TWAS hub - CAMK2N2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0145	0.0090	0.00430	0.012	0.013	0.005	NA	0.009	0.0016	0.00074	0.02700	NA	0.0052
2	TCGA	Lung Squamous Cell Carcinoma	0.0385	0.0214	0.00082	0.010	0.020	0.027	NA	0.022	0.0250	0.00190	0.00039	NA	0.0014
3	TCGA	Thyroid Carcinoma	0.0520	0.0300	0.00170	0.025	0.032	0.019	NA	0.023	0.0017	0.00044	0.00570	NA	0.0024

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Seen doctor (GP) for nerves, anxiety, tension or depression	11.7	17.9	24.9	4.1	5.0	3.5
Guilty feelings	10.8	16.2	23.3	4.8	3.4	3.7
Seen a psychiatrist for nerves, anxiety, tension or depression	9.8	12.7	15.1	3.9	3.4	3.4
Bilateral oophorectomy (both ovaries removed)	9.6	11.1	15.3	-3.9	-2.8	-3.2
Medication for pain relief, constipation, heartburn	8.8	15.1	18.3	-4.3	-4.0	-3.3
Medication: Co-codamol	8.4	9.7	11.8	3.4	2.6	3.3
Cardiovascular Disease	7.4	24.5	37.6	4.9	6.1	3.4
Number of self-reported non-cancer illnesses	5.9	10.2	14.3	3.4	3.8	2.2
Medication: Simvastatin	5.8	8.6	11.8	3.1	3.4	2.2
High blood pressure (siblings)	5.4	7.7	9.4	2.7	3.1	2.6
Smoking status: Previous	5.4	8.0	13.4	2.7	3.7	1.8
Miserableness	5.4	9.3	10.5	3.2	3.2	2.7
Hand grip strength (right)	5.3	14.5	22.8	3.6	4.8	2.8
Hearing difficulty/problems with background noise	5.0	8.0	10.3	-3.2	-2.0	-3.1
Medication: Paracetamol	5.0	8.3	10.9	3.3	2.4	2.9
Hypertension (Self-reported)	5.0	13.8	24.5	3.4	4.9	2.3
Ever had hysterectomy (womb removed)	4.9	5.5	7.8	-2.8	-2.0	-2.1
Medication: Bendroflumethiazide	4.9	7.5	13.7	2.5	3.7	1.6
Average weekly champagne plus white wine intake	4.8	6.6	8.3	-2.9	-2.1	-2.7
Frequency of tiredness / lethargy in last 2 weeks	4.7	7.6	9.6	2.7	3.1	2.4
Medication: Paracetamol	4.7	7.3	8.9	3.0	2.5	2.6
High blood pressure	4.5	12.5	22.4	3.2	4.7	2.2
Nervous feelings	4.5	8.4	10.6	3.2	2.1	3.2
Noisy workplace	4.5	5.5	7.7	2.8	1.8	2.4
Illnesses of siblings	4.4	6.1	7.1	-2.5	-2.7	-2.2
Average weekly red wine intake	4.4	6.5	10.8	-3.3	-2.2	-2.0
Medication: Omeprazole (e.g. Zanprol)	4.4	5.4	7.3	2.1	2.7	2.0
Medication: Omeprazole	4.2	5.0	6.9	1.9	2.6	2.1
Impedance of leg (right)	4.0	19.2	51.6	-2.4	-7.2	-0.5
Impedance of leg (left)	3.8	18.4	50.6	-2.1	-7.1	-0.2
Reaction Time	3.7	7.1	10.1	-2.5	-3.2	-2.2
Neuroticism (Nagel 2018)	3.6	8.6	11.9	3.5	2.2	3.0
Number of treatments/medications taken	3.6	6.4	9.2	2.3	3.0	2.1
Alzheimer’s Disease (in mother)	3.5	4.1	5.2	-2.3	-1.6	-2.1
Neuroticism	3.4	8.3	10.5	3.2	2.0	3.2
Medication: Blood pressure	3.4	6.0	9.1	2.2	3.0	2.0
Hand grip strength (left)	3.2	8.5	14.7	2.5	3.8	2.1
Past tobacco smoking	3.2	5.9	12.7	-2.0	-3.6	-1.0
Neuroticism score	3.2	6.7	8.4	2.9	2.1	2.7
Age when periods started (menarche)	3.1	7.4	10.3	3.2	2.2	2.6
Medication for cholesterol, blood pressure or diabetes	3.1	5.2	6.7	-2.1	-2.6	-2.1
Qualifications: College or University degree	3.1	9.7	12.2	-3.5	-2.1	-3.5
Mean time to correctly identify matches	3.1	5.9	6.0	-2.5	-2.5	-2.4
Wheeze or whistling in the chest in last year	3.0	5.4	8.4	2.9	2.2	1.6
Qualifications: NVQ or HND or HNC or equivalent	3.0	3.6	5.6	2.4	1.5	1.7
Mouth/teeth dental problems: Loose teeth	2.8	3.3	5.1	2.0	0.9	2.3
Ever smoked	2.8	4.8	10.1	1.9	3.2	0.8
Alzheimer’s Disease (including proxy)	2.7	3.9	4.7	-2.2	-1.9	-1.9
Medication: Ibuprofen	2.7	3.3	4.4	2.1	1.5	1.7
Basal cell carcinoma (self-reported)	2.7	3.2	5.9	1.1	2.4	1.6
Worry too long after embarrassment	2.6	4.4	5.9	2.4	2.1	1.8
Knee pain experienced in last month	2.6	4.1	7.0	2.0	2.6	1.2
Mineral and other dietary supplements	2.6	3.6	5.5	-2.4	-1.5	-1.7
Leg fat-free mass (right)	2.5	13.3	36.2	1.9	6.0	0.4
Worry (Nagel 2018)	2.4	5.1	7.7	2.6	1.1	2.8
Fed-up feelings	2.4	4.3	6.0	2.4	1.9	1.9
Medication: Lansoprazole	2.4	2.7	5.1	1.6	2.3	0.8
Number of full sisters	2.4	3.0	4.5	2.1	1.4	1.6
Leg predicted mass (right)	2.4	12.9	35.2	1.8	5.9	0.4
Medication: Blood pressure	2.4	4.5	9.8	1.8	3.1	0.7
Vascular/heart problems diagnosed by doctor	2.4	6.6	12.6	-2.2	-3.5	-1.5
Major Depression (MDD)	2.3	2.8	3.1	1.8	1.8	1.5
Ovarian Cancer	2.3	3.0	3.8	-2.0	-1.3	-1.9
Medication: Ibuprofen (e.g. Nurofen)	2.3	2.9	4.6	2.1	1.0	1.8
Ever had stillbirth, spontaneous miscarriage or termination	2.3	2.4	3.4	1.7	1.0	1.8
Breast cancer (self-reported)	2.3	2.7	3.4	1.8	1.5	1.6
Impedance of whole body	2.3	11.9	33.3	-1.6	-5.8	0.3
Systolic Blood Pressure	2.2	11.2	16.2	3.3	4.0	2.6
Leg fat-free mass (left)	2.2	11.6	32.1	1.6	5.7	0.3
Medication: Aspirin	2.2	2.9	6.3	1.4	2.5	0.6
Depressed Affect (Nagel 2018)	2.1	4.4	5.6	2.4	1.8	2.1
Other serious medical condition/disability diagnosed by doctor	2.1	2.7	4.0	1.8	2.0	1.0
Leg predicted mass (left)	2.1	11.1	31.0	1.5	5.6	0.3
Qualifications: A levels/AS levels or equivalent	2.1	4.7	7.3	-2.7	-0.7	-2.5
Supplements: Fish oil (including cod liver oil)	2.1	2.7	4.3	2.1	1.2	1.6
Neuroticism (2016)	2.0	2.9	3.1	1.6	1.7	1.8
Qualifications: None of the above	2.0	4.2	7.0	2.3	0.7	2.6
Medication: Cholesterol lowering	2.0	3.1	4.5	1.6	2.1	1.5
Headache pain in last month	2.0	3.4	4.8	2.2	1.8	1.4
Mood swings	2.0	3.7	4.3	2.1	2.1	1.6
Back pain experienced in last month	2.0	2.9	4.3	2.1	1.3	1.6
Schizophrenia vs Biploar Disorder	1.9	2.5	3.3	-1.8	-1.2	-1.7
Systolic blood pressure, automated reading	1.9	5.4	7.2	2.3	2.7	1.9
Qualifications: CSEs or equivalent	1.9	2.6	3.8	1.9	1.0	1.7
Pulse wave Arterial Stiffness index	1.9	2.2	4.0	1.6	0.4	2.0
Medication: Aspirin	1.9	2.5	5.3	1.3	2.3	0.5
Frequency of depressed mood in last 2 weeks	1.8	2.5	3.7	1.9	0.4	1.9
Townsend deprivation index at recruitment	1.8	2.5	3.8	1.9	1.7	0.9
Illness, injury, bereavement, stress in last 2 years	1.8	2.2	2.3	-1.4	-1.5	-1.5
Risk taking	1.8	2.6	4.2	-1.7	-2.0	-0.8
Diastolic blood pressure, automated reading	1.8	5.6	7.3	2.7	1.9	2.4
Diabetes (father)	1.7	2.1	2.8	1.7	1.3	1.4
Heart disease (mother)	1.7	2.1	5.6	0.7	2.4	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.7	1.9	3.8	1.4	2.0	0.4
Whole body fat-free mass	1.7	9.7	27.8	1.2	5.3	-0.2
Smoking Status	1.6	3.8	7.9	1.8	2.8	0.4
Hypothyroidism (self reported)	1.6	3.7	5.1	1.9	2.2	1.6
Time employed in main current job	1.6	1.8	3.7	0.9	1.9	1.0
Exposure to tobacco smoke at home	1.6	1.8	2.2	1.1	1.5	1.4
Pulse wave peak to peak time	1.6	1.9	3.4	-1.5	-0.2	-1.9
Alcohol intake frequency.	1.6	3.7	5.4	1.8	2.3	1.6
Suffer from ‘nerves’	1.6	2.6	2.6	1.6	1.6	1.6
Ever had bowel cancer screening	1.6	1.8	2.8	1.7	1.1	1.3
Whole body water mass	1.6	9.4	26.8	1.2	5.2	-0.2
Basal metabolic rate	1.6	8.7	24.6	1.2	5.0	0.0
Primary Biliary Cirrhosis	1.5	2.1	4.7	1.1	2.2	-0.4
High blood pressure (mother)	1.5	2.1	4.0	1.2	2.0	1.0
Qualifications: O levels/GCSEs or equivalent	1.5	2.4	3.8	-1.7	0.8	-1.9
Chest pain or discomfort	1.5	2.1	5.1	1.1	2.3	-0.3
Commuting to job workplace: Public transport	1.5	1.8	2.3	-1.5	-1.2	-1.3
Illnesses of father: High blood pressure	1.5	1.9	2.4	1.3	1.6	1.2
Number of operations (self-reported)	1.5	2.2	4.3	-2.1	-0.9	-1.2
Intelligence (Savage-Jansen 2018)	1.4	4.2	6.8	-2.6	-0.5	-2.3
Body Mass Index (BMI) (2010)	1.4	1.9	4.0	1.0	2.0	0.9
Mean Putamen Volume	1.4	1.6	4.1	0.7	-0.6	2.0
HbA1C	1.4	1.5	2.9	1.7	0.5	1.2
Ever unenthusiastic/disinterested for a whole week	1.4	1.7	2.1	1.4	1.4	0.9
Hypothyroidism/myxoedema (self-reported)	1.4	2.7	3.6	1.6	1.9	1.4
Forced expiratory volume in 1-second (FEV1), predicted	1.4	2.9	3.6	1.8	1.9	1.3
Medication for cholesterol	1.4	2.1	4.8	-1.1	-2.2	-0.6
Trunk fat-free mass	1.3	7.4	21.5	0.8	4.6	-0.5
Worrier / anxious feelings	1.3	2.5	2.8	1.7	1.6	1.5
Depression (self-reported)	1.3	1.6	1.9	1.4	1.0	1.3
Trunk predicted mass	1.3	7.4	21.2	0.8	4.6	-0.5
Pulse wave reflection index	1.3	1.7	2.0	1.4	1.2	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	2.4	1.5	0.8	1.2
Supplements: Vitamin C	1.3	1.5	2.2	1.4	-0.5	1.5
Ever had prostate specific antigen (PSA) test	1.3	1.5	2.9	1.2	1.7	0.5
Lupus	1.2	1.8	3.0	1.4	1.7	0.5
Chronotype (morning person)	1.2	2.8	3.9	-2.0	-1.4	-1.6
Medication: Atenolol	1.2	1.4	3.7	0.7	1.9	0.3
Impedance of arm (left)	1.2	5.6	15.4	-0.9	-3.9	0.7
Arm fat-free mass (right)	1.2	5.9	16.9	0.9	4.1	-0.3
Number of children fathered	1.2	1.3	2.2	1.5	0.2	1.4
Wears glasses or contact lenses	1.2	1.4	2.0	-1.4	-1.0	-1.1
Heart attack/myocardial infarction (self-reported)	1.2	1.5	3.1	1.2	1.8	0.4
Arm predicted mass (left)	1.2	6.3	18.2	0.8	4.3	-0.4
Lung FVC	1.1	5.5	7.6	2.1	2.1	2.8
Hearing difficulty/problems: Yes	1.1	1.7	2.7	-1.4	-0.6	-1.6
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.8	3.1	1.5	-0.4	1.8
Had other major operations	1.1	1.3	2.3	-1.5	-0.7	-1.1
Angina (self-reported)	1.1	1.4	4.0	0.6	2.0	-0.2
Arm predicted mass (right)	1.1	5.7	16.1	0.9	4.0	-0.2
Eye problems/disorders: Cataract	1.1	1.3	1.6	1.2	1.2	1.0
Pain type(s) experienced in last month: Hip pain	1.1	1.4	2.5	0.9	1.6	1.0
Alcohol drinker status: Never	1.1	1.3	2.6	0.7	1.6	1.0
Arm fat-free mass (left)	1.1	5.7	16.5	0.6	4.1	-0.4
Heart disease (siblings)	1.1	1.4	3.0	1.0	1.7	0.2
Depression (Nagel 2018)	1.0	1.5	2.3	1.5	-0.2	1.5
BMI	1.0	5.7	14.7	1.3	3.8	0.7
Angina	1.0	1.3	3.5	0.7	1.9	-0.1
Taking other prescription medications	1.0	1.6	3.0	1.0	1.7	0.9
Stomach or abdominal pain in last month	1.0	1.3	2.3	1.5	0.9	0.9
Impedance of arm (right)	1.0	4.7	13.1	-1.0	-3.6	0.4
Arm fat mass (right)	1.0	4.0	9.6	1.3	3.1	0.8
Peak expiratory flow (PEF)	1.0	2.4	4.1	1.1	2.0	1.4
Arm fat mass (left)	1.0	4.2	9.7	1.4	3.1	1.0
Unable to work because of sickness or disability	1.0	1.3	1.6	1.2	1.0	1.2
Age at First Birth	0.9	1.3	2.7	-1.1	-1.6	-0.4
Blood Platelet Count	0.9	10.7	31.5	-0.8	-5.6	0.3
Supplements: Glucosamine	0.9	1.2	1.7	1.3	0.6	1.2
Weight	0.9	4.5	12.7	0.8	3.6	0.2
Mouth/teeth dental problems: Dentures	0.9	1.4	2.9	1.1	1.7	0.6
Chronic bronchitis/emphysema (mother)	0.9	1.1	1.3	1.1	1.1	0.9
Shortness of breath walking on level ground	0.9	1.1	1.3	1.0	1.0	1.2
Pulse rate, automated reading	0.9	2.9	6.5	-0.1	-2.5	1.5
Illnesses of father: Heart disease	0.9	1.2	2.8	0.8	-0.3	1.7
Medication: Atorvastatin	0.9	1.1	2.1	-1.5	-0.9	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	3.1	0.5	1.8	-0.2
Bipolar Disorder or Schizophrenia	0.8	1.9	3.5	1.0	1.1	1.9
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	2.2	0.3	1.5	-0.5
Chronic bronchitis/emphysema (father)	0.8	1.0	1.4	-1.0	-1.2	-0.6
Body mass index (BMI)	0.8	3.2	8.7	0.9	3.0	0.5
Number of incorrect matches in round	0.8	1.3	2.2	1.3	-0.1	1.5
Forced vital capacity (FVC)	0.8	3.1	5.4	1.3	2.3	1.4
Birth weight of first child	0.8	1.4	2.2	-1.5	-0.5	-1.3
Birth weight	0.8	1.8	4.0	-2.0	0.1	-1.2
Forced vital capacity (FVC), Best measure	0.8	2.8	4.1	1.3	2.0	1.7
Had major operations	0.8	1.0	1.4	-1.2	-0.7	-1.0
Illnesses of father: None of the above (group 1)	0.8	0.9	2.0	-0.7	0.5	-1.4
High cholesterol (Self-reported)	0.8	1.4	1.8	0.8	1.3	1.3
Pain experienced in last month	0.8	1.4	1.9	-1.4	-0.7	-1.3
Breast Cancer	0.7	1.6	2.3	0.9	-1.3	1.5
Fasting Glucose	0.7	0.8	2.0	0.6	0.3	1.4
Arm fat percentage (right)	0.7	2.8	5.0	1.4	2.2	1.2
Falls in the last year	0.7	0.9	2.2	-0.8	-1.5	-0.2
Blood clot in the leg (DVT)	0.7	0.9	2.3	0.2	1.5	-0.5
Medication: Amlodipine	0.7	0.9	2.5	0.5	1.6	0.3
Medication: Lisinopril	0.7	0.8	1.3	0.8	1.2	0.8
Schizophrenia (2018)	0.6	1.2	2.1	0.9	0.8	1.5
Supplements: Zinc	0.6	0.6	0.8	0.8	0.7	0.9
Medication: Levothyroxine sodium	0.6	1.0	1.7	1.0	0.5	1.3
Mouth/teeth dental problems	0.6	1.0	1.9	-1.0	-1.4	-0.2
Heart attack	0.6	0.7	1.6	0.7	1.3	0.1
Pulse rate	0.6	1.0	2.6	0.2	-1.6	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.5	0.7	0.5	1.2
Illnesses of mother	0.6	0.7	2.1	0.0	-1.5	0.2
Age at first live birth	0.6	1.0	1.6	-1.3	-1.2	-0.3
Age at last live birth	0.6	0.8	1.6	-1.3	-0.6	-0.7
Arm fat percentage (left)	0.6	2.6	4.0	1.4	2.0	1.4
Osteoporosis (self-reported)	0.6	0.7	2.0	0.2	1.4	0.2
Bipolar Disorder (2018)	0.5	0.7	1.3	0.4	0.8	1.1
Waist Hip Ratio (WHR)	0.5	2.2	3.3	1.7	-0.6	1.8
Severe depression (siblings)	0.5	0.5	1.5	0.3	1.2	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.5	1.2	-0.3	0.6
Multivitamins +/- minerals	0.5	0.6	0.9	-0.1	1.0	-1.0
Trunk fat mass	0.5	2.2	4.4	1.1	2.1	1.1
Hair/balding pattern: Pattern 2	0.5	0.6	1.2	-0.4	1.1	-0.6
Breastfed as a baby	0.5	0.6	1.5	-0.6	-1.2	-0.2
Eye problems/disorders: None of the above	0.5	0.6	1.1	-0.7	-0.3	-1.0
Family relationship satisfaction	0.5	0.6	1.1	0.7	0.5	1.1
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.1	1.0	0.8	0.2
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.1	-0.6	0.6	-1.1
Long-standing illness, disability or infirmity	0.5	0.8	1.4	0.8	1.2	0.6
Qualifications: nursing, teaching	0.5	0.8	2.1	0.4	1.4	0.0
Leg fat mass (left)	0.5	1.8	4.1	0.8	2.0	0.8
Crohns Disease (2017)	0.4	0.8	1.3	1.0	1.1	0.1
Coronary Artery Disease (CAD)	0.4	0.5	1.4	0.1	1.2	-0.3
Height	0.4	7.5	21.3	1.1	4.6	-0.1
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.9	-0.4	0.6	-1.4
Waist circumference	0.4	1.3	3.7	0.4	1.9	0.3
Diabetes (self-reported)	0.4	0.6	1.3	-0.0	0.7	-1.1
Alcohol intake versus 10 years previously	0.4	0.7	1.1	0.9	1.0	-0.2
Happiness	0.4	0.5	0.8	0.8	0.1	0.9
Lung cancer (father)	0.4	0.5	1.5	-0.3	0.1	-1.2
Length of working week for main job	0.4	0.4	1.0	-0.4	-0.0	-1.0
Loud music exposure frequency	0.4	0.4	0.9	0.1	0.7	-0.9
Medication: Allopurinol	0.4	0.5	1.1	0.6	0.4	1.0
Whole body fat mass	0.4	1.8	4.3	0.8	2.1	0.7
Illnesses of siblings: Diabetes	0.4	0.5	0.7	-0.9	-0.7	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	0.9	-0.5	-0.9	-0.7
Medication: Gliclazide	0.4	0.5	1.0	-1.0	0.0	-0.7
Hearing aid user	0.4	0.4	0.9	0.9	-0.1	0.6
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.2	0.5	-0.3	1.1
Average weekly beer plus cider intake	0.4	0.5	1.0	1.0	-0.2	0.7
Ever depressed for a whole week	0.4	0.5	1.0	0.6	1.0	0.3
Commuting to job workplace: Cycle	0.4	0.5	1.0	0.7	-0.4	1.0
Cholesterol lowering medication	0.4	0.5	0.6	0.6	0.8	0.8
Alzheimer’s Disease (in father)	0.3	0.3	0.6	-0.1	-0.8	0.5
Triglycerides	0.3	0.5	1.1	0.5	1.1	-0.3
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.7	-0.0	0.7	-0.8
Blood Eosinophil Count	0.3	2.0	4.1	1.2	2.0	0.8
Respiratory disease	0.3	0.6	0.8	-0.6	-0.8	-0.9
Lung FEV1/FVC ratio	0.3	1.3	2.1	-1.4	-0.6	-1.2
Medication: Metformin	0.3	0.4	0.8	-0.5	0.3	-0.9
Pack years adult smoking proportion	0.3	0.4	1.1	1.1	-0.3	0.2
Trunk fat percentage	0.3	1.2	1.9	0.9	0.9	1.4
Alcohol usually taken with meals	0.3	0.5	0.8	-0.8	-0.9	0.4
Fluid intelligence score	0.3	0.7	1.1	-1.0	0.5	-0.8
Hip circumference	0.3	1.2	2.0	-0.9	1.4	-0.9
Number of live births	0.3	0.4	0.8	-0.4	-0.2	-0.9
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	2.4	0.2	1.6	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	1.6	0.5	1.3	1.1
Medication: Ventolin 100micrograms inhaler	0.3	0.3	0.5	-0.4	-0.7	0.6
Comparative body size at age 10	0.3	0.8	1.3	-1.1	0.5	-0.9
Health satisfaction	0.3	0.4	0.6	-0.4	-0.7	-0.8
Migraine (self-reported)	0.3	0.4	0.6	0.8	0.5	0.6
Leg fat mass (right)	0.3	1.3	3.3	0.5	1.8	0.6
Overall health rating	0.3	0.6	0.8	0.9	0.9	0.6
Osteoarthritis (self-reported)	0.3	0.4	1.0	0.5	-0.2	1.0
Financial situation satisfaction	0.3	0.4	0.7	0.7	0.0	0.9
Eye problems/disorders: Glaucoma	0.3	0.3	1.0	0.2	0.1	1.0
Supplements: Calcium	0.3	0.3	0.7	0.4	0.8	0.1
Verbal and Numeric Reasoning (VNR)	0.2	0.5	0.7	-0.6	0.8	-0.6
Prostate Cancer	0.2	0.3	0.5	0.7	-0.3	0.4
LDL Cholesterol	0.2	0.3	0.8	0.2	-0.9	0.1
Schizophrenia (2014)	0.2	0.4	0.6	0.1	0.8	0.7
Ulcerative Colitis	0.2	0.3	0.5	-0.0	0.7	-0.5
Blood White Count	0.2	1.1	1.7	0.9	-0.9	1.3
Allergy or Eczema	0.2	0.5	1.2	0.3	1.1	0.4
Relative age of first facial hair	0.2	0.4	0.9	-0.6	-0.9	0.3
Average weekly fortified wine intake	0.2	0.3	0.8	-0.1	-0.9	-0.1
Maternal smoking around birth	0.2	0.3	0.9	-0.3	-1.0	-0.2
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.5	-0.4	-0.7	-0.1
Serious illness, injury or assault to yourself	0.2	0.3	0.8	0.2	0.9	0.3
Sitting height	0.2	1.1	2.6	0.1	1.6	-0.9
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.5	-0.4	-0.7	-0.5
Body fat percentage	0.2	0.7	1.3	0.6	0.5	1.1
Exposure to tobacco smoke outside home	0.2	0.2	0.5	0.5	0.7	0.0
Number of full brothers	0.2	0.3	0.3	-0.5	0.4	-0.5
Emphysema/chronic bronchitis	0.2	0.2	0.5	0.0	0.7	-0.1
Neck or shoulder pain in last month	0.2	0.3	0.8	0.3	-0.1	0.9
Comparative height size at age 10	0.2	1.0	2.3	-0.2	1.5	-0.8
Leg pain on walking	0.2	0.2	0.5	0.3	0.2	0.7
Diabetes diagnosed by doctor	0.2	0.3	0.6	0.0	0.6	-0.7
Pack years of smoking	0.2	0.3	0.8	0.9	-0.2	0.0
Irritable Bowel Disease (IBD)	0.1	0.3	0.4	0.5	0.6	-0.3
Crohns Disease (2012)	0.1	0.1	0.2	0.5	-0.1	0.1
Blood Red Count	0.1	1.2	3.0	-0.4	1.7	-0.6
Tanning	0.1	1.3	2.0	1.2	1.4	0.6
Average weekly spirits intake	0.1	0.1	0.2	-0.4	-0.5	-0.3
Sensitivity / hurt feelings	0.1	0.1	0.1	0.4	0.2	0.3
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.3	-0.5	0.3	-0.0
Vitamin and mineral supplements	0.1	0.1	0.2	-0.4	-0.3	0.2
Diabetes (mother)	0.1	0.1	0.3	-0.3	0.5	0.1
Current tobacco smoking	0.1	0.2	0.4	0.3	0.6	0.2
Relative age voice broke	0.1	0.2	0.5	0.5	0.1	0.7
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.4	-0.6	0.3	-0.3
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.1	0.4	-0.0	0.4
Had menopause	0.1	0.1	0.2	0.1	0.4	0.1
Financial difficulties in last 2 years	0.1	0.1	0.2	-0.2	-0.4	0.2
Allergy	0.1	0.3	0.6	0.2	-0.8	0.5
Medication: Ramipril	0.1	0.1	0.3	0.0	0.5	-0.2
Asthma	0.1	0.2	0.3	0.6	0.2	0.4
Prospective memory result	0.1	0.1	0.2	0.4	0.4	-0.3
Standing height	0.1	1.5	4.2	0.4	2.1	-0.2
Tense / ‘highly strung’	0.1	0.2	0.4	0.3	-0.5	0.6
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.4	-0.1	0.3	-0.6
Leg fat percentage (right)	0.1	0.2	0.6	0.2	-0.2	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.2	-0.4	-0.2	-0.5
Medication: Seretide 50 evohaler	0.1	0.1	0.2	0.2	0.3	-0.5
Loneliness, isolation	0.1	0.1	0.1	0.3	0.3	0.1
Commuting to job workplace: Walk	0.1	0.2	0.3	-0.5	0.2	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	0.2	0.4	0.0
Asthma (self-reported)	0.1	0.2	0.3	0.6	0.3	0.4
Smoking status: Current	0.1	0.1	0.2	0.2	0.5	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.3	-0.0	0.6	0.4
Ever taken oral contraceptive pill	0.1	0.1	0.3	0.0	0.2	-0.5
Mother’s age at death	0.1	0.1	0.3	-0.4	-0.0	-0.5
Leg fat percentage (left)	0.1	0.5	1.1	0.6	0.1	1.1
Fractured/broken bones in last 5 years	0.1	0.1	0.2	0.0	0.2	-0.5
Age started oral contraceptive pill	0.1	0.1	0.3	0.2	0.6	0.2
Myopia	0.1	0.1	0.3	0.1	0.6	-0.1
Alcohol drinker status: Previous	0.1	0.1	0.1	-0.3	-0.2	0.2
Ulcerative Colitis (UC)	0.0	0.0	0.1	0.2	0.1	-0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
HDL Cholesterol	0.0	0.1	0.2	-0.2	-0.4	0.1
Rheumatoid Arthritis	0.0	0.0	0.0	0.0	0.1	-0.1
Heel T-Score	0.0	0.4	0.9	-0.4	0.0	-0.9
Hair Pigment	0.0	0.1	0.1	0.3	-0.4	0.1
Medication for hormone replacement therapy	0.0	0.0	0.0	-0.2	0.0	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.2	-0.4	-0.1	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.0	0.0	-0.0	-0.1	-0.1
Pain all over the body in last month	0.0	0.0	0.0	0.0	-0.0	0.1
Father’s age at death	0.0	0.0	0.1	-0.0	0.3	0.1
Hair/balding pattern: Pattern 3	0.0	0.0	0.1	-0.0	-0.3	-0.0
Hair/balding pattern: Pattern 4	0.0	0.0	0.0	0.2	0.0	-0.1
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.0	0.2	-0.1	0.0
Glaucoma (self-reported)	0.0	0.0	0.1	0.1	0.1	0.3
Gout (self-reported)	0.0	0.1	0.2	-0.4	-0.0	-0.2
Friendships satisfaction	0.0	0.0	0.0	-0.2	-0.2	0.2
Irritability	0.0	0.1	0.2	0.1	-0.5	0.1

Hub : Genes

CAMK2N2

Models

Trait associations