[Hub]/) : Traits : Leg fat-free mass (right) : ← →

chr2:197,660,966-201,571,143

Best TWAS P=1.28e-10 · Best GWAS P=1.84e-12 conditioned to 0.0179

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	TYW5	0.08	0.14	lasso	8	0.13	2.2e-15	-5.14	5.4	8.1e-08	-0.05	0.03	0.97	FALSE
2	GTEx	Adipose Subcutaneous	RFTN2	0.14	0.10	enet	11	0.13	5.3e-11	-5.76	-5.9	4.5e-09	0.86	0.36	0.64	FALSE
3	GTEx	Brain Nucleus accumbens basal ganglia	C2orf47	0.25	0.01	lasso	3	0.00	2.8e-01	5.05	-5.6	2.5e-08	0.04	0.06	0.42	TRUE
4	GTEx	Cells EBV-transformed lymphocytes	HSPD1	0.15	0.04	lasso	7	0.04	2.0e-02	-4.36	5.3	1.1e-07	-0.64	0.12	0.51	FALSE
5	GTEx	Lung	RFTN2	0.06	0.08	lasso	8	0.06	2.7e-05	-6.34	-6.1	8.7e-10	0.86	0.15	0.84	FALSE
6	GTEx	Skin Sun Exposed Lower leg	MARS2	0.04	0.05	enet	8	0.03	1.2e-03	-6.53	6.4	1.4e-10	-0.86	0.12	0.88	FALSE
7	GTEx	Spleen	RFTN2	0.11	0.03	enet	26	0.05	2.4e-02	-6.55	-5.9	3.0e-09	0.84	0.09	0.35	FALSE
8	GTEx	Spleen	MARS2	0.12	0.04	lasso	5	0.00	3.4e-01	-6.50	5.9	3.1e-09	-0.82	0.07	0.32	FALSE
9	GTEx	Thyroid	PLCL1	0.04	0.01	lasso	4	0.00	2.6e-01	-6.37	-5.4	6.5e-08	0.76	0.20	0.50	FALSE
10	GTEx	Thyroid	RFTN2	0.04	0.01	enet	11	0.01	9.5e-02	-6.47	-6.0	1.5e-09	0.80	0.10	0.71	FALSE
11	GTEx	Whole Blood	PLCL1	0.08	0.08	enet	15	0.05	4.1e-05	-6.05	-6.4	1.3e-10	0.92	0.14	0.86	TRUE
12	ROSMAP	Brain Pre-frontal Cortex	TYW5	0.11	0.12	lasso	5	0.11	5.5e-14	-5.14	5.3	1.3e-07	-0.04	0.03	0.97	FALSE
13	ROSMAP	Brain Pre-frontal Cortex	C2orf69	0.07	0.04	enet	13	0.06	3.6e-08	-4.93	5.4	8.3e-08	-0.05	0.04	0.96	FALSE
14	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PLCL1	0.04	0.00	blup	130	0.02	4.0e-03	0.75	-5.5	5.2e-08	0.65	0.05	0.38	FALSE
15	The Cancer Genome Atlas	Lung Adenocarcinoma	C2orf60	0.03	0.03	blup	44	0.03	1.8e-04	-5.12	5.5	3.0e-08	-0.05	0.01	0.97	FALSE
16	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C2orf60	0.04	0.05	lasso	5	0.03	2.1e-03	-5.28	5.3	1.3e-07	-0.04	0.01	0.89	FALSE