Hub : Genes

PHC2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.118	0.0290	4.9e-11	0.088	0.113	0.096	0.117	0.105	8.4e-11	1.1e-13	9.6e-12	4.8e-14	9.9e-13
2	GTEx	Cells EBV-transformed lymphocytes	0.585	0.0880	1.6e-09	0.341	NA	0.192	NA	0.284	6.7e-12	NA	7.3e-07	NA	7.3e-10
3	ROSMAP	Brain Pre-frontal Cortex	0.108	0.0311	1.1e-06	0.068	0.048	0.051	0.052	0.053	3.7e-09	8.7e-07	3.2e-07	2.5e-07	2.2e-07
4	TCGA	Thyroid Carcinoma	0.043	0.0210	8.8e-05	0.045	0.029	0.036	NA	0.031	3.1e-05	7.1e-04	1.8e-04	NA	4.8e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.3	0.5	1.0	-0.8	0.2	-0.3	1.0
Bipolar Disorder or Schizophrenia	0.3	0.7	1.4	-0.8	0.6	-0.6	1.2
Depressed Affect (Nagel 2018)	0.5	1.0	1.3	-0.8	1.0	-1.2	1.0
Depression (Nagel 2018)	0.2	0.3	0.6	-0.1	0.6	-0.8	0.4
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.5	0.2	-1.2	0.8	-0.5
Neuroticism (Nagel 2018)	0.4	1.0	1.6	-1.3	0.6	-0.7	1.2
Schizophrenia (2018)	0.2	0.3	0.5	-0.4	0.6	-0.6	0.7
Schizophrenia vs Biploar Disorder	1.8	2.4	4.4	-0.9	-2.1	2.1	0.5
Worry (Nagel 2018)	0.1	0.2	0.3	-0.6	0.1	-0.1	0.6
Alzheimer’s Disease (in mother)	0.1	0.2	0.4	0.6	0.0	-0.2	-0.4
Alzheimer’s Disease (in father)	0.6	0.7	1.5	0.2	-1.2	1.1	-0.4
Alzheimer’s Disease (including proxy)	0.2	0.2	0.7	0.8	-0.3	0.1	-0.5
Crohns Disease (2017)	0.8	1.8	3.5	0.8	1.8	-1.9	-0.1
Irritable Bowel Disease (IBD)	2.5	6.0	12.4	1.1	3.2	-3.5	-0.2
Ulcerative Colitis (UC)	3.5	6.6	13.6	1.2	3.3	-3.7	-0.5
Major Depression (MDD)	1.1	1.3	1.9	-0.2	1.4	-1.3	1.3
Reaction Time	1.2	2.2	3.6	0.5	-1.9	1.9	-1.2
Verbal and Numeric Reasoning (VNR)	0.4	0.9	1.7	0.7	-1.3	1.0	-0.6
Breast Cancer	0.7	1.6	3.9	1.5	0.4	-0.2	-2.0
Ovarian Cancer	2.3	3.1	4.1	2.0	1.4	-1.6	-1.9
Prostate Cancer	0.6	0.8	1.3	1.0	0.9	-1.1	-0.3
Age at First Birth	0.7	1.0	2.8	1.0	0.0	0.4	-1.7
Bipolar Disorder (2011)	0.3	0.3	0.5	-0.3	0.7	-0.7	0.1
Body Mass Index (BMI) (2010)	1.7	2.3	4.4	1.1	2.1	-1.9	-0.4
Coronary Artery Disease (CAD)	0.1	0.2	0.3	-0.5	-0.1	0.5	0.3
Crohns Disease (2012)	0.6	1.0	1.8	0.7	1.3	-1.3	0.1
Mean Putamen Volume	1.5	1.7	2.3	1.4	1.3	-1.5	-0.8
Fasting Glucose	4.6	5.5	7.6	2.2	2.8	-2.6	-1.6
HbA1C	2.5	2.8	4.5	1.7	1.9	-2.1	-0.0
HDL Cholesterol	0.4	0.6	1.8	0.8	0.1	-0.2	-1.3
LDL Cholesterol	0.0	0.1	0.2	-0.4	-0.1	-0.1	0.4
Lupus	0.0	0.1	0.1	-0.1	-0.2	0.4	0.3
Neuroticism (2016)	1.0	1.5	1.6	-1.1	1.3	-1.2	1.3
Primary Biliary Cirrhosis	1.4	2.0	3.2	-1.7	-0.9	1.1	1.8
Rheumatoid Arthritis	0.3	0.4	1.0	-0.8	0.1	-0.1	1.0
Schizophrenia (2014)	0.4	0.9	1.9	-0.9	0.6	-0.7	1.4
Triglycerides	0.6	1.0	1.7	0.7	1.3	-1.2	-0.5
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.7	-0.4	-0.3	0.3	0.8
Ulcerative Colitis	4.3	6.3	13.5	0.5	3.4	-3.7	0.3
Blood Eosinophil Count	3.9	29.9	40.1	-4.8	-6.3	6.2	4.3
Blood Platelet Count	1.8	20.9	27.0	4.1	5.0	-5.2	-3.8
Blood Red Count	3.0	28.7	41.9	-6.4	-3.7	4.3	6.5
Blood White Count	0.1	0.8	1.8	-1.0	0.6	-0.4	1.3
Heel T-Score	1.0	7.6	13.8	-1.8	-3.6	3.7	0.9
BMI	3.5	20.3	36.0	2.9	6.0	-5.6	-2.2
Height	1.5	28.4	55.5	2.0	7.3	-7.5	-0.3
Waist Hip Ratio (WHR)	0.4	1.9	3.4	-1.8	-0.5	0.8	1.9
Systolic Blood Pressure	1.6	8.0	11.0	-2.7	-3.2	3.3	1.8
Smoking Status	7.0	16.7	34.7	1.3	5.9	-5.5	-0.8
Allergy or Eczema	4.3	11.4	14.7	-3.8	-3.0	3.3	3.4
Cardiovascular Disease	2.0	6.6	9.1	-2.4	-2.5	2.4	3.0
Hypothyroidism (self reported)	0.7	1.7	3.0	0.9	1.5	-1.7	-0.6
Respiratory disease	2.5	5.7	10.1	-3.2	-0.9	1.3	3.2
Type 2 Diabetes (T2D) (2018)	0.9	1.7	2.7	1.1	1.6	-1.6	-0.5
Lung FEV1/FVC ratio	0.7	3.4	4.9	1.9	1.5	-1.6	-2.2
Lung FVC	1.1	5.6	10.2	2.2	-1.8	2.0	-3.2
Neuroticism	0.7	1.6	2.2	-1.4	1.2	-1.1	1.5
Chronotype (morning person)	0.4	1.0	1.2	0.9	-1.0	1.1	-1.1
Hair Pigment	0.1	1.6	2.9	0.5	-1.7	1.5	-1.0
Tanning	0.1	1.2	2.8	1.2	0.5	-0.5	-1.7
Hand grip strength (left)	5.1	13.4	22.5	2.7	4.7	-4.6	-1.8
Number of treatments/medications taken	1.6	2.8	3.4	-1.5	-1.9	1.8	1.6
Average weekly spirits intake	2.3	2.8	4.1	1.9	1.4	-1.4	-2.0
Sensitivity / hurt feelings	0.1	0.2	0.4	-0.6	-0.1	0.4	0.2
Frequency of depressed mood in last 2 weeks	1.1	1.5	3.4	-1.7	-0.0	-0.0	1.9
Hearing difficulty/problems: Yes	0.5	0.8	1.1	-0.9	0.8	-0.8	1.1
Relative age of first facial hair	2.2	4.4	8.0	0.9	2.8	-2.8	-1.0
Other serious medical condition/disability diagnosed by doctor	1.1	1.5	2.9	-1.4	-0.9	0.4	1.7
Ever used hormone-replacement therapy (HRT)	1.8	2.3	2.5	-1.4	-1.6	1.5	1.6
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	-0.3	-0.1	0.4	-0.1
Systolic blood pressure, automated reading	0.8	2.4	2.7	-1.6	-1.6	1.5	1.3
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	-0.0	0.5	-0.3	-0.0
Angina	0.5	0.7	1.4	-0.2	-1.2	1.1	-0.1
Medication for hormone replacement therapy	0.3	0.4	0.6	-0.4	-0.8	0.7	0.5
Vitamin and mineral supplements	0.4	0.5	1.2	0.0	1.1	-0.9	-0.1
Supplements: Zinc	1.1	1.2	2.2	-1.2	-0.7	0.8	1.5
Medication: Co-codamol	0.1	0.1	0.2	-0.4	-0.4	0.5	0.0
Medication: Metformin	0.6	0.8	2.0	1.4	0.2	-0.1	-1.0
Diabetes (father)	1.1	1.4	3.5	-0.2	1.9	-1.4	0.3
Diabetes (mother)	0.8	1.1	2.3	0.6	1.5	-1.2	-0.4
Severe depression (siblings)	1.5	1.6	2.4	-1.1	1.5	-1.3	1.1
Pack years adult smoking proportion	1.4	2.1	2.6	-1.5	1.5	-1.2	1.6
Impedance of leg (right)	3.5	17.1	21.6	-3.9	-4.7	4.6	3.1
Leg fat-free mass (left)	7.6	40.4	68.9	4.2	8.3	-8.1	-3.1
Trunk fat percentage	0.4	1.7	3.8	0.1	2.0	-1.7	0.3
Hand grip strength (right)	2.8	7.7	12.3	2.2	3.5	-3.4	-1.5
Townsend deprivation index at recruitment	1.6	2.2	2.5	-1.5	1.5	-1.6	1.3
Current tobacco smoking	1.8	2.9	6.7	0.0	2.6	-2.2	-0.1
Average weekly fortified wine intake	0.2	0.2	0.3	-0.6	-0.5	0.5	0.4
Maternal smoking around birth	0.8	1.1	2.3	-1.4	0.2	0.4	1.5
Fed-up feelings	0.4	0.7	0.9	-0.8	0.8	-0.8	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.7	0.3	0.8	-0.8	-0.0
Relative age voice broke	2.0	3.0	4.7	1.2	2.2	-2.0	-1.4
Taking other prescription medications	1.8	2.7	6.2	-2.0	-0.6	0.5	2.5
Age when periods started (menarche)	5.5	13.1	21.4	4.6	2.1	-2.4	-4.6
Bilateral oophorectomy (both ovaries removed)	3.4	3.9	4.4	-2.1	-1.9	2.1	1.8
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.1	0.3	0.4	0.2	-0.3	-0.5
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.0	0.1	-0.1	-0.0	0.1
Qualifications: CSEs or equivalent	0.0	0.0	0.1	0.0	0.3	-0.1	-0.2
Serious illness, injury or assault to yourself	1.2	1.5	3.8	-1.5	-0.1	0.2	1.9
High blood pressure	2.1	6.0	6.7	-2.1	-2.6	2.5	2.6
Hayfever, allergic rhinitis or eczema	4.1	8.9	12.5	-3.5	-2.3	2.6	3.3
Multivitamins +/- minerals	0.1	0.1	0.2	0.4	-0.3	0.1	-0.2
Stomach or abdominal pain in last month	1.3	1.7	3.3	-0.6	1.8	-1.4	1.0
Supplements: Glucosamine	0.9	1.2	1.7	1.3	0.9	-1.1	-1.0
Diverticular disease/diverticulitis (self-reported)	2.1	2.5	4.0	2.0	1.0	-1.1	-2.0
Medication: Atenolol	0.0	0.0	0.0	0.1	0.1	-0.0	0.0
Medication: Levothyroxine sodium	0.9	1.5	3.2	0.2	1.6	-1.8	0.0
Sitting height	1.2	8.6	12.2	2.5	3.5	-3.4	-2.2
Chronic bronchitis/emphysema (father)	0.6	0.6	1.4	0.2	1.2	-1.1	-0.1
High blood pressure (mother)	1.4	2.0	2.5	-1.3	-1.3	1.4	1.6
Body mass index (BMI)	3.5	14.9	27.5	2.4	5.2	-4.8	-1.6
Impedance of leg (left)	3.5	16.9	20.7	-4.0	-4.5	4.5	3.2
Leg predicted mass (left)	7.5	39.8	68.1	4.1	8.2	-8.0	-3.0
Trunk fat mass	2.2	9.3	18.4	1.5	4.3	-4.0	-0.8
Waist circumference	3.7	13.4	26.8	1.7	5.2	-4.8	-0.9
Number of incorrect matches in round	1.8	2.9	5.7	-2.4	-0.3	0.8	2.3
Past tobacco smoking	7.7	14.2	27.8	-1.5	-5.3	5.2	0.4
Alcohol usually taken with meals	0.9	1.5	3.2	1.8	-0.2	0.1	-1.7
Nervous feelings	0.1	0.2	0.2	-0.5	-0.4	0.4	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.0	2.0	-0.1	1.4	-1.3	0.6
Hearing difficulty/problems with background noise	1.7	2.7	6.2	-2.2	-0.3	0.1	2.5
Hair/balding pattern: Pattern 2	0.9	1.2	1.6	-1.0	-1.3	1.2	0.8
Had menopause	0.5	0.6	1.0	-1.0	-0.6	0.6	0.8
Had other major operations	0.1	0.2	0.3	0.2	0.6	-0.4	-0.4
Forced vital capacity (FVC)	2.2	8.4	13.0	3.3	2.2	-2.0	-3.6
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.8	0.3	0.8	-0.9	-0.1
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.6	-0.2	1.1	-1.3	0.9
Qualifications: None of the above	0.5	1.1	1.2	-1.1	1.1	-1.1	1.0
Financial difficulties in last 2 years	1.2	1.6	3.2	-0.1	1.8	-1.8	0.3
Mouth/teeth dental problems	2.5	3.9	4.7	2.0	1.7	-1.9	-2.2
Heart attack	0.7	0.9	1.8	-0.5	-1.1	1.3	0.7
Allergy	3.8	8.6	12.4	3.5	2.1	-2.6	-3.3
Pain all over the body in last month	0.6	0.7	0.8	-0.7	-0.9	0.7	0.9
Diabetes (self-reported)	0.5	0.7	1.0	0.9	0.9	-1.0	-0.5
Hayfever/allergic rhinitis (self-reported)	4.6	6.1	6.8	-2.3	-2.6	2.6	2.4
Medication: Ramipril	5.4	7.0	8.9	-2.4	-3.0	3.0	2.0
Medication: Simvastatin	0.9	1.4	4.1	-1.1	-0.3	-0.0	2.0
Fluid intelligence score	0.2	0.4	0.8	0.9	-0.7	0.3	-0.6
Illnesses of siblings	2.5	3.5	5.5	1.8	1.9	-2.3	-1.4
Neuroticism score	1.0	2.2	4.4	-0.4	2.1	-2.0	0.6
Weight	7.1	34.9	62.5	3.7	7.9	-7.6	-2.5
Impedance of arm (right)	9.8	45.8	62.1	-5.9	-7.9	7.8	5.1
Arm fat percentage (right)	0.3	1.3	2.9	0.0	1.7	-1.4	0.5
Trunk fat-free mass	9.7	55.6	91.0	5.3	9.5	-9.3	-4.0
Hip circumference	5.5	23.9	40.2	3.3	6.3	-6.2	-2.5
Time employed in main current job	0.4	0.4	1.2	-0.0	-0.6	1.1	-0.3
Alcohol intake versus 10 years previously	0.3	0.4	0.8	-0.9	0.3	-0.0	0.8
Father’s age at death	1.1	1.4	2.9	1.6	-0.3	-0.3	-1.7
Worrier / anxious feelings	0.3	0.7	1.1	-0.5	0.9	-1.1	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	2.2	-1.5	0.4	0.1	1.5
Falls in the last year	3.2	4.3	5.1	-2.0	2.3	-1.8	2.2
Hair/balding pattern: Pattern 3	0.1	0.1	0.2	0.1	0.3	-0.5	0.3
Number of live births	0.1	0.1	0.4	0.0	-0.1	0.7	0.4
Forced expiratory volume in 1-second (FEV1)	2.5	8.4	14.6	3.5	2.0	-1.7	-3.8
Pulse rate	0.2	0.3	0.6	0.2	0.8	-0.6	-0.3
Happiness	0.3	0.4	0.7	-0.5	0.4	-0.6	0.8
Noisy workplace	0.1	0.1	0.3	-0.5	0.1	0.0	0.4
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.4	0.7	-0.6	-0.1	-0.6
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.9	3.2	0.8	1.8	-1.8	-0.7
Mouth/teeth dental problems: Dentures	0.2	0.4	1.0	-0.5	0.5	-0.4	1.0
Asthma	1.3	2.5	5.4	-2.1	0.0	0.4	2.3
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	0.3	-0.2	0.2	-0.4
Medication: Cholesterol lowering	1.1	1.7	3.1	-0.6	-1.8	1.5	1.1
Depression (self-reported)	1.1	1.3	1.4	-1.2	-1.0	1.2	1.2
Medication: Lansoprazole	0.1	0.1	0.3	-0.0	0.4	-0.5	-0.1
Prospective memory result	1.3	1.6	2.0	1.4	1.0	-1.3	-1.3
Lung cancer (father)	0.0	0.0	0.1	-0.2	-0.0	0.3	-0.0
Illnesses of mother	2.1	2.5	5.1	1.9	0.9	-0.8	-2.3
Forced expiratory volume in 1-second (FEV1), Best measure	2.4	7.7	13.5	3.1	2.0	-1.9	-3.7
Pulse wave Arterial Stiffness index	7.9	9.3	16.3	2.3	4.0	-3.5	-1.9
Impedance of arm (left)	8.2	38.2	56.2	-5.0	-7.5	7.3	4.2
Arm fat mass (right)	2.6	10.8	21.7	1.5	4.7	-4.3	-0.7
Trunk predicted mass	9.7	55.2	90.6	5.3	9.5	-9.3	-4.0
Standing height	2.5	24.8	42.9	3.0	6.5	-6.5	-2.2
Length of working week for main job	5.6	6.2	10.4	1.6	3.2	-3.0	-1.8
Exposure to tobacco smoke at home	3.2	3.6	4.6	1.9	2.1	-2.0	-1.5
Breastfed as a baby	0.9	1.1	2.0	1.4	-0.6	0.6	-1.4
Tense / ‘highly strung’	0.9	1.4	1.8	1.3	1.1	-1.0	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	2.3	3.5	7.1	0.7	2.5	-2.7	0.0
Hair/balding pattern: Pattern 4	2.7	6.6	12.6	-1.9	-3.2	3.5	0.2
Birth weight of first child	0.5	1.0	1.8	-0.5	1.2	-1.3	0.5
Peak expiratory flow (PEF)	3.3	7.6	10.0	2.5	3.2	-3.1	-2.2
Pulse wave reflection index	3.5	4.3	9.2	0.9	3.0	-2.6	-0.7
Ever highly irritable/argumentative for 2 days	2.0	2.5	4.6	1.0	2.0	-2.1	-0.4
Loud music exposure frequency	0.3	0.3	0.8	-0.3	0.9	-0.5	0.4
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	3.2	0.7	-1.8	1.7	-0.8
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	1.7	-0.8	-1.3	1.3	0.7
Blood clot in the leg (DVT)	0.2	0.3	0.8	-0.9	-0.1	0.5	0.4
Medication: Paracetamol	3.2	5.3	5.9	-2.3	-2.2	2.4	2.2
Headache pain in last month	0.2	0.4	0.7	-0.8	0.4	-0.3	0.8
Medication for cholesterol, blood pressure or diabetes	1.4	2.3	3.3	1.1	1.8	-1.6	-1.4
Glaucoma (self-reported)	0.4	0.5	0.7	0.4	0.9	-0.7	-0.7
Gout (self-reported)	0.4	0.5	0.8	0.8	-0.6	0.3	-0.9
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	2.5	0.0	1.3	-1.6	0.1
Medication: Amlodipine	2.9	4.1	5.7	-1.7	-2.3	2.4	1.6
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.3	-0.8	0.1	-0.2	1.1
Birth weight	0.2	0.5	0.7	0.6	0.7	-0.8	-0.6
Chronic bronchitis/emphysema (mother)	1.9	2.3	5.3	-1.8	-0.6	0.7	2.3
High blood pressure (siblings)	2.6	3.7	5.3	-2.0	-1.8	2.3	1.6
Forced vital capacity (FVC), Best measure	1.9	7.1	12.0	3.0	1.9	-1.9	-3.5
Body fat percentage	0.7	2.6	5.8	0.3	2.4	-2.1	0.2
Leg fat percentage (right)	1.3	4.8	10.6	0.8	3.2	-2.8	-0.2
Arm fat-free mass (right)	11.7	59.8	98.8	5.3	9.9	-9.7	-4.3
Exposure to tobacco smoke outside home	0.0	0.1	0.1	0.0	0.4	-0.3	-0.0
Comparative body size at age 10	0.3	0.8	1.5	0.3	-1.2	1.2	-0.3
Number of full brothers	1.8	2.3	2.8	1.5	1.7	-1.6	-1.3
Worry too long after embarrassment	2.2	3.7	7.9	-0.5	2.5	-2.8	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.2	2.8	0.4	1.4	-1.7	0.4
Wheeze or whistling in the chest in last year	0.2	0.3	0.9	-0.3	0.5	-0.2	0.9
Number of children fathered	1.1	1.2	2.6	1.3	-0.3	0.7	-1.6
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.3	-0.2	-0.4	0.5	0.1
Age at first live birth	1.0	1.8	3.8	1.8	-0.2	0.0	-2.0
Pulse wave peak to peak time	5.9	6.9	12.4	-2.0	-3.5	3.0	1.6
Health satisfaction	1.2	1.5	3.3	-1.7	0.3	-0.0	1.8
Shortness of breath walking on level ground	0.5	0.5	1.1	0.4	1.1	-0.8	-0.4
Qualifications: College or University degree	0.2	0.5	1.1	-0.3	-0.8	0.3	1.0
Eye problems/disorders: None of the above	0.6	0.8	1.9	-1.1	-0.2	0.0	1.4
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.3	-0.2	0.4	-0.6	0.5
Emphysema/chronic bronchitis	0.2	0.2	0.3	0.5	0.6	-0.2	-0.4
Medication for pain relief, constipation, heartburn	1.0	1.8	3.2	0.9	1.6	-1.8	-0.7
Neck or shoulder pain in last month	1.7	2.4	3.0	-1.2	1.6	-1.7	1.6
Medication: Blood pressure	1.6	2.8	5.0	-1.0	-2.2	2.1	0.8
Angina (self-reported)	0.5	0.6	1.2	0.1	-1.1	1.0	-0.4
Migraine (self-reported)	1.1	1.4	2.2	-1.1	-1.4	1.5	0.6
Medication: Ibuprofen	0.4	0.5	1.0	0.4	-0.7	0.6	-1.0
Medication: Allopurinol	0.4	0.5	0.9	0.5	-1.0	0.6	-0.6
Medication: Omeprazole	0.2	0.2	0.4	0.6	0.2	0.1	-0.6
Medication: Seretide 50 evohaler	0.1	0.2	0.4	-0.1	-0.6	0.5	0.1
Mean time to correctly identify matches	2.1	4.0	8.4	-0.2	-2.9	2.7	-0.5
Heart disease (mother)	3.0	3.6	6.0	-2.4	-1.1	1.2	2.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.3	0.5	-0.6	0.6	-0.4
Whole body fat mass	3.0	12.7	24.6	1.8	5.0	-4.7	-1.0
Leg fat mass (right)	3.9	15.2	30.1	1.9	5.5	-5.1	-1.0
Arm predicted mass (right)	11.7	59.8	96.8	5.5	9.8	-9.7	-4.3
Pulse rate, automated reading	0.4	1.4	1.9	-1.2	1.4	-0.8	1.3
Alcohol intake frequency.	2.6	6.1	8.8	-3.0	-1.9	1.9	2.9
Comparative height size at age 10	1.2	6.7	13.2	0.4	3.6	-3.6	0.5
Number of full sisters	0.5	0.6	0.7	0.9	0.8	-0.5	-0.8
Suffer from ‘nerves’	0.4	0.6	1.1	-1.0	-0.0	0.4	1.1
Overall health rating	3.4	7.2	14.1	-3.8	-0.6	0.7	3.7
Chest pain or discomfort	0.4	0.5	0.9	-0.3	0.8	-0.7	0.9
Had major operations	3.4	4.0	8.4	-2.3	-1.1	1.1	2.9
Age at last live birth	1.4	2.0	3.4	1.8	0.8	-0.8	-1.8
Family relationship satisfaction	1.2	1.5	2.2	0.9	1.4	-1.5	-1.0
Leg pain on walking	1.8	2.2	3.3	1.0	1.8	-1.8	-1.1
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.5	-0.4	0.7	-0.7	0.6
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.1	1.0	1.0	-0.7	-1.1
Illness, injury, bereavement, stress in last 2 years	1.7	2.0	4.8	1.7	-0.6	0.5	-2.2
Medication: Aspirin	0.1	0.2	0.5	-0.3	-0.1	-0.1	0.7
Supplements: Vitamin C	0.7	0.9	1.5	-0.7	-1.2	1.1	0.4
Knee pain experienced in last month	0.4	0.6	1.6	0.5	-0.2	0.6	-1.3
Hypertension (Self-reported)	1.9	5.3	6.5	-2.0	-2.4	2.2	2.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.7	-0.1	1.3	-0.9	0.5
Illnesses of father: Heart disease	2.4	3.3	7.0	-1.9	1.2	-1.1	2.6
Illnesses of siblings: Diabetes	0.1	0.1	0.5	0.1	0.2	0.0	-0.7
Smoking status: Previous	6.2	9.3	17.5	1.5	4.1	-4.2	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	1.8	3.6	6.9	1.1	2.6	-2.2	-1.3
Whole body fat-free mass	9.2	52.7	87.8	5.0	9.4	-9.1	-3.8
Leg fat-free mass (right)	7.7	40.9	69.9	4.2	8.4	-8.2	-3.1
Arm fat percentage (left)	0.5	1.9	4.2	0.4	2.1	-1.8	0.1
Average weekly red wine intake	2.6	3.8	5.7	2.0	2.1	-2.4	-1.1
Handedness (chirality/laterality): Left-handed	0.0	0.0	0.1	0.2	0.2	-0.1	0.1
Mood swings	1.0	1.9	3.3	-1.8	0.7	-0.6	1.8
Loneliness, isolation	0.4	0.6	1.0	0.4	1.0	-0.8	-0.6
Long-standing illness, disability or infirmity	1.9	2.8	5.4	-2.3	-0.7	0.6	2.2
Ever had bowel cancer screening	0.4	0.5	1.0	-0.5	-1.0	0.8	0.4
Diabetes diagnosed by doctor	0.1	0.2	0.3	0.4	0.6	-0.6	0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.4	0.1	1.2	-0.9	0.0
Friendships satisfaction	0.4	0.5	0.7	-0.5	0.6	-0.8	0.8
Qualifications: nursing, teaching	0.1	0.2	0.6	0.8	0.3	-0.3	-0.2
Commuting to job workplace: Walk	0.4	0.5	0.6	0.7	-0.6	0.6	-0.8
Eye problems/disorders: Cataract	0.4	0.5	0.7	0.8	0.5	-0.7	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	1.9	-0.9	-1.0	1.4	0.7
Medication for cholesterol	5.9	8.9	13.5	3.2	2.4	-2.5	-3.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	2.2	-0.3	-1.5	1.4	-0.3
Back pain experienced in last month	0.6	0.9	2.0	-0.1	1.4	-1.2	0.5
Mineral and other dietary supplements	0.1	0.1	0.3	-0.0	0.6	-0.2	-0.0
Breast cancer (self-reported)	0.1	0.2	0.3	0.3	-0.4	0.5	-0.3
Asthma (self-reported)	1.1	2.3	5.1	-2.0	0.0	0.4	2.2
Osteoporosis (self-reported)	1.0	1.2	2.8	-1.7	-0.7	0.8	0.9
Osteoarthritis (self-reported)	3.6	4.7	5.5	-2.3	-2.2	2.2	1.9
Medication: Aspirin	0.2	0.3	0.6	-0.6	-0.4	0.2	0.8
Medication: Gliclazide	0.0	0.0	0.1	0.1	0.2	-0.2	0.1
Illnesses of father: None of the above (group 1)	0.7	0.8	1.1	0.4	-1.0	1.0	-1.1
Smoking status: Current	2.0	3.1	7.2	0.0	2.7	-2.3	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.0	4.3	5.6	1.7	-2.0	2.1	-2.4
Whole body water mass	9.2	52.5	86.9	5.0	9.3	-9.1	-3.8
Leg predicted mass (right)	7.6	40.3	68.7	4.2	8.3	-8.1	-3.1
Arm fat mass (left)	2.7	11.2	22.0	1.7	4.7	-4.4	-0.8
Number of self-reported non-cancer illnesses	3.2	5.6	9.4	-2.7	-1.8	1.7	3.1
Average weekly champagne plus white wine intake	0.5	0.6	1.2	0.3	-1.1	1.1	-0.3
Miserableness	0.5	0.9	1.5	-0.6	1.0	-1.2	1.0
Guilty feelings	0.8	1.2	2.4	0.1	1.5	-1.6	-0.1
Wears glasses or contact lenses	0.3	0.4	1.0	0.4	0.6	-1.0	-0.3
Ever taken oral contraceptive pill	2.3	2.5	5.5	2.3	0.5	-0.7	-2.0
Hearing aid user	0.1	0.1	0.3	0.5	-0.4	0.3	-0.1
Mother’s age at death	0.0	0.0	0.1	0.2	-0.2	0.1	-0.3
Financial situation satisfaction	3.8	4.7	9.5	1.0	3.1	-2.8	-0.9
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.2	-1.1	-0.1	0.1	1.0
Commuting to job workplace: Public transport	0.3	0.3	1.0	0.3	0.5	-1.0	-0.1
Eye problems/disorders: Glaucoma	0.7	0.8	1.9	1.0	0.4	-0.3	-1.4
Medication: Blood pressure	5.1	9.7	14.9	-3.5	-2.3	2.5	3.9
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.5	-1.2	0.8	-0.5	1.1
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.8	-0.4	-0.9	0.6	0.0
High cholesterol (Self-reported)	2.9	5.1	9.9	-1.1	-3.1	2.6	1.5
Medication: Bendroflumethiazide	1.2	1.9	3.0	-1.0	-1.3	1.2	1.7
Medication: Paracetamol	2.9	4.5	7.0	-1.6	-2.5	2.6	1.4
Medication: Lisinopril	0.2	0.2	0.3	0.5	0.5	-0.4	-0.4
Medication: Atorvastatin	0.4	0.5	1.0	1.0	-0.5	0.5	-0.8
Illnesses of father: High blood pressure	0.1	0.1	0.1	-0.4	0.2	0.2	0.2
Alcohol drinker status: Never	0.5	0.6	1.1	-0.3	-1.1	0.9	0.7
Ever smoked	8.3	14.6	27.7	1.9	5.3	-5.1	-1.0
Basal metabolic rate	9.1	50.3	85.6	4.7	9.2	-9.0	-3.5
Leg fat percentage (left)	1.5	5.3	12.0	0.7	3.5	-3.0	-0.2
Arm fat-free mass (left)	10.0	50.6	86.1	4.7	9.3	-9.0	-3.6
Number of operations (self-reported)	0.5	0.8	1.6	-1.1	0.2	-0.3	1.3
Average weekly beer plus cider intake	1.5	2.1	3.0	1.3	1.7	-1.7	-1.0
Irritability	0.7	1.3	2.3	0.7	1.5	-1.4	-0.6
Risk taking	5.2	7.7	15.2	0.6	3.9	-3.9	-0.0
Ever had prostate specific antigen (PSA) test	0.7	0.9	2.0	0.9	-0.6	0.5	-1.4
Fractured/broken bones in last 5 years	2.7	3.4	8.0	-2.4	0.2	-0.0	2.8
Age started oral contraceptive pill	2.5	3.2	6.9	-0.2	-2.6	2.4	0.2
Diastolic blood pressure, automated reading	1.1	3.3	7.0	0.6	2.6	-2.3	-0.7
Ever depressed for a whole week	2.7	3.3	5.3	1.5	2.3	-2.3	-0.7
Unable to work because of sickness or disability	0.4	0.5	0.9	-0.6	-0.9	0.8	0.3
Commuting to job workplace: Cycle	0.1	0.1	0.3	0.2	0.3	-0.5	0.0
Myopia	2.2	3.2	6.9	-0.5	-2.6	2.3	-0.5
Vascular/heart problems diagnosed by doctor	2.1	5.8	6.4	2.1	2.5	-2.5	-2.5
Cholesterol lowering medication	1.1	1.6	3.5	-1.4	-0.6	0.8	1.9
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.3	0.4	0.0	0.3	-0.6
Pain experienced in last month	0.3	0.6	1.4	1.2	-0.2	0.2	-0.9
Supplements: Calcium	0.4	0.5	0.8	-0.8	-0.5	0.3	0.9
Basal cell carcinoma (self-reported)	0.3	0.3	0.6	0.8	0.2	-0.2	-0.8
Heart attack/myocardial infarction (self-reported)	0.9	1.2	2.4	-0.4	-1.4	1.6	0.6
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.3	-1.1	-0.5	0.8	0.6
Heart disease (siblings)	1.7	2.0	2.5	-1.6	-1.1	1.4	1.6
Alcohol drinker status: Previous	1.4	1.6	2.5	-0.5	1.4	-1.6	1.3
Pack years of smoking	1.5	2.3	3.6	-1.7	1.2	-1.0	1.9
Impedance of whole body	7.0	35.5	50.3	-5.1	-7.1	7.0	4.0
Leg fat mass (left)	4.1	16.0	31.8	1.9	5.6	-5.2	-1.0
Arm predicted mass (left)	9.7	49.3	84.1	4.7	9.2	-8.9	-3.5