Best TWAS P=1.31e-09 · Best GWAS P=2.09e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | RP11-298P3.4 | 0.09 | 0.01 | lasso | 7 | 0.00 | 1.9e-01 | -5.9 | -6.1 | 1.3e-09 | 0.97 | 0.03 | 0.94 | TRUE |
| 2 | GTEx | Whole Blood | KL | 0.12 | 0.00 | lasso | 7 | 0.00 | 4.9e-01 | -2.1 | 5.4 | 6.7e-08 | -0.65 | 0.04 | 0.73 | FALSE |
| 3 | YFS | Blood | PDS5B | 0.03 | 0.04 | lasso | 1 | 0.03 | 1.4e-11 | -5.3 | -5.3 | 1.3e-07 | 0.93 | 0.09 | 0.91 | FALSE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | N4BP2L2 | 0.02 | 0.02 | lasso | 2 | 0.01 | 1.4e-03 | -5.3 | -5.2 | 2.5e-07 | 0.76 | 0.00 | 0.96 | FALSE |
| 5 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | N4BP2L2 | 0.04 | 0.04 | lasso | 2 | 0.03 | 1.5e-04 | -5.3 | -5.4 | 5.6e-08 | 0.77 | 0.00 | 0.99 | FALSE |
| 6 | The Cancer Genome Atlas | Prostate Adenocarcinoma | N4BP2L2 | 0.06 | 0.03 | lasso | 3 | 0.05 | 1.0e-05 | 4.4 | -5.2 | 1.9e-07 | 0.67 | 0.02 | 0.97 | FALSE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | PDS5B | 0.02 | 0.01 | blup | 78 | 0.02 | 1.2e-02 | -4.8 | 5.2 | 1.6e-07 | -0.90 | 0.05 | 0.58 | FALSE |