sisters	0.5	0.6	2.4	0.0	0.2	1.0	0.4	0.9	-0.0	0.8	0.8	1.0	1.5	0.9	0.4
Illnesses of siblings: Diabetes	0.5	0.6	3.3	0.4	-0.2	0.6	-0.1	1.2	-0.3	0.0	0.8	1.0	1.8	0.4	-0.1
Eye problems/disorders: Cataract	0.5	0.6	3.0	-0.2	-0.8	-0.5	-0.7	-0.3	-0.4	-0.9	-1.7	-0.4	0.7	-0.8	-0.7
Financial situation satisfaction	0.5	0.6	1.3	-0.8	-0.9	-0.2	-0.7	-0.6	-0.7	-0.9	-0.5	0.8	0.3	-1.1	-0.9
Depression (Nagel 2018)	0.4	0.6	2.9	-1.2	0.7	0.8	1.7	0.1	0.1	1.2	0.6	0.3	0.6	0.2	0.3
Irritable Bowel Disease (IBD)	0.4	0.9	2.7	-1.6	-0.7	-0.3	0.2	-0.8	-1.6	-0.1	-0.6	-1.3	-1.0	-0.7	-0.8
Ulcerative Colitis (UC)	0.4	0.7	2.3	-0.9	-0.7	-0.6	-0.2	-0.8	-1.1	-0.4	-0.6	-1.5	-1.1	-0.7	-0.7
Rheumatoid Arthritis	0.4	0.6	2.3	0.0	-1.0	-0.3	-0.4	-0.9	-1.5	-0.6	0.0	-0.7	-0.4	-1.0	-1.0
Ulcerative Colitis	0.4	0.6	2.2	-1.0	-0.5	-0.4	-0.2	-0.7	-0.9	-0.3	-0.9	-1.5	-1.0	-0.7	-0.6
Heel T-Score	0.4	2.9	7.0	1.7	1.2	1.5	1.6	2.6	2.6	1.3	-0.0	1.2	1.5	1.7	1.6
Chronotype (morning person)	0.4	1.0	4.7	-0.6	0.0	-0.0	0.7	-0.6	-0.6	-0.2	-1.9	-2.2	-1.3	-0.6	-0.2
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.8	-0.7	-0.6	-0.3	-0.2	-0.2	-0.9	-0.6	-0.8	0.9	0.9	-0.6	-0.8
Supplements: Zinc	0.4	0.5	2.0	0.6	0.6	0.7	0.3	0.4	0.6	0.7	0.4	1.4	0.5	0.9	0.6
Townsend deprivation index at recruitment	0.4	0.6	2.6	-0.0	0.1	0.8	0.7	1.0	-0.5	0.5	-0.7	1.1	1.6	0.3	0.2
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	3.4	-1.8	-0.0	-0.2	0.6	-0.5	0.1	0.7	0.1	-0.9	-0.4	-0.1	-0.3
High blood pressure	0.4	1.0	5.0	-0.3	0.2	-0.4	0.3	-0.5	0.5	0.6	-2.2	-1.9	-1.4	0.6	0.2
Hayfever, allergic rhinitis or eczema	0.4	1.0	3.0	-1.7	-1.1	-0.4	-0.3	-1.0	-1.5	-0.3	-0.8	-1.3	0.1	-0.4	-1.1
Nervous feelings	0.4	0.7	1.1	-0.5	-0.9	-0.8	-1.0	-1.1	-0.4	-0.8	-0.4	-1.0	-1.0	-0.6	-0.9
Medication: Ramipril	0.4	0.5	3.1	-0.7	0.2	0.0	0.6	-0.3	0.2	0.6	-1.8	-0.9	-0.4	0.1	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.8	0.1	0.5	1.0	1.0	1.4	-0.1	0.6	0.5	0.2	0.7	0.4	0.5
Illnesses of mother	0.4	0.5	1.9	-0.4	-0.5	0.2	0.2	0.4	-1.4	-0.6	0.8	0.9	0.8	-0.7	-0.6
Pulse wave reflection index	0.4	0.5	1.5	0.4	0.4	0.8	0.7	0.9	0.7	0.5	-1.0	0.5	1.2	0.5	0.4
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	2.4	1.6	0.6	0.7	0.3	1.3	0.6	-0.1	-0.2	-0.0	-0.1	0.5	0.7
Birth weight	0.4	0.8	1.8	-0.6	-1.3	-0.9	-0.5	-0.6	-0.6	-1.3	-0.7	-0.4	0.6	-1.2	-1.2
Pulse wave peak to peak time	0.4	0.4	3.2	0.0	-0.0	0.5	0.4	0.5	-0.7	0.1	1.8	0.7	0.5	0.3	0.0
Eye problems/disorders: None of the above	0.4	0.4	2.6	-0.9	0.1	0.5	0.6	-0.0	-0.2	0.8	1.6	-0.3	-0.2	0.4	0.1
Migraine (self-reported)	0.4	0.5	2.2	-0.4	0.9	0.8	1.5	0.4	0.0	1.1	-0.2	0.6	0.0	0.4	0.6
Medication: Allopurinol	0.4	0.5	1.1	0.2	-0.9	-0.9	-0.7	-0.2	0.2	-1.0	-0.7	-1.1	-0.7	-0.4	-0.8
Heart disease (mother)	0.4	0.5	1.1	0.3	1.0	0.8	1.0	0.4	0.8	0.9	0.1	0.3	-0.6	0.8	0.8
Alcohol intake frequency.	0.4	1.0	4.2	-0.0	1.1	0.5	2.1	0.7	1.3	1.4	0.3	-0.5	-0.1	0.9	1.1
Overall health rating	0.4	0.9	2.3	-1.4	-0.6	-0.8	-0.5	-1.5	-0.4	-0.3	-1.0	-1.3	-1.3	-0.8	-0.6
Hypertension (Self-reported)	0.4	1.0	4.3	-0.3	0.2	-0.4	0.3	-0.5	0.6	0.6	-2.1	-2.0	-1.4	0.5	0.2
Arm fat percentage (left)	0.4	1.8	4.8	-1.5	-0.6	-1.1	-0.0	-1.7	0.1	-0.2	-2.1	-1.9	-2.2	-0.7	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	2.4	-0.4	-0.3	0.4	0.1	0.6	0.1	-0.2	-1.6	0.1	1.2	-0.3	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	3.0	-0.8	-0.2	0.6	0.7	-0.1	-0.2	0.2	0.3	0.7	1.7	-0.1	-0.3
Medication: Aspirin	0.4	0.5	2.5	-0.0	0.4	0.3	0.3	-0.4	0.9	0.6	-1.2	-1.6	0.6	0.4	0.4
Ever had prostate specific antigen (PSA) test	0.4	0.5	3.6	0.5	0.2	-0.1	0.2	0.0	1.2	0.1	-1.9	-0.2	-0.4	0.1	0.2
Vascular/heart problems diagnosed by doctor	0.4	1.0	5.6	0.6	-0.2	0.4	-0.3	0.7	-0.4	-0.7	2.4	1.8	1.0	-0.6	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	2.0	0.9	0.3	0.9	0.6	1.4	0.6	0.1	-0.1	-0.0	1.3	0.5	0.4
Bipolar Disorder (2018)	0.3	0.4	2.0	0.9	0.3	-0.2	-0.2	0.3	1.4	-0.0	-0.2	-0.9	-0.7	0.4	0.4
Schizophrenia (2018)	0.3	0.7	3.3	1.0	-0.4	-0.2	-1.8	0.0	-0.4	-0.8	-0.3	1.3	0.9	-0.0	-0.3
Blood Eosinophil Count	0.3	2.1	6.7	-2.6	-1.5	-1.1	-1.7	-2.2	-1.5	-0.7	0.2	0.4	-0.0	-1.3	-1.8
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.4	-0.5	0.5	0.4	1.1	0.5	0.6	1.2	0.6	0.5	0.8	1.0	0.5
Age when periods started (menarche)	0.3	0.8	4.3	-0.4	0.7	1.1	0.5	-0.4	0.5	1.0	2.1	0.8	0.9	0.2	0.7
Serious illness, injury or assault to yourself	0.3	0.3	0.7	0.5	0.5	0.3	0.5	0.7	0.8	0.7	0.5	-0.5	-0.2	0.8	0.6
Multivitamins +/- minerals	0.3	0.4	1.2	1.1	0.6	0.4	0.2	0.4	0.8	0.3	-0.3	0.9	0.1	0.8	0.7
High blood pressure (mother)	0.3	0.4	1.3	0.2	0.2	-0.6	-0.5	-0.4	1.1	0.2	-1.0	-0.2	-0.9	0.3	0.2
Alcohol usually taken with meals	0.3	0.5	1.1	0.1	0.8	0.9	0.9	0.9	0.3	0.6	1.0	0.3	0.9	0.2	0.7
Neuroticism score	0.3	0.7	3.3	-0.9	0.1	-0.4	0.2	-1.5	-0.0	0.0	-0.3	-1.1	-1.8	-0.5	-0.2
Time employed in main current job	0.3	0.4	1.2	1.0	-0.2	-0.8	-0.8	-0.1	-0.1	-0.4	0.9	-1.1	-0.6	0.3	-0.0
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	3.6	-0.5	0.6	0.1	1.1	-0.2	0.5	0.8	-0.0	1.9	0.2	0.1	0.4
Number of live births	0.3	0.4	1.0	0.6	-0.4	-0.5	-0.9	0.0	-0.3	-0.9	-0.7	0.3	-1.0	-0.4	-0.3
Lung cancer (father)	0.3	0.3	1.6	0.1	-0.2	0.4	0.6	0.6	-0.6	-0.2	-0.9	-0.5	1.2	-0.0	-0.2
Neck or shoulder pain in last month	0.3	0.4	1.3	-0.5	0.6	0.7	1.1	-0.1	0.2	0.8	-0.0	-0.2	1.1	-0.0	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	1.6	0.6	0.1	0.1	0.0	0.6	1.3	0.2	0.5	-0.0	0.9	0.5	0.3
Age at last live birth	0.3	0.4	1.3	-1.1	-0.3	-0.1	0.3	0.2	-0.7	0.1	-0.9	1.1	0.4	-0.5	-0.4
Illnesses of father: Heart disease	0.3	0.5	0.8	0.3	0.9	0.4	0.8	0.3	0.8	0.8	0.1	-0.9	-0.6	0.9	0.7
Breast cancer (self-reported)	0.3	0.4	2.1	-0.8	-0.3	-0.4	-0.2	-0.4	-0.8	-0.1	0.0	-1.5	-0.8	-0.2	-0.5
Average weekly champagne plus white wine intake	0.3	0.4	2.0	-0.3	-0.3	-0.6	-0.4	-0.5	-0.5	-0.8	-1.4	0.4	-0.3	-1.0	-0.5
Guilty feelings	0.3	0.5	1.2	0.4	0.7	1.0	0.6	0.3	0.4	0.9	1.1	0.6	-0.4	0.8	0.7
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.0	-0.7	-0.5	0.1	-0.0	0.5	-1.0	-0.1	0.9	0.6	1.0	-0.1	-0.5
Eye problems/disorders: Glaucoma	0.3	0.3	0.8	0.5	0.6	-0.1	-0.1	-0.0	0.9	0.5	0.5	0.8	-0.8	0.6	0.7
Ever depressed for a whole week	0.3	0.4	1.3	-1.1	-0.8	-0.1	0.0	0.2	0.1	-0.3	-0.6	-0.0	1.0	-0.5	-0.9
Commuting to job workplace: Cycle	0.3	0.3	1.1	0.7	0.5	0.6	0.8	1.0	0.7	0.3	0.2	0.1	0.3	0.5	0.4
Bipolar Disorder or Schizophrenia	0.2	0.4	2.0	1.4	-0.1	-0.3	-1.4	0.2	0.6	-0.7	-0.4	0.4	0.3	0.2	0.0
Breast Cancer	0.2	0.4	1.7	-0.8	-0.0	-0.6	0.0	-0.9	-0.4	0.1	-0.8	-0.7	-1.3	-0.3	-0.1
Ovarian Cancer	0.2	0.3	2.1	-0.5	-0.0	-0.0	0.7	-0.5	0.3	0.3	0.1	-1.5	-0.3	0.0	-0.1
Body Mass Index (BMI) (2010)	0.2	0.3	1.0	-0.4	-0.3	-0.8	-0.1	-0.7	0.4	-0.3	-0.1	-1.0	-0.6	-0.5	-0.3
Crohns Disease (2012)	0.2	0.4	1.5	-1.2	-0.3	0.0	0.1	-0.2	-0.9	0.2	0.0	-0.9	-1.1	-0.2	-0.4
HDL Cholesterol	0.2	0.4	1.1	-0.3	-0.5	0.0	0.5	0.7	-0.6	-0.5	-1.0	-1.1	0.3	-0.4	-0.4
Smoking Status	0.2	0.5	1.1	0.2	0.8	0.4	0.7	0.4	1.0	0.8	0.6	1.0	0.6	0.6	0.7
Cardiovascular Disease	0.2	0.6	2.3	-0.7	0.0	-0.1	0.4	-0.2	-0.2	0.6	-1.5	-1.4	-1.3	0.5	0.0
Diabetes (father)	0.2	0.2	1.0	-0.1	-0.6	-0.0	-0.5	-0.1	-0.0	-0.6	-1.0	-0.1	0.8	-0.2	-0.6
Fed-up feelings	0.2	0.4	1.9	-0.7	0.5	0.1	1.4	-0.8	0.2	0.6	-0.4	-0.4	-1.1	0.1	0.2
Medication: Levothyroxine sodium	0.2	0.3	1.4	-1.2	-0.2	0.2	0.4	-0.7	-0.4	0.2	-0.5	-0.9	0.3	-0.6	-0.2
Past tobacco smoking	0.2	0.3	1.1	0.3	-0.5	-0.5	-0.6	-0.1	-0.1	-0.7	-1.1	-0.6	-0.5	-0.4	-0.4
Had other major operations	0.2	0.2	1.2	0.1	0.3	0.6	0.8	0.2	0.3	0.3	0.1	-1.1	-0.0	0.3	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.7	0.2	0.7	0.2	1.1	0.4	1.3	0.9	-0.3	0.2	0.1	0.8	0.8
Medication: Lansoprazole	0.2	0.2	1.3	-0.6	-0.1	-0.2	0.4	-0.3	-0.6	0.1	-0.5	-0.6	-1.2	-0.1	-0.1
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.9	-0.5	0.3	0.2	1.0	-0.4	0.5	0.7	0.8	0.4	0.5	0.3	0.2
High blood pressure (siblings)	0.2	0.3	0.8	0.9	0.3	0.4	0.1	0.4	0.9	0.1	-0.7	-0.4	0.4	0.6	0.4
Comparative body size at age 10	0.2	0.7	2.0	-0.7	-0.5	-1.2	-0.0	-1.0	0.8	-0.2	-1.1	-1.4	-0.8	-0.5	-0.4
Emphysema/chronic bronchitis	0.2	0.2	0.6	-0.1	0.5	0.2	0.7	0.2	0.7	0.5	-0.2	-0.0	-0.4	0.3	0.5
Suffer from ‘nerves’	0.2	0.2	1.3	0.3	-0.0	-0.3	-0.4	-0.7	0.3	-0.4	0.1	-0.7	-1.1	-0.4	0.0
Mood swings	0.2	0.4	1.5	-0.6	0.6	0.3	0.9	-0.4	0.1	0.6	0.3	-0.7	-1.2	-0.0	0.3
Loneliness, isolation	0.2	0.3	1.2	-1.1	0.2	0.1	1.0	-0.5	-0.7	0.3	0.5	-0.4	-0.5	-0.3	-0.1
Back pain experienced in last month	0.2	0.3	1.3	-0.7	-0.3	0.1	1.1	0.1	-0.1	0.2	-0.5	-0.6	0.9	-0.1	-0.3
Mineral and other dietary supplements	0.2	0.3	0.8	-0.6	-0.4	-0.5	-0.1	-0.3	-0.7	-0.5	0.2	0.4	-0.9	-0.8	-0.4
Ever taken oral contraceptive pill	0.2	0.2	0.4	-0.6	0.2	0.4	0.4	0.6	-0.5	0.5	-0.1	0.5	0.4	0.3	-0.0
Illnesses of father: High blood pressure	0.2	0.3	1.3	-0.0	-0.1	-0.9	-0.4	-0.5	0.9	-0.3	-0.0	0.3	-1.2	-0.2	-0.1
Diastolic blood pressure, automated reading	0.2	0.7	3.6	1.2	0.6	-0.0	-0.1	0.4	1.9	0.5	-0.4	-0.7	-0.6	1.0	0.8
Myopia	0.2	0.3	1.1	0.5	0.2	0.1	0.3	0.2	1.1	0.3	-0.8	-0.2	-0.6	0.5	0.4
Alzheimer’s Disease (including proxy)	0.1	0.1	0.5	-0.4	0.3	0.0	0.3	-0.7	-0.0	0.5	0.4	-0.1	-0.5	0.3	0.1
Blood Platelet Count	0.1	0.6	2.8	-1.7	-0.4	0.3	0.2	-0.4	-1.5	0.2	-0.7	-0.4	0.7	-0.9	-0.5
Blood Red Count	0.1	0.9	2.8	0.4	1.2	0.0	0.9	-0.2	1.7	1.2	0.5	0.5	-1.1	1.0	1.0
Waist Hip Ratio (WHR)	0.1	0.4	1.4	0.3	0.5	1.0	0.6	1.2	0.4	0.5	-0.4	0.8	0.4	0.3	0.5
Lung FEV1/FVC ratio	0.1	0.5	1.9	0.7	0.3	-0.6	0.3	-0.2	0.6	0.1	-1.3	-0.9	-1.4	0.1	0.5
Hair Pigment	0.1	2.9	6.1	2.0	2.0	1.0	1.6	1.7	2.5	1.8	0.6	0.6	-0.4	2.3	2.0
Hearing difficulty/problems: Yes	0.1	0.2	0.8	-0.9	-0.0	0.1	0.7	-0.4	-0.4	0.4	0.2	0.3	-0.7	0.1	-0.1
Vitamin and mineral supplements	0.1	0.1	1.0	0.4	0.2	0.1	0.3	0.3	0.2	0.1	1.0	-0.1	-0.5	0.2	0.3
Diabetes (mother)	0.1	0.2	0.7	0.4	0.2	0.2	-0.2	0.3	0.5	0.5	0.1	0.0	0.4	0.9	0.3
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.7	-0.8	-0.1	-0.1	-0.1	-0.4	0.6	0.3	0.3	-0.3	0.6	-0.2	-0.1
Pain all over the body in last month	0.1	0.1	0.3	0.5	0.2	0.2	0.1	0.3	0.2	-0.3	0.2	-0.2	-0.1	-0.3	0.2
Diabetes (self-reported)	0.1	0.1	0.3	-0.5	-0.1	-0.4	-0.1	0.1	0.0	0.4	0.5	0.4	0.3	0.5	-0.1
Illnesses of siblings	0.1	0.1	0.9	-0.4	0.2	-0.2	0.4	-0.4	-0.3	0.1	-0.1	0.0	-0.9	-0.4	0.1
Father’s age at death	0.1	0.2	0.6	-0.2	-0.2	-0.4	0.1	0.1	0.8	0.0	0.4	-0.8	-0.7	0.2	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.5	0.2	-0.0	0.0	-0.3	-0.3	-0.1	0.0	-0.7	-0.6	-0.2	0.2	0.1
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.4	-0.4	0.3	0.6	0.7	-0.3	0.3	0.5	0.2	-0.6	0.1	-0.1	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.6	0.2	0.3	0.1	0.8	0.2	0.3	0.0	0.3	0.5	0.2	-0.3	0.2
Wheeze or whistling in the chest in last year	0.1	0.2	1.4	-0.1	-0.3	0.2	0.3	0.5	-0.1	-0.1	0.0	0.4	1.2	0.2	-0.3
Age at first live birth	0.1	0.2	0.4	-0.6	0.2	0.2	0.4	0.6	0.2	0.5	-0.5	0.2	-0.5	0.3	0.1
Chest pain or discomfort	0.1	0.1	0.5	-0.4	0.2	0.2	0.2	-0.3	0.0	0.7	-0.7	-0.3	0.2	0.6	0.1
Had major operations	0.1	0.1	0.4	0.3	-0.2	-0.1	-0.3	0.4	-0.4	-0.6	0.0	-0.2	0.2	-0.5	-0.2
Smoking status: Previous	0.1	0.2	0.6	-0.7	-0.3	-0.5	-0.1	-0.5	-0.6	-0.1	0.2	-0.2	-0.3	-0.2	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.8	0.2	0.1	0.7	0.1	0.4	0.3	0.1	0.9	0.7	0.7	0.0	0.2
Diabetes diagnosed by doctor	0.1	0.2	0.9	-0.5	-0.4	-0.3	-0.1	0.3	-0.1	0.2	-0.1	0.5	0.9	0.3	-0.3
Medication for cholesterol	0.1	0.1	0.2	0.4	0.3	0.3	0.5	0.3	-0.1	-0.2	0.4	0.2	0.2	-0.2	0.2
Osteoporosis (self-reported)	0.1	0.2	1.2	-0.7	-0.1	0.4	0.0	0.2	-0.4	0.1	0.2	-1.1	0.1	-0.1	-0.3
Miserableness	0.1	0.2	0.8	-0.9	0.0	-0.1	0.2	-0.5	-0.8	0.3	-0.4	-0.1	-0.8	0.1	-0.3
Medication: Blood pressure	0.1	0.2	0.8	0.3	0.3	-0.3	-0.0	-0.2	0.9	0.5	-0.4	-0.7	-0.3	0.7	0.3
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.3	0.5	0.3	0.1	-0.1	-0.2	0.4	0.2	-0.1	-0.6	-0.0	0.5	0.2
High cholesterol (Self-reported)	0.1	0.1	0.3	0.6	0.1	0.5	0.1	0.5	-0.1	-0.0	-0.6	-0.1	0.4	0.2	0.2
Risk taking	0.1	0.1	0.5	-0.1	0.1	0.1	0.4	0.0	0.1	-0.1	-0.1	0.7	0.6	-0.4	-0.1
Supplements: Calcium	0.1	0.1	0.6	-0.1	-0.2	-0.3	0.1	-0.2	0.6	-0.2	-0.5	-0.8	0.2	-0.1	-0.3
Heart disease (siblings)	0.1	0.1	0.7	0.4	-0.0	0.2	-0.2	0.4	0.5	-0.1	-0.1	-0.1	0.8	0.2	-0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Blood White Count	0.0	0.3	1.1	-0.1	0.1	-0.4	-1.1	-1.0	0.2	0.1	0.2	-0.3	-0.6	0.4	-0.1
Hypothyroidism (self reported)	0.0	0.1	0.3	0.2	0.4	0.4	0.5	-0.4	0.1	0.4	0.0	-0.2	-0.3	0.1	0.4
Tanning	0.0	0.2	0.9	0.5	-0.1	-0.1	-0.7	-0.3	0.9	-0.4	0.2	-0.8	-0.5	-0.1	-0.1
Worry too long after embarrassment	0.0	0.1	0.2	-0.1	-0.1	-0.0	-0.5	-0.4	0.2	-0.3	-0.3	0.2	-0.1	-0.2	-0.2

Hub : Genes

LIN7B

Models

Trait associations