[Hub]/) : Traits : Leg predicted mass (right) :

chr3:182,655,858-186,072,370

Best TWAS P=6.12e-23 · Best GWAS P=3.01e-22 conditioned to 0.138

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex ECE2 0.24 0.20 bslmm 542 0.19 1.6e-22 8.9 8.7 3.1e-18 -0.37 0.60 0.40 FALSE
2 CommonMind Brain Pre-frontal Cortex SENP2 0.21 0.18 enet 33 0.19 4.2e-22 -5.5 5.6 2.5e-08 0.02 1.00 0.00 TRUE
3 GTEx Artery Tibial PSMD2 0.13 0.09 lasso 5 0.08 1.3e-06 -5.8 6.1 1.3e-09 -0.42 0.88 0.02 FALSE
4 GTEx Brain Cerebellum KLHL24 0.52 0.14 enet 26 0.16 1.9e-05 -5.0 5.5 4.0e-08 -0.04 0.04 0.94 TRUE
5 GTEx Brain Putamen basal ganglia ECE2 0.38 0.03 enet 22 0.11 1.4e-03 8.9 6.4 2.1e-10 -0.28 0.08 0.17 FALSE
6 GTEx Breast Mammary Tissue KLHL24 0.25 0.13 lasso 5 0.11 3.4e-06 -5.0 5.1 2.7e-07 -0.05 0.04 0.95 FALSE
7 GTEx Esophagus Mucosa ABCF3 0.11 0.10 lasso 3 0.08 3.6e-06 -5.6 5.8 8.6e-09 -0.31 0.37 0.54 TRUE
8 GTEx Pancreas ECE2 0.26 0.04 enet 24 0.09 1.2e-04 8.9 6.1 9.7e-10 -0.24 0.15 0.14 FALSE
9 GTEx Pituitary ECE2 0.52 0.30 lasso 7 0.23 1.5e-06 8.9 7.8 7.5e-15 -0.31 0.31 0.38 FALSE
10 GTEx Skin Sun Exposed Lower leg ABCF3 0.13 0.08 lasso 4 0.11 1.6e-09 5.4 7.2 7.4e-13 -0.36 0.98 0.01 FALSE
11 GTEx Skin Sun Exposed Lower leg PSMD2 0.13 0.14 lasso 4 0.15 1.4e-12 -5.8 5.8 6.0e-09 -0.39 1.00 0.00 FALSE
12 METSIM Adipose SENP2 0.06 0.04 lasso 5 0.03 6.2e-06 -5.4 -5.2 2.6e-07 -0.04 0.99 0.00 FALSE
13 YFS Blood PSMD2 0.26 0.22 lasso 5 0.24 2.4e-77 -5.8 5.6 1.9e-08 -0.39 1.00 0.00 FALSE
14 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma ETV5 0.03 0.01 blup 55 0.02 1.3e-03 -8.4 -8.2 3.4e-16 -0.04 0.01 0.86 TRUE
15 The Cancer Genome Atlas Brain Lower Grade Glioma ECE2 0.04 0.02 blup 61 0.03 3.5e-04 8.9 8.1 4.1e-16 -0.24 0.42 0.24 FALSE
16 The Cancer Genome Atlas Liver Hepatocellular Carcinoma ABCF3 0.08 0.03 blup 51 0.06 6.1e-04 2.3 5.2 1.6e-07 -0.25 0.01 0.80 FALSE
17 The Cancer Genome Atlas Lung Adenocarcinoma PSMD2 0.09 0.02 blup 50 0.05 1.2e-06 -9.2 9.9 6.1e-23 -0.73 0.03 0.86 TRUE
18 The Cancer Genome Atlas Lung Squamous Cell Carcinoma CAMK2N2 0.04 0.01 enet 8 0.03 3.9e-04 3.4 5.9 2.9e-09 -0.32 0.14 0.06 FALSE
19 The Cancer Genome Atlas Lung Squamous Cell Carcinoma PSMD2 0.05 0.00 enet 10 0.01 3.6e-02 8.9 7.0 3.6e-12 -0.49 0.01 0.10 FALSE
20 The Cancer Genome Atlas Testicular Germ Cell Tumors VWA5B2 0.10 0.04 blup 51 0.04 1.8e-02 5.4 -8.7 3.3e-18 0.43 0.03 0.33 FALSE