Best TWAS P=5.53e-14 · Best GWAS P=1.54e-12 conditioned to 2.53e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | HTR1D | 0.11 | 0.07 | enet | 21 | 0.09 | 1.1e-10 | -4.8 | 5.5 | 3.5e-08 | 0.01 | 0.19 | 0.81 | FALSE |
| 2 | GTEx | Brain Cortex | LUZP1 | 0.23 | 0.14 | lasso | 5 | 0.10 | 7.8e-04 | -6.6 | 6.7 | 2.9e-11 | -0.02 | 0.02 | 0.80 | TRUE |
| 3 | GTEx | Cells Transformed fibroblasts | LUZP1 | 0.09 | 0.09 | lasso | 4 | 0.08 | 2.8e-06 | -6.6 | 6.6 | 3.5e-11 | -0.02 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Testis | LUZP1 | 0.17 | 0.09 | lasso | 4 | 0.08 | 2.6e-04 | -6.0 | -5.9 | 3.9e-09 | 0.07 | 0.13 | 0.56 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | WNT4 | 0.03 | 0.01 | blup | 72 | 0.02 | 3.8e-05 | 5.8 | 7.5 | 5.5e-14 | 0.46 | 0.24 | 0.53 | TRUE |
| 6 | The Cancer Genome Atlas | Colon Adenocarcinoma | HTR1D | 0.10 | 0.07 | enet | 7 | 0.08 | 3.8e-05 | -5.1 | 5.9 | 2.8e-09 | 0.00 | 0.02 | 0.98 | FALSE |
| 7 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | HTR1D | 0.24 | 0.12 | lasso | 4 | 0.12 | 1.2e-05 | -6.1 | 6.5 | 5.7e-11 | -0.07 | 0.06 | 0.92 | FALSE |
| 8 | The Cancer Genome Atlas | Rectum Adenocarcinoma | HTR1D | 0.19 | 0.12 | enet | 11 | 0.13 | 7.3e-04 | -6.7 | 6.0 | 2.2e-09 | -0.01 | 0.01 | 0.89 | FALSE |