Best TWAS P=4.89e-18 · Best GWAS P=3.82e-18 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | PEF1 | 0.04 | 0.04 | lasso | 4 | 0.03 | 2.8e-04 | -5.2 | 5.2 | 1.9e-07 | -0.01 | 0.63 | 0.27 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | TMEM54 | 0.05 | 0.00 | blup | 281 | 0.02 | 4.5e-03 | 1.7 | -7.6 | 2.5e-14 | 0.50 | 0.11 | 0.23 | FALSE |
3 | CommonMind | Brain Pre-frontal Cortex | ZNF362 | 0.05 | 0.06 | lasso | 1 | 0.06 | 2.2e-07 | -8.7 | -8.7 | 4.9e-18 | 0.98 | 0.01 | 0.99 | TRUE |
4 | GTEx | Artery Aorta | PEF1 | 0.15 | 0.05 | lasso | 5 | 0.04 | 2.2e-03 | -5.7 | 6.3 | 2.3e-10 | -0.05 | 0.30 | 0.43 | TRUE |
5 | GTEx | Cells EBV-transformed lymphocytes | KPNA6 | 0.19 | 0.14 | enet | 18 | 0.10 | 4.9e-04 | 4.8 | 5.5 | 2.9e-08 | -0.03 | 0.19 | 0.18 | FALSE |
6 | GTEx | Cells EBV-transformed lymphocytes | PHC2 | 0.58 | 0.34 | lasso | 7 | 0.28 | 7.3e-10 | -8.6 | 8.3 | 1.1e-16 | -0.99 | 0.02 | 0.98 | FALSE |
7 | GTEx | Colon Sigmoid | PEF1 | 0.16 | 0.09 | lasso | 3 | 0.09 | 4.3e-04 | -5.6 | 5.9 | 3.3e-09 | -0.04 | 0.18 | 0.19 | FALSE |
8 | GTEx | Muscle Skeletal | ZNF362 | 0.04 | 0.01 | enet | 7 | 0.02 | 4.9e-03 | 3.2 | -5.4 | 8.3e-08 | 0.68 | 0.06 | 0.82 | FALSE |
9 | METSIM | Adipose | ZNF362 | 0.09 | 0.02 | enet | 32 | 0.03 | 1.5e-05 | -8.7 | -6.1 | 8.4e-10 | 0.70 | 0.01 | 0.98 | FALSE |
10 | ROSMAP | Brain Pre-frontal Cortex | PHC2 | 0.11 | 0.07 | lasso | 3 | 0.05 | 2.2e-07 | -8.6 | -8.1 | 5.9e-16 | 0.99 | 0.01 | 0.99 | FALSE |
11 | YFS | Blood | KPNA6 | 0.03 | 0.03 | bslmm | 236 | 0.04 | 1.1e-11 | 5.0 | 5.3 | 9.9e-08 | 0.01 | 0.95 | 0.05 | FALSE |
12 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ZNF362 | 0.03 | 0.01 | blup | 49 | 0.01 | 1.3e-03 | 3.7 | -6.5 | 8.9e-11 | 0.72 | 0.01 | 0.32 | FALSE |
13 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | S100PBP | 0.06 | 0.03 | blup | 48 | 0.06 | 6.8e-04 | -4.8 | 5.7 | 1.3e-08 | -0.06 | 0.01 | 0.76 | TRUE |
14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | S100PBP | 0.06 | 0.06 | blup | 47 | 0.05 | 5.2e-06 | -5.1 | 5.2 | 1.7e-07 | -0.07 | 0.01 | 0.99 | FALSE |
15 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | PTP4A2 | 0.09 | -0.01 | blup | 26 | 0.00 | 4.1e-01 | 6.2 | 7.3 | 2.3e-13 | 0.00 | 0.01 | 0.60 | TRUE |