Best TWAS P=7.68e-11 · Best GWAS P=2.75e-10 conditioned to 0.892
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Cells Transformed fibroblasts | RP1-125I3.2 | 0.06 | 0.04 | enet | 19 | 0.03 | 3.3e-03 | 4.7 | -5.2 | 2.6e-07 | -0.50 | 0.10 | 0.36 | FALSE |
2 | GTEx | Esophagus Mucosa | PDIK1L | 0.10 | 0.09 | lasso | 6 | 0.09 | 8.8e-07 | 6.1 | -5.9 | 4.6e-09 | -0.95 | 0.02 | 0.98 | FALSE |
3 | GTEx | Thyroid | DHDDS | 0.14 | 0.08 | enet | 22 | 0.07 | 5.8e-06 | 5.3 | -5.1 | 2.9e-07 | -0.14 | 0.48 | 0.31 | TRUE |
4 | GTEx | Thyroid | CNKSR1 | 0.10 | 0.04 | lasso | 7 | 0.03 | 2.1e-03 | 5.1 | -5.4 | 5.7e-08 | -0.73 | 0.11 | 0.87 | FALSE |
5 | GTEx | Whole Blood | CEP85 | 0.07 | 0.01 | enet | 17 | 0.02 | 1.3e-02 | -2.7 | -5.2 | 2.3e-07 | -0.29 | 0.16 | 0.41 | FALSE |
6 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | TRIM63 | 0.03 | 0.02 | blup | 33 | 0.02 | 4.6e-03 | 6.2 | 6.0 | 2.6e-09 | 0.91 | 0.01 | 0.89 | FALSE |
7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TRIM63 | 0.15 | 0.16 | lasso | 2 | 0.16 | 2.3e-32 | 6.2 | 6.3 | 3.9e-10 | 0.97 | 0.00 | 1.00 | FALSE |
8 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | TRIM63 | 0.14 | 0.15 | lasso | 1 | 0.14 | 2.2e-07 | 6.2 | 6.2 | 5.6e-10 | 0.95 | 0.00 | 1.00 | FALSE |
9 | The Cancer Genome Atlas | Colon Adenocarcinoma | TRIM63 | 0.08 | 0.10 | lasso | 4 | 0.10 | 3.7e-06 | 6.0 | 5.7 | 9.2e-09 | 0.95 | 0.01 | 0.99 | FALSE |
10 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | GRRP1 | 0.11 | 0.02 | blup | 52 | 0.03 | 8.8e-05 | -3.0 | 5.2 | 2.3e-07 | 0.47 | 0.02 | 0.27 | FALSE |
11 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PDIK1L | 0.02 | 0.02 | blup | 37 | 0.02 | 2.8e-03 | 6.1 | -6.2 | 7.6e-10 | -0.93 | 0.01 | 0.83 | FALSE |
12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TRIM63 | 0.11 | 0.11 | enet | 4 | 0.12 | 9.0e-14 | 6.0 | 5.3 | 8.7e-08 | 0.95 | 0.01 | 0.99 | FALSE |
13 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PDIK1L | 0.03 | 0.01 | blup | 37 | 0.02 | 2.6e-03 | 5.1 | -6.5 | 7.7e-11 | -0.85 | 0.01 | 0.55 | TRUE |
14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TRIM63 | 0.29 | 0.33 | enet | 20 | 0.33 | 2.5e-38 | 6.0 | 6.4 | 1.8e-10 | 0.92 | 0.01 | 0.99 | FALSE |
15 | The Cancer Genome Atlas | Lung Adenocarcinoma | TRIM63 | 0.14 | 0.20 | enet | 7 | 0.21 | 9.4e-24 | 6.0 | 5.7 | 1.6e-08 | 0.95 | 0.01 | 0.99 | FALSE |
16 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | TRIM63 | 0.16 | 0.11 | lasso | 1 | 0.10 | 2.0e-11 | 6.0 | 6.0 | 1.5e-09 | 0.96 | 0.01 | 0.99 | FALSE |
17 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | TRIM63 | 0.14 | 0.18 | lasso | 7 | 0.15 | 3.0e-10 | 6.0 | 5.8 | 6.1e-09 | 0.95 | 0.01 | 0.99 | FALSE |
18 | The Cancer Genome Atlas | Thyroid Carcinoma | TRIM63 | 0.18 | 0.26 | enet | 7 | 0.26 | 3.0e-25 | 6.0 | 6.0 | 2.5e-09 | 0.94 | 0.01 | 0.99 | FALSE |
19 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | TRIM63 | 0.19 | 0.07 | blup | 33 | 0.14 | 1.3e-04 | 6.0 | 5.5 | 4.8e-08 | 0.88 | 0.01 | 0.99 | FALSE |