TWAS hub - GAR1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0790	0.0250	8.7e-06	0.072	0.039	0.047	0.043	0.057	4.4e-09	1.3e-05	1.9e-06	5.3e-06	1.9e-07
2	GTEx	Brain Frontal Cortex BA9	0.2166	0.0885	3.2e-03	0.083	NA	-0.008	NA	0.042	3.2e-03	NA	5.9e-01	NA	2.9e-02
3	GTEx	Esophagus Mucosa	0.1670	0.0460	8.1e-07	0.159	NA	0.120	NA	0.153	8.6e-11	NA	2.0e-08	NA	1.9e-10
4	NTR	Blood	0.0156	0.0074	7.5e-03	0.004	0.003	0.002	0.004	0.002	1.3e-02	2.9e-02	4.9e-02	1.8e-02	7.2e-02
5	ROSMAP	Brain Pre-frontal Cortex	0.1838	0.0352	0.0e+00	0.238	0.190	0.239	0.235	0.234	3.2e-30	8.4e-24	2.2e-30	8.8e-30	1.2e-29
6	YFS	Blood	0.0182	0.0075	6.4e-04	0.014	0.013	0.011	0.012	0.010	1.6e-05	3.9e-05	9.1e-05	5.4e-05	1.9e-04
7	TCGA	Bladder Urothelial Carcinoma	0.0670	0.0760	9.3e-03	-0.001	-0.001	0.011	NA	-0.003	3.6e-01	4.5e-01	4.0e-02	NA	6.6e-01
8	TCGA	Cervical Squamous Cell Carcinoma	0.0390	0.0230	5.3e-03	0.022	0.035	0.007	NA	0.010	2.9e-02	8.0e-03	1.3e-01	NA	1.0e-01
9	TCGA	Head and Neck Squamous Cell Carcinoma	0.0432	0.0227	9.8e-05	0.059	0.038	0.047	NA	0.055	3.3e-07	3.4e-05	5.4e-06	NA	8.0e-07
10	TCGA	Brain Lower Grade Glioma	0.0390	0.0260	5.8e-03	0.002	0.006	0.015	NA	0.007	1.8e-01	5.5e-02	7.4e-03	NA	4.4e-02
11	TCGA	Lung Squamous Cell Carcinoma	0.0340	0.0214	6.2e-04	0.009	0.026	0.020	NA	0.014	2.6e-02	5.3e-04	2.0e-03	NA	8.1e-03
12	TCGA	Pheochromocytoma and Paraganglioma	0.1020	0.0570	2.2e-03	0.094	0.058	0.074	NA	0.074	1.4e-04	2.5e-03	7.2e-04	NA	6.8e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Diabetes (father)	6.6	8.2	10.3	-2.9	-2.9	3.2	-2.7	-3.1	-2.3	2.0	2.9	3.2	-2.8	2.8	-3.1
Diabetes (self-reported)	5.0	7.7	12.0	-3.1	-3.0	3.1	-2.5	-3.0	-3.5	1.5	2.2	3.3	-1.3	2.4	-3.4
Diabetes diagnosed by doctor	5.0	8.2	15.2	-3.4	-2.8	3.2	-3.0	-3.0	-3.9	2.0	2.1	3.2	-1.3	2.4	-3.3
Supplements: Calcium	4.6	5.0	7.2	2.2	2.7	-2.6	1.9	2.4	1.8	-1.4	-2.4	-2.5	1.4	-2.6	2.4
Leg fat-free mass (right)	3.9	20.9	30.2	-4.4	-5.5	5.1	-3.2	-5.3	-3.9	2.6	4.5	5.5	-3.5	4.8	-5.4
Leg predicted mass (right)	3.9	20.8	29.9	-4.4	-5.5	5.1	-3.2	-5.3	-3.9	2.6	4.5	5.4	-3.6	4.8	-5.4
Leg fat-free mass (left)	3.8	20.1	29.5	-4.2	-5.4	5.1	-3.0	-5.2	-3.6	2.7	4.3	5.4	-3.5	4.7	-5.4
Leg predicted mass (left)	3.8	20.0	29.4	-4.2	-5.4	5.1	-3.0	-5.2	-3.6	2.6	4.3	5.4	-3.4	4.7	-5.4
Whole body fat-free mass	3.8	21.5	31.4	-4.3	-5.5	5.3	-3.3	-5.4	-3.6	2.8	4.4	5.6	-3.8	4.8	-5.6
Mean time to correctly identify matches	3.7	7.1	24.8	3.1	2.7	-2.3	2.8	2.0	5.0	-2.1	-2.4	-2.3	1.2	-2.2	2.3
Basal metabolic rate	3.7	20.5	30.0	-4.3	-5.4	5.2	-3.1	-5.3	-3.6	2.7	4.3	5.5	-3.7	4.7	-5.5
Whole body water mass	3.6	20.5	29.8	-4.2	-5.4	5.1	-3.3	-5.3	-3.6	2.7	4.3	5.5	-3.7	4.7	-5.4
Eye problems/disorders: Glaucoma	3.5	4.1	6.7	2.6	2.4	-2.2	2.4	1.9	1.0	-1.6	-1.9	-1.9	2.5	-1.6	1.8
Other serious medical condition/disability diagnosed by doctor	3.4	4.4	5.9	-2.4	-2.4	2.4	-2.0	-2.1	-1.4	1.2	2.2	2.3	-2.3	2.0	-2.2
Trunk fat-free mass	3.4	19.6	28.2	-4.1	-5.3	5.0	-3.4	-5.1	-3.2	2.8	4.2	5.3	-3.8	4.6	-5.3
Trunk predicted mass	3.4	19.7	28.4	-4.1	-5.3	5.0	-3.4	-5.1	-3.2	2.8	4.3	5.3	-3.7	4.7	-5.3
Arm predicted mass (right)	3.3	16.7	25.2	-3.9	-4.7	4.7	-2.4	-4.8	-2.7	2.0	4.2	5.0	-3.8	4.4	-4.9
Ever had hysterectomy (womb removed)	3.2	3.6	6.2	-2.1	-1.6	1.9	-1.7	-1.8	-1.4	1.4	2.5	1.8	-2.1	2.5	-1.7
Hip circumference	3.1	13.4	20.0	-3.4	-4.2	4.1	-2.7	-4.3	-2.6	2.4	3.6	4.5	-2.9	4.0	-4.4
Illnesses of father: None of the above (group 1)	3.1	3.8	7.8	1.4	2.7	-2.0	2.8	1.9	1.6	-1.8	-1.5	-2.0	1.1	-1.8	2.2
Arm fat-free mass (left)	3.1	15.5	23.1	-3.6	-4.7	4.5	-2.7	-4.6	-3.0	2.0	3.8	4.8	-3.4	4.1	-4.8
Arm predicted mass (left)	3.1	15.5	23.3	-3.5	-4.7	4.5	-2.7	-4.7	-2.9	2.2	3.8	4.8	-3.4	4.1	-4.8
Blood Platelet Count	2.9	34.0	76.9	5.0	6.6	-6.0	5.0	6.2	8.8	-3.2	-4.9	-6.0	5.4	-5.6	5.8
Headache pain in last month	2.9	5.0	8.7	2.5	2.8	-2.5	1.7	2.7	1.5	-2.0	-1.6	-2.8	0.4	-2.1	3.0
Arm fat-free mass (right)	2.9	14.6	22.7	-3.5	-4.5	4.4	-2.0	-4.6	-2.5	1.8	3.9	4.8	-3.5	4.1	-4.7
Weight	2.8	13.7	20.5	-3.4	-4.4	4.3	-2.2	-4.3	-3.0	2.3	3.5	4.5	-3.1	3.8	-4.5
Medication: Allopurinol	2.7	3.6	6.3	-2.2	-1.9	2.2	-1.4	-2.4	-2.5	1.5	0.9	2.1	-0.6	1.3	-2.3
Age when periods started (menarche)	2.5	6.1	15.4	2.7	3.0	-2.3	1.8	2.4	3.9	-1.3	-1.3	-2.6	2.8	-1.4	2.7
Medication: Metformin	2.4	3.4	7.1	-2.7	-1.4	1.6	-2.5	-1.8	-2.5	1.1	1.6	1.8	-1.0	1.4	-1.8
Hand grip strength (right)	2.4	6.6	10.2	-2.7	-2.9	2.9	-1.7	-2.8	-1.8	2.6	2.0	2.8	-3.2	2.2	-2.9
Fluid intelligence score	2.4	5.0	7.3	-2.4	-2.7	2.5	-2.7	-2.5	-1.7	2.0	1.6	2.5	-0.9	2.1	-2.6
Medication: Ibuprofen	2.4	2.8	4.8	1.7	2.2	-1.9	1.9	1.8	0.9	-1.5	-1.5	-1.7	0.1	-2.0	1.8
Osteoporosis (self-reported)	2.4	3.0	4.7	1.7	2.2	-2.0	2.0	1.8	1.7	-2.1	-0.6	-1.8	0.9	-1.0	2.0
Medication: Atorvastatin	2.4	3.0	4.8	-1.9	-1.8	1.8	-2.1	-1.8	-1.1	2.0	0.9	2.1	-1.6	0.9	-2.2
Ever had prostate specific antigen (PSA) test	2.4	2.8	5.2	1.4	1.5	-1.7	0.8	1.6	1.5	0.2	-2.3	-1.8	2.3	-2.1	1.6
Arm fat mass (right)	2.3	9.3	14.1	-2.8	-3.6	3.6	-1.4	-3.6	-2.3	2.1	3.0	3.7	-2.6	3.2	-3.7
Mouth/teeth dental problems: Bleeding gums	2.3	2.9	6.0	1.7	2.5	-2.0	0.3	1.7	1.3	-1.3	-1.9	-1.7	1.9	-1.7	1.7
Alcohol drinker status: Never	2.3	2.8	4.6	-1.8	-1.8	1.6	-2.1	-1.8	-1.9	1.8	0.7	1.8	-1.0	1.0	-2.0
Cholesterol lowering medication	2.3	3.4	5.2	-2.1	-1.9	1.9	-2.0	-1.8	-1.2	1.4	1.9	1.8	-2.3	2.0	-1.7
Pulse rate	2.2	3.6	4.6	1.9	1.9	-2.1	2.1	2.1	2.0	-2.0	-1.3	-2.0	1.6	-1.3	2.1
Type 2 Diabetes (T2D) (2018)	2.1	4.0	5.5	-2.2	-1.6	2.2	-1.7	-2.1	-2.3	1.6	1.9	2.3	-1.3	2.0	-2.3
Eye problems/disorders: Diabetes related eye disease	2.1	2.3	4.6	-0.8	-1.8	2.0	-0.3	-2.0	-1.9	0.0	0.6	2.0	-1.4	1.0	-2.1
Impedance of leg (right)	2.1	10.4	19.1	2.9	4.4	-3.6	2.4	3.7	2.8	-2.0	-2.8	-3.8	2.4	-3.2	3.8
Waist circumference	2.1	7.7	12.0	-2.5	-3.0	3.2	-1.9	-3.3	-1.7	1.8	2.9	3.5	-2.3	3.1	-3.4
Hand grip strength (left)	2.0	5.2	6.5	-2.5	-2.3	2.3	-2.2	-2.4	-1.5	2.5	1.9	2.5	-2.4	2.0	-2.5
Fed-up feelings	2.0	3.7	5.9	-1.6	-2.3	2.0	-1.6	-2.1	-2.4	1.7	1.6	2.0	-1.9	1.5	-2.0
Wears glasses or contact lenses	2.0	2.3	5.3	1.1	2.3	-1.5	1.8	1.6	1.8	-1.2	-0.9	-1.5	1.1	-1.1	1.5
Reaction Time	1.9	3.6	10.4	2.2	2.0	-1.7	2.3	1.3	3.2	-1.8	-1.7	-1.5	0.6	-1.6	1.5
Number of incorrect matches in round	1.9	3.1	6.2	1.5	1.8	-1.5	2.0	2.1	1.2	-2.5	-1.1	-2.0	1.4	-1.3	2.1
Pulse rate, automated reading	1.9	6.0	10.6	3.1	2.7	-2.4	3.3	2.3	2.7	-2.2	-1.9	-2.2	2.1	-1.9	2.2
Height	1.8	35.3	46.0	-5.6	-6.5	6.6	-5.8	-6.5	-4.6	3.9	5.5	6.8	-6.2	5.8	-6.8
Bilateral oophorectomy (both ovaries removed)	1.8	2.1	4.1	-2.0	-0.9	1.3	-1.6	-1.3	-0.9	1.6	1.7	1.4	-1.0	1.6	-1.4
Medication: Aspirin	1.8	2.4	5.4	-1.6	-1.6	1.8	-0.3	-2.0	-1.5	1.0	0.9	2.2	-1.1	1.1	-2.3
Medication: Aspirin	1.8	2.3	5.3	-1.7	-1.5	1.7	-0.6	-2.0	-1.5	1.0	0.8	2.1	-0.7	1.1	-2.3
Arm fat mass (left)	1.8	7.5	11.3	-2.5	-3.2	3.2	-1.0	-3.2	-2.0	1.7	2.8	3.4	-2.4	3.0	-3.3
Ovarian Cancer	1.7	2.2	6.5	1.4	1.8	-1.6	0.8	1.5	2.5	-0.3	-0.8	-1.7	1.5	-1.0	1.7
Body mass index (BMI)	1.7	7.1	11.2	-2.4	-3.3	3.1	-0.8	-3.2	-2.0	1.6	2.5	3.3	-2.3	2.7	-3.3
Impedance of leg (left)	1.7	8.4	15.6	2.4	3.9	-3.3	2.0	3.5	2.2	-1.7	-2.5	-3.6	2.0	-3.0	3.5
Whole body fat mass	1.7	7.2	11.2	-2.5	-3.1	3.2	-1.1	-3.2	-1.7	1.8	2.7	3.3	-2.3	2.8	-3.3
Medication for cholesterol	1.7	2.5	5.0	1.6	1.8	-1.7	2.2	1.6	1.8	-0.3	-0.7	-1.5	2.1	-0.9	1.6
Leg fat mass (left)	1.7	6.7	10.8	-2.3	-3.1	3.1	-0.5	-3.1	-1.6	1.6	2.5	3.3	-2.3	2.7	-3.3
Schizophrenia (2018)	1.6	3.3	16.2	1.6	2.2	-1.5	2.5	1.4	4.0	-1.0	-0.6	0.0	0.1	-1.2	1.8
Trunk fat mass	1.6	6.7	10.4	-2.4	-3.0	3.1	-1.1	-3.1	-1.9	1.9	2.5	3.2	-2.0	2.6	-3.2
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.0	3.9	1.6	2.0	-1.5	1.1	1.6	0.6	-1.0	-1.5	-1.4	0.0	-1.9	1.5
Leg fat mass (right)	1.6	6.1	10.2	-2.1	-2.9	3.0	-0.4	-3.1	-1.4	1.4	2.4	3.2	-2.3	2.5	-3.2
Medication: Blood pressure	1.6	3.0	5.0	-1.4	-1.9	2.0	-1.2	-2.2	-2.1	0.2	1.1	2.1	-2.0	1.2	-2.2
Medication: Atenolol	1.5	1.9	3.7	-1.4	-1.5	1.4	-0.9	-1.6	0.0	0.8	1.7	1.6	-1.2	1.9	-1.6
Length of working week for main job	1.5	1.6	3.6	-1.1	-1.9	1.5	-0.8	-1.2	-1.0	0.2	1.3	1.3	-1.9	1.1	-1.2
Tense / ‘highly strung’	1.5	2.5	4.9	1.8	1.9	-1.5	1.7	1.7	2.2	-1.4	-1.0	-1.6	0.5	-1.1	1.7
HbA1C	1.4	1.5	4.8	1.1	1.5	-1.2	0.7	1.2	2.2	-0.8	-0.1	-1.1	1.4	-0.4	1.5
Systolic blood pressure, automated reading	1.4	4.1	6.8	-1.8	-2.6	2.3	0.0	-2.5	-2.0	1.4	1.4	2.5	-2.1	1.4	-2.6
Chronic bronchitis/emphysema (father)	1.4	1.6	5.8	-1.2	-1.7	1.1	-2.4	-0.9	-1.1	1.5	0.7	1.1	-0.7	0.8	-1.2
Hayfever/allergic rhinitis (self-reported)	1.4	1.8	3.7	0.9	1.4	-1.4	1.4	1.3	0.9	0.1	-1.9	-1.3	1.6	-1.9	1.2
Blood clot in the leg (DVT)	1.4	1.8	3.2	-1.7	-0.8	1.3	-1.7	-1.1	-0.6	1.8	1.5	1.5	-0.5	1.4	-1.4
Mouth/teeth dental problems: Loose teeth	1.4	1.7	4.8	1.4	1.0	-1.3	0.7	1.3	2.2	-0.6	-1.2	-1.5	0.2	-1.6	1.6
Emphysema/chronic bronchitis	1.4	1.5	3.1	-1.4	-1.3	1.4	-0.6	-1.4	-0.5	1.1	1.6	1.4	0.2	1.8	-1.2
Leg pain on walking	1.4	1.8	4.2	1.3	1.0	-1.1	1.9	1.2	-0.3	-1.3	-1.5	-1.0	2.0	-1.5	1.0
Pain experienced in last month	1.4	2.3	4.7	-1.5	-1.9	1.8	-0.7	-2.0	-0.2	2.2	1.0	1.8	0.3	1.4	-1.9
Heel T-Score	1.3	10.5	13.5	-2.9	-3.7	3.5	-3.2	-3.7	-3.2	2.5	3.1	3.3	-2.5	3.6	-3.4
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	3.0	1.3	0.9	-1.0	1.3	1.2	1.6	-0.6	-1.0	-1.1	1.7	-0.8	1.1
Hair/balding pattern: Pattern 3	1.3	1.9	2.9	1.7	1.6	-1.7	0.7	1.7	1.1	-0.7	-1.2	-1.6	1.3	-1.1	1.6
Mouth/teeth dental problems: Dentures	1.3	2.2	3.8	-1.2	-1.6	2.0	-0.1	-1.6	0.8	1.5	1.9	1.5	-1.5	1.8	-1.5
Exposure to tobacco smoke at home	1.3	1.5	2.4	-1.5	-1.1	1.2	-1.4	-1.1	0.1	1.5	1.4	1.3	-1.0	1.2	-1.1
Eye problems/disorders: None of the above	1.3	1.5	4.0	-1.6	-1.2	1.1	-1.6	-0.8	-1.4	0.7	0.9	1.0	-2.0	0.6	-0.9
Mother’s age at death	1.3	1.6	3.6	1.3	1.5	-1.2	1.6	1.2	1.9	-1.0	-0.1	-1.5	0.5	-0.2	1.6
Alcohol drinker status: Previous	1.3	1.4	4.3	1.0	1.1	-1.1	2.1	1.3	1.4	-0.6	-0.4	-1.3	1.0	-0.7	1.4
Impedance of whole body	1.3	6.5	13.5	2.1	3.7	-3.0	1.1	3.2	1.6	-1.3	-2.2	-3.2	1.9	-2.5	3.2
Vitamin and mineral supplements	1.2	1.6	3.7	0.7	0.9	-1.1	1.8	1.1	0.7	-1.6	-0.9	-1.4	1.9	-0.8	1.5
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.7	4.6	-1.3	-2.1	1.9	-1.7	-1.6	-1.6	1.3	1.5	1.6	-1.4	1.7	-1.6
Medication: Seretide 50 evohaler	1.2	1.4	2.7	-0.6	-1.3	1.2	-1.6	-1.2	-0.5	0.3	1.6	1.3	-0.7	1.6	-1.2
Handedness (chirality/laterality): Left-handed	1.2	1.4	7.2	-1.0	-0.8	0.4	-2.7	-0.3	-2.3	0.9	0.2	0.3	1.3	0.4	-0.3
Basal cell carcinoma (self-reported)	1.2	1.4	3.2	1.4	0.4	-0.8	1.5	0.6	-0.7	-1.8	-1.7	-0.9	1.2	-1.6	0.8
Rheumatoid Arthritis	1.1	1.5	4.1	-0.7	-1.4	1.4	-1.4	-1.3	-0.4	2.0	0.6	1.5	-0.3	0.8	-1.5
Blood White Count	1.1	8.3	21.3	3.3	3.1	-3.0	3.5	2.7	4.6	-2.4	-1.6	-2.7	1.4	-1.8	2.9
Systolic Blood Pressure	1.1	5.3	10.6	-2.4	-2.7	2.1	-1.1	-2.6	-3.2	2.4	0.9	2.5	-2.7	0.8	-2.6
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.5	3.6	-1.2	-1.9	1.8	-1.6	-1.6	-1.4	0.7	1.6	1.7	-1.6	1.8	-1.7
Arm fat percentage (right)	1.1	4.3	6.4	-1.8	-2.5	2.5	-1.0	-2.4	-1.6	1.7	1.9	2.5	-1.6	2.1	-2.5
Financial situation satisfaction	1.1	1.4	3.4	-0.8	-1.1	1.6	-0.7	-1.4	0.8	0.6	1.9	1.1	-0.5	1.8	-0.9
Risk taking	1.1	1.7	2.7	-1.6	-1.7	1.4	-1.3	-1.2	0.9	1.2	1.5	1.2	-0.2	1.6	-1.2
Deep venous thrombosis (DVT) (self-reported)	1.1	1.5	2.8	-1.7	-0.7	1.1	-1.6	-0.8	-0.7	1.7	1.4	1.2	-0.4	1.2	-1.2
BMI	1.0	5.7	9.0	-2.3	-2.6	2.6	-0.7	-2.7	-1.7	1.0	3.0	2.7	-2.5	3.0	-2.6
Angina	1.0	1.3	4.2	-1.1	-2.0	1.3	-0.6	-1.2	-0.9	0.5	0.1	1.3	-1.0	0.3	-1.5
High blood pressure	1.0	2.7	5.4	-1.2	-1.7	1.9	-0.4	-2.3	-1.1	0.5	1.4	2.1	-1.7	1.6	-2.2
Pain all over the body in last month	1.0	1.1	2.5	-0.7	-1.3	1.3	-0.1	-1.5	-0.8	0.6	0.5	1.6	-0.7	0.6	-1.6
Standing height	1.0	9.6	12.2	-3.1	-3.1	3.4	-3.4	-3.3	-2.8	2.0	3.0	3.5	-2.4	3.3	-3.5
Gout (self-reported)	1.0	1.4	3.5	-1.4	-0.8	1.1	-1.0	-1.6	-1.9	0.7	0.8	1.3	-0.4	1.0	-1.4
Number of full brothers	1.0	1.2	5.0	0.4	1.4	-1.2	-0.1	1.2	0.4	-0.3	-0.7	-1.3	2.2	-0.7	1.3
Neck or shoulder pain in last month	1.0	1.4	2.2	-1.1	-1.4	1.2	-1.0	-1.2	-1.3	1.5	1.0	1.3	-1.0	1.0	-1.3
Comparative height size at age 10	1.0	5.7	7.5	-2.4	-2.7	2.7	-2.5	-2.5	-2.0	1.6	2.1	2.7	-2.4	2.3	-2.6
Arm fat percentage (left)	1.0	3.8	5.8	-1.8	-2.2	2.4	-0.5	-2.3	-1.4	1.4	2.0	2.4	-1.6	2.1	-2.4
Medication: Gliclazide	1.0	1.1	1.8	-1.4	-0.7	1.0	-1.3	-0.9	-1.2	1.1	1.0	1.2	-0.2	1.0	-1.1
Medication: Bendroflumethiazide	1.0	1.6	3.0	-0.8	-1.3	1.4	-0.1	-1.6	0.0	1.6	1.1	1.7	-0.6	1.5	-1.7
Intelligence (Savage-Jansen 2018)	0.9	2.8	4.9	-2.2	-1.6	1.7	-1.8	-1.6	-0.2	2.1	1.8	1.7	0.6	2.1	-1.5
Verbal and Numeric Reasoning (VNR)	0.9	2.2	3.6	-1.7	-1.5	1.6	-1.5	-1.6	0.0	1.5	1.7	1.5	-0.3	1.9	-1.5
Coronary Artery Disease (CAD)	0.9	1.1	4.0	1.2	0.9	-0.6	1.2	0.4	2.0	-1.5	-0.8	0.0	1.1	-0.5	0.5
Schizophrenia (2014)	0.9	1.9	9.3	1.4	1.8	-1.1	1.7	0.9	3.0	-0.4	-0.8	0.0	-0.3	-1.1	1.1
Medication: Co-codamol	0.9	1.1	3.8	-1.0	-0.8	1.1	-0.8	-1.0	-1.9	0.7	0.7	1.1	-0.7	0.8	-1.2
Glaucoma (self-reported)	0.9	1.0	1.7	1.3	1.1	-1.1	1.0	0.9	0.1	-0.5	-1.2	-1.0	1.3	-1.0	0.9
Angina (self-reported)	0.9	1.1	4.2	-1.1	-2.1	1.2	-0.5	-1.0	-0.8	0.5	0.1	1.2	-1.0	0.3	-1.4
Illnesses of siblings: Diabetes	0.9	1.1	2.1	-1.1	-1.4	1.2	-1.4	-0.8	-1.4	0.8	0.8	0.9	-0.2	0.9	-0.9
Long-standing illness, disability or infirmity	0.9	1.4	3.3	-1.7	-1.3	1.1	-1.0	-1.0	-1.8	1.2	0.7	1.2	-0.7	0.6	-1.2
Supplements: Fish oil (including cod liver oil)	0.9	1.2	2.7	1.6	1.1	-1.0	0.9	1.0	0.9	-0.7	-1.5	-1.0	0.9	-1.2	0.9
Bipolar Disorder or Schizophrenia	0.8	2.0	10.2	1.3	1.7	-1.1	2.1	0.8	3.2	-1.4	-0.3	0.0	-0.4	-0.7	1.1
Prostate Cancer	0.8	1.2	3.1	-0.9	-0.9	1.2	-0.3	-1.3	-1.7	0.5	0.7	1.4	-0.7	0.9	-1.5
Neuroticism (2016)	0.8	1.2	2.4	1.1	1.2	-1.0	0.8	1.1	1.3	0.2	-0.9	-1.4	-0.1	-1.3	1.5
Chronotype (morning person)	0.8	1.9	4.8	2.2	1.5	-1.2	1.1	1.3	0.6	-1.8	-1.2	-1.4	1.2	-0.9	1.4
Trunk fat percentage	0.8	3.1	4.7	-1.7	-1.9	2.1	-0.5	-2.1	-1.4	1.3	1.7	2.2	-1.3	1.8	-2.2
Maternal smoking around birth	0.8	1.2	2.4	-1.2	-1.6	1.2	-1.3	-1.3	-1.4	1.0	-0.0	1.0	-0.0	0.2	-1.2
Relative age voice broke	0.8	1.2	3.6	1.5	0.7	-0.9	1.2	0.9	0.7	-0.7	-1.2	-0.9	1.9	-0.9	0.8
Sitting height	0.8	5.7	10.3	-2.0	-2.6	2.4	-2.4	-2.4	-3.2	0.8	2.0	2.4	-2.6	2.3	-2.6
Time employed in main current job	0.8	0.9	2.7	-0.7	-1.2	1.1	-0.1	-0.9	-1.6	0.6	0.1	1.0	-1.3	0.2	-1.1
Pulse wave Arterial Stiffness index	0.8	1.0	1.8	-1.1	-0.8	0.7	-1.2	-0.7	0.4	1.1	1.4	0.9	-1.2	1.2	-0.8
Medication: Ventolin 100micrograms inhaler	0.8	1.1	2.3	1.1	1.3	-1.0	1.5	1.4	0.9	-0.9	-0.4	-1.0	0.5	-0.6	1.1
Comparative body size at age 10	0.8	2.2	3.5	-1.9	-1.8	1.5	-0.4	-1.5	-1.6	1.7	1.4	1.5	-1.0	1.4	-1.5
Health satisfaction	0.8	1.1	3.0	1.0	0.7	-0.8	-0.0	0.7	1.7	-0.6	-1.3	-0.9	1.5	-1.2	0.8
Heart disease (mother)	0.8	1.0	2.5	-1.3	-1.4	0.9	1.1	-1.0	-1.6	0.4	0.8	0.7	-0.7	0.6	-0.6
Breast cancer (self-reported)	0.8	0.9	2.5	1.0	0.6	-1.1	1.0	0.9	1.3	-0.2	-0.8	-0.9	1.6	-0.7	0.9
Medication: Paracetamol	0.8	1.2	2.0	1.3	1.2	-1.0	1.4	1.1	0.6	-1.4	-0.7	-1.2	1.0	-0.8	1.2
Diastolic blood pressure, automated reading	0.8	2.3	4.7	-1.3	-1.4	1.8	-0.1	-2.1	-0.8	1.2	1.1	2.1	-1.5	1.2	-2.2
Vascular/heart problems diagnosed by doctor	0.8	2.2	4.9	0.9	1.7	-1.9	0.1	2.2	0.8	-0.3	-0.9	-2.1	1.5	-1.3	2.2
Primary Biliary Cirrhosis	0.7	1.0	3.3	-1.0	-0.9	1.0	-0.3	-0.9	-1.2	0.6	1.0	1.0	-1.8	0.7	-0.9
Townsend deprivation index at recruitment	0.7	1.0	3.8	1.8	0.1	-0.5	0.4	0.5	1.9	-0.3	-0.3	-0.6	1.8	0.2	0.6
Multivitamins +/- minerals	0.7	0.9	2.6	-0.5	-0.8	0.9	-1.3	-1.0	-0.3	1.0	0.3	1.0	-1.6	0.3	-1.1
High blood pressure (mother)	0.7	1.0	2.9	1.3	0.6	-0.7	1.7	0.7	0.5	-1.5	-0.8	-0.7	1.4	-0.7	0.8
Had other major operations	0.7	0.9	2.2	-1.4	-1.2	0.9	-0.6	-0.6	-1.5	1.0	0.1	0.8	-1.1	-0.1	-0.9
Financial difficulties in last 2 years	0.7	1.0	2.2	-1.0	-1.5	1.3	-0.6	-1.1	-0.1	0.5	1.0	1.0	-1.3	0.9	-1.0
Mouth/teeth dental problems	0.7	1.0	1.8	0.3	1.0	-1.3	1.4	1.1	-0.6	-1.3	-0.6	-1.2	0.9	-0.9	1.2
Pulse wave reflection index	0.7	0.9	2.2	-0.8	-0.8	0.8	-1.5	-0.8	0.2	1.2	0.9	1.0	-0.5	1.0	-1.0
Body fat percentage	0.7	2.9	4.7	-1.6	-1.9	2.1	-0.4	-2.1	-1.1	1.3	1.7	2.2	-1.4	1.8	-2.1
Medication: Blood pressure	0.7	1.3	3.2	-0.8	-1.5	1.4	0.3	-1.7	-0.0	0.7	0.5	1.7	-0.5	0.9	-1.8
Overall health rating	0.7	1.5	3.4	-0.6	-1.4	1.5	-0.5	-1.4	-1.8	-0.0	0.6	1.6	-1.1	0.7	-1.7
Had major operations	0.7	0.8	3.0	-0.8	-0.8	0.7	-1.1	-0.7	-1.2	1.7	-0.4	0.7	-0.0	0.0	-1.0
Ever taken oral contraceptive pill	0.7	0.8	2.4	-0.7	-0.5	0.8	-1.6	-1.0	-0.0	1.0	0.5	0.8	-1.4	0.4	-0.8
Illnesses of siblings	0.6	0.9	4.5	0.0	0.5	0.3	-0.8	-0.4	1.5	-0.3	1.1	0.4	-2.1	1.0	-0.2
Alcohol intake versus 10 years previously	0.6	0.8	1.6	-0.6	-1.0	1.1	-1.3	-1.1	-0.8	0.6	-0.1	1.0	-1.1	0.1	-1.2
Number of live births	0.6	0.9	5.2	0.2	1.6	-0.7	0.8	0.6	2.3	-0.9	0.1	-0.5	0.4	-0.1	0.6
Prospective memory result	0.6	0.7	2.4	1.0	1.5	-0.8	0.3	0.8	0.9	-0.3	-0.6	-0.8	0.9	-0.5	0.9
Impedance of arm (left)	0.6	2.9	6.7	1.3	2.6	-2.0	0.2	2.2	0.8	-0.5	-1.3	-2.3	1.5	-1.5	2.3
Birth weight of first child	0.6	1.0	3.1	1.0	0.9	-0.9	1.8	0.9	1.4	-0.5	-0.8	-1.0	0.7	-1.0	1.0
Birth weight	0.6	1.4	2.0	1.4	1.2	-1.3	1.1	1.4	1.1	-0.1	-1.2	-1.2	1.0	-1.4	1.2
Number of children fathered	0.6	0.7	3.5	-0.1	-0.4	0.1	-0.3	0.1	-1.1	0.4	-1.9	-0.2	-0.2	-1.8	-0.1
Migraine (self-reported)	0.6	0.7	1.9	0.6	1.4	-1.0	-0.0	0.9	0.0	-0.8	-0.9	-0.8	1.0	-0.9	0.9
Supplements: Vitamin C	0.6	0.7	1.3	-0.7	-1.0	0.9	-0.5	-0.6	-1.1	1.1	0.4	0.9	-0.6	0.5	-1.0
Hypertension (Self-reported)	0.6	1.6	3.7	-0.7	-1.3	1.4	-0.0	-1.9	-0.9	0.1	1.1	1.7	-1.3	1.4	-1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	2.8	0.5	1.0	-0.4	1.7	0.7	1.5	0.1	-0.2	-0.6	0.4	-0.6	0.7
Asthma (self-reported)	0.6	1.2	2.0	0.9	0.7	-1.2	1.0	1.3	0.2	-1.4	-1.1	-1.2	1.3	-1.1	1.2
Miserableness	0.6	1.1	2.7	0.8	0.7	-1.1	-0.1	1.0	-0.4	-0.2	-1.4	-1.2	1.6	-1.2	1.2
Hearing aid user	0.6	0.7	2.7	0.2	0.5	-0.4	1.6	0.8	1.6	-0.9	0.5	-0.4	-0.5	0.1	0.7
Commuting to job workplace: Public transport	0.6	0.7	2.4	-0.9	-0.6	0.7	-1.4	-0.7	-1.5	0.6	0.6	0.4	-0.8	0.7	-0.4
Leg fat percentage (left)	0.6	2.2	3.6	-1.3	-1.9	1.8	0.3	-1.8	-0.6	1.0	1.4	1.9	-1.5	1.4	-1.9
Irritability	0.6	1.1	2.7	-1.6	-1.0	1.1	-1.0	-1.2	-0.6	1.2	0.8	1.0	-0.9	0.6	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	3.8	0.7	1.1	-0.4	0.4	0.7	2.0	-0.0	0.1	-0.7	0.8	0.0	0.9
Body Mass Index (BMI) (2010)	0.5	0.7	1.3	-0.2	-1.0	1.1	0.6	-1.1	0.8	1.1	0.4	0.9	-0.7	0.4	-1.1
Mean Putamen Volume	0.5	0.6	1.1	0.9	0.8	-0.6	-0.3	1.0	0.9	0.1	-0.7	-0.8	1.1	-0.4	0.8
Lupus	0.5	0.7	1.7	-0.1	1.1	-0.3	1.1	0.3	1.3	-1.0	0.8	-0.4	1.1	0.9	0.6
Cardiovascular Disease	0.5	1.6	5.2	-1.5	-0.6	1.2	-0.7	-1.4	-0.9	0.8	1.4	1.2	-2.3	1.2	-1.2
Average weekly fortified wine intake	0.5	0.5	1.9	-0.0	1.0	-0.7	0.7	0.7	-0.4	-0.3	-0.7	-0.7	1.4	-0.7	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.6	0.9	0.4	-0.8	0.3	0.8	0.3	-0.0	-1.3	-0.9	0.8	-1.2	0.9
Nervous feelings	0.5	0.8	2.9	0.9	0.9	-0.6	0.8	0.7	1.7	-1.0	0.2	-1.0	-0.8	-0.0	1.2
Heart attack	0.5	0.6	1.3	-0.1	-1.2	0.7	0.8	-0.9	0.0	-0.7	-0.6	1.0	-0.9	-0.4	-1.2
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.7	1.7	0.6	0.1	-0.6	0.5	1.1	-1.3	-1.1	-0.9	-0.9	0.2	-1.0	1.0
Medication: Lansoprazole	0.5	0.6	1.4	-1.0	-0.6	0.9	-0.6	-0.5	-0.6	1.2	0.9	0.7	-0.0	0.9	-0.6
Lung cancer (father)	0.5	0.6	1.0	-0.7	-0.7	0.9	0.1	-0.8	0.2	0.9	0.7	1.0	-1.0	0.6	-1.0
Illnesses of mother	0.5	0.7	2.5	-1.0	-0.4	0.1	-1.6	-0.3	-1.6	0.8	-0.7	0.3	0.1	-0.5	-0.6
Breastfed as a baby	0.5	0.7	1.8	0.5	0.8	-0.9	0.3	0.5	1.1	0.2	-1.3	-0.7	1.0	-1.2	0.5
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	2.7	0.7	1.2	-1.0	-0.5	1.3	-0.0	-0.6	0.2	-1.5	0.6	-0.1	1.6
High blood pressure (siblings)	0.5	0.7	2.4	0.4	-0.7	-0.2	1.5	0.2	-0.7	-0.3	-1.4	-0.3	1.2	-1.2	0.1
Leg fat percentage (right)	0.5	1.8	3.2	-1.1	-1.6	1.7	0.4	-1.7	-0.3	0.8	1.2	1.8	-1.4	1.2	-1.8
Shortness of breath walking on level ground	0.5	0.5	1.0	-0.6	-0.8	0.9	0.1	-1.0	0.4	0.1	0.9	0.9	-0.4	0.9	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.5	-0.4	-0.9	0.6	-1.0	-0.7	-0.5	0.9	0.5	0.9	-1.2	0.5	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	3.8	0.3	0.3	-0.0	0.3	0.1	1.9	0.8	0.3	-0.2	1.2	0.4	0.4
Illnesses of father: Heart disease	0.5	0.6	2.2	0.1	-0.9	0.5	-1.3	-0.7	-1.5	0.8	-0.5	0.5	0.4	-0.2	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	3.9	-0.7	-0.7	0.6	-0.8	-0.3	-0.0	0.3	0.5	0.5	-2.0	0.2	-0.4
Age started oral contraceptive pill	0.5	0.6	3.0	0.9	-0.2	-0.1	1.5	0.2	1.7	0.2	-0.4	-0.1	0.9	-0.2	0.1
Ever depressed for a whole week	0.5	0.6	4.6	-0.0	1.0	-0.1	0.1	-0.2	2.1	0.1	0.4	-0.3	1.1	0.3	0.5
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.6	-0.2	-1.3	0.8	0.6	-1.0	-0.3	-0.6	-0.6	1.0	-0.8	-0.4	-1.2
Heart disease (siblings)	0.5	0.6	5.6	-0.8	-0.6	0.4	0.2	-0.2	-2.4	0.7	0.0	0.3	0.3	-0.0	-0.4
Worry (Nagel 2018)	0.4	0.9	2.4	0.4	1.6	-0.9	0.7	1.1	1.1	-1.0	-0.3	-1.1	-0.9	-0.6	1.2
Alzheimer’s Disease (in father)	0.4	0.5	3.5	0.9	0.2	-0.3	0.3	0.4	1.9	0.3	-0.6	-0.4	0.3	-0.5	0.5
Crohns Disease (2017)	0.4	0.8	1.7	0.8	1.0	-1.0	0.6	1.1	0.1	-1.0	-1.1	-1.0	-0.1	-1.3	0.8
Irritable Bowel Disease (IBD)	0.4	1.0	1.6	1.0	1.2	-1.2	0.9	1.3	0.0	-1.1	-0.9	-1.1	-0.3	-1.2	1.1
Ulcerative Colitis (UC)	0.4	0.7	1.0	1.0	0.9	-1.0	0.9	1.0	0.7	-0.9	-0.4	-0.9	-0.4	-0.8	1.0
Major Depression (MDD)	0.4	0.5	1.4	0.8	0.7	-0.7	0.1	0.5	-0.2	-0.2	-1.2	-0.6	0.6	-1.0	0.6
HDL Cholesterol	0.4	0.7	2.4	-0.9	-0.9	0.7	-1.5	-0.8	-0.6	-0.2	0.9	0.8	-0.5	0.8	-0.8
Relative age of first facial hair	0.4	0.8	2.1	1.4	0.0	-0.6	1.3	0.4	0.8	-0.8	-1.5	-0.4	0.7	-1.1	0.2
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.2	0.5	1.1	-0.5	0.6	0.7	1.0	-1.1	0.5	-0.8	0.0	0.4	0.8
Qualifications: CSEs or equivalent	0.4	0.5	1.4	0.8	0.6	-0.7	1.0	0.6	-1.2	-1.0	-0.2	-0.6	0.1	-0.4	0.7
Hayfever, allergic rhinitis or eczema	0.4	0.9	1.8	0.2	1.2	-1.1	0.9	1.1	0.8	-0.8	-0.4	-1.2	1.1	-0.7	1.3
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.0	-0.7	-0.9	0.8	-1.0	-0.7	-0.3	1.0	0.1	0.7	0.7	0.3	-0.8
Hair/balding pattern: Pattern 2	0.4	0.5	1.6	-0.5	0.4	-0.7	1.0	0.6	0.3	0.7	-0.8	-0.6	0.2	-1.2	0.5
Impedance of arm (right)	0.4	1.8	3.5	0.8	1.9	-1.5	-0.9	1.7	0.1	0.2	-1.2	-1.7	1.7	-1.2	1.6
Noisy workplace	0.4	0.5	1.9	-0.2	-0.3	0.5	0.5	-0.4	1.1	0.3	1.0	0.5	-1.4	0.7	-0.3
Asthma	0.4	0.8	1.8	0.6	0.4	-0.9	0.8	1.0	0.1	-1.3	-0.9	-1.0	1.0	-0.9	0.9
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.1	-1.0	-0.4	0.8	-1.1	-0.6	-0.3	0.5	0.9	0.5	-0.5	0.9	-0.3
Medication: Paracetamol	0.4	0.6	1.6	0.9	0.7	-0.5	1.3	0.7	0.5	-1.1	-0.5	-0.7	0.5	-0.7	0.8
Wheeze or whistling in the chest in last year	0.4	0.6	1.7	-0.6	-1.3	1.1	0.1	-0.9	-0.0	0.6	0.8	1.0	-0.4	0.7	-0.9
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.8	1.4	0.7	-0.5	0.5	-0.1	0.0	-0.6	-1.1	0.1	1.1	-0.5	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	3.3	-0.9	-0.5	0.3	-1.6	-0.3	-1.8	0.7	0.7	0.5	0.5	0.8	-0.5
Mood swings	0.4	0.7	1.4	0.6	0.6	-0.8	0.5	0.9	0.4	-0.3	-0.9	-1.1	0.5	-1.2	1.2
Loneliness, isolation	0.4	0.5	1.3	0.4	0.4	-0.8	-0.2	0.8	1.2	0.0	-0.4	-1.0	0.4	-0.6	1.1
Friendships satisfaction	0.4	0.4	1.1	0.2	-0.1	0.3	-0.5	-0.5	1.1	-1.0	1.0	0.2	-0.8	1.0	-0.1
Eye problems/disorders: Cataract	0.4	0.4	2.2	0.8	0.2	-0.2	0.8	0.2	1.2	-0.1	-0.2	-0.3	1.5	0.1	0.3
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	2.9	-0.2	-1.0	0.7	-1.7	-0.7	-0.9	0.3	0.4	0.6	0.2	0.8	-0.5
Back pain experienced in last month	0.4	0.6	1.5	0.7	0.7	-0.7	0.2	1.0	-0.7	-1.2	-0.5	-1.0	0.0	-0.7	1.1
Mineral and other dietary supplements	0.4	0.6	1.5	-1.2	-0.8	0.6	-0.0	-0.6	-1.1	0.2	1.2	0.5	-0.0	1.1	-0.4
Medication: Lisinopril	0.4	0.6	4.0	0.1	0.4	-0.5	2.0	0.3	0.8	0.5	-0.7	-0.4	0.1	-0.8	0.3
Average weekly beer plus cider intake	0.4	0.5	4.8	0.0	-0.6	0.4	0.0	-0.4	-0.0	0.3	0.8	0.2	-2.2	0.4	-0.0
Fractured/broken bones in last 5 years	0.4	0.5	1.5	-0.1	-0.8	0.0	0.1	-0.5	-1.1	0.0	-1.2	0.3	-0.3	-1.2	-0.4
Schizophrenia vs Biploar Disorder	0.3	0.3	0.8	-0.1	0.6	-0.5	0.9	0.7	0.0	0.5	-0.6	0.0	0.8	-0.7	0.8
Alzheimer’s Disease (in mother)	0.3	0.3	1.2	-0.4	0.3	-0.0	-0.7	0.4	0.4	-0.2	1.1	-0.2	-0.8	1.0	0.3
Age at First Birth	0.3	0.4	2.0	-1.1	0.2	0.1	-0.2	0.2	-0.9	1.4	0.4	0.2	0.3	0.3	-0.3
Bipolar Disorder (2011)	0.3	0.3	1.1	0.4	0.6	-0.2	0.7	0.0	0.9	-1.1	-0.3	0.0	-0.6	-0.4	0.1
LDL Cholesterol	0.3	0.5	2.5	0.3	0.4	-0.1	1.6	0.3	1.6	-0.3	0.2	-0.5	0.1	0.1	0.4
Type 2 Diabetes (T2D) (2012)	0.3	0.3	2.7	0.7	-0.5	0.3	0.5	-0.4	0.3	0.3	0.0	0.0	-1.6	0.1	-0.4
Blood Red Count	0.3	3.2	5.9	-1.4	-1.8	2.2	-0.2	-2.4	-1.0	1.3	1.7	2.4	-1.8	1.6	-2.3
Allergy or Eczema	0.3	0.9	1.6	0.5	0.9	-1.0	1.0	1.1	1.0	-0.9	-0.6	-1.2	1.1	-0.8	1.3
Lung FVC	0.3	1.5	2.6	1.1	1.2	-1.6	0.7	1.2	1.3	-1.6	-0.4	-1.5	1.3	-0.3	1.5
Number of treatments/medications taken	0.3	0.5	2.0	0.2	1.1	-0.6	1.4	0.8	0.8	-0.4	0.1	-0.6	-0.6	-0.3	0.7
Average weekly spirits intake	0.3	0.4	1.7	0.5	0.6	-0.4	0.4	0.2	1.3	-0.7	0.8	-0.2	0.6	0.8	0.3
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.0	0.7	0.3	-0.5	1.0	0.7	0.7	0.2	-0.4	-0.9	-0.2	-0.5	1.0
Supplements: Zinc	0.3	0.3	0.7	0.5	-0.2	-0.5	0.7	0.6	-0.8	-0.9	-0.5	-0.5	0.5	-0.5	0.5
Stomach or abdominal pain in last month	0.3	0.4	1.0	0.2	0.5	-0.5	-0.6	0.9	-0.3	-1.0	-0.6	-0.7	-0.1	-0.8	0.6
Supplements: Glucosamine	0.3	0.3	1.7	-0.0	-0.5	0.5	-0.9	-0.2	1.3	0.7	-0.1	0.4	0.2	0.0	-0.4
Had menopause	0.3	0.4	1.2	-0.1	0.3	0.5	0.8	-0.1	0.0	0.7	1.1	0.2	-0.7	1.0	-0.1
Qualifications: None of the above	0.3	0.6	2.0	0.6	1.4	-1.0	0.8	0.8	0.5	-0.9	-0.5	-0.9	-0.1	-0.6	0.9
Father’s age at death	0.3	0.3	1.7	-0.3	-1.3	0.7	-0.8	-0.6	-0.3	-0.2	0.1	0.5	-0.2	0.2	-0.5
Falls in the last year	0.3	0.4	1.0	1.0	0.2	-0.5	1.0	0.4	-0.1	-0.4	-1.0	-0.4	0.4	-0.9	0.3
Hair/balding pattern: Pattern 4	0.3	0.6	1.2	-0.4	-1.0	1.0	-0.9	-1.0	-1.1	0.2	0.0	1.1	0.2	0.2	-1.0
Peak expiratory flow (PEF)	0.3	0.8	1.9	-1.1	-0.5	0.8	-1.4	-0.9	-1.2	0.5	0.7	0.9	-0.3	0.9	-1.0
Loud music exposure frequency	0.3	0.4	2.5	0.3	-0.6	-0.0	0.4	0.0	-1.6	-1.1	0.0	0.1	0.2	0.1	-0.0
Forced vital capacity (FVC), Best measure	0.3	1.0	2.3	-1.3	-0.7	0.7	-1.4	-1.0	-1.5	0.0	1.2	0.8	-0.2	1.3	-0.8
Worry too long after embarrassment	0.3	0.5	2.2	0.3	-0.7	0.8	0.4	-0.8	-0.4	-0.3	0.6	0.6	-1.5	0.4	-0.5
Pulse wave peak to peak time	0.3	0.4	0.7	0.6	0.4	-0.2	0.9	0.3	-0.6	-0.8	-0.8	-0.4	0.8	-0.6	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.6	0.8	0.7	-0.5	0.6	0.7	-0.4	-0.3	-0.7	-0.5	0.1	-0.6	0.4
Chest pain or discomfort	0.3	0.5	1.3	-0.3	-1.1	0.9	-1.1	-0.7	-0.8	0.3	0.1	0.8	0.0	0.1	-0.8
Family relationship satisfaction	0.3	0.4	1.4	-0.0	-0.8	0.7	-0.2	-0.8	-0.0	-0.3	0.9	0.5	-0.4	1.2	-0.5
Smoking status: Previous	0.3	0.4	1.3	0.8	0.8	-0.4	-1.2	0.4	0.9	0.2	-0.2	-0.4	-0.6	-0.3	0.4
Number of self-reported non-cancer illnesses	0.3	0.4	1.2	-0.8	-0.8	0.7	-0.1	-0.6	-0.8	-0.0	0.3	0.7	-1.1	0.3	-0.7
Average weekly champagne plus white wine intake	0.3	0.5	1.9	1.0	0.7	-0.7	0.4	0.4	0.7	-1.4	-0.5	-0.5	0.1	-0.5	0.5
Number of operations (self-reported)	0.3	0.5	1.4	-1.1	-0.4	0.5	-0.8	-0.3	-0.9	1.2	0.5	0.3	-1.1	0.2	-0.2
Unable to work because of sickness or disability	0.3	0.4	1.9	0.4	-0.4	-0.3	1.4	0.4	0.2	-0.4	-0.7	-0.3	-0.3	-1.0	0.3
Pack years of smoking	0.3	0.4	2.3	0.1	-0.7	0.2	-0.4	-0.2	-1.5	-0.5	0.6	0.4	0.2	0.6	-0.3
Bipolar Disorder (2018)	0.2	0.3	1.3	-0.0	-0.0	0.2	0.2	-0.4	0.1	-1.1	0.3	0.0	-1.1	0.4	-0.5
Alzheimer’s Disease (including proxy)	0.2	0.4	1.1	-0.1	-0.5	0.6	-0.3	-0.1	0.4	0.8	0.9	0.2	-1.0	0.8	-0.4
Fasting Glucose	0.2	0.2	1.1	-0.1	0.1	0.4	-0.5	-0.5	0.2	1.1	0.2	0.6	-0.1	0.2	-0.6
Ulcerative Colitis	0.2	0.2	0.8	0.8	0.3	-0.3	0.3	0.4	-0.6	-0.9	-0.2	0.0	-0.4	-0.3	0.4
Smoking Status	0.2	0.4	2.0	0.7	0.7	-0.8	-0.2	0.5	1.4	0.2	-0.2	-0.6	0.6	-0.3	0.6
Hearing difficulty/problems: Yes	0.2	0.2	0.9	-0.3	-0.3	0.5	0.1	-0.4	-0.2	-0.3	0.8	0.4	-0.3	1.0	-0.3
Medication for hormone replacement therapy	0.2	0.3	1.4	-0.5	-0.0	-0.0	-1.0	0.2	-1.2	-0.5	-0.2	-0.1	-0.4	-0.2	0.0
Diabetes (mother)	0.2	0.3	1.8	0.0	0.2	0.4	-0.1	-0.6	0.5	0.1	0.4	0.4	-1.3	0.4	-0.4
Severe depression (siblings)	0.2	0.2	1.8	0.0	0.2	0.1	-0.7	0.0	0.3	-0.4	-0.3	-0.3	1.4	-0.2	0.3
Pack years adult smoking proportion	0.2	0.4	1.9	0.1	-0.6	0.2	-0.3	-0.1	-1.4	-0.8	0.8	0.4	0.0	0.7	-0.2
Current tobacco smoking	0.2	0.3	1.5	0.2	0.3	-0.5	0.3	0.3	1.2	0.1	0.5	-0.3	1.1	0.4	0.5
Serious illness, injury or assault to yourself	0.2	0.3	1.0	0.3	0.3	-0.5	0.2	0.7	-0.3	-0.3	-1.0	-0.7	0.1	-0.8	0.5
Past tobacco smoking	0.2	0.4	1.7	-0.3	-0.6	0.1	1.3	-0.1	-0.8	-0.1	-0.6	0.2	0.8	-0.4	-0.3
Hearing difficulty/problems with background noise	0.2	0.4	3.0	0.3	0.5	-0.3	0.2	0.3	1.7	0.0	0.6	-0.3	0.1	0.6	0.4
Forced vital capacity (FVC)	0.2	0.7	2.1	-1.1	-0.3	0.4	-1.1	-0.7	-0.8	-0.1	1.4	0.6	-0.3	1.5	-0.5
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.7	-0.6	0.2	0.4	-0.4	-0.5	0.8	0.7	0.6	0.3	0.3	0.5	-0.1
Medication: Ramipril	0.2	0.3	1.5	0.2	-0.3	-0.0	-0.3	0.0	-0.1	0.3	-1.2	0.0	0.9	-0.9	-0.2
Medication: Simvastatin	0.2	0.3	0.8	-0.1	-0.7	0.7	0.6	-0.9	-0.4	0.5	-0.3	0.8	-0.4	0.1	-0.9
Forced expiratory volume in 1-second (FEV1)	0.2	0.5	1.3	-1.0	-0.2	0.4	-0.8	-0.7	-0.7	-0.0	1.1	0.5	-0.6	1.2	-0.4
Medication: Cholesterol lowering	0.2	0.3	1.1	-0.0	-0.6	0.3	0.2	-0.5	0.3	0.1	-1.0	0.5	-0.4	-1.0	-0.6
Depression (self-reported)	0.2	0.2	1.6	0.1	-0.1	0.1	0.4	-0.1	1.2	-0.2	0.5	-0.2	-0.2	0.6	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	2.0	-1.1	-0.2	0.4	-1.1	-0.7	-1.4	0.2	0.8	0.5	-0.4	0.8	-0.5
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.1	-0.2	-0.3	-0.2	0.4	0.4	-0.6	0.9	-0.9	-0.4	-0.7	-1.1	0.2
Exposure to tobacco smoke outside home	0.2	0.3	1.1	-0.5	-0.5	0.4	-0.4	-0.4	-1.1	0.4	-0.4	0.5	0.7	-0.2	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.9	-0.3	0.1	-0.3	0.5	0.1	-0.8	-1.0	-0.0	-0.4	-0.7	-0.4	0.4
Medication: Omeprazole	0.2	0.3	2.0	0.1	0.3	0.4	-0.1	-0.2	1.4	0.1	0.7	0.1	0.0	0.6	0.1
Number of full sisters	0.2	0.2	0.7	-0.4	-0.3	0.1	0.8	-0.2	0.4	-0.7	0.2	0.3	-0.9	-0.1	-0.3
Average weekly red wine intake	0.2	0.3	0.8	0.2	0.0	-0.3	0.9	0.4	0.1	-0.4	-0.7	-0.4	0.7	-0.9	0.3
Ever had bowel cancer screening	0.2	0.3	1.4	-0.4	-0.3	0.6	-1.2	-0.5	-0.4	0.7	0.1	0.5	-0.2	0.0	-0.5
Qualifications: nursing, teaching	0.2	0.3	0.9	-0.4	-1.0	0.6	0.1	-0.6	-0.9	0.2	0.3	0.4	0.4	0.2	-0.5
Commuting to job workplace: Walk	0.2	0.3	1.0	1.0	0.0	-0.5	0.3	0.3	0.2	-0.9	-0.3	-0.4	-0.5	-0.3	0.4
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.9	0.1	0.1	-0.5	0.3	0.5	-0.9	-0.5	-0.5	-0.5	0.3	-0.7	0.5
High cholesterol (Self-reported)	0.2	0.4	2.3	0.1	-0.1	-0.1	-0.1	-0.1	1.5	0.6	-0.5	-0.0	-1.1	-0.5	-0.1
Illnesses of father: High blood pressure	0.2	0.3	1.2	-0.1	-0.0	-0.3	1.1	0.4	-0.2	-0.3	-0.3	-0.6	1.0	-0.3	0.5
Ever smoked	0.2	0.3	0.9	0.3	0.8	-0.4	-0.9	0.5	0.9	-0.2	0.3	-0.5	-0.4	0.0	0.6
Commuting to job workplace: Cycle	0.2	0.2	0.8	0.3	0.1	-0.2	0.3	0.2	-0.9	-0.2	-0.0	-0.5	-0.6	0.0	0.6
Depressed Affect (Nagel 2018)	0.1	0.2	0.5	-0.6	-0.4	0.1	-0.6	-0.2	-0.6	0.7	-0.1	-0.1	-0.6	-0.2	0.1
Depression (Nagel 2018)	0.1	0.2	1.1	-0.3	-0.4	0.1	-0.3	0.0	-0.5	1.0	-0.4	-0.1	-0.7	-0.4	0.1
Breast Cancer	0.1	0.2	0.5	0.6	0.3	-0.5	-0.2	0.4	-0.6	0.4	-0.2	-0.6	0.5	-0.3	0.7
Crohns Disease (2012)	0.1	0.1	0.6	-0.0	0.3	-0.1	0.8	0.4	-0.0	-0.3	0.3	0.0	-0.2	0.1	0.2
Triglycerides	0.1	0.2	1.6	-0.5	-0.2	-0.3	1.3	-0.1	-0.5	-0.3	0.1	-0.1	0.1	-0.0	0.2
Blood Eosinophil Count	0.1	0.8	3.6	0.2	1.4	-1.1	-0.0	1.0	1.9	0.1	0.5	-0.9	-0.0	0.1	1.1
Waist Hip Ratio (WHR)	0.1	0.5	2.3	0.8	1.5	-0.6	-0.1	1.0	0.8	-0.7	0.2	-0.6	-0.1	-0.0	0.8
Hypothyroidism (self reported)	0.1	0.3	1.0	-0.0	-0.3	-0.1	0.1	0.4	-1.0	0.3	-0.9	-0.3	-0.3	-1.0	0.2
Lung FEV1/FVC ratio	0.1	0.5	1.8	-0.6	-0.5	0.8	-0.3	-0.5	0.0	1.4	0.8	0.4	-0.9	0.7	-0.2
Neuroticism	0.1	0.3	1.7	-0.7	-0.4	0.6	-0.6	-0.5	-0.3	-0.2	0.7	0.3	-1.3	0.5	-0.2
Hair Pigment	0.1	2.3	6.3	2.1	0.2	-1.4	1.4	1.2	0.9	-1.2	-2.5	-1.0	1.6	-2.1	0.8
Sensitivity / hurt feelings	0.1	0.2	0.6	-0.2	0.1	0.1	-0.0	-0.1	-0.5	-0.7	0.8	0.1	-0.3	0.6	0.1
Medication: Levothyroxine sodium	0.1	0.2	0.5	-0.3	0.0	-0.3	0.1	0.6	0.3	0.7	0.2	-0.6	-0.7	-0.2	0.7
Alcohol usually taken with meals	0.1	0.2	0.9	0.4	0.4	0.0	-0.6	-0.1	0.9	0.1	-0.3	-0.0	0.4	-0.0	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.5	-0.6	-0.7	0.6	0.4	-0.1	-0.3	0.5	0.0	0.1	-0.4	-0.1	-0.0
Allergy	0.1	0.3	0.5	0.3	-0.6	0.5	-0.7	-0.6	-0.3	0.4	-0.5	0.5	-0.7	-0.2	-0.7
Neuroticism score	0.1	0.2	0.9	-0.5	-0.1	0.3	-0.5	-0.4	-0.0	-0.0	0.8	0.1	-0.9	0.4	0.1
Worrier / anxious feelings	0.1	0.2	0.6	-0.2	0.8	-0.1	0.0	0.4	0.5	-0.3	0.2	-0.5	-0.6	-0.0	0.6
Happiness	0.1	0.1	0.8	-0.3	-0.2	0.2	-0.2	-0.0	0.9	-0.4	-0.1	-0.4	0.2	-0.3	0.4
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.6	0.2	-0.4	0.0	-0.1	-0.0	-0.7	-0.5	-0.2	-0.0	0.8	-0.1	-0.0
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	1.1	-0.3	0.1	-0.0	-0.2	0.2	0.2	-0.1	0.4	-0.1	-1.0	-0.2	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.4	-0.3	-0.2	0.4	-0.6	-0.2	0.5	0.2	-0.0	-0.2	-0.1	0.0	0.2
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.8	-0.4	-0.6	0.0	0.6	-0.2	-0.9	-0.4	0.1	0.3	0.0	0.0	-0.3
Medication: Amlodipine	0.1	0.1	0.4	-0.2	-0.3	0.1	0.6	-0.3	-0.2	-0.1	-0.2	-0.1	0.6	-0.4	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	1.3	-0.3	-0.3	0.2	-0.5	-0.3	1.1	-0.3	-0.2	-0.2	-0.3	-0.2	0.1
Age at first live birth	0.1	0.2	1.1	-0.2	-0.1	-0.2	-0.5	0.0	-0.1	0.7	-1.1	-0.3	-0.1	-0.9	-0.0
Qualifications: College or University degree	0.1	0.3	0.8	-0.0	-0.8	0.8	-0.1	-0.7	-0.3	-0.0	0.5	0.6	0.4	0.9	-0.8
Medication for pain relief, constipation, heartburn	0.1	0.1	0.3	0.4	-0.3	-0.4	-0.4	0.2	-0.1	0.2	-0.2	-0.5	0.6	0.0	0.5
Alcohol intake frequency.	0.1	0.3	0.7	-0.1	-0.7	0.8	-0.1	-0.7	0.2	-0.0	0.2	0.7	-0.8	0.5	-0.7
Suffer from ‘nerves’	0.1	0.2	0.5	0.5	0.2	-0.4	0.0	0.5	-0.1	-0.7	-0.3	-0.7	-0.5	-0.4	0.7
Age at last live birth	0.1	0.2	0.7	-0.5	0.0	-0.0	-0.7	-0.0	-0.1	0.8	-0.5	-0.1	0.3	-0.4	-0.1
Commuting to job workplace: Car/motor vehicle	0.1	0.2	0.4	-0.6	-0.5	0.4	-0.3	-0.1	0.4	0.3	0.5	0.5	-0.1	0.3	-0.4
Knee pain experienced in last month	0.1	0.2	0.7	0.3	-0.4	0.2	-0.7	-0.0	0.2	-0.6	0.4	0.4	-0.8	0.2	-0.3
Smoking status: Current	0.1	0.2	0.9	0.0	0.2	-0.4	0.1	0.2	0.9	-0.0	0.7	-0.2	0.9	0.5	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	1.2	-0.4	-0.1	0.4	-0.0	-0.2	0.7	-0.3	1.1	0.1	-0.4	1.1	0.0
Guilty feelings	0.1	0.1	0.7	-0.0	-0.3	0.3	0.8	-0.2	0.2	0.8	-0.1	0.1	-0.1	-0.1	-0.0
Tinnitus: Yes, now most or all of the time	0.1	0.2	0.8	0.3	0.0	-0.0	-0.2	-0.1	0.2	-0.5	0.7	-0.2	0.3	0.9	0.3
Myopia	0.1	0.1	0.3	-0.3	-0.1	-0.2	0.1	0.2	-0.5	0.3	-0.4	-0.2	0.4	-0.6	0.1
Neuroticism (Nagel 2018)	0.0	0.1	0.9	-0.3	0.2	0.0	0.2	0.1	0.3	0.0	0.0	-0.2	-0.9	-0.2	0.3
Respiratory disease	0.0	0.1	0.4	0.2	-0.2	-0.1	0.4	0.2	-0.2	-0.6	-0.1	-0.1	0.4	0.1	0.1
Tanning	0.0	0.4	2.0	-1.4	-0.2	0.7	-0.2	-0.2	0.3	1.1	0.9	0.4	-0.6	0.2	-0.2
Taking other prescription medications	0.0	0.1	0.4	-0.3	0.1	0.1	0.4	-0.1	0.2	-0.1	0.2	0.1	-0.7	0.1	-0.1
Chronic bronchitis/emphysema (mother)	0.0	0.1	0.1	0.2	-0.3	0.1	0.2	0.2	0.2	-0.3	0.0	-0.3	-0.1	-0.2	0.3
Osteoarthritis (self-reported)	0.0	0.1	0.2	-0.4	-0.0	0.1	-0.3	-0.1	0.1	-0.2	0.4	0.1	-0.4	0.2	0.0

Hub : Genes

GAR1

Models

Trait associations