[Hub]/) : Traits : Leg predicted mass (right) :

chr1:31,402,148-34,592,020

Best TWAS P=4.89e-18 · Best GWAS P=3.82e-18 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex PEF1 0.04 0.04 lasso 4 0.03 2.8e-04 -5.2 5.2 1.9e-07 -0.01 0.63 0.27 FALSE
2 CommonMind Brain Pre-frontal Cortex TMEM54 0.05 0.00 blup 281 0.02 4.5e-03 1.7 -7.6 2.5e-14 0.50 0.11 0.23 FALSE
3 CommonMind Brain Pre-frontal Cortex ZNF362 0.05 0.06 lasso 1 0.06 2.2e-07 -8.7 -8.7 4.9e-18 0.98 0.01 0.99 TRUE
4 GTEx Artery Aorta PEF1 0.15 0.05 lasso 5 0.04 2.2e-03 -5.7 6.3 2.3e-10 -0.05 0.30 0.43 TRUE
5 GTEx Cells EBV-transformed lymphocytes KPNA6 0.19 0.14 enet 18 0.10 4.9e-04 4.8 5.5 2.9e-08 -0.03 0.19 0.18 FALSE
6 GTEx Cells EBV-transformed lymphocytes PHC2 0.58 0.34 lasso 7 0.28 7.3e-10 -8.6 8.3 1.1e-16 -0.99 0.02 0.98 FALSE
7 GTEx Colon Sigmoid PEF1 0.16 0.09 lasso 3 0.09 4.3e-04 -5.6 5.9 3.3e-09 -0.04 0.18 0.19 FALSE
8 GTEx Muscle Skeletal ZNF362 0.04 0.01 enet 7 0.02 4.9e-03 3.2 -5.4 8.3e-08 0.68 0.06 0.82 FALSE
9 METSIM Adipose ZNF362 0.09 0.02 enet 32 0.03 1.5e-05 -8.7 -6.1 8.4e-10 0.70 0.01 0.98 FALSE
10 ROSMAP Brain Pre-frontal Cortex PHC2 0.11 0.07 lasso 3 0.05 2.2e-07 -8.6 -8.1 5.9e-16 0.99 0.01 0.99 FALSE
11 YFS Blood KPNA6 0.03 0.03 bslmm 236 0.04 1.1e-11 5.0 5.3 9.9e-08 0.01 0.95 0.05 FALSE
12 The Cancer Genome Atlas Breast Invasive Carcinoma ZNF362 0.03 0.01 blup 49 0.01 1.3e-03 3.7 -6.5 8.9e-11 0.72 0.01 0.32 FALSE
13 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma S100PBP 0.06 0.03 blup 48 0.06 6.8e-04 -4.8 5.7 1.3e-08 -0.06 0.01 0.76 TRUE
14 The Cancer Genome Atlas Brain Lower Grade Glioma S100PBP 0.06 0.06 blup 47 0.05 5.2e-06 -5.1 5.2 1.7e-07 -0.07 0.01 0.99 FALSE
15 The Cancer Genome Atlas Testicular Germ Cell Tumors PTP4A2 0.09 -0.01 blup 26 0.00 4.1e-01 6.2 7.3 2.3e-13 0.00 0.01 0.60 TRUE