TWAS hub - SNRNP70

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0940	0.0320	4.0e-04	0.003	0.030	0.003	0.030	0.007	1.1e-01	1.3e-04	1.2e-01	1.4e-04	4.0e-02
2	GTEx	Adipose Subcutaneous	0.0950	0.0380	6.2e-03	0.060	NA	0.081	NA	0.084	1.2e-05	NA	3.8e-07	NA	2.1e-07
3	GTEx	Nerve Tibial	0.2091	0.0508	8.5e-06	0.105	NA	0.109	NA	0.100	7.4e-08	NA	3.8e-08	NA	1.4e-07
4	METSIM	Adipose	0.1297	0.0326	1.8e-06	0.066	0.038	0.058	0.065	0.059	4.2e-10	2.1e-06	4.5e-09	5.0e-10	2.8e-09
5	TCGA	Breast Invasive Carcinoma	0.0220	0.0133	3.3e-03	0.008	0.015	0.008	NA	0.007	6.6e-03	3.9e-04	8.4e-03	NA	1.1e-02
6	TCGA	Colon Adenocarcinoma	0.0510	0.0340	6.4e-03	0.017	0.015	0.018	NA	0.018	3.4e-02	4.1e-02	3.1e-02	NA	2.9e-02
7	TCGA	Prostate Adenocarcinoma	0.0459	0.0268	7.5e-03	0.009	0.011	0.007	NA	0.003	3.3e-02	2.1e-02	5.3e-02	NA	1.6e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Long-standing illness, disability or infirmity	6.6	10.1	18.5	-1.0	-4.2	-4.3	-3.9	-3.0	-1.8	-2.4
Depression (self-reported)	4.3	5.1	9.6	-1.3	-3.1	-3.1	-2.8	-2.0	0.3	-1.8
Bilateral oophorectomy (both ovaries removed)	4.1	4.7	8.8	0.5	-2.5	-2.1	-1.6	-2.4	-2.2	-3.0
Fractured/broken bones in last 5 years	3.8	4.9	9.1	2.3	-2.7	-2.2	-2.6	-3.0	0.6	-0.9
Schizophrenia (2014)	3.5	7.6	12.2	2.5	3.1	2.7	2.6	2.1	2.5	3.5
Depression (Nagel 2018)	3.2	4.9	9.3	-0.2	-3.0	-2.8	-2.5	-2.3	-1.1	-2.0
Number of full brothers	3.2	4.1	6.8	1.7	2.4	1.6	1.9	2.6	1.9	1.9
Medication: Co-codamol	3.0	3.5	6.5	0.2	-2.5	-1.9	-1.8	-2.1	-1.3	-2.1
Schizophrenia (2018)	2.9	6.0	8.9	2.5	2.8	2.2	3.0	2.1	1.8	2.5
Mean time to correctly identify matches	2.8	5.4	9.9	-1.1	-2.8	-2.8	-2.7	-3.2	-1.9	-0.0
Medication: Metformin	2.7	3.9	6.2	-0.0	-2.4	-2.3	-2.4	-2.0	-0.7	-2.5
Qualifications: nursing, teaching	2.7	4.2	6.7	2.0	2.2	2.6	2.3	2.0	1.2	1.8
Alcohol drinker status: Never	2.7	3.3	6.9	-2.6	-1.1	-1.0	-1.3	-1.0	-2.4	-2.3
Maternal smoking around birth	2.6	3.8	13.9	-1.2	-1.2	-1.5	-1.1	-1.4	-3.7	-2.0
Medication: Simvastatin	2.5	3.6	7.4	-2.7	-2.0	-1.5	-1.2	-1.7	-1.1	-2.4
Relative age of first facial hair	2.4	5.0	13.2	-2.6	-2.3	-1.7	-1.8	-1.3	-1.4	-3.6
Frequency of unenthusiasm / disinterest in last 2 weeks	2.4	3.2	8.5	-0.2	-2.9	-2.5	-2.1	-1.2	-0.7	-1.2
Reaction Time	2.3	4.4	7.0	-1.0	-2.5	-2.6	-2.4	-2.5	-2.1	-0.6
Hearing difficulty/problems with background noise	2.3	3.7	5.1	-1.6	-2.3	-2.1	-1.6	-2.0	-1.8	-2.0
Glaucoma (self-reported)	2.3	2.7	4.9	1.2	1.7	2.2	2.0	1.4	-1.3	-1.3
BMI	2.0	11.8	36.4	-1.6	-3.0	-2.1	-2.8	-2.6	-6.0	-3.9
Falls in the last year	2.0	2.7	6.7	0.1	-2.6	-2.2	-2.2	-1.4	-0.1	-0.7
Shortness of breath walking on level ground	2.0	2.4	6.2	-1.9	-1.1	-1.2	-0.9	-0.9	-2.5	-1.6
Crohns Disease (2017)	1.9	4.1	6.2	-1.7	-2.5	-2.0	-1.2	-2.3	-1.5	-2.5
LDL Cholesterol	1.9	3.0	7.3	-1.0	2.4	2.2	2.7	1.4	0.2	0.4
Taking other prescription medications	1.9	2.9	5.0	-0.6	-1.8	-1.3	-1.3	-2.1	-1.9	-2.2
Multivitamins +/- minerals	1.9	2.4	6.0	1.6	1.8	1.3	2.5	1.1	0.7	1.3
Medication: Cholesterol lowering	1.9	2.9	4.9	-1.8	-2.2	-1.5	-1.6	-1.7	-1.1	-1.8
Lung cancer (father)	1.9	2.2	5.2	0.8	-1.4	-1.6	-1.7	-2.3	0.9	1.0
Medication: Gliclazide	1.9	2.2	5.0	1.7	-1.9	-2.2	-1.5	-0.8	0.5	-0.6
Number of self-reported non-cancer illnesses	1.9	3.3	8.2	-1.0	-1.8	-1.4	-0.8	-2.2	-1.6	-2.9
Tinnitus: Yes, but not now, but have in the past	1.8	1.9	4.4	0.1	-1.3	-2.1	-1.8	-0.6	-1.8	-0.6
Supplements: Glucosamine	1.8	2.3	6.1	2.5	1.6	1.5	2.0	0.9	0.1	0.7
Allergy	1.8	4.1	6.9	1.1	2.0	2.6	2.5	2.6	0.9	1.7
Mouth/teeth dental problems: Dentures	1.8	3.0	7.2	-2.6	-0.9	-1.0	-0.1	-0.9	-2.7	-2.1
Medication: Blood pressure	1.8	3.2	12.0	-0.1	-1.3	-0.7	-0.6	-2.1	-3.5	-1.9
Back pain experienced in last month	1.8	2.6	5.6	0.8	-2.0	-2.4	-2.0	-1.6	-0.5	-0.9
Arm fat-free mass (left)	1.8	9.1	41.1	-1.5	-0.6	-1.0	-0.4	-1.3	-6.4	-4.1
Alcohol drinker status: Previous	1.8	2.0	5.1	0.0	-2.3	-1.6	-1.8	0.1	1.0	-1.5
Depressed Affect (Nagel 2018)	1.7	3.5	7.2	-1.2	-1.9	-2.1	-1.5	-1.8	-2.7	-1.4
Average weekly fortified wine intake	1.7	2.0	4.4	1.3	-1.9	-2.1	-1.8	-0.8	0.3	0.3
Ever unenthusiastic/disinterested for a whole week	1.7	2.0	4.5	0.6	-1.7	-1.8	-0.8	-1.4	-0.8	-2.1
Breastfed as a baby	1.7	2.1	7.1	2.7	1.0	1.0	0.7	0.5	1.2	1.8
Tense / ‘highly strung’	1.7	2.7	5.7	-2.0	1.6	2.1	1.1	2.4	-0.9	0.5
Loneliness, isolation	1.7	2.3	3.3	-1.8	-1.7	-1.6	-1.3	-1.3	-1.0	-1.7
Mouth/teeth dental problems: Mouth ulcers	1.7	2.7	6.4	1.0	2.4	2.4	2.5	0.5	-0.3	0.1
Medication: Atenolol	1.6	2.1	3.3	-1.4	-1.8	-1.1	-1.8	-1.6	-1.2	-0.8
Waist circumference	1.6	5.9	19.2	-1.1	-1.9	-1.4	-1.6	-1.9	-4.4	-3.0
Weight	1.6	7.7	33.3	-1.3	-1.1	-1.2	-0.9	-1.6	-5.8	-3.6
Alcohol intake versus 10 years previously	1.6	2.4	5.4	-0.4	-1.9	-2.1	-2.3	-1.6	0.9	0.5
Loud music exposure frequency	1.6	1.8	5.7	-0.1	-1.8	-2.4	-1.4	-1.1	0.8	0.1
Qualifications: O levels/GCSEs or equivalent	1.6	2.5	5.0	0.4	1.4	1.9	1.3	1.4	1.8	2.2
Leg fat mass (right)	1.6	6.2	29.1	-1.1	-1.2	-0.7	-1.0	-1.4	-5.4	-2.8
Illnesses of father: None of the above (group 1)	1.6	2.0	7.0	0.6	1.0	0.9	0.8	1.4	2.6	1.4
Supplements: Fish oil (including cod liver oil)	1.6	2.1	3.8	1.2	1.9	1.9	1.6	1.0	0.2	1.5
Pain experienced in last month	1.6	2.6	5.3	-1.1	1.7	2.3	1.0	1.5	1.4	1.9
Leg fat mass (left)	1.6	6.4	29.8	-0.9	-1.2	-0.8	-1.0	-1.5	-5.5	-3.0
Arm predicted mass (left)	1.6	8.2	39.3	-1.3	-0.2	-0.5	0.0	-1.0	-6.3	-3.9
Severe depression (siblings)	1.5	1.6	3.3	-0.1	1.5	1.8	1.6	1.2	-1.3	-0.0
Medication: Ramipril	1.5	2.0	4.5	-1.4	-1.5	-2.1	-1.2	-1.2	-1.2	-1.0
Hip circumference	1.5	6.2	22.6	-0.5	-1.6	-1.5	-1.3	-1.5	-4.8	-3.4
Medication: Amlodipine	1.5	2.1	6.2	-0.2	-1.4	-0.6	-1.0	-1.8	-2.5	-1.4
Arm predicted mass (right)	1.5	7.9	37.3	-1.3	-0.4	-0.6	-0.1	-1.0	-6.1	-3.9
Age at last live birth	1.5	2.2	4.8	-1.0	-1.8	-2.2	-1.7	-1.3	-0.2	-1.4
Bipolar Disorder or Schizophrenia	1.4	3.5	6.6	2.0	2.1	1.5	1.9	1.4	1.3	2.6
Body mass index (BMI)	1.4	5.8	26.3	-0.0	-1.6	-1.1	-1.5	-1.6	-5.1	-2.3
Impedance of arm (left)	1.4	6.7	32.9	-0.6	1.1	1.1	1.1	0.8	5.7	3.0
Arm fat mass (right)	1.4	6.0	23.9	-0.9	-1.6	-1.2	-1.4	-1.9	-4.9	-2.7
Medication for cholesterol, blood pressure or diabetes	1.4	2.4	4.8	0.9	1.4	0.9	0.9	2.0	2.2	1.8
Arm fat-free mass (right)	1.4	7.1	34.0	-1.0	-0.1	-0.3	0.2	-0.6	-5.8	-3.7
Health satisfaction	1.4	1.9	3.0	-1.7	-1.4	-1.7	-1.1	-1.6	-0.3	-1.1
Emphysema/chronic bronchitis	1.4	1.5	2.9	-1.2	-1.4	-1.5	-1.7	-0.8	-0.9	-1.0
Hypertension (Self-reported)	1.4	3.8	9.3	-0.2	-2.3	-1.7	-1.9	-3.1	-2.3	-0.7
Leg fat-free mass (right)	1.4	7.2	30.2	-1.8	-0.4	-0.4	0.1	-0.6	-5.5	-4.0
Mineral and other dietary supplements	1.4	1.9	3.4	-1.8	-1.4	-1.3	-1.9	-0.6	-0.7	-1.4
Basal metabolic rate	1.4	7.8	33.6	-1.8	-0.4	-0.6	-0.1	-0.9	-5.8	-4.0
Irritability	1.4	2.4	12.8	-1.7	0.3	0.7	-0.2	0.6	-3.6	-0.1
Vascular/heart problems diagnosed by doctor	1.4	3.8	7.1	0.5	2.3	1.7	1.9	2.7	2.5	0.9
Leg fat-free mass (left)	1.3	6.7	29.0	-1.9	-0.3	-0.2	0.1	-0.5	-5.4	-3.7
High blood pressure	1.3	3.6	7.7	-0.3	-2.3	-1.8	-1.9	-2.8	-2.3	-0.7
Leg predicted mass (left)	1.3	6.9	29.6	-1.9	-0.4	-0.3	-0.0	-0.5	-5.4	-3.8
Happiness	1.3	1.6	2.4	-1.4	-1.5	-1.5	-1.3	-0.9	0.2	-1.4
Asthma	1.3	2.5	4.6	1.2	-1.7	-1.8	-1.6	-2.1	-0.7	-1.6
Migraine (self-reported)	1.3	1.6	3.8	-0.1	-1.9	-1.6	-1.6	-0.5	-0.6	-1.4
Whole body fat mass	1.3	5.5	23.1	-1.1	-1.4	-1.1	-1.3	-1.9	-4.8	-2.4
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	5.6	1.8	-0.9	-1.0	-0.4	0.7	2.4	0.4
Whole body fat-free mass	1.3	7.3	31.8	-1.8	-0.1	-0.3	0.2	-0.6	-5.6	-3.9
Whole body water mass	1.3	7.5	32.7	-1.8	-0.2	-0.4	0.1	-0.8	-5.7	-4.0
Leg predicted mass (right)	1.3	7.1	29.3	-1.9	-0.4	-0.3	0.2	-0.5	-5.4	-4.0
Pack years of smoking	1.3	2.0	9.1	-1.1	-0.5	-0.6	-1.0	-1.2	-3.0	-0.6
Impedance of whole body	1.3	6.4	33.5	0.1	0.9	0.7	0.8	0.6	5.8	3.1
Age at First Birth	1.2	1.7	4.6	-0.2	-1.2	-1.4	-1.1	-2.1	-1.4	-1.1
Number of treatments/medications taken	1.2	2.2	4.2	-1.5	-0.7	-0.3	-0.6	-2.0	-2.0	-2.0
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.7	5.0	-2.0	-2.2	-1.7	-2.2	-0.5	-1.0	-0.8
Trunk fat-free mass	1.2	6.9	28.8	-2.0	0.0	-0.4	0.3	-0.6	-5.4	-3.9
Time employed in main current job	1.2	1.3	2.9	1.4	1.7	1.2	1.3	0.4	0.0	1.0
Trunk predicted mass	1.2	6.8	28.5	-1.9	-0.0	-0.4	0.3	-0.6	-5.3	-3.8
Angina (self-reported)	1.2	1.6	4.6	-0.5	-1.8	-1.5	-2.1	-0.5	0.2	-0.3
Arm fat mass (left)	1.2	5.0	21.9	-0.5	-1.4	-1.1	-1.2	-1.6	-4.7	-2.4
Leg fat percentage (left)	1.2	4.4	18.9	-0.5	-1.4	-1.0	-1.3	-1.6	-4.3	-2.1
Number of operations (self-reported)	1.2	1.8	4.6	2.1	-1.1	-1.6	-0.2	-1.5	-0.7	-1.0
Mean Putamen Volume	1.1	1.2	2.5	0.2	1.1	1.6	1.4	0.1	1.3	1.2
Cardiovascular Disease	1.1	3.7	8.6	-0.8	-2.6	-1.5	-1.8	-2.9	-1.6	-1.3
Respiratory disease	1.1	2.5	3.7	1.0	-1.6	-1.9	-1.5	-1.8	-1.1	-1.9
Relative age voice broke	1.1	1.7	6.1	-2.5	0.0	0.4	-0.0	0.5	-1.5	-1.7
Trunk fat mass	1.1	4.7	18.6	-1.1	-1.3	-1.0	-1.2	-2.0	-4.3	-2.2
Hair/balding pattern: Pattern 2	1.1	1.4	2.2	-1.3	-1.4	-1.3	-0.9	-1.2	0.1	-1.5
Impedance of arm (right)	1.1	5.1	27.4	-1.1	0.7	0.7	0.6	0.2	5.2	2.4
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	3.9	-1.1	-1.4	-1.6	-1.3	-0.2	-1.2	-2.0
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	3.1	-0.4	-1.5	-1.8	-0.5	-1.3	1.1	-0.6
Exposure to tobacco smoke at home	1.1	1.2	2.5	1.4	-1.6	-1.5	-1.0	-0.8	0.7	0.2
Exposure to tobacco smoke outside home	1.1	1.4	6.1	0.9	0.8	1.0	0.5	0.7	0.9	2.5
Medication: Ibuprofen	1.1	1.4	2.6	-0.8	1.6	1.2	1.1	1.0	0.2	1.6
Alcohol intake frequency.	1.1	2.6	4.9	-1.1	-1.6	-1.7	-2.2	-0.7	-1.1	-2.2
Overall health rating	1.1	2.3	5.3	-1.9	-0.7	-1.6	-0.7	-1.2	-2.3	-1.5
Asthma (self-reported)	1.1	2.2	3.4	1.1	-1.7	-1.8	-1.6	-1.8	-0.4	-1.3
Ever taken oral contraceptive pill	1.1	1.3	4.4	0.1	-1.1	-1.2	-0.6	-2.1	0.0	-1.1
Hearing aid user	1.1	1.2	4.3	-1.6	0.6	0.8	0.3	-0.1	-2.1	-0.6
Eye problems/disorders: Glaucoma	1.1	1.3	2.5	0.8	1.2	1.4	1.2	1.6	-0.4	-1.0
Commuting to job workplace: Cycle	1.1	1.4	6.2	2.5	-1.0	-0.9	-0.3	-0.6	0.9	0.7
Irritable Bowel Disease (IBD)	1.0	2.4	5.2	-2.3	-1.5	-0.7	-0.6	-2.0	-1.3	-1.9
Lupus	1.0	1.5	3.1	1.5	-1.4	-0.4	-1.8	-0.7	-1.4	-0.8
Sensitivity / hurt feelings	1.0	1.7	5.2	-0.5	0.4	0.4	1.6	0.1	-2.3	-1.8
Age when periods started (menarche)	1.0	2.5	6.3	-0.6	1.0	2.0	1.6	2.5	0.6	-1.7
Medication: Levothyroxine sodium	1.0	1.7	3.7	-1.9	-1.4	-1.0	-0.9	-0.5	-1.3	-1.5
Number of incorrect matches in round	1.0	1.7	3.1	1.6	1.6	1.8	1.6	0.2	-1.0	-0.4
Arm fat percentage (right)	1.0	3.9	12.1	-0.6	-1.8	-1.2	-1.8	-2.1	-3.5	-1.7
Pulse rate	1.0	1.6	5.4	1.6	-1.2	-2.3	-0.6	-0.4	-1.1	-0.2
Noisy workplace	1.0	1.3	6.6	-0.1	0.5	0.5	0.2	0.6	-2.6	-1.2
Body fat percentage	1.0	3.8	13.2	-0.6	-1.5	-1.1	-1.5	-2.1	-3.6	-1.6
Leg fat percentage (right)	1.0	3.6	15.7	-0.7	-1.3	-0.9	-1.4	-1.5	-4.0	-1.5
Osteoarthritis (self-reported)	1.0	1.3	2.3	-0.9	1.5	1.2	1.3	0.1	-1.5	-0.8
Wears glasses or contact lenses	1.0	1.2	5.8	-1.3	0.4	-0.2	0.4	-0.5	-2.4	-0.4
Medication: Atorvastatin	1.0	1.2	3.0	0.0	-1.6	-1.7	-1.2	-0.7	-0.4	-1.0
Crohns Disease (2012)	0.9	1.5	3.3	-1.0	-1.2	-1.1	-1.2	-1.8	-0.9	-1.1
Neuroticism (2016)	0.9	1.3	1.8	-1.3	-1.0	-1.2	-1.3	-1.3	-0.5	-1.0
Rheumatoid Arthritis	0.9	1.2	3.5	-0.7	-1.4	-1.9	-1.1	0.1	-0.4	-1.1
Angina	0.9	1.2	3.7	-0.2	-1.6	-1.3	-1.9	-0.6	0.2	-0.2
Pack years adult smoking proportion	0.9	1.4	6.7	-1.0	-0.5	-0.6	-0.9	-0.8	-2.6	-0.5
Prospective memory result	0.9	1.1	2.5	1.6	-0.9	-0.9	-1.3	-0.7	-0.7	-0.9
Length of working week for main job	0.9	1.0	2.5	-0.5	-1.0	-0.4	-0.8	-0.9	-1.2	-1.6
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	3.6	0.6	0.1	0.4	-0.6	0.3	1.9	1.9
Headache pain in last month	0.9	1.6	3.6	-1.5	-0.4	-1.2	-0.6	-1.3	-1.4	-1.9
Comparative body size at age 10	0.9	2.6	9.1	-3.0	-0.7	-0.6	-1.7	-0.4	-2.3	-0.4
Mood swings	0.9	1.7	3.2	-1.8	-1.2	-0.6	-1.8	-0.9	-1.4	-0.9
Breast cancer (self-reported)	0.9	1.1	2.2	1.0	-0.2	-1.3	0.4	-1.5	-0.9	-1.4
Ever depressed for a whole week	0.9	1.1	2.4	-0.4	-1.6	-1.5	-1.1	-1.2	0.0	-0.5
HDL Cholesterol	0.8	1.3	3.1	-0.0	-1.2	-1.7	-1.1	-1.8	0.6	-0.5
Ever had hysterectomy (womb removed)	0.8	0.9	2.7	0.4	-0.1	-0.1	0.6	-0.8	-1.6	-1.6
Impedance of leg (right)	0.8	4.0	19.5	0.4	0.8	0.3	0.4	0.5	4.4	2.7
Trunk fat percentage	0.8	3.1	10.0	-0.6	-1.4	-1.1	-1.4	-2.1	-3.2	-1.2
Qualifications: CSEs or equivalent	0.8	1.0	1.8	-1.1	-1.2	-1.4	-0.9	-0.6	0.9	-0.9
Hair/balding pattern: Pattern 3	0.8	1.2	4.7	1.0	0.5	0.4	-0.4	0.9	1.1	2.2
Qualifications: A levels/AS levels or equivalent	0.8	1.8	7.8	0.1	-0.4	0.0	0.2	0.4	2.8	2.1
Medication: Lansoprazole	0.8	0.9	1.8	-0.1	-0.9	-0.7	-1.3	-1.1	-1.1	-1.1
Peak expiratory flow (PEF)	0.8	1.9	8.2	-2.9	0.9	0.3	1.0	0.9	-0.5	-1.3
Blood clot in the leg (DVT)	0.8	1.0	3.2	1.0	-0.5	-0.7	-0.9	-0.4	1.8	1.1
Mouth/teeth dental problems: Loose teeth	0.8	1.0	3.0	-0.1	1.0	0.8	1.7	0.7	-1.2	-0.7
Medication: Seretide 50 evohaler	0.8	0.9	1.7	1.2	-1.3	-1.3	-0.4	-0.8	0.6	-0.6
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.3	-0.7	1.5	0.8	0.9	1.1	0.8	0.4
Arm fat percentage (left)	0.8	3.2	10.7	-0.3	-1.7	-1.0	-1.5	-1.8	-3.3	-1.5
Average weekly red wine intake	0.8	1.2	3.8	-0.6	0.7	0.7	0.6	2.0	1.0	1.3
Handedness (chirality/laterality): Left-handed	0.8	1.0	1.9	1.1	1.4	1.2	1.1	-0.4	-0.7	0.7
Osteoporosis (self-reported)	0.8	1.0	3.4	0.2	-1.0	-1.6	-0.5	-1.8	0.1	0.1
Mother’s age at death	0.8	1.0	4.8	-1.0	0.3	0.4	0.1	-0.9	2.2	0.2
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.1	1.1	-0.9	-1.1	-0.3	-1.4	-1.2	0.6
Average weekly beer plus cider intake	0.8	1.1	3.5	1.6	-0.4	0.6	-0.6	-0.6	1.9	0.7
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	3.3	1.1	-0.4	-0.6	-0.8	-0.2	1.8	1.1
Ulcerative Colitis (UC)	0.7	1.2	5.4	-2.3	-0.3	0.5	-0.2	-1.1	-1.0	-0.8
Prostate Cancer	0.7	1.0	3.1	0.7	-0.5	-0.8	-0.2	-0.5	1.8	1.5
Triglycerides	0.7	1.2	4.0	-2.0	0.7	0.9	0.3	-0.1	-1.5	-0.7
Ulcerative Colitis	0.7	1.1	2.4	-1.3	-0.7	-0.4	-0.8	-1.5	-1.1	-0.9
Allergy or Eczema	0.7	1.9	4.9	-2.2	-0.2	-0.8	-0.7	-1.5	-1.8	-1.3
Supplements: Zinc	0.7	0.8	1.5	1.1	0.8	0.6	1.2	0.7	0.8	0.8
Diabetes (mother)	0.7	0.9	3.2	-0.5	1.3	0.8	1.8	0.1	0.4	0.7
Heart attack	0.7	0.8	1.5	-0.1	-1.2	-1.2	-0.3	-0.5	-1.2	-1.1
Fluid intelligence score	0.7	1.5	6.2	-0.7	-0.7	-1.1	-0.7	-0.0	2.5	1.2
Forced expiratory volume in 1-second (FEV1)	0.7	2.2	9.0	-3.0	0.7	-0.0	0.7	0.3	-1.2	-2.0
Illnesses of mother	0.7	0.9	1.8	0.8	-0.9	-0.9	-1.1	-0.7	1.4	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	7.7	-2.8	0.6	0.4	0.8	0.0	-1.4	-2.2
Chronic bronchitis/emphysema (mother)	0.7	0.9	2.7	-0.0	1.6	1.1	1.1	0.2	-0.9	0.3
Neck or shoulder pain in last month	0.7	1.0	3.9	0.1	-1.0	-1.3	-0.1	-0.6	-0.5	-2.0
Supplements: Vitamin C	0.7	0.8	2.9	-1.0	-0.6	-0.2	-0.7	-0.6	-0.9	-1.7
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	1.6	-1.3	-0.6	-0.6	-0.9	-0.9	0.9	0.8
Commuting to job workplace: Walk	0.7	0.8	2.3	1.5	-0.4	-0.6	-0.5	-0.4	0.7	1.3
Age started oral contraceptive pill	0.7	0.9	3.1	-0.6	0.3	-0.3	0.3	-0.5	-1.8	-1.5
Cholesterol lowering medication	0.7	1.1	2.0	-1.4	-1.1	-1.2	-0.4	-1.1	-0.6	-1.1
Major Depression (MDD)	0.6	0.8	2.4	-1.5	-1.1	-1.2	-0.3	0.2	-0.1	-0.4
Body Mass Index (BMI) (2010)	0.6	0.8	1.8	1.1	-1.0	-0.3	-1.2	0.2	-1.3	-0.5
Blood Platelet Count	0.6	7.2	20.4	-4.5	-3.1	-3.2	-0.9	-1.6	-0.8	-2.4
Diabetes (father)	0.6	0.8	1.5	0.2	0.8	-0.1	1.0	1.2	1.1	1.0
Fed-up feelings	0.6	1.1	2.6	-0.5	-1.0	-1.0	-0.5	-1.1	-1.6	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	2.7	-1.4	-1.6	-1.5	-1.4	-0.1	-0.7	-0.2
Hayfever, allergic rhinitis or eczema	0.6	1.2	2.6	-1.6	-0.6	-1.1	-1.0	-1.4	-0.8	-1.1
Impedance of leg (left)	0.6	2.7	14.8	0.3	0.6	0.1	0.4	0.1	3.9	1.9
Had menopause	0.6	0.8	1.4	0.2	-0.8	-0.7	-1.2	-1.1	-1.2	-0.3
Forced vital capacity (FVC)	0.6	2.1	5.9	-2.4	0.6	-0.3	1.2	0.0	-1.1	-2.4
Qualifications: None of the above	0.6	1.4	4.6	-1.7	0.8	0.5	0.3	-0.7	-2.2	-0.8
Financial difficulties in last 2 years	0.6	0.8	4.8	-2.2	-0.1	0.2	-0.2	0.6	0.3	-0.4
Mouth/teeth dental problems	0.6	0.9	2.9	1.4	-0.0	-0.1	-0.6	0.6	1.7	0.6
Number of live births	0.6	0.9	2.2	-0.0	1.3	1.1	0.0	0.6	0.8	1.5
Medication: Ventolin 100micrograms inhaler	0.6	0.7	3.1	1.8	0.3	0.3	0.6	-0.8	-0.7	-0.6
Forced vital capacity (FVC), Best measure	0.6	2.3	6.0	-2.2	0.9	0.6	1.5	0.4	-1.3	-2.4
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.0	1.4	0.5	0.6	1.1	-0.8	0.5	0.6
Eye problems/disorders: None of the above	0.6	0.6	2.2	-0.9	-0.6	-0.6	-0.3	-0.7	-0.5	-1.5
Pulse rate, automated reading	0.6	2.0	4.3	1.6	-1.4	-2.1	-0.4	-0.4	-2.0	-0.9
Had major operations	0.6	0.7	3.4	1.8	-0.5	-0.6	0.5	-0.4	0.6	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.6	-1.6	0.4	0.2	0.2	-0.6	-0.6	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	3.7	-1.3	0.9	0.3	1.4	-0.4	-1.9	-0.9
Medication: Lisinopril	0.6	0.8	3.3	1.8	-1.2	-0.5	-0.7	-0.2	-0.0	-0.6
Heart attack/myocardial infarction (self-reported)	0.6	0.7	1.5	0.1	-1.1	-1.0	-0.1	-0.4	-1.2	-1.1
Intelligence (Savage-Jansen 2018)	0.5	1.5	5.6	-2.4	-1.4	-1.1	-0.8	-0.1	0.9	-0.7
Schizophrenia vs Biploar Disorder	0.5	0.7	3.0	-0.6	0.2	0.6	0.0	0.1	1.7	1.1
HbA1C	0.5	0.6	1.9	-0.6	1.4	0.9	0.7	0.6	0.4	0.3
Blood White Count	0.5	3.6	13.2	2.1	1.5	0.7	3.6	1.9	-0.6	-0.8
Type 2 Diabetes (T2D) (2018)	0.5	1.0	3.5	-0.1	-1.1	-1.0	-0.6	-0.7	-0.6	-1.9
Neuroticism	0.5	1.3	5.2	-0.9	-0.9	-0.8	-0.6	-0.9	-2.3	-0.7
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.5	-0.9	-1.1	-1.2	-0.5	-0.3	-0.2	-1.2
Townsend deprivation index at recruitment	0.5	0.7	1.6	-0.3	-1.1	-0.7	-1.3	-0.7	1.1	-0.4
Stomach or abdominal pain in last month	0.5	0.7	1.1	-1.1	-0.6	-0.7	-0.9	-0.8	-1.0	-0.6
Sitting height	0.5	3.4	9.4	-1.4	-1.3	-1.7	-0.9	-1.7	-2.1	-3.1
Chronic bronchitis/emphysema (father)	0.5	0.6	1.3	-1.1	-0.5	-0.1	-0.9	-0.7	-1.0	-0.5
High blood pressure (mother)	0.5	0.7	1.7	-1.2	0.4	0.5	0.9	0.8	-1.3	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	2.5	-1.4	-0.8	0.2	-0.4	-0.2	-0.5	-1.6
Birth weight of first child	0.5	0.8	3.0	1.1	0.3	-0.2	-0.4	-0.3	-1.7	-1.2
Ever highly irritable/argumentative for 2 days	0.5	0.6	0.9	-0.8	-0.5	-0.8	-0.7	0.9	-0.8	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	2.1	1.5	-0.6	-0.3	-0.8	-1.0	-0.5	0.3
Number of children fathered	0.5	0.6	1.6	0.2	1.0	1.3	0.6	0.7	-0.7	0.4
Age at first live birth	0.5	0.8	2.0	-0.7	-0.9	-1.4	-0.6	-1.3	-0.2	-0.8
Leg pain on walking	0.5	0.6	3.2	-0.3	-0.3	-0.6	0.1	-0.5	-1.8	-0.0
Medication: Aspirin	0.5	0.6	1.3	-0.5	-0.9	-1.2	-0.5	-0.7	-1.1	0.2
Diabetes diagnosed by doctor	0.5	0.8	1.6	0.9	-0.8	-0.7	-0.8	-1.3	-0.5	-1.1
Financial situation satisfaction	0.5	0.7	2.8	-1.7	0.5	0.3	0.4	0.9	0.7	-0.1
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.7	-0.7	-0.5	-0.5	0.9	-0.3	0.9	-1.3
Medication: Bendroflumethiazide	0.5	0.7	2.7	-1.6	-0.1	0.1	0.0	-0.3	-1.4	-0.2
Medication: Paracetamol	0.5	0.7	2.3	-0.7	0.3	0.3	0.5	-0.3	-1.3	-1.5
Supplements: Calcium	0.5	0.5	2.5	1.6	-0.3	-0.5	0.7	-0.4	-0.2	0.3
Neuroticism (Nagel 2018)	0.4	0.9	5.1	-1.0	-0.0	-0.0	0.2	-0.3	-2.3	-0.3
Verbal and Numeric Reasoning (VNR)	0.4	0.9	1.8	-0.5	-1.3	-1.2	-0.9	-0.6	1.3	-0.5
Breast Cancer	0.4	0.9	3.3	0.6	-0.7	0.2	-0.3	-0.6	-1.8	-1.3
Blood Eosinophil Count	0.4	3.4	8.2	2.9	0.5	-0.1	2.4	1.6	-1.2	-2.3
Heel T-Score	0.4	3.4	6.6	-1.8	-2.3	-2.2	-2.6	-1.1	1.4	0.7
Height	0.4	6.8	21.8	-4.7	2.2	1.0	1.5	0.1	-3.4	-2.4
Lung FVC	0.4	1.8	3.9	-1.5	-0.4	-0.9	0.7	-1.1	-1.9	-2.0
Chronotype (morning person)	0.4	1.0	3.0	0.1	-0.9	-1.1	-1.0	-1.7	-0.9	0.5
Hand grip strength (left)	0.4	1.0	2.0	0.2	0.8	1.2	1.0	0.4	-1.4	-1.2
Hearing difficulty/problems: Yes	0.4	0.6	1.2	-0.8	-0.8	-0.3	-0.2	-0.6	-1.1	-1.1
Ever used hormone-replacement therapy (HRT)	0.4	0.5	2.7	0.0	-0.3	-0.2	-0.5	-0.4	-1.6	-0.3
Hand grip strength (right)	0.4	1.2	2.2	0.3	0.9	1.5	1.3	0.6	-1.3	-1.2
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.3	-0.4	-0.2	0.1	0.6	0.9	-0.7	-1.1
Nervous feelings	0.4	0.7	1.4	0.7	0.9	1.1	1.2	0.9	-0.5	0.2
Had other major operations	0.4	0.5	2.4	1.5	0.1	-0.3	0.3	0.2	0.7	0.4
Pain all over the body in last month	0.4	0.5	2.3	1.5	-0.0	-0.6	0.4	0.1	0.3	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	2.2	-1.5	0.7	0.4	0.0	-0.0	-0.1	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.3	1.1	0.3	0.9	-0.1	0.1	1.0	1.1
Worry too long after embarrassment	0.4	0.7	2.0	0.2	0.8	0.8	1.2	1.4	0.3	0.1
Medication: Allopurinol	0.4	0.5	1.1	0.9	0.7	1.1	0.5	0.3	0.1	1.0
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.5	0.5	-0.3	-0.4	-0.1	0.1	-1.2	-1.1
Knee pain experienced in last month	0.4	0.6	2.2	-0.4	-0.6	-0.0	0.2	-0.7	-1.5	-1.1
Illnesses of siblings: Diabetes	0.4	0.6	2.6	-0.0	0.6	0.1	0.6	-0.2	1.6	0.7
Ever had bowel cancer screening	0.4	0.5	1.0	1.0	0.8	0.7	0.9	0.3	-0.4	0.6
Miserableness	0.4	0.7	1.6	0.2	-0.9	-1.0	-0.5	-1.3	-0.9	-0.4
Illnesses of father: High blood pressure	0.4	0.4	1.5	0.3	0.1	0.4	0.6	0.3	-1.2	-0.9
Risk taking	0.4	0.6	1.5	1.2	-1.1	-0.8	-0.5	-0.4	0.3	0.6
Heart disease (siblings)	0.4	0.5	2.1	1.5	0.1	-0.4	0.5	0.1	0.7	0.7
Alzheimer’s Disease (in father)	0.3	0.4	1.3	-0.4	0.4	0.7	0.4	1.1	-0.4	-0.2
Fasting Glucose	0.3	0.4	1.5	1.2	-0.7	-0.6	-0.1	0.4	-0.4	-0.5
Waist Hip Ratio (WHR)	0.3	1.2	2.1	-1.5	-1.4	-0.8	-1.2	-1.1	0.8	-0.1
Systolic Blood Pressure	0.3	1.3	3.8	-0.6	-1.6	-0.5	-1.4	-0.3	-1.9	0.2
Average weekly spirits intake	0.3	0.4	1.2	0.6	0.7	0.0	-0.3	0.8	-1.1	0.4
Other serious medical condition/disability diagnosed by doctor	0.3	0.5	1.3	-0.6	-0.5	-1.1	-0.1	-0.3	-0.9	-0.6
Systolic blood pressure, automated reading	0.3	0.8	2.8	0.2	-0.2	0.4	-0.6	-0.2	-1.7	1.4
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	1.4	1.0	-0.4	0.2	0.1	-1.2	-0.0	-0.3
Medication for hormone replacement therapy	0.3	0.3	0.6	-0.3	-0.2	0.8	0.7	0.7	0.7	-0.3
Alcohol usually taken with meals	0.3	0.5	2.0	0.3	-1.1	-1.4	-0.1	-0.2	0.6	-0.5
Diabetes (self-reported)	0.3	0.5	1.4	1.1	-0.4	-0.4	-0.1	-0.3	-0.7	-1.2
Neuroticism score	0.3	0.7	4.0	-0.3	-0.2	0.2	0.1	0.1	-2.0	-0.9
Father’s age at death	0.3	0.4	1.8	1.4	-0.2	-0.6	0.4	-0.2	-0.6	-0.5
Standing height	0.3	3.2	8.6	-2.8	1.0	-0.0	1.2	-0.1	-1.9	-2.9
Pulse wave reflection index	0.3	0.3	1.3	-0.2	-0.3	-0.5	-0.3	-0.6	1.1	0.5
Birth weight	0.3	0.7	3.1	-1.8	-0.0	0.5	-1.1	-0.2	-0.1	0.2
High blood pressure (siblings)	0.3	0.5	2.4	-0.1	0.5	0.0	-0.1	0.2	0.8	1.5
Wheeze or whistling in the chest in last year	0.3	0.6	2.5	1.6	-0.1	-0.4	-0.1	-0.4	0.8	0.5
Medication for pain relief, constipation, heartburn	0.3	0.6	2.2	1.5	0.5	0.5	0.4	0.6	0.9	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	1.5	0.7	0.1	0.2	0.0	0.3	0.5	1.2
Suffer from ‘nerves’	0.3	0.5	1.2	-0.6	0.8	0.9	0.5	1.1	-0.3	0.1
Family relationship satisfaction	0.3	0.3	1.6	-0.2	-0.5	-0.5	-0.3	0.1	1.3	0.4
Illnesses of father: Heart disease	0.3	0.3	0.8	0.9	-0.4	-0.7	-0.2	-0.6	-0.6	0.5
Eye problems/disorders: Cataract	0.3	0.3	1.3	-0.6	0.0	-0.4	-0.5	0.2	0.2	1.1
Guilty feelings	0.3	0.5	1.4	-0.8	0.4	1.2	0.2	0.5	0.8	0.1
Commuting to job workplace: Public transport	0.3	0.4	1.3	-0.4	-0.4	0.7	0.5	1.1	0.4	0.3
High cholesterol (Self-reported)	0.3	0.5	1.1	-0.5	-0.9	-0.8	0.1	-0.4	1.1	0.4
Ever smoked	0.3	0.5	1.5	-0.2	-1.2	-0.9	-0.7	0.1	0.7	-0.6
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.8	0.2	-0.6	0.0	-0.3	-0.5	-0.3	1.3
Worry (Nagel 2018)	0.2	0.5	1.6	-0.8	0.6	0.6	0.5	0.3	-1.3	0.6
Primary Biliary Cirrhosis	0.2	0.4	1.1	1.1	-0.2	-0.1	-0.1	-0.7	0.8	-0.1
Smoking Status	0.2	0.4	0.8	0.9	-0.0	0.7	0.9	0.5	-0.2	-0.6
Lung FEV1/FVC ratio	0.2	1.0	2.3	-1.2	0.2	0.8	-1.5	-0.8	-1.4	0.1
Vitamin and mineral supplements	0.2	0.3	1.1	-0.6	-0.5	-0.4	-1.1	0.5	0.0	0.1
Serious illness, injury or assault to yourself	0.2	0.3	0.7	0.5	-0.5	-0.6	-0.8	-0.6	-0.1	0.1
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.0	-0.2	-0.1	0.0	-0.1	0.5	1.0	-0.8
Illnesses of siblings	0.2	0.3	1.5	-0.1	-0.5	0.1	-0.3	-0.2	-0.7	-1.2
Worrier / anxious feelings	0.2	0.4	1.1	0.4	0.3	0.3	0.5	-1.0	-0.9	0.3
Pulse wave Arterial Stiffness index	0.2	0.3	1.4	0.1	0.2	-0.6	0.2	0.3	-1.2	-0.0
Hair/balding pattern: Pattern 4	0.2	0.4	1.1	-0.1	-0.0	-0.6	0.1	0.8	1.0	1.0
Gout (self-reported)	0.2	0.3	1.0	-0.7	0.1	0.5	0.1	-0.3	-1.0	0.3
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	1.0	-0.9	-1.0	-0.1	-0.4	-0.5	-0.9	-0.6
Pulse wave peak to peak time	0.2	0.2	1.0	-0.4	0.0	0.6	-0.0	-0.2	1.0	-0.1
Qualifications: College or University degree	0.2	0.8	1.9	-0.1	-1.4	-1.1	-0.9	-0.5	1.0	-0.3
Medication: Omeprazole	0.2	0.3	0.7	-0.5	-0.7	-0.2	-0.3	0.3	-0.6	-0.8
Heart disease (mother)	0.2	0.3	1.3	1.1	-0.4	-0.5	0.4	-0.3	-0.2	0.3
Comparative height size at age 10	0.2	0.9	2.6	-1.6	0.3	-1.2	0.2	-0.8	-0.8	-0.8
Number of full sisters	0.2	0.3	1.4	-0.3	-0.2	-0.3	0.2	-0.5	1.2	-0.3
Chest pain or discomfort	0.2	0.3	1.0	-1.0	-0.1	-0.4	-0.4	-0.7	-0.7	0.0
Smoking status: Previous	0.2	0.4	1.0	0.5	-0.7	-0.4	0.1	-0.1	-1.0	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.3	1.4	-0.7	0.0	-0.2	-0.1	0.6	1.2	-0.1
Friendships satisfaction	0.2	0.3	0.5	0.7	-0.5	-0.6	-0.6	0.5	0.3	0.5
Medication for cholesterol	0.2	0.3	1.6	1.3	0.4	-0.1	-0.2	0.1	0.6	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.4	-0.5	-0.6	-0.5	0.1	-0.1	0.6	-0.3
Medication: Aspirin	0.2	0.2	0.7	0.2	-0.5	-0.5	-0.1	-0.6	-0.8	0.4
Smoking status: Current	0.2	0.3	1.1	-0.1	0.3	0.3	0.3	0.9	1.0	0.2
Average weekly champagne plus white wine intake	0.2	0.3	0.8	0.0	-0.2	-0.3	0.9	0.8	-0.5	-0.5
Medication: Blood pressure	0.2	0.5	1.0	-0.7	-0.5	-0.6	-0.7	-0.6	-1.0	0.4
Diastolic blood pressure, automated reading	0.2	0.7	2.3	1.5	0.2	0.3	0.6	-0.2	-0.5	1.3
Myopia	0.2	0.3	0.9	-0.1	0.4	0.7	-0.3	0.1	-0.4	0.9
Bipolar Disorder (2018)	0.1	0.2	0.9	0.0	-0.2	-0.4	-0.6	-0.4	-0.1	1.0
Alzheimer’s Disease (in mother)	0.1	0.1	0.2	-0.1	0.5	0.5	0.2	0.3	-0.1	0.5
Alzheimer’s Disease (including proxy)	0.1	0.2	1.1	-0.3	-0.1	0.1	-0.0	-0.0	-1.1	-0.3
Ovarian Cancer	0.1	0.2	0.5	0.6	0.2	-0.2	0.0	-0.3	-0.4	-0.7
Blood Red Count	0.1	1.3	3.1	-1.7	-0.5	-0.9	1.0	0.7	-1.8	-0.5
Hypothyroidism (self reported)	0.1	0.1	0.4	-0.6	-0.3	0.2	0.0	0.2	-0.6	-0.3
Tanning	0.1	1.4	4.2	0.9	1.4	0.7	2.0	0.7	0.4	1.4
Current tobacco smoking	0.1	0.2	0.6	0.2	0.1	0.1	0.2	0.8	0.7	0.0
Past tobacco smoking	0.1	0.2	0.5	0.2	0.5	0.2	-0.3	-0.4	0.2	0.7
Medication: Paracetamol	0.1	0.2	0.6	-0.2	-0.2	-0.0	-0.2	-0.7	-0.5	-0.8
Unable to work because of sickness or disability	0.1	0.2	0.4	0.6	0.4	0.0	-0.1	0.7	-0.1	0.4
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.4	-0.5	-0.5	-0.3	-0.2	0.1	-0.2	-0.6
Basal cell carcinoma (self-reported)	0.1	0.2	0.8	0.1	0.0	-0.4	0.3	0.0	-0.3	-0.9
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	1.1	3.3	1.8	-0.5	-0.5	-1.3	-0.5	-0.1	1.4

Hub : Genes

SNRNP70

Models

Trait associations