TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Leg fat percentage (left)
:
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chr13:30,336,006-31,886,850
Best TWAS P=3.44e-09 · Best GWAS P=1.09e-11 conditioned to 0.000714
30.4M
30.6M
30.8M
31M
31.2M
31.4M
31.6M
31.8M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Breast Mammary Tissue
HMGB1
0.26
0.02
lasso
6
0.03
9.1e-03
-6.8
5.9
3.4e-09
-0.90
0.00
0.98
TRUE
2
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
HMGB1
0.08
0.04
lasso
1
0.04
6.9e-05
-5.5
5.5
3.3e-08
-0.78
0.06
0.90
FALSE
3
The Cancer Genome Atlas
Prostate Adenocarcinoma
HMGB1
0.10
0.07
lasso
4
0.06
1.4e-06
-5.0
5.1
3.1e-07
-0.80
0.34
0.65
FALSE