Best TWAS P=4.52e-23 · Best GWAS P=2.33e-16 conditioned to 0.62
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | RP11-723O4.9 | 0.12 | 0.04 | lasso | 5 | 0.06 | 3.4e-05 | 1.7 | 5.7 | 1.0e-08 | -0.52 | 0.09 | 0.84 | FALSE |
| 2 | GTEx | Brain Cerebellar Hemisphere | RP11-723O4.2 | 0.29 | 0.02 | lasso | 4 | 0.07 | 6.2e-03 | 1.5 | 5.7 | 1.3e-08 | -0.09 | 0.10 | 0.15 | FALSE |
| 3 | GTEx | Testis | RPN1 | 0.30 | 0.15 | enet | 22 | 0.15 | 2.8e-07 | -4.3 | -5.2 | 1.5e-07 | 0.15 | 0.06 | 0.87 | TRUE |
| 4 | GTEx | Testis | HMCES | 0.75 | 0.56 | lasso | 8 | 0.55 | 8.4e-29 | 7.6 | 7.6 | 3.3e-14 | -0.15 | 0.16 | 0.84 | FALSE |
| 5 | METSIM | Adipose | COPG1 | 0.04 | 0.02 | bslmm | 303 | 0.03 | 7.6e-06 | 7.6 | -6.8 | 1.2e-11 | 0.33 | 0.10 | 0.87 | FALSE |
| 6 | YFS | Blood | H1FX | 0.02 | 0.01 | lasso | 3 | 0.01 | 1.4e-03 | -7.3 | 7.3 | 3.1e-13 | -0.84 | 0.11 | 0.41 | FALSE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | H1FX | 0.02 | 0.02 | lasso | 5 | 0.03 | 6.5e-07 | 7.7 | 9.8 | 1.3e-22 | -0.62 | 0.05 | 0.93 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | H1FX | 0.02 | 0.00 | blup | 36 | 0.00 | 5.1e-01 | -8.2 | 9.9 | 4.5e-23 | -0.65 | 0.01 | 0.66 | TRUE |
| 9 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | COL6A4P2 | 0.11 | 0.04 | blup | 45 | 0.05 | 2.9e-03 | -4.6 | -5.1 | 2.9e-07 | 0.12 | 0.02 | 0.55 | TRUE |