[Hub]/) : Traits : Leg predicted mass (right) :

chr1:22,197,336-24,216,118

Best TWAS P=5.53e-14 · Best GWAS P=1.54e-12 conditioned to 2.53e-05

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex HTR1D 0.11 0.07 enet 21 0.09 1.1e-10 -4.8 5.5 3.5e-08 0.01 0.19 0.81 FALSE
2 GTEx Brain Cortex LUZP1 0.23 0.14 lasso 5 0.10 7.8e-04 -6.6 6.7 2.9e-11 -0.02 0.02 0.80 TRUE
3 GTEx Cells Transformed fibroblasts LUZP1 0.09 0.09 lasso 4 0.08 2.8e-06 -6.6 6.6 3.5e-11 -0.02 0.01 0.99 FALSE
4 GTEx Testis LUZP1 0.17 0.09 lasso 4 0.08 2.6e-04 -6.0 -5.9 3.9e-09 0.07 0.13 0.56 FALSE
5 The Cancer Genome Atlas Breast Invasive Carcinoma WNT4 0.03 0.01 blup 72 0.02 3.8e-05 5.8 7.5 5.5e-14 0.46 0.24 0.53 TRUE
6 The Cancer Genome Atlas Colon Adenocarcinoma HTR1D 0.10 0.07 enet 7 0.08 3.8e-05 -5.1 5.9 2.8e-09 0.00 0.02 0.98 FALSE
7 The Cancer Genome Atlas Pancreatic Adenocarcinoma HTR1D 0.24 0.12 lasso 4 0.12 1.2e-05 -6.1 6.5 5.7e-11 -0.07 0.06 0.92 FALSE
8 The Cancer Genome Atlas Rectum Adenocarcinoma HTR1D 0.19 0.12 enet 11 0.13 7.3e-04 -6.7 6.0 2.2e-09 -0.01 0.01 0.89 FALSE