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chr10:69,348,758-70,981,217

Best TWAS P=1.61e-12 · Best GWAS P=7e-10 conditioned to 0.337

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Visceral Omentum	DNA2	0.32	0.18	lasso	9	0.20	1.9e-10	-5.2	5.4	8.0e-08	-0.81	0.68	0.32	FALSE
2	GTEx	Artery Coronary	DNA2	0.12	0.12	lasso	5	0.12	5.3e-05	-5.1	5.4	6.6e-08	-0.85	0.07	0.81	FALSE
3	GTEx	Brain Hypothalamus	SLC25A16	0.20	0.19	lasso	5	0.14	3.6e-04	-5.2	-5.3	1.2e-07	0.83	0.11	0.33	FALSE
4	GTEx	Cells EBV-transformed lymphocytes	DNA2	0.32	0.14	lasso	2	0.10	2.9e-04	-5.2	5.2	1.6e-07	-0.84	0.11	0.77	FALSE
5	GTEx	Cells Transformed fibroblasts	SLC25A16	0.10	0.02	enet	25	0.01	2.5e-02	-3.5	-5.2	1.9e-07	0.63	0.75	0.13	FALSE
6	GTEx	Heart Atrial Appendage	PBLD	0.08	0.02	lasso	2	0.02	6.1e-02	-6.1	-6.6	4.0e-11	0.86	0.02	0.80	FALSE
7	GTEx	Lung	DNA2	0.22	0.17	enet	12	0.24	3.9e-18	-5.1	5.3	1.1e-07	-0.80	0.70	0.29	FALSE
8	GTEx	Pancreas	DNA2	0.12	0.06	enet	9	0.08	4.1e-04	-4.3	5.5	3.9e-08	-0.84	0.08	0.84	FALSE
9	GTEx	Skin Not Sun Exposed Suprapubic	DNA2	0.29	0.16	lasso	14	0.22	2.4e-12	-4.6	5.3	9.3e-08	-0.81	0.67	0.33	FALSE
10	NTR	Blood	SLC25A16	0.03	0.02	enet	16	0.03	1.7e-09	-5.1	-5.2	2.6e-07	0.88	0.04	0.96	FALSE
11	ROSMAP	Brain Pre-frontal Cortex	PBLD	0.04	0.01	bslmm	388	0.02	1.3e-03	-3.7	-5.2	1.7e-07	0.64	0.20	0.79	FALSE
12	ROSMAP	Brain Pre-frontal Cortex	SLC25A16	0.17	0.11	lasso	6	0.15	2.9e-19	-4.3	-5.5	5.0e-08	0.90	0.16	0.84	FALSE
13	YFS	Blood	SLC25A16	0.09	0.13	lasso	3	0.13	6.8e-39	-5.1	-5.4	5.4e-08	0.89	0.11	0.89	FALSE
14	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PBLD	0.06	0.07	lasso	2	0.04	2.3e-04	-5.9	-5.9	4.5e-09	0.47	0.00	1.00	FALSE
15	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLC25A16	0.01	0.02	lasso	2	0.01	5.5e-04	-5.2	-5.2	2.0e-07	0.84	0.18	0.49	FALSE
16	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	DNA2	0.08	0.09	lasso	1	0.06	7.3e-04	-6.2	6.2	7.3e-10	-1.00	0.00	0.99	FALSE
17	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ATOH7	0.05	0.01	lasso	3	0.02	2.6e-03	-5.9	5.2	1.8e-07	-0.46	0.01	0.81	FALSE
18	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PBLD	0.03	0.03	lasso	9	0.02	1.6e-03	-5.4	-5.4	7.2e-08	0.51	0.02	0.86	FALSE
19	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PBLD	0.10	0.03	lasso	3	0.04	2.2e-05	-5.9	-5.4	5.1e-08	0.46	0.00	1.00	FALSE
20	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ATOH7	0.08	0.04	enet	19	0.06	3.1e-04	-3.7	5.6	2.4e-08	-0.46	0.04	0.86	FALSE
21	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	DNA2	0.05	0.00	blup	43	0.00	3.0e-01	-5.3	5.5	4.0e-08	-0.86	0.01	0.83	FALSE
22	The Cancer Genome Atlas	Brain Lower Grade Glioma	SLC25A16	0.05	0.01	blup	42	0.02	2.9e-03	-5.3	-5.7	1.6e-08	0.76	0.07	0.82	FALSE
23	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SLC25A16	0.02	0.02	enet	8	0.02	7.7e-04	-6.2	-6.0	1.6e-09	0.97	0.01	0.90	FALSE
24	The Cancer Genome Atlas	Soft Tissue Sarcoma	SLC25A16	0.07	0.03	blup	42	0.02	1.7e-02	-6.2	-7.1	1.6e-12	0.92	0.01	0.93	TRUE
25	The Cancer Genome Atlas	Testicular Germ Cell Tumors	DNA2	0.14	0.07	blup	43	0.08	8.6e-04	-5.7	-5.7	1.1e-08	0.76	0.04	0.74	FALSE
26	The Cancer Genome Atlas	Thyroid Carcinoma	SLC25A16	0.05	0.05	lasso	3	0.04	3.8e-05	-5.1	-5.3	9.4e-08	0.83	0.07	0.80	FALSE