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chr5:125,679,739-128,220,643

Best TWAS P=6.33e-45 · Best GWAS P=6.25e-44 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	C5orf63	0.12	0.12	enet	14	0.15	5.9e-18	4.55	-5.1	3.1e-07	0.06	0.24	0.74	FALSE
2	CommonMind	Brain Pre-frontal Cortex	FLJ33630	0.06	0.07	lasso	6	0.07	8.6e-09	-3.59	-7.0	2.5e-12	-0.52	0.62	0.38	FALSE
3	GTEx	Adipose Subcutaneous	CTC-228N24.3	0.24	0.15	enet	16	0.20	3.4e-16	13.90	-13.1	2.5e-39	-0.97	0.00	1.00	FALSE
4	GTEx	Adipose Visceral Omentum	CTC-228N24.3	0.24	0.16	enet	19	0.16	1.8e-08	13.90	-12.0	4.3e-33	-0.80	0.00	1.00	FALSE
5	GTEx	Adrenal Gland	CTC-228N24.3	0.34	0.10	lasso	9	0.09	4.2e-04	10.50	-11.9	1.3e-32	-0.88	0.03	0.96	FALSE
6	GTEx	Artery Aorta	CTC-228N24.3	0.20	0.04	lasso	8	0.07	7.4e-05	5.62	-12.5	5.8e-36	-0.91	0.11	0.86	FALSE
7	GTEx	Artery Coronary	CTC-228N24.3	0.31	0.10	lasso	3	0.10	2.9e-04	13.10	-13.0	7.9e-39	-0.86	0.01	0.90	FALSE
8	GTEx	Artery Tibial	CTC-228N24.3	0.20	0.16	lasso	7	0.14	3.0e-11	13.90	-14.1	6.3e-45	-0.99	0.00	1.00	TRUE
9	GTEx	Brain Caudate basal ganglia	PRRC1	0.39	0.00	enet	5	0.06	7.1e-03	5.25	-5.1	3.1e-07	-0.19	0.07	0.05	FALSE
10	GTEx	Brain Cerebellar Hemisphere	SLC12A2	0.45	-0.01	enet	20	0.01	2.1e-01	10.20	-7.9	2.8e-15	-0.46	0.04	0.33	FALSE
11	GTEx	Brain Cerebellar Hemisphere	CTC-228N24.3	0.25	0.00	lasso	6	0.05	2.2e-02	0.45	-6.4	2.0e-10	-0.49	0.03	0.62	FALSE
12	GTEx	Brain Cerebellum	C5orf63	0.20	0.07	lasso	3	0.05	1.7e-02	4.85	-5.7	1.6e-08	0.04	0.06	0.80	TRUE
13	GTEx	Brain Cerebellum	CTC-228N24.3	0.31	0.04	lasso	5	0.12	2.9e-04	13.90	-11.7	1.2e-31	-0.84	0.01	0.97	FALSE
14	GTEx	Cells EBV-transformed lymphocytes	CTC-228N24.3	0.24	-0.01	enet	26	0.04	2.2e-02	8.61	-8.6	8.9e-18	-0.57	0.03	0.70	FALSE
15	GTEx	Cells Transformed fibroblasts	CTC-228N24.3	0.24	0.16	enet	26	0.16	8.6e-12	13.90	-13.0	1.8e-38	-0.89	0.00	1.00	FALSE
16	GTEx	Colon Sigmoid	CTC-228N24.3	0.20	0.22	enet	11	0.23	1.1e-08	13.10	-13.1	6.2e-39	-0.92	0.01	0.99	FALSE
17	GTEx	Esophagus Gastroesophageal Junction	CTC-228N24.3	0.20	0.04	enet	22	0.13	2.1e-05	-3.62	-7.7	1.9e-14	-0.51	0.05	0.68	FALSE
18	GTEx	Esophagus Mucosa	CTC-228N24.3	0.18	0.14	enet	11	0.14	9.8e-10	13.90	-13.6	2.4e-42	-0.93	0.00	1.00	FALSE
19	GTEx	Esophagus Muscularis	CTC-228N24.3	0.24	0.08	enet	29	0.14	1.4e-08	13.10	-10.5	7.8e-26	-0.75	0.01	0.99	FALSE
20	GTEx	Heart Atrial Appendage	CTC-228N24.3	0.22	0.07	lasso	5	0.07	4.1e-04	13.10	-11.3	1.2e-29	-0.87	0.00	0.99	FALSE
21	GTEx	Heart Left Ventricle	CTC-228N24.3	0.24	0.15	lasso	7	0.19	1.9e-10	12.40	-11.5	1.7e-30	-0.84	0.01	0.99	FALSE
22	GTEx	Lung	CTC-228N24.3	0.18	0.14	enet	16	0.14	3.2e-11	13.90	-12.3	8.8e-35	-0.95	0.00	1.00	FALSE
23	GTEx	Muscle Skeletal	CTC-228N24.3	0.25	0.20	lasso	5	0.21	1.6e-20	13.90	-12.9	4.2e-38	-0.95	0.00	1.00	FALSE
24	GTEx	Nerve Tibial	CTC-228N24.3	0.32	0.18	lasso	10	0.16	1.6e-11	13.10	-13.3	4.1e-40	-0.96	0.01	0.99	FALSE
25	GTEx	Pancreas	CTC-228N24.3	0.14	0.19	lasso	2	0.17	1.1e-07	13.90	-13.9	6.3e-44	-1.00	0.00	1.00	FALSE
26	GTEx	Skin Not Sun Exposed Suprapubic	CTC-228N24.3	0.29	0.21	lasso	7	0.22	1.7e-12	13.90	-13.8	4.0e-43	-0.97	0.00	1.00	FALSE
27	GTEx	Skin Sun Exposed Lower leg	CTC-228N24.3	0.29	0.17	enet	12	0.22	4.3e-18	13.10	-13.0	1.1e-38	-0.90	0.00	1.00	FALSE
28	GTEx	Spleen	CTC-228N24.3	0.26	0.03	enet	15	0.05	1.8e-02	5.62	-10.7	1.4e-26	-0.66	0.04	0.56	FALSE
29	GTEx	Stomach	SLC12A2	0.23	0.17	enet	19	0.17	1.6e-08	8.56	-8.9	3.9e-19	-0.45	0.80	0.16	FALSE
30	GTEx	Stomach	CTC-228N24.3	0.17	0.04	lasso	6	0.08	1.5e-04	12.40	-12.7	7.7e-37	-0.81	0.02	0.95	FALSE
31	GTEx	Testis	CTC-228N24.3	0.30	0.16	lasso	6	0.14	1.1e-06	13.90	-12.5	1.1e-35	-0.93	0.00	1.00	FALSE
32	GTEx	Thyroid	CTC-228N24.3	0.31	0.15	enet	32	0.18	4.6e-14	13.90	-11.1	1.8e-28	-0.78	0.00	1.00	FALSE
33	METSIM	Adipose	CTC-228N24.3	0.17	0.19	lasso	6	0.18	1.9e-26	13.90	-13.8	2.3e-43	-1.00	0.00	1.00	FALSE
34	ROSMAP	Brain Pre-frontal Cortex	CTC-228N24.3	0.15	0.09	lasso	3	0.12	8.0e-15	13.90	-12.2	4.1e-34	-0.88	0.00	1.00	FALSE
35	The Cancer Genome Atlas	Breast Invasive Carcinoma	FLJ33630	0.05	0.04	enet	14	0.03	2.1e-07	13.90	-13.3	3.5e-40	-0.88	0.00	1.00	FALSE
36	The Cancer Genome Atlas	Glioblastoma Multiforme	FLJ33630	0.38	0.20	lasso	5	0.17	6.5e-06	13.90	-13.8	2.1e-43	-0.99	0.00	1.00	FALSE
37	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FLJ33630	0.10	0.07	lasso	3	0.08	7.0e-09	13.10	-13.0	1.0e-38	-0.95	0.00	1.00	FALSE
38	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FLJ33630	0.10	0.06	enet	18	0.08	2.0e-09	13.90	-10.7	9.2e-27	-0.79	0.00	1.00	FALSE
39	The Cancer Genome Atlas	Brain Lower Grade Glioma	FBN2	0.12	0.02	enet	17	0.05	1.7e-06	9.60	-7.3	3.4e-13	-0.53	0.04	0.93	FALSE
40	The Cancer Genome Atlas	Brain Lower Grade Glioma	FLJ33630	0.19	0.16	enet	4	0.16	1.2e-17	13.90	-13.8	3.6e-43	-1.00	0.00	1.00	FALSE
41	The Cancer Genome Atlas	Lung Adenocarcinoma	FLJ33630	0.07	0.05	lasso	1	0.04	1.3e-05	13.10	-13.1	1.7e-39	-0.96	0.01	0.99	FALSE
42	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FLJ33630	0.09	0.08	lasso	4	0.09	4.9e-10	13.90	-13.8	1.6e-43	-1.00	0.00	1.00	FALSE
43	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	FLJ33630	0.08	0.03	lasso	2	0.04	5.7e-03	13.10	-13.5	3.1e-41	-0.90	0.01	0.89	FALSE
44	The Cancer Genome Atlas	Prostate Adenocarcinoma	FLJ33630	0.08	0.05	blup	70	0.04	4.4e-05	13.10	-13.5	2.9e-41	-0.86	0.00	1.00	FALSE
45	The Cancer Genome Atlas	Prostate Adenocarcinoma	MEGF10	0.05	0.06	enet	4	0.06	1.3e-06	4.99	-5.2	2.4e-07	0.06	0.02	0.98	FALSE
46	The Cancer Genome Atlas	Prostate Adenocarcinoma	SLC12A2	0.04	0.02	enet	17	0.02	3.3e-03	13.10	8.0	1.2e-15	0.69	0.01	0.86	FALSE
47	The Cancer Genome Atlas	Stomach Adenocarcinoma	FLJ33630	0.07	0.02	blup	70	0.02	1.5e-02	8.22	-9.6	7.4e-22	-0.48	0.12	0.14	FALSE
48	The Cancer Genome Atlas	Testicular Germ Cell Tumors	FLJ33630	0.26	0.14	lasso	3	0.13	2.2e-05	13.90	-14.0	2.2e-44	-0.99	0.00	1.00	FALSE
49	The Cancer Genome Atlas	Thyroid Carcinoma	FLJ33630	0.10	0.10	lasso	2	0.09	5.3e-09	13.90	-13.9	1.0e-43	-1.00	0.00	1.00	FALSE