Best TWAS P=1.47e-08 · Best GWAS P=4.51e-07 conditioned to 0.925
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Colon Sigmoid | PRR12 | 0.20 | 0.01 | lasso | 8 | 0.00 | 4.9e-01 | 3.4 | 5.2 | 1.8e-07 | -0.28 | 0.03 | 0.18 | FALSE |
| 2 | GTEx | Esophagus Mucosa | AP2A1 | 0.18 | 0.09 | enet | 8 | 0.13 | 7.7e-09 | -4.5 | -5.7 | 1.5e-08 | 0.85 | 0.02 | 0.97 | TRUE |
| 3 | GTEx | Nerve Tibial | AP2A1 | 0.16 | 0.05 | lasso | 4 | 0.07 | 1.3e-05 | -4.5 | -5.6 | 2.0e-08 | 0.84 | 0.01 | 0.97 | FALSE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LIN7B | 0.02 | 0.00 | enet | 7 | 0.02 | 5.1e-05 | 4.6 | -5.4 | 6.0e-08 | 0.05 | 0.01 | 0.88 | TRUE |
| 5 | The Cancer Genome Atlas | Colon Adenocarcinoma | SNRNP70 | 0.05 | 0.02 | lasso | 3 | 0.02 | 2.9e-02 | 4.3 | -5.4 | 6.2e-08 | 0.08 | 0.01 | 0.59 | FALSE |