TWAS hub - ZNF12

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.1551	0.0441	1.8e-04	0.104	NA	0.153	NA	0.141	7.8e-08	NA	5.3e-11	NA	3.6e-10
2	TCGA	Brain Lower Grade Glioma	0.0455	0.0223	5.3e-05	0.025	0.025	0.011	NA	0.018	7.5e-04	7.1e-04	1.8e-02	NA	3.3e-03
3	TCGA	Thyroid Carcinoma	0.0750	0.0570	1.9e-04	0.017	0.046	0.031	NA	0.045	7.3e-03	2.8e-05	4.6e-04	NA	3.3e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Leg fat percentage (left)	8.6	31.2	37.0	-6.1	-5.2	-5.5
Leg fat percentage (right)	8.4	30.3	36.9	-6.1	-4.8	-5.6
Body fat percentage	7.3	28.7	31.4	-5.6	-5.2	-5.3
Age at first live birth	7.2	12.7	13.6	3.7	3.4	3.6
Trunk fat percentage	6.0	24.0	25.2	-5.0	-4.9	-4.8
Body Mass Index (BMI) (2010)	5.9	8.1	8.7	-3.0	-2.8	-2.8
Leg fat mass (right)	5.9	22.7	28.6	-5.3	-4.1	-4.7
Arm fat percentage (right)	5.8	22.7	25.7	-5.1	-4.7	-4.6
Qualifications: O levels/GCSEs or equivalent	5.8	9.3	12.6	3.5	2.7	2.8
Leg fat mass (left)	5.8	22.7	28.1	-5.3	-4.3	-4.6
Alcohol intake versus 10 years previously	5.7	8.5	11.1	-3.3	-2.3	-3.0
Qualifications: nursing, teaching	5.7	8.8	12.1	3.5	2.7	2.6
Arm fat percentage (left)	5.3	21.2	24.5	-5.0	-4.5	-4.3
Blood White Count	5.2	38.3	49.1	-6.6	-4.7	-7.0
Whole body fat mass	5.1	21.3	24.8	-5.0	-4.3	-4.5
Schizophrenia vs Biploar Disorder	4.8	6.4	7.6	-2.7	-2.1	-2.8
Trunk fat mass	4.8	20.4	23.4	-4.8	-4.3	-4.4
Arm fat mass (right)	4.8	19.9	24.5	-5.0	-4.2	-4.2
Age started oral contraceptive pill	4.8	6.1	7.2	-2.7	-2.4	-2.3
Body mass index (BMI)	4.4	18.9	25.1	-5.0	-3.8	-4.1
Prospective memory result	4.4	5.4	6.9	-2.2	-2.1	-2.6
Arm fat mass (left)	4.4	18.0	22.9	-4.8	-3.9	-3.9
Forced expiratory volume in 1-second (FEV1)	4.3	14.5	16.6	3.8	3.5	4.1
Had major operations	4.2	5.0	5.9	-2.4	-2.3	-1.9
Waist circumference	4.1	14.9	19.6	-4.4	-3.6	-3.5
Medication: Metformin	4.0	5.6	11.2	-3.3	-2.1	-1.0
Mouth/teeth dental problems: Dentures	4.0	6.8	9.2	-3.0	-1.8	-2.8
Schizophrenia (2018)	3.7	7.8	12.9	-2.9	-3.6	-1.4
Taking other prescription medications	3.6	5.5	8.0	-2.1	-2.1	-2.8
Bilateral oophorectomy (both ovaries removed)	3.6	4.1	6.9	-2.6	-1.7	-1.6
Qualifications: A levels/AS levels or equivalent	3.6	8.0	9.2	2.8	2.7	3.0
Ovarian Cancer	3.5	4.7	5.3	2.0	2.3	2.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.5	4.2	6.5	1.8	1.7	2.5
Number of self-reported non-cancer illnesses	3.5	6.0	11.5	-2.1	-1.5	-3.4
Medication: Gliclazide	3.4	3.8	4.7	-1.9	-2.2	-1.8
Frequency of tenseness / restlessness in last 2 weeks	3.2	5.0	10.2	-1.9	-1.0	-3.2
Forced vital capacity (FVC)	3.1	12.0	14.5	3.4	3.1	3.8
Illnesses of father: None of the above (group 1)	3.1	3.8	6.0	2.5	2.0	1.1
Vascular/heart problems diagnosed by doctor	3.1	8.5	10.3	3.0	2.5	3.2
Schizophrenia (2014)	3.0	6.7	10.3	-3.2	-2.8	-1.5
Hypertension (Self-reported)	3.0	8.2	9.4	-2.9	-2.6	-3.1
Pain all over the body in last month	2.7	2.8	4.2	-1.6	-1.3	-2.0
Forced vital capacity (FVC), Best measure	2.7	9.9	11.7	2.9	3.1	3.4
High blood pressure	2.6	7.4	8.8	-2.8	-2.4	-3.0
Sitting height	2.6	18.5	26.6	4.5	2.9	5.2
Primary Biliary Cirrhosis	2.5	3.6	6.2	-1.2	-2.5	-1.8
BMI	2.5	14.3	19.4	-4.4	-3.5	-3.3
Ever had hysterectomy (womb removed)	2.5	2.8	4.5	-2.1	-1.5	-1.2
Systolic blood pressure, automated reading	2.5	7.3	8.2	-2.9	-2.7	-2.5
Hip circumference	2.5	10.9	15.2	-3.9	-3.2	-2.6
Migraine (self-reported)	2.5	3.0	5.2	1.4	2.3	1.4
Average weekly red wine intake	2.5	3.7	4.7	1.9	1.6	2.2
Respiratory disease	2.4	5.4	12.3	-1.3	-1.5	-3.5
Lung FVC	2.4	12.0	22.3	2.9	2.3	4.7
Serious illness, injury or assault of a close relative in last 2 years	2.4	2.8	3.1	1.6	1.8	1.7
Forced expiratory volume in 1-second (FEV1), Best measure	2.4	7.7	10.0	2.4	2.7	3.2
Breastfed as a baby	2.4	3.0	3.6	1.9	1.6	1.7
Age at last live birth	2.4	3.5	4.1	2.0	1.9	1.7
Happiness	2.3	2.8	4.8	1.4	2.2	1.3
Average weekly spirits intake	2.2	2.7	4.6	-2.1	-1.4	-1.2
Diabetes (self-reported)	2.2	3.4	5.5	-2.4	-1.6	-1.5
Tense / ‘highly strung’	2.2	3.6	9.1	1.3	3.0	0.4
Gout (self-reported)	2.2	3.1	3.2	-1.8	-1.7	-1.7
Medication: Allopurinol	2.2	3.0	3.5	-1.9	-1.5	-1.8
Illnesses of siblings: Diabetes	2.2	2.7	4.8	-1.6	-2.2	-0.8
Pain type(s) experienced in last month: Hip pain	2.2	2.8	3.3	-1.4	-1.8	-1.7
Bipolar Disorder or Schizophrenia	2.1	5.1	7.2	-2.5	-2.7	-1.3
Weight	2.1	10.3	14.4	-3.8	-2.8	-3.0
Seen doctor (GP) for nerves, anxiety, tension or depression	2.1	3.2	5.0	2.2	2.1	0.3
Pulse wave peak to peak time	2.1	2.4	5.1	1.2	0.9	2.3
Alcohol drinker status: Previous	2.1	2.4	3.3	-1.6	-1.2	-1.8
Diabetes (mother)	2.0	2.5	3.4	-1.8	-1.0	-1.8
Qualifications: None of the above	2.0	4.3	5.6	-2.2	-2.4	-1.5
Medication: Lisinopril	2.0	2.6	3.8	-1.9	-1.2	-1.6
Supplements: Calcium	2.0	2.2	2.9	1.7	1.7	0.9
Blood Red Count	1.8	17.8	22.1	-4.7	-4.5	-3.3
Peak expiratory flow (PEF)	1.8	4.1	4.4	2.0	2.1	2.0
Medication for cholesterol, blood pressure or diabetes	1.8	3.0	3.3	1.8	1.6	1.8
Mean time to correctly identify matches	1.8	3.4	4.9	-2.2	-2.1	-0.9
Hypothyroidism (self reported)	1.7	4.0	6.0	-2.1	-2.4	-1.3
Wheeze or whistling in the chest in last year	1.7	3.1	7.7	-1.2	-0.6	-2.8
Health satisfaction	1.7	2.2	4.5	0.9	2.1	-1.2
Neck or shoulder pain in last month	1.7	2.4	7.1	-0.3	-0.4	-2.7
Medication: Seretide 50 evohaler	1.7	1.9	3.1	-0.7	-1.8	-1.5
Commuting to job workplace: Public transport	1.7	2.1	2.7	1.2	1.6	1.4
Diastolic blood pressure, automated reading	1.7	5.4	6.3	-2.3	-2.1	-2.5
Intelligence (Savage-Jansen 2018)	1.6	5.0	6.1	2.0	2.5	2.2
Hayfever, allergic rhinitis or eczema	1.6	3.5	5.5	2.4	2.0	0.9
Illnesses of siblings	1.6	2.3	3.3	1.1	1.8	1.6
Medication: Cholesterol lowering	1.6	2.4	3.7	-1.9	-1.5	-1.2
Breast cancer (self-reported)	1.6	1.9	2.5	-1.3	-1.6	-1.2
Alzheimer’s Disease (in father)	1.5	1.6	2.7	-1.7	-0.9	-1.1
Fed-up feelings	1.5	2.8	3.8	-1.7	-1.2	-2.0
Pulse wave Arterial Stiffness index	1.5	1.8	3.6	-1.0	-0.8	-1.9
Comparative body size at age 10	1.5	4.0	6.8	-1.7	-2.6	-1.5
Number of full brothers	1.5	1.9	2.8	1.3	1.1	1.7
Worry too long after embarrassment	1.5	2.5	3.3	1.5	1.4	1.8
Diabetes diagnosed by doctor	1.5	2.5	4.9	-2.2	-1.3	-0.9
Eye problems/disorders: Glaucoma	1.5	1.8	2.8	1.3	1.0	1.7
Medication: Bendroflumethiazide	1.5	2.2	2.7	-1.3	-1.4	-1.6
Number of treatments/medications taken	1.4	2.6	5.6	-1.4	-0.5	-2.4
Medication for pain relief, constipation, heartburn	1.4	2.4	3.6	1.9	1.1	1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	3.0	4.3	1.3	2.1	1.7
Ever depressed for a whole week	1.4	1.7	2.4	1.0	1.6	1.3
Hand grip strength (left)	1.3	3.4	6.0	1.8	1.0	2.4
Medication: Simvastatin	1.3	1.9	3.2	-1.8	-1.3	-0.9
Medication: Lansoprazole	1.3	1.4	2.5	-1.3	-0.4	-1.6
Headache pain in last month	1.3	2.2	3.6	-1.9	-1.5	-0.7
Number of children fathered	1.3	1.4	2.7	-0.9	-0.9	-1.6
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.6	2.9	-1.7	-0.4	-1.3
Medication: Omeprazole	1.3	1.5	3.3	-0.7	-0.8	-1.8
Ever taken oral contraceptive pill	1.3	1.4	2.9	1.2	1.7	-0.2
Cardiovascular Disease	1.2	3.8	5.3	-2.0	-1.5	-2.3
Ever unenthusiastic/disinterested for a whole week	1.2	1.4	3.9	0.6	2.0	-0.1
Chronic bronchitis/emphysema (mother)	1.2	1.4	2.1	-0.1	-1.4	-1.4
Shortness of breath walking on level ground	1.2	1.4	3.4	-0.8	0.3	-1.8
Overall health rating	1.2	2.6	5.5	-1.5	-0.4	-2.3
Commuting to job workplace: Car/motor vehicle	1.2	1.4	1.9	-1.3	-0.8	-1.4
Unable to work because of sickness or disability	1.2	1.6	2.5	-1.2	-0.8	-1.6
Pack years of smoking	1.2	1.7	2.2	-1.0	-1.5	-1.4
Depression (Nagel 2018)	1.1	1.6	3.2	-1.2	-0.5	-1.8
Type 2 Diabetes (T2D) (2012)	1.1	1.3	2.0	1.4	0.2	1.4
Number of incorrect matches in round	1.1	1.9	2.4	-1.6	-1.3	-1.3
Financial difficulties in last 2 years	1.1	1.5	2.3	-0.9	-1.2	-1.5
Asthma	1.1	2.2	6.0	-0.4	-0.7	-2.4
Blood clot in the leg (DVT)	1.1	1.4	3.3	0.0	1.8	-0.9
Eye problems/disorders: None of the above	1.1	1.3	1.8	-0.8	-1.1	-1.3
Mouth/teeth dental problems: Loose teeth	1.1	1.3	2.0	1.1	1.4	0.7
Medication: Blood pressure	1.1	2.0	2.1	-1.4	-1.4	-1.4
Knee pain experienced in last month	1.1	1.7	2.2	1.1	1.3	-1.5
Medication for cholesterol	1.1	1.6	2.6	1.1	1.0	1.6
Depressed Affect (Nagel 2018)	1.0	2.1	4.5	-1.2	-0.6	-2.1
Vitamin and mineral supplements	1.0	1.3	1.8	0.8	1.3	1.2
Serious illness, injury or assault to yourself	1.0	1.2	2.1	1.5	0.5	1.1
Diverticular disease/diverticulitis (self-reported)	1.0	1.1	1.3	-0.9	-1.2	1.1
Asthma (self-reported)	1.0	2.0	5.4	-0.5	-0.6	-2.3
Number of operations (self-reported)	1.0	1.5	2.7	-1.4	-0.4	-1.6
Pain experienced in last month	1.0	1.6	4.3	0.7	0.3	2.1
Fasting Glucose	0.9	1.1	2.3	-1.5	-0.9	-0.3
Allergy or Eczema	0.9	2.4	3.8	1.8	2.0	0.1
Type 2 Diabetes (T2D) (2018)	0.9	1.7	3.6	-1.9	-1.2	-0.4
Supplements: Zinc	0.9	0.9	2.0	0.9	0.1	1.4
Allergy	0.9	2.1	2.9	-1.6	-1.7	0.9
Medication: Ramipril	0.9	1.2	2.2	-1.1	-1.5	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	2.2	-0.5	-1.5	-0.9
Exposure to tobacco smoke at home	0.9	1.0	1.6	0.8	0.8	-1.3
Heart disease (mother)	0.9	1.1	1.5	-1.2	-0.6	-1.2
Alcohol intake frequency.	0.9	2.0	2.4	-1.6	-1.5	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	2.5	0.5	1.6	0.7
Tinnitus: Yes, now most or all of the time	0.9	1.1	1.1	1.1	1.1	1.0
Arm predicted mass (left)	0.9	4.4	8.6	-2.9	-1.4	-1.6
Coronary Artery Disease (CAD)	0.8	1.0	1.2	-0.9	-1.1	-1.0
Neuroticism (2016)	0.8	1.2	1.9	-1.1	-0.6	-1.4
Heel T-Score	0.8	6.3	9.2	3.0	2.0	2.4
Chronic bronchitis/emphysema (father)	0.8	0.9	2.0	0.7	1.4	0.6
Falls in the last year	0.8	1.1	1.8	-0.9	-0.9	-1.3
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	2.2	-1.3	-1.5	-0.8
Qualifications: College or University degree	0.8	2.6	3.4	1.8	1.7	1.2
Illnesses of father: Heart disease	0.8	1.1	1.6	-1.3	-0.2	-1.3
Hearing aid user	0.8	0.9	1.5	-0.6	-1.2	-0.9
Financial situation satisfaction	0.8	1.0	2.6	-1.6	-0.3	-0.4
Arm fat-free mass (left)	0.8	4.2	7.6	-2.8	-1.5	-1.6
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	1.8	-0.6	-1.0	-1.3
Verbal and Numeric Reasoning (VNR)	0.7	1.7	2.8	1.3	1.7	0.8
Triglycerides	0.7	1.1	2.1	-1.5	-1.1	-0.1
Medication: Levothyroxine sodium	0.7	1.1	2.0	-0.9	-1.4	-0.8
Fluid intelligence score	0.7	1.5	2.8	0.9	1.7	0.9
Father’s age at death	0.7	1.0	1.7	0.8	0.8	1.3
Leg pain on walking	0.7	0.8	2.4	-0.1	0.2	-1.6
Medication: Aspirin	0.7	0.9	1.6	-1.3	-1.0	-0.6
Mood swings	0.7	1.2	1.9	-1.0	-0.8	-1.4
Risk taking	0.7	1.1	2.1	-1.1	-0.1	-1.4
Fractured/broken bones in last 5 years	0.7	0.9	1.2	1.1	0.7	0.9
Deep venous thrombosis (DVT) (self-reported)	0.7	1.0	1.9	-0.0	1.4	-1.0
Alzheimer’s Disease (in mother)	0.6	0.7	1.4	0.0	0.8	1.2
Major Depression (MDD)	0.6	0.7	1.3	0.0	0.8	1.2
Smoking Status	0.6	1.5	4.4	0.1	0.2	-2.1
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.7	0.5	-0.7	-1.3
Townsend deprivation index at recruitment	0.6	0.8	1.9	0.6	0.5	1.4
Hair/balding pattern: Pattern 2	0.6	0.7	1.8	-0.6	-1.3	-0.0
Noisy workplace	0.6	0.7	1.4	1.2	0.8	-0.3
Chest pain or discomfort	0.6	0.8	1.5	1.2	0.6	-0.8
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	1.0	-1.0	-0.7	-0.9
Osteoporosis (self-reported)	0.6	0.7	1.6	0.7	1.3	-0.3
Guilty feelings	0.6	0.9	1.6	1.0	1.3	0.2
Irritability	0.6	1.0	2.2	-0.8	0.6	-1.5
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.1	0.3	1.0	-0.9
LDL Cholesterol	0.5	0.7	1.0	-0.5	-1.0	-1.0
Rheumatoid Arthritis	0.5	0.7	1.1	-1.1	-0.3	-1.0
Medication for hormone replacement therapy	0.5	0.6	0.7	-0.6	-0.8	-0.9
Medication: Co-codamol	0.5	0.6	1.8	0.0	0.1	-1.3
Pack years adult smoking proportion	0.5	0.8	1.3	-0.5	-1.1	-0.9
Relative age voice broke	0.5	0.7	1.5	0.6	1.2	-0.6
Qualifications: CSEs or equivalent	0.5	0.7	1.1	-0.8	-1.0	-0.5
Supplements: Glucosamine	0.5	0.6	1.5	1.2	0.4	-0.4
Medication: Atenolol	0.5	0.6	1.3	-0.6	-1.1	-0.1
Past tobacco smoking	0.5	0.9	2.5	0.5	0.1	1.6
Had menopause	0.5	0.6	0.7	-0.8	-0.7	-0.7
Time employed in main current job	0.5	0.6	1.5	-0.5	-0.3	1.2
Depression (self-reported)	0.5	0.6	0.7	0.8	0.9	-0.6
Impedance of arm (left)	0.5	2.3	5.1	2.3	0.4	1.3
Length of working week for main job	0.5	0.5	1.5	-0.3	0.1	-1.2
Glaucoma (self-reported)	0.5	0.6	1.0	1.0	0.7	0.6
High blood pressure (siblings)	0.5	0.8	1.5	0.2	-1.2	-0.9
Emphysema/chronic bronchitis	0.5	0.5	0.9	-0.6	-0.9	-0.6
Basal metabolic rate	0.5	2.9	5.4	-2.3	-1.2	-1.3
Commuting to job workplace: Cycle	0.5	0.6	1.6	-0.1	-1.2	-0.3
Reaction Time	0.4	0.7	1.0	-0.9	-1.0	0.5
HDL Cholesterol	0.4	0.7	1.2	1.1	0.8	0.5
Ulcerative Colitis	0.4	0.6	1.2	1.1	0.8	0.2
Blood Eosinophil Count	0.4	3.3	4.6	-2.1	-1.9	-1.3
Lung FEV1/FVC ratio	0.4	2.3	5.8	-0.8	-0.6	-2.4
Leg fat-free mass (left)	0.4	1.9	3.3	-1.8	-1.0	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	1.8	0.8	0.5	1.4
Stomach or abdominal pain in last month	0.4	0.5	0.7	-0.6	-0.6	-0.8
Had other major operations	0.4	0.5	0.8	-0.8	-0.4	-0.9
Pulse rate	0.4	0.7	1.1	-1.1	-0.7	-0.8
Standing height	0.4	4.2	5.0	2.1	1.8	2.2
Ever highly irritable/argumentative for 2 days	0.4	0.5	0.8	-0.6	0.5	-0.9
Loud music exposure frequency	0.4	0.5	0.9	-0.9	-0.4	-0.6
Medication: Amlodipine	0.4	0.5	1.0	-1.0	-0.3	-0.7
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.1	-0.6	-0.2	-1.0
Arm fat-free mass (right)	0.4	1.9	4.3	-2.1	-0.7	-0.9
Supplements: Vitamin C	0.4	0.5	0.5	-0.6	-0.7	-0.7
Smoking status: Previous	0.4	0.5	1.4	0.2	0.4	-1.2
Loneliness, isolation	0.4	0.5	1.4	-0.3	-0.2	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.9	-0.3	-0.9	-0.5
Osteoarthritis (self-reported)	0.4	0.5	1.2	-0.2	0.4	-1.1
Medication: Blood pressure	0.4	0.8	1.4	-0.5	-0.9	-1.2
High cholesterol (Self-reported)	0.4	0.8	0.8	-0.9	-0.9	-0.8
Medication: Atorvastatin	0.4	0.6	0.7	-0.8	-0.6	-0.8
Cholesterol lowering medication	0.4	0.7	1.2	-0.6	-0.7	-1.1
Crohns Disease (2012)	0.3	0.4	0.7	0.7	0.8	-0.3
Mean Putamen Volume	0.3	0.3	0.5	0.7	0.0	-0.7
HbA1C	0.3	0.3	0.5	0.6	0.7	-0.2
Blood Platelet Count	0.3	3.3	5.9	-0.9	-1.7	-2.4
Systolic Blood Pressure	0.3	1.7	2.6	-1.1	-1.6	-1.1
Sensitivity / hurt feelings	0.3	0.6	1.2	-0.7	0.2	-1.1
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.7	-0.2	0.8	0.5
Diabetes (father)	0.3	0.3	0.8	-0.2	-0.2	0.9
Hand grip strength (right)	0.3	0.9	1.4	1.1	0.2	1.2
Leg predicted mass (left)	0.3	1.6	2.7	-1.6	-0.9	-1.1
Hearing difficulty/problems with background noise	0.3	0.5	0.7	-0.8	-0.7	-0.6
Impedance of arm (right)	0.3	1.6	4.3	2.1	0.2	0.7
Lung cancer (father)	0.3	0.4	0.5	-0.7	-0.5	-0.5
Illnesses of mother	0.3	0.4	0.9	0.4	0.2	0.9
Birth weight of first child	0.3	0.5	1.2	-0.1	0.4	1.1
Pulse wave reflection index	0.3	0.3	0.7	0.8	0.0	-0.6
Birth weight	0.3	0.6	1.0	-0.9	-0.2	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.0	-0.2	1.0	-0.4
Medication: Ibuprofen	0.3	0.3	0.4	-0.4	-0.6	-0.7
Comparative height size at age 10	0.3	1.8	2.9	-1.7	-1.3	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.7	0.8	0.6	0.3
Medication: Aspirin	0.3	0.3	0.7	-0.8	-0.5	-0.3
Smoking status: Current	0.3	0.5	0.8	-0.7	-0.4	-0.9
Impedance of whole body	0.3	1.5	3.6	1.9	0.2	0.9
Neuroticism (Nagel 2018)	0.2	0.5	1.1	-0.4	0.6	-1.1
Worry (Nagel 2018)	0.2	0.5	1.3	-0.1	1.1	0.5
Alzheimer’s Disease (including proxy)	0.2	0.3	0.5	-0.7	-0.3	0.5
Crohns Disease (2017)	0.2	0.3	0.8	0.3	0.2	-0.9
Irritable Bowel Disease (IBD)	0.2	0.5	1.4	0.1	0.1	-1.2
Prostate Cancer	0.2	0.3	0.5	-0.6	0.7	-0.3
Lupus	0.2	0.3	0.7	0.8	0.4	0.2
Height	0.2	3.8	4.6	2.1	1.5	2.1
Neuroticism	0.2	0.6	0.8	-0.7	0.6	-0.9
Hearing difficulty/problems: Yes	0.2	0.3	0.6	-0.4	0.2	-0.8
Relative age of first facial hair	0.2	0.4	0.8	-0.0	0.7	-0.9
Current tobacco smoking	0.2	0.3	0.5	-0.4	-0.3	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.5	0.0	-0.4	-0.7
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.4	0.2	0.5	-0.6
Multivitamins +/- minerals	0.2	0.3	0.7	-0.4	-0.8	0.1
Nervous feelings	0.2	0.3	0.7	-0.8	-0.2	-0.4
Mouth/teeth dental problems	0.2	0.4	0.5	0.7	-0.2	0.7
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.5	-0.2	-0.4	-0.7
Neuroticism score	0.2	0.4	0.6	-0.2	0.6	-0.8
Worrier / anxious feelings	0.2	0.5	1.0	-1.0	-0.6	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.7	-0.5	-0.2	-0.9
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.6	0.1	0.8	0.0
Arm predicted mass (right)	0.2	1.2	2.9	-1.7	-0.4	-0.8
Pulse rate, automated reading	0.2	0.6	1.6	0.0	1.3	-0.4
Suffer from ‘nerves’	0.2	0.4	0.8	0.4	0.9	0.4
Family relationship satisfaction	0.2	0.2	0.6	0.0	0.8	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.4	-0.3	0.4	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.7	0.3	0.7	0.8
Whole body fat-free mass	0.2	1.4	3.1	-1.8	-0.6	-0.7
Leg fat-free mass (right)	0.2	0.9	1.6	-1.3	-0.8	-0.7
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.8	-0.9	-0.2	-0.3
Ever had bowel cancer screening	0.2	0.3	0.6	0.3	0.4	-0.8
Commuting to job workplace: Walk	0.2	0.2	0.3	-0.5	-0.4	-0.2
Eye problems/disorders: Cataract	0.2	0.3	0.6	0.2	0.8	0.4
Back pain experienced in last month	0.2	0.3	0.5	0.0	0.7	-0.7
Mineral and other dietary supplements	0.2	0.2	0.6	-0.1	0.1	0.8
Whole body water mass	0.2	1.3	2.9	-1.7	-0.6	-0.7
Leg predicted mass (right)	0.2	0.9	1.5	-1.2	-0.8	-0.7
Miserableness	0.2	0.4	0.7	-0.2	-0.7	-0.8
Medication: Paracetamol	0.2	0.4	1.1	0.3	1.0	-0.1
Alcohol drinker status: Never	0.2	0.3	0.4	-0.4	-0.5	0.6
Ever smoked	0.2	0.3	0.7	-0.1	0.3	-0.8
Heart disease (siblings)	0.2	0.3	0.4	-0.7	-0.6	-0.2
Bipolar Disorder (2018)	0.1	0.1	0.1	-0.4	0.2	-0.3
Ulcerative Colitis (UC)	0.1	0.2	0.5	0.2	0.1	-0.7
Breast Cancer	0.1	0.2	0.3	0.3	0.3	0.5
Age at First Birth	0.1	0.1	0.3	-0.6	0.1	0.2
Waist Hip Ratio (WHR)	0.1	0.6	1.1	-0.5	-0.8	-1.0
Chronotype (morning person)	0.1	0.3	0.3	-0.4	-0.6	0.5
Tanning	0.1	0.8	1.3	-0.5	-1.1	-1.0
Angina	0.1	0.1	0.2	-0.2	0.1	-0.5
Severe depression (siblings)	0.1	0.1	0.2	-0.3	0.4	0.2
Impedance of leg (right)	0.1	0.3	0.7	0.8	0.4	0.2
Average weekly fortified wine intake	0.1	0.1	0.3	-0.3	0.1	-0.5
Maternal smoking around birth	0.1	0.1	0.2	0.3	0.4	-0.1
Age when periods started (menarche)	0.1	0.3	0.6	0.8	0.6	-0.2
High blood pressure (mother)	0.1	0.2	0.4	0.3	0.4	-0.6
Impedance of leg (left)	0.1	0.3	0.8	0.9	0.1	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.5	0.3	0.5	0.7
Heart attack	0.1	0.2	0.5	0.1	0.7	-0.2
Trunk fat-free mass	0.1	0.8	2.2	-1.5	-0.1	-0.3
Number of live births	0.1	0.2	0.5	0.3	0.7	0.1
Trunk predicted mass	0.1	0.7	2.1	-1.4	-0.1	-0.3
Medication: Paracetamol	0.1	0.2	0.3	0.5	0.6	0.1
Exposure to tobacco smoke outside home	0.1	0.2	0.4	0.6	-0.2	-0.2
Number of full sisters	0.1	0.2	0.4	-0.1	-0.3	-0.6
Long-standing illness, disability or infirmity	0.1	0.2	0.3	-0.3	-0.4	-0.6
Friendships satisfaction	0.1	0.2	0.4	0.2	0.6	0.0
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.4	0.3	0.4	0.6
Average weekly champagne plus white wine intake	0.1	0.1	0.1	0.2	0.4	0.2
Wears glasses or contact lenses	0.1	0.1	0.2	0.1	-0.4	-0.3
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.1	0.1	0.2	-0.4
Illnesses of father: High blood pressure	0.1	0.2	0.4	-0.1	-0.6	0.4
Average weekly beer plus cider intake	0.1	0.1	0.2	0.1	-0.3	0.5
Myopia	0.1	0.1	0.1	-0.1	0.4	-0.4
Basal cell carcinoma (self-reported)	0.1	0.2	0.3	0.4	0.5	0.2
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	0.0	0.5	-0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.5	0.8	0.9	0.7	0.3
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.0	-0.1	0.1	-0.1
Ever used hormone-replacement therapy (HRT)	0.0	0.0	0.1	-0.0	0.1	-0.2
Alcohol usually taken with meals	0.0	0.1	0.2	0.1	0.4	0.1
Hair/balding pattern: Pattern 3	0.0	0.1	0.1	0.0	0.2	0.3
Hair/balding pattern: Pattern 4	0.0	0.1	0.2	0.2	0.4	-0.1
Angina (self-reported)	0.0	0.0	0.1	-0.2	-0.0	-0.3
Mother’s age at death	0.0	0.0	0.1	0.1	0.1	-0.2

Hub : Genes

ZNF12

Models

Trait associations