Best TWAS P=7.62e-10 · Best GWAS P=2.79e-08 conditioned to 0.593
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | FAM185BP | 0.11 | 0.02 | enet | 22 | 0.02 | 1.1e-02 | 4.2 | 5.3 | 9.9e-08 | 0.19 | 0.02 | 0.29 | TRUE |
| 2 | GTEx | Muscle Skeletal | TMEM60 | 0.11 | 0.12 | lasso | 4 | 0.12 | 4.6e-12 | -5.0 | 5.2 | 2.2e-07 | 0.88 | 0.08 | 0.92 | FALSE |
| 3 | GTEx | Pituitary | TMEM60 | 0.19 | 0.06 | lasso | 6 | 0.04 | 2.8e-02 | 4.8 | -5.3 | 1.4e-07 | -0.96 | 0.03 | 0.91 | FALSE |
| 4 | METSIM | Adipose | TMEM60 | 0.10 | 0.07 | enet | 9 | 0.08 | 2.1e-12 | 5.4 | -5.4 | 5.1e-08 | -0.97 | 0.01 | 0.99 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | RSBN1L | 0.09 | 0.07 | enet | 42 | 0.08 | 9.9e-11 | -4.4 | -6.2 | 7.6e-10 | -0.68 | 0.26 | 0.72 | TRUE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RSBN1L | 0.02 | 0.02 | blup | 58 | 0.02 | 3.4e-03 | -5.0 | 5.5 | 4.6e-08 | 0.89 | 0.02 | 0.82 | FALSE |
| 7 | The Cancer Genome Atlas | Soft Tissue Sarcoma | PHTF2 | 0.06 | 0.04 | blup | 72 | 0.04 | 2.0e-03 | 4.7 | -5.2 | 1.7e-07 | -0.90 | 0.03 | 0.80 | FALSE |