Best TWAS P=5.41e-20 · Best GWAS P=6.27e-22 conditioned to 0.000929
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PPA2 | 0.08 | 0.03 | bslmm | 429 | 0.04 | 2.2e-05 | -6.1 | -6.7 | 1.7e-11 | 0.66 | 0.04 | 0.95 | FALSE |
| 2 | GTEx | Artery Aorta | PPA2 | 0.11 | -0.01 | enet | 24 | 0.01 | 1.6e-01 | -9.5 | -6.6 | 5.2e-11 | 0.63 | 0.04 | 0.65 | FALSE |
| 3 | GTEx | Brain Cerebellum | PPA2 | 0.22 | 0.01 | lasso | 4 | 0.03 | 3.7e-02 | -6.7 | -5.3 | 1.0e-07 | 0.62 | 0.09 | 0.16 | FALSE |
| 4 | GTEx | Brain Cortex | PPA2 | 0.14 | 0.09 | lasso | 9 | 0.09 | 1.6e-03 | -8.0 | -8.1 | 5.7e-16 | 0.88 | 0.04 | 0.68 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | PPA2 | 0.11 | 0.03 | lasso | 3 | 0.01 | 6.5e-02 | -6.6 | -6.9 | 4.1e-12 | 0.67 | 0.36 | 0.23 | FALSE |
| 6 | GTEx | Esophagus Gastroesophageal Junction | PPA2 | 0.29 | 0.15 | lasso | 5 | 0.14 | 8.8e-06 | -9.5 | -9.2 | 5.4e-20 | 0.88 | 0.02 | 0.97 | TRUE |
| 7 | GTEx | Esophagus Mucosa | PPA2 | 0.18 | 0.06 | enet | 14 | 0.12 | 2.5e-08 | 6.1 | -7.5 | 7.2e-14 | 0.72 | 0.02 | 0.98 | FALSE |
| 8 | GTEx | Heart Atrial Appendage | PPA2 | 0.15 | 0.05 | lasso | 7 | 0.06 | 7.4e-04 | -7.8 | -6.1 | 1.3e-09 | 0.71 | 0.22 | 0.44 | FALSE |
| 9 | GTEx | Nerve Tibial | PPA2 | 0.13 | 0.07 | enet | 23 | 0.07 | 2.1e-05 | -6.7 | -6.2 | 4.4e-10 | 0.66 | 0.35 | 0.48 | FALSE |
| 10 | GTEx | Ovary | PPA2 | 0.18 | 0.10 | lasso | 3 | 0.14 | 2.2e-04 | -6.7 | -7.5 | 9.2e-14 | 0.76 | 0.04 | 0.77 | FALSE |
| 11 | GTEx | Skin Sun Exposed Lower leg | TET2 | 0.09 | 0.01 | enet | 18 | 0.02 | 3.6e-03 | -9.5 | -6.5 | 7.5e-11 | 0.69 | 0.01 | 0.93 | FALSE |
| 12 | The Cancer Genome Atlas | Thyroid Carcinoma | PPA2 | 0.04 | 0.02 | blup | 84 | 0.04 | 6.1e-05 | -7.8 | -7.1 | 1.6e-12 | 0.77 | 0.14 | 0.65 | FALSE |