Best TWAS P=2.33e-11 · Best GWAS P=1.35e-10 conditioned to 0.0892
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | DHX36 | 0.05 | 0.06 | blup | 357 | 0.05 | 1.3e-06 | -5.7 | -5.8 | 8.1e-09 | -0.49 | 0.32 | 0.68 | FALSE |
2 | GTEx | Adipose Subcutaneous | ARHGEF26 | 0.10 | 0.06 | enet | 8 | 0.07 | 2.2e-06 | -5.8 | 5.8 | 8.6e-09 | 0.39 | 0.24 | 0.75 | FALSE |
3 | GTEx | Artery Tibial | ARHGEF26 | 0.11 | 0.12 | enet | 12 | 0.12 | 5.9e-10 | -5.7 | 5.2 | 1.6e-07 | 0.36 | 0.33 | 0.67 | FALSE |
4 | GTEx | Ovary | ARHGEF26 | 0.14 | 0.03 | enet | 15 | 0.06 | 1.4e-02 | 6.4 | 6.7 | 2.3e-11 | 0.81 | 0.03 | 0.76 | TRUE |
5 | GTEx | Pancreas | ARHGEF26 | 0.26 | 0.26 | lasso | 5 | 0.28 | 3.2e-12 | -5.6 | 6.6 | 5.1e-11 | 0.48 | 0.26 | 0.74 | FALSE |
6 | GTEx | Skin Not Sun Exposed Suprapubic | ARHGEF26 | 0.13 | 0.11 | lasso | 4 | 0.07 | 6.8e-05 | -5.6 | 6.2 | 5.4e-10 | 0.45 | 0.28 | 0.70 | FALSE |
7 | GTEx | Skin Sun Exposed Lower leg | ARHGEF26 | 0.10 | 0.08 | enet | 12 | 0.11 | 2.9e-09 | -5.7 | 5.7 | 1.6e-08 | 0.33 | 0.33 | 0.67 | FALSE |
8 | GTEx | Thyroid | ARHGEF26 | 0.09 | 0.07 | enet | 17 | 0.08 | 1.9e-06 | -5.8 | 5.8 | 6.2e-09 | 0.44 | 0.28 | 0.69 | FALSE |
9 | METSIM | Adipose | ARHGEF26 | 0.07 | 0.08 | lasso | 6 | 0.07 | 3.5e-11 | -5.7 | 5.9 | 4.6e-09 | 0.45 | 0.32 | 0.68 | FALSE |
10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SGEF | 0.04 | 0.04 | enet | 12 | 0.04 | 1.1e-05 | -5.5 | 6.3 | 3.7e-10 | 0.50 | 0.13 | 0.83 | FALSE |