Hub : Genes

C2orf47

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.046 0.019 0.00024 0.016 0.016 0.003 0.012 0.013 3.9e-03 0.0043 0.13000 0.0099 0.00800
2 GTEx Brain Nucleus accumbens basal ganglia 0.252 0.091 0.00140 0.009 NA -0.009 NA 0.002 1.7e-01 NA 0.64000 NA 0.28000
3 GTEx Whole Blood 0.040 0.020 0.00480 0.047 NA 0.030 NA 0.035 3.8e-05 NA 0.00084 NA 0.00036
4 TCGA Testicular Germ Cell Tumors 0.147 0.085 0.00052 0.051 0.050 0.027 NA 0.048 7.0e-03 0.0076 0.03900 NA 0.00840

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 5.8 9.1 10.1 -3.0 2.8 3.2 -3.0
Bipolar Disorder or Schizophrenia 15.7 38.4 54.3 -7.4 3.9 6.8 -6.1
Depressed Affect (Nagel 2018) 1.0 2.1 2.2 -1.3 1.4 1.5 -1.5
Depression (Nagel 2018) 6.0 9.0 9.5 -3.0 3.1 2.8 -3.0
Intelligence (Savage-Jansen 2018) 3.4 10.3 17.2 3.1 -1.3 -4.2 3.6
Neuroticism (Nagel 2018) 1.8 4.3 6.7 -2.6 2.0 1.9 -1.7
Schizophrenia (2018) 15.0 31.2 49.2 -7.0 2.7 6.3 -5.4
Schizophrenia vs Biploar Disorder 3.6 4.7 11.8 -3.4 0.2 2.0 -1.8
Worry (Nagel 2018) 5.8 12.1 20.3 -4.5 3.1 3.2 -2.9
Alzheimer’s Disease (in mother) 0.1 0.1 0.2 -0.1 0.5 -0.1 -0.4
Alzheimer’s Disease (in father) 0.4 0.4 1.6 -0.1 -1.3 0.2 0.1
Alzheimer’s Disease (including proxy) 0.5 0.7 0.9 -1.0 -0.8 0.7 -0.8
Crohns Disease (2017) 1.8 3.9 7.1 -2.7 2.3 1.4 -1.2
Irritable Bowel Disease (IBD) 3.6 8.5 10.1 -3.1 3.2 2.6 -2.8
Ulcerative Colitis (UC) 3.1 5.9 7.3 -2.0 2.6 2.4 -2.7
Major Depression (MDD) 0.8 1.0 2.6 -0.8 1.6 0.6 0.4
Reaction Time 10.5 20.1 23.3 -4.4 4.8 4.7 -4.0
Verbal and Numeric Reasoning (VNR) 6.1 14.6 21.0 3.5 -2.7 -4.6 4.3
Breast Cancer 1.3 3.1 4.6 2.1 -0.3 -1.8 2.1
Ovarian Cancer 0.1 0.1 0.2 0.2 -0.4 -0.3 0.3
Prostate Cancer 2.6 3.6 4.0 -1.9 2.0 1.8 -1.8
Age at First Birth 2.8 4.0 6.1 1.5 -1.3 -2.5 2.5
Bipolar Disorder (2011) 1.8 1.8 2.8 -1.7 1.7 1.1 -0.6
Body Mass Index (BMI) (2010) 0.4 0.6 1.5 1.2 0.1 -0.6 0.5
Coronary Artery Disease (CAD) 2.3 2.7 4.3 1.4 -1.7 -1.4 2.1
Crohns Disease (2012) 0.6 0.9 2.7 -1.6 0.8 0.5 -0.3
Mean Putamen Volume 0.7 0.8 1.3 0.6 1.2 -0.7 0.8
Fasting Glucose 0.2 0.3 0.8 0.2 0.5 0.2 -0.9
HbA1C 0.1 0.2 0.5 -0.3 0.7 -0.1 0.2
HDL Cholesterol 0.1 0.1 0.2 -0.2 0.1 -0.3 0.4
LDL Cholesterol 0.6 1.0 1.6 1.3 -0.8 -0.8 0.9
Lupus 0.6 0.9 2.0 -1.4 1.1 0.5 -0.4
Neuroticism (2016) 0.4 0.6 0.8 -0.7 -0.6 0.9 -0.9
Primary Biliary Cirrhosis 0.8 1.2 1.8 -1.3 0.3 1.3 -1.0
Rheumatoid Arthritis 0.1 0.1 0.2 0.3 0.5 0.3 -0.0
Schizophrenia (2014) 15.9 35.2 54.0 -7.3 3.1 6.6 -5.8
Triglycerides 0.3 0.5 1.8 -0.1 -1.3 -0.4 0.3
Type 2 Diabetes (T2D) (2012) 1.1 1.2 3.4 0.6 -1.8 -0.5 0.9
Ulcerative Colitis 1.7 2.5 3.9 -1.0 1.3 1.8 -2.0
Blood Eosinophil Count 0.9 7.0 8.5 2.7 -2.4 -2.6 2.9
Blood Platelet Count 0.2 2.7 4.6 -2.1 1.1 1.5 -1.7
Blood Red Count 2.0 19.1 26.1 5.1 -3.4 -4.4 4.4
Blood White Count 0.2 1.5 2.8 -1.0 1.3 1.7 -0.9
Heel T-Score 0.4 3.0 6.7 -1.5 1.1 1.4 -2.6
BMI 4.5 26.0 40.4 6.4 -3.8 -4.8 5.0
Height 0.2 3.3 12.2 0.3 -3.5 0.8 -0.6
Waist Hip Ratio (WHR) 0.9 4.2 9.0 0.3 -3.0 -1.7 2.1
Systolic Blood Pressure 4.6 22.9 27.6 -5.2 5.2 4.2 -4.4
Smoking Status 3.9 9.4 16.4 2.8 -2.4 -2.7 4.1
Allergy or Eczema 0.1 0.3 0.4 -0.6 -0.5 0.3 -0.6
Cardiovascular Disease 1.0 3.5 9.7 -1.1 3.1 1.1 -1.4
Hypothyroidism (self reported) 2.5 5.8 9.7 -3.1 -0.1 2.8 -2.4
Respiratory disease 3.0 6.7 11.3 -3.0 -0.2 3.4 -2.6
Type 2 Diabetes (T2D) (2018) 0.3 0.6 1.3 1.1 -0.9 0.0 0.6
Lung FEV1/FVC ratio 0.7 3.3 12.4 0.6 3.5 -0.6 0.5
Lung FVC 0.3 1.3 4.1 0.7 -2.0 -0.8 0.4
Neuroticism 1.6 3.9 6.0 -2.4 1.6 1.9 -1.8
Chronotype (morning person) 0.5 1.1 2.4 -1.5 0.6 1.0 -0.8
Hair Pigment 0.0 0.3 1.0 -1.0 -0.4 -0.0 0.2
Tanning 0.1 1.8 6.9 0.4 2.6 0.2 -0.1
Hand grip strength (left) 2.1 5.5 20.2 0.8 -4.5 -0.5 1.0
Number of treatments/medications taken 0.9 1.6 2.6 -1.5 0.4 1.6 -1.2
Average weekly spirits intake 0.8 0.9 2.6 1.6 0.8 -0.4 0.6
Sensitivity / hurt feelings 1.2 2.0 3.1 1.8 -0.3 -1.5 1.7
Frequency of depressed mood in last 2 weeks 2.0 2.8 4.3 -2.1 1.6 1.5 -1.4
Hearing difficulty/problems: Yes 1.6 2.4 4.3 1.5 -0.2 -1.7 2.1
Relative age of first facial hair 0.7 1.5 1.9 1.2 -0.8 -1.3 1.4
Other serious medical condition/disability diagnosed by doctor 0.2 0.2 0.5 0.0 -0.5 0.7 -0.4
Ever used hormone-replacement therapy (HRT) 0.8 1.0 2.3 -0.9 0.1 1.5 -1.0
Ever had hysterectomy (womb removed) 0.3 0.4 0.7 -0.8 -0.3 0.7 -0.5
Systolic blood pressure, automated reading 1.3 3.9 9.4 -1.5 3.1 1.2 -1.5
Eye problems/disorders: Diabetes related eye disease 5.0 5.5 6.9 -1.9 2.6 2.3 -2.4
Angina 0.2 0.3 0.6 -0.1 0.3 0.8 -0.5
Medication for hormone replacement therapy 0.8 0.9 1.7 -1.3 -0.7 0.9 -0.7
Vitamin and mineral supplements 1.1 1.5 2.1 1.4 -0.4 -1.4 1.4
Supplements: Zinc 1.3 1.4 5.2 0.0 -2.3 -0.2 0.6
Medication: Co-codamol 0.1 0.1 0.2 0.4 0.1 0.5 -0.2
Medication: Metformin 0.4 0.6 1.1 1.1 -0.9 -0.1 0.6
Diabetes (father) 0.3 0.4 1.3 0.5 -1.1 0.3 -0.3
Diabetes (mother) 0.1 0.1 0.3 -0.2 -0.2 0.5 -0.2
Severe depression (siblings) 0.4 0.4 0.9 0.4 -0.5 -0.5 0.9
Pack years adult smoking proportion 0.9 1.4 2.5 0.9 0.4 -1.6 1.4
Impedance of leg (right) 3.9 19.0 25.6 -4.6 5.1 3.9 -3.8
Leg fat-free mass (left) 3.1 16.3 25.7 4.2 -5.1 -3.1 3.5
Trunk fat percentage 1.5 6.1 14.4 3.8 -0.1 -2.1 2.3
Hand grip strength (right) 1.4 3.8 14.7 -0.1 -3.8 0.7 -0.0
Townsend deprivation index at recruitment 1.9 2.7 4.8 -1.2 0.9 2.2 -1.9
Current tobacco smoking 1.9 3.1 6.8 1.2 -0.4 -2.0 2.6
Average weekly fortified wine intake 3.0 3.5 4.6 1.9 -1.6 -1.8 2.1
Maternal smoking around birth 0.7 1.1 1.8 1.3 -0.5 -0.8 1.2
Fed-up feelings 2.7 4.8 7.2 -1.6 1.8 2.7 -2.5
Frequency of unenthusiasm / disinterest in last 2 weeks 4.0 5.3 7.2 -2.5 1.5 2.4 -2.7
Relative age voice broke 0.4 0.6 1.5 0.4 -0.6 -0.8 1.2
Taking other prescription medications 0.0 0.1 0.1 -0.3 -0.2 0.3 -0.3
Age when periods started (menarche) 2.6 6.2 9.3 -2.8 0.4 3.1 -2.7
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 1.4 -0.8 0.5 1.2 -1.1
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.7 -0.7 0.8 -0.3 -0.2
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 1.0 0.7 0.4 -1.0 1.0
Qualifications: CSEs or equivalent 0.3 0.5 1.0 -1.0 0.3 0.8 -0.3
Serious illness, injury or assault to yourself 0.4 0.5 1.4 -0.5 1.2 0.6 -0.5
High blood pressure 1.2 3.4 8.1 -1.6 2.9 1.1 -1.3
Hayfever, allergic rhinitis or eczema 0.1 0.2 0.7 -0.4 -0.8 -0.1 0.0
Multivitamins +/- minerals 4.5 5.7 8.2 -2.8 0.4 2.6 -2.9
Stomach or abdominal pain in last month 1.5 1.8 4.1 -0.9 2.0 1.0 -1.1
Supplements: Glucosamine 1.4 1.8 2.7 1.0 -1.6 -1.3 1.3
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 1.0 -0.7 -0.7 0.9 -1.0
Medication: Atenolol 0.8 1.0 1.6 1.3 -0.4 -1.2 0.8
Medication: Levothyroxine sodium 2.1 3.6 7.9 -2.8 0.7 1.7 -1.8
Sitting height 0.8 5.7 22.6 0.3 -4.8 0.4 -0.1
Chronic bronchitis/emphysema (father) 0.0 0.1 0.1 -0.2 -0.1 -0.3 0.3
High blood pressure (mother) 1.4 1.9 4.0 -1.4 2.0 1.1 -0.8
Body mass index (BMI) 3.0 12.9 20.4 4.5 -2.1 -3.5 3.8
Impedance of leg (left) 3.0 14.8 18.7 -3.9 4.3 3.6 -3.5
Leg predicted mass (left) 3.0 15.8 25.4 4.1 -5.0 -3.1 3.4
Trunk fat mass 2.1 9.2 18.5 4.3 -1.5 -2.6 3.0
Waist circumference 3.1 11.5 17.8 4.2 -2.9 -2.9 3.4
Number of incorrect matches in round 1.7 2.8 4.2 -2.0 0.5 2.0 -1.6
Past tobacco smoking 3.5 6.5 9.1 -2.9 3.0 1.6 -2.4
Alcohol usually taken with meals 1.0 1.6 3.1 0.5 -1.8 -1.4 1.0
Nervous feelings 3.3 6.1 13.4 -3.7 0.8 2.5 -2.0
Frequency of tenseness / restlessness in last 2 weeks 3.8 6.0 8.4 -2.1 2.9 2.1 -2.6
Hearing difficulty/problems with background noise 3.8 6.1 9.4 1.9 -2.1 -2.6 3.1
Hair/balding pattern: Pattern 2 5.8 7.4 8.5 -2.5 2.9 2.9 -2.6
Had menopause 0.1 0.2 0.4 -0.7 -0.2 0.4 -0.0
Had other major operations 0.7 0.8 2.4 0.3 -1.6 0.8 -0.1
Forced vital capacity (FVC) 1.0 3.8 11.8 0.9 -3.4 -1.0 1.2
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.2 0.2 -0.5 -0.5 -0.1 -0.4
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.4 -0.4 1.2 -0.1 0.9
Qualifications: None of the above 1.2 2.6 6.2 -0.9 2.5 1.5 -1.2
Financial difficulties in last 2 years 0.2 0.3 0.8 0.2 0.9 0.5 0.0
Mouth/teeth dental problems 1.2 1.9 3.8 -1.5 -2.0 0.9 -0.8
Heart attack 0.3 0.4 1.4 0.4 1.2 0.1 0.2
Allergy 0.1 0.2 0.4 0.7 0.5 0.1 -0.5
Pain all over the body in last month 1.5 1.6 2.7 -1.2 -0.8 1.4 -1.6
Diabetes (self-reported) 0.1 0.1 0.2 0.5 -0.4 0.4 0.1
Hayfever/allergic rhinitis (self-reported) 1.6 2.1 3.0 -1.7 -0.2 1.7 -1.6
Medication: Ramipril 0.5 0.6 1.5 -0.8 1.2 0.6 -0.4
Medication: Simvastatin 1.9 2.7 6.6 -1.3 2.6 1.5 -0.8
Fluid intelligence score 3.0 6.3 10.9 1.9 -1.3 -3.3 3.0
Illnesses of siblings 1.1 1.6 4.5 -1.0 -2.1 0.8 -0.4
Neuroticism score 1.1 2.2 3.1 -1.8 1.5 1.3 -1.4
Weight 3.0 14.8 21.5 4.6 -3.8 -3.2 3.6
Impedance of arm (right) 3.0 13.8 22.4 -3.2 4.7 3.2 -3.5
Arm fat percentage (right) 2.0 8.0 15.6 4.0 -0.3 -2.8 2.9
Trunk fat-free mass 2.8 16.1 33.6 3.5 -5.8 -2.9 3.2
Hip circumference 1.7 7.3 13.2 3.6 -2.2 -2.1 2.5
Time employed in main current job 0.8 1.0 1.8 1.4 -0.5 -0.9 1.0
Alcohol intake versus 10 years previously 0.4 0.6 1.5 -0.2 0.3 1.2 -0.9
Father’s age at death 0.1 0.2 0.5 -0.0 0.3 0.4 -0.7
Worrier / anxious feelings 6.2 11.7 19.3 -4.4 3.1 2.9 -3.1
Frequency of tiredness / lethargy in last 2 weeks 1.4 2.2 3.6 -1.5 -0.2 1.8 -1.9
Falls in the last year 0.9 1.2 3.3 0.3 -1.8 -0.8 0.9
Hair/balding pattern: Pattern 3 1.9 2.9 4.8 1.6 -2.2 -1.4 1.5
Number of live births 0.1 0.1 0.2 0.2 0.4 -0.4 0.1
Forced expiratory volume in 1-second (FEV1) 0.5 1.5 3.8 0.7 -1.9 -0.8 1.1
Pulse rate 3.3 5.5 17.3 1.5 -4.2 -1.2 1.1
Happiness 1.1 1.3 3.3 -0.3 1.8 0.9 -1.0
Noisy workplace 0.2 0.3 0.5 -0.7 0.7 0.3 -0.3
Qualifications: A levels/AS levels or equivalent 3.6 7.9 11.3 2.3 -3.4 -2.9 2.6
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 1.5 -1.2 0.6 0.1 -0.1
Mouth/teeth dental problems: Dentures 1.0 1.7 3.8 -1.4 2.0 0.9 -0.6
Asthma 2.3 4.6 8.9 -3.0 -0.6 2.5 -1.7
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 0.5 0.5 -0.6 -0.6 0.7
Medication: Cholesterol lowering 0.4 0.6 1.9 0.6 1.4 0.4 0.1
Depression (self-reported) 1.8 2.2 5.9 -2.4 -0.3 1.1 -1.2
Medication: Lansoprazole 3.3 3.7 6.1 2.0 -1.1 -1.9 2.5
Prospective memory result 2.1 2.6 4.2 -0.9 1.3 1.9 -2.1
Lung cancer (father) 2.1 2.4 3.3 -1.8 1.6 1.7 -1.1
Illnesses of mother 0.6 0.8 1.3 -1.0 0.0 0.9 -1.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.5 1.8 -0.0 -1.4 0.3 0.0
Pulse wave Arterial Stiffness index 0.3 0.3 0.4 -0.4 -0.6 0.7 -0.6
Impedance of arm (left) 2.6 12.1 22.2 -2.6 4.7 3.0 -3.2
Arm fat mass (right) 2.5 10.1 16.6 4.1 -2.1 -3.0 3.2
Trunk predicted mass 2.6 15.1 32.8 3.3 -5.7 -2.7 3.0
Standing height 0.4 4.4 16.6 0.9 -4.1 0.3 -0.0
Length of working week for main job 0.2 0.2 0.5 0.0 -0.2 -0.7 0.7
Exposure to tobacco smoke at home 2.1 2.3 3.2 -1.3 1.8 1.8 -1.2
Breastfed as a baby 3.2 4.0 6.4 2.5 -0.8 -2.3 1.9
Tense / ‘highly strung’ 1.3 2.1 4.9 -2.2 0.9 0.9 -1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 1.1 1.7 4.7 -2.2 0.3 1.1 -0.9
Hair/balding pattern: Pattern 4 2.7 6.6 8.4 2.1 -2.9 -2.7 2.5
Birth weight of first child 0.3 0.6 1.1 1.1 0.1 -0.8 0.7
Peak expiratory flow (PEF) 0.7 1.6 2.3 1.4 -0.8 -1.3 1.5
Pulse wave reflection index 1.6 1.9 2.9 -1.7 1.3 1.3 -1.3
Ever highly irritable/argumentative for 2 days 0.2 0.3 0.5 0.4 0.5 -0.5 0.7
Loud music exposure frequency 1.9 2.1 2.4 1.3 -1.5 -1.5 1.5
Qualifications: O levels/GCSEs or equivalent 4.1 6.6 9.0 3.0 -1.7 -2.8 2.6
Mouth/teeth dental problems: Bleeding gums 4.9 6.4 10.2 3.2 -0.3 -2.8 2.7
Blood clot in the leg (DVT) 1.6 2.0 2.8 1.4 1.1 -1.4 1.7
Medication: Paracetamol 1.1 1.9 2.7 -1.7 1.2 1.4 -1.2
Headache pain in last month 1.1 1.8 6.7 -0.3 2.6 0.4 -0.7
Medication for cholesterol, blood pressure or diabetes 0.6 1.0 2.5 0.4 -1.6 -1.1 0.4
Glaucoma (self-reported) 1.7 2.0 2.4 -1.4 1.2 1.6 -1.4
Gout (self-reported) 3.7 5.0 8.9 3.0 -0.1 -2.4 2.3
Hypothyroidism/myxoedema (self-reported) 2.7 5.2 9.7 -3.1 0.2 2.3 -2.5
Medication: Amlodipine 0.1 0.1 0.5 0.7 0.2 -0.1 0.2
Medication: Ventolin 100micrograms inhaler 4.3 5.5 8.1 -2.9 0.7 2.8 -2.4
Birth weight 0.2 0.4 0.7 0.8 0.5 0.5 -0.7
Chronic bronchitis/emphysema (mother) 0.7 0.8 1.1 -1.0 0.6 1.1 -1.0
High blood pressure (siblings) 0.5 0.8 2.2 1.5 0.5 -0.6 0.4
Forced vital capacity (FVC), Best measure 0.6 2.0 8.0 -0.1 -2.8 0.2 0.2
Body fat percentage 1.5 6.0 13.2 3.6 -0.0 -2.2 2.5
Leg fat percentage (right) 1.1 4.0 7.1 2.7 0.1 -2.0 2.2
Arm fat-free mass (right) 2.9 14.6 28.6 3.7 -5.3 -2.7 3.0
Exposure to tobacco smoke outside home 2.9 3.9 5.7 -1.2 2.1 2.4 -2.1
Comparative body size at age 10 1.6 4.5 7.1 2.6 0.5 -2.7 2.0
Number of full brothers 0.5 0.7 1.4 1.2 0.5 -0.7 0.8
Worry too long after embarrassment 0.1 0.2 0.5 -0.6 0.0 -0.1 0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 1.2 1.6 4.0 -2.0 -0.3 1.2 -0.8
Wheeze or whistling in the chest in last year 0.6 1.0 2.2 -1.5 0.2 1.1 -0.8
Number of children fathered 2.3 2.6 4.2 1.3 -1.0 -1.9 2.0
Reason for reducing amount of alcohol drunk: Health precaution 6.0 7.0 10.4 -3.2 0.9 2.8 -3.0
Age at first live birth 1.5 2.7 5.1 1.5 -2.3 -1.5 1.0
Pulse wave peak to peak time 0.1 0.1 0.3 0.2 0.2 -0.5 0.4
Health satisfaction 0.1 0.2 0.4 0.3 0.3 -0.6 0.3
Shortness of breath walking on level ground 0.1 0.2 0.3 -0.0 0.5 0.4 -0.5
Qualifications: College or University degree 0.5 1.5 5.2 0.0 -2.3 -1.0 -0.1
Eye problems/disorders: None of the above 0.5 0.5 1.7 0.5 -1.3 0.0 0.4
Mouth/teeth dental problems: Loose teeth 1.9 2.3 3.8 1.2 -1.3 -1.5 1.9
Emphysema/chronic bronchitis 0.4 0.5 0.9 -0.8 0.4 0.9 -0.6
Medication for pain relief, constipation, heartburn 1.0 1.8 3.1 0.9 -1.1 -1.8 1.4
Neck or shoulder pain in last month 0.6 0.8 1.7 -0.5 -0.7 1.3 -1.0
Medication: Blood pressure 0.2 0.4 0.9 -0.1 0.9 0.7 -0.2
Angina (self-reported) 0.1 0.1 0.5 0.1 0.2 0.7 -0.3
Migraine (self-reported) 1.1 1.4 2.8 0.8 -0.8 -1.7 1.2
Medication: Ibuprofen 0.3 0.3 0.6 0.4 -0.6 -0.7 0.5
Medication: Allopurinol 4.8 6.4 9.5 2.9 0.6 -2.7 3.1
Medication: Omeprazole 2.0 2.4 4.9 -1.2 0.9 2.2 -1.6
Medication: Seretide 50 evohaler 0.8 0.9 1.6 -0.7 1.1 1.3 -0.6
Mean time to correctly identify matches 5.3 10.1 15.5 -2.6 3.9 3.3 -2.7
Heart disease (mother) 1.3 1.6 3.2 1.4 -1.8 -0.7 0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.0 0.0 0.0 0.0 0.2 -0.0 -0.0
Whole body fat mass 2.3 9.8 18.5 4.3 -1.7 -2.8 3.1
Leg fat mass (right) 2.1 8.0 13.0 3.6 -1.9 -2.6 3.0
Arm predicted mass (right) 2.9 14.6 27.5 3.7 -5.2 -2.7 3.1
Pulse rate, automated reading 3.5 11.2 36.1 2.5 -6.0 -1.2 1.1
Alcohol intake frequency. 1.0 2.3 3.5 -1.6 1.9 1.2 -1.3
Comparative height size at age 10 0.5 3.0 4.0 2.0 -2.0 -1.4 1.4
Number of full sisters 1.8 2.2 7.1 1.2 2.7 -0.3 0.6
Suffer from ‘nerves’ 4.5 7.0 9.5 -3.1 1.8 3.0 -2.5
Overall health rating 0.5 1.0 2.4 -0.8 0.6 1.5 -0.8
Chest pain or discomfort 0.1 0.1 0.3 -0.6 -0.4 0.4 -0.0
Had major operations 0.3 0.3 0.8 -0.9 0.3 0.5 0.3
Age at last live birth 0.9 1.3 2.2 1.2 -0.6 -1.5 1.1
Family relationship satisfaction 0.2 0.2 0.7 -0.1 0.1 0.8 -0.5
Leg pain on walking 0.2 0.2 0.5 0.7 0.6 0.4 0.2
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.3 1.0 0.1 1.0 0.1 -0.1
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.3 0.1 -0.0 0.0 0.6
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 0.7 -0.4 -0.3 0.8 -0.8
Medication: Aspirin 0.5 0.6 2.0 1.4 -0.6 -0.3 0.4
Supplements: Vitamin C 0.1 0.1 0.1 -0.4 0.2 0.3 -0.3
Knee pain experienced in last month 0.3 0.5 1.1 -0.7 -0.4 1.0 -0.5
Hypertension (Self-reported) 1.1 3.2 7.6 -1.4 2.8 1.0 -1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.3 2.7 7.9 -1.1 2.8 0.9 -0.9
Illnesses of father: Heart disease 0.2 0.2 0.8 0.2 -0.9 0.1 -0.0
Illnesses of siblings: Diabetes 0.2 0.2 0.7 0.8 -0.1 0.4 -0.3
Smoking status: Previous 2.2 3.4 5.1 2.3 -2.3 -1.1 1.5
Forced expiratory volume in 1-second (FEV1), predicted 1.0 2.1 5.0 1.6 -2.2 -0.6 0.9
Whole body fat-free mass 3.0 17.0 32.3 3.9 -5.7 -3.0 3.3
Leg fat-free mass (right) 3.6 19.2 31.0 4.6 -5.6 -3.3 3.7
Arm fat percentage (left) 2.1 8.3 16.4 4.0 -0.1 -2.8 2.9
Average weekly red wine intake 1.7 2.5 7.6 0.5 -2.8 -1.1 0.9
Handedness (chirality/laterality): Left-handed 0.4 0.5 2.0 -0.3 1.4 -0.0 0.1
Mood swings 1.7 3.0 4.1 -1.7 1.7 1.5 -2.0
Loneliness, isolation 0.1 0.2 0.7 -0.1 0.8 0.2 -0.0
Long-standing illness, disability or infirmity 0.4 0.6 1.3 -0.7 0.1 1.1 -0.9
Ever had bowel cancer screening 2.4 2.8 4.8 -0.8 -1.7 2.2 -1.7
Diabetes diagnosed by doctor 0.4 0.6 1.7 0.6 -1.3 0.6 0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.7 -0.0 0.9 0.2 -0.4
Friendships satisfaction 0.5 0.7 2.2 0.1 1.5 0.4 -0.6
Qualifications: nursing, teaching 0.3 0.5 1.1 0.0 -1.1 -0.9 -0.0
Commuting to job workplace: Walk 0.2 0.2 0.4 -0.2 0.5 0.0 -0.6
Eye problems/disorders: Cataract 0.1 0.2 0.4 -0.1 -0.1 -0.6 0.5
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.5 0.2 0.7 0.5 -0.5
Medication for cholesterol 0.1 0.2 0.6 0.8 -0.4 -0.0 0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.5 1.8 4.8 -0.8 0.7 2.2 -1.1
Back pain experienced in last month 0.4 0.5 1.2 0.7 1.1 0.6 -0.3
Mineral and other dietary supplements 0.8 1.1 3.1 -0.2 1.8 0.6 -0.9
Breast cancer (self-reported) 1.7 2.1 3.2 -1.8 0.9 1.4 -1.5
Asthma (self-reported) 2.2 4.4 8.8 -3.0 -0.3 2.5 -1.7
Osteoporosis (self-reported) 3.0 3.7 6.1 2.1 -0.8 -2.0 2.5
Osteoarthritis (self-reported) 0.1 0.1 0.4 -0.2 -0.6 0.4 -0.0
Medication: Aspirin 0.3 0.4 1.4 1.2 -0.5 -0.1 0.1
Medication: Gliclazide 0.2 0.3 0.5 0.7 -0.7 0.2 0.2
Illnesses of father: None of the above (group 1) 0.6 0.8 1.0 1.0 0.7 -0.9 1.0
Smoking status: Current 1.9 3.1 6.9 1.2 -0.1 -2.0 2.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.0 2.0 2.7 -1.7 1.2 1.4 -1.4
Whole body water mass 3.0 16.8 32.6 3.9 -5.7 -3.0 3.3
Leg predicted mass (right) 3.5 18.9 31.0 4.5 -5.6 -3.3 3.6
Arm fat mass (left) 2.7 11.2 19.1 4.4 -2.0 -3.2 3.4
Number of self-reported non-cancer illnesses 1.6 2.8 5.2 -2.3 0.4 2.1 -1.1
Average weekly champagne plus white wine intake 0.8 1.1 2.0 1.4 -0.9 -1.3 0.4
Miserableness 1.4 2.5 2.9 -1.7 1.7 1.3 -1.6
Guilty feelings 0.2 0.4 1.1 0.1 -1.0 -0.5 0.4
Wears glasses or contact lenses 0.4 0.4 1.1 0.0 -0.2 -1.0 0.8
Ever taken oral contraceptive pill 0.3 0.3 0.4 0.6 -0.4 -0.7 0.6
Hearing aid user 0.7 0.7 2.9 -0.2 1.7 -0.1 -0.0
Mother’s age at death 5.9 7.4 11.6 3.4 -2.6 -2.5 2.2
Financial situation satisfaction 0.3 0.4 1.0 0.3 1.0 0.6 -0.1
Tinnitus: Yes, now most or all of the time 0.6 0.7 1.2 1.0 0.5 -0.6 1.1
Commuting to job workplace: Public transport 0.2 0.3 0.6 0.4 0.8 0.3 -0.5
Eye problems/disorders: Glaucoma 0.6 0.7 1.6 -0.5 1.3 0.7 -0.7
Medication: Blood pressure 0.5 0.9 3.0 -0.5 1.7 -0.4 -0.0
Pain type(s) experienced in last month: Hip pain 0.7 0.9 1.7 1.1 1.3 -0.5 0.5
Supplements: Fish oil (including cod liver oil) 0.4 0.5 1.3 -0.6 -1.1 0.4 -0.3
High cholesterol (Self-reported) 3.6 6.4 8.2 -2.5 1.9 2.9 -2.7
Medication: Bendroflumethiazide 1.8 2.7 3.3 -1.4 1.7 1.6 -1.8
Medication: Paracetamol 2.1 3.2 4.7 -2.2 1.9 1.5 -1.5
Medication: Lisinopril 4.5 5.8 8.9 -1.8 3.0 2.2 -2.5
Medication: Atorvastatin 0.4 0.5 1.5 0.0 -1.2 0.5 -0.4
Illnesses of father: High blood pressure 6.4 8.0 11.7 -3.4 1.6 3.1 -2.8
Alcohol drinker status: Never 0.0 0.1 0.1 -0.2 -0.2 -0.1 -0.4
Ever smoked 5.5 9.6 13.2 3.0 -3.6 -2.4 3.3
Basal metabolic rate 3.2 17.6 29.4 4.3 -5.4 -3.2 3.5
Leg fat percentage (left) 1.7 6.2 11.3 3.4 -0.6 -2.5 2.7
Arm fat-free mass (left) 3.1 15.6 30.1 3.6 -5.5 -2.9 3.3
Number of operations (self-reported) 0.3 0.5 1.1 -0.0 -0.9 1.0 -0.3
Average weekly beer plus cider intake 0.3 0.5 1.5 -0.0 1.2 0.6 -0.4
Irritability 0.5 0.8 1.3 1.1 -0.0 -1.1 0.8
Risk taking 2.1 3.0 6.1 1.7 -0.6 -2.5 1.7
Ever had prostate specific antigen (PSA) test 1.1 1.3 1.9 -0.8 -1.0 1.4 -1.3
Fractured/broken bones in last 5 years 0.3 0.4 1.4 -0.1 1.2 0.2 -0.1
Age started oral contraceptive pill 0.2 0.2 0.4 -0.5 -0.7 -0.2 -0.2
Diastolic blood pressure, automated reading 0.1 0.2 0.5 -0.6 0.7 0.2 0.2
Ever depressed for a whole week 0.1 0.2 0.6 0.2 0.2 -0.1 0.8
Unable to work because of sickness or disability 2.7 3.4 7.8 -1.4 2.8 1.5 -1.3
Commuting to job workplace: Cycle 1.0 1.2 2.1 1.4 -0.2 -1.4 0.7
Myopia 0.3 0.4 1.3 -1.1 -0.2 0.2 0.3
Vascular/heart problems diagnosed by doctor 1.4 3.9 10.8 1.3 -3.3 -1.1 1.4
Cholesterol lowering medication 0.4 0.6 0.9 -0.7 0.2 1.0 -0.9
Medication: Omeprazole (e.g. Zanprol) 2.8 3.4 6.6 -1.8 0.4 2.6 -1.8
Pain experienced in last month 1.1 1.8 2.4 0.6 -1.4 -1.5 1.6
Supplements: Calcium 4.5 5.0 6.5 2.3 -1.6 -2.3 2.5
Basal cell carcinoma (self-reported) 1.9 2.2 3.3 1.4 -0.7 -1.8 1.7
Heart attack/myocardial infarction (self-reported) 0.5 0.7 2.5 0.0 1.6 0.4 -0.1
Deep venous thrombosis (DVT) (self-reported) 1.7 2.2 3.0 1.6 1.0 -1.5 1.7
Heart disease (siblings) 0.3 0.3 1.0 -0.4 1.0 0.2 -0.4
Alcohol drinker status: Previous 1.1 1.2 2.3 -1.5 1.4 0.5 -0.4
Pack years of smoking 0.6 0.9 1.4 0.9 0.4 -1.2 1.2
Impedance of whole body 3.4 17.3 26.2 -3.7 5.1 3.8 -3.9
Leg fat mass (left) 2.6 10.1 16.5 4.1 -2.2 -2.9 3.2
Arm predicted mass (left) 2.7 13.8 28.5 3.5 -5.3 -2.5 2.9