Best TWAS P=4.6e-08 · Best GWAS P=4.02e-08 conditioned to 0.304
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Frontal Cortex BA9 | GAR1 | 0.22 | 0.08 | lasso | 3 | 0.04 | 2.9e-02 | 5.2 | -5.5 | 4.6e-08 | -0.94 | 0.01 | 0.85 | TRUE |
| 2 | GTEx | Esophagus Mucosa | GAR1 | 0.17 | 0.16 | lasso | 3 | 0.15 | 1.9e-10 | 5.2 | 5.1 | 3.0e-07 | 0.99 | 0.01 | 0.99 | FALSE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | GAR1 | 0.18 | 0.24 | enet | 17 | 0.24 | 2.2e-30 | 5.5 | -5.3 | 1.2e-07 | -0.98 | 0.00 | 1.00 | FALSE |
| 4 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | GAR1 | 0.04 | 0.06 | lasso | 2 | 0.06 | 8.1e-07 | 5.5 | 5.4 | 5.7e-08 | 0.99 | 0.00 | 1.00 | FALSE |
| 5 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | GAR1 | 0.10 | 0.09 | lasso | 2 | 0.07 | 6.8e-04 | 5.5 | -5.4 | 8.3e-08 | -0.99 | 0.00 | 0.95 | FALSE |