TWAS
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Models
Genes
Traits
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Traits
:
Leg fat percentage (left)
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chr7:100,110,324-101,482,413
Best TWAS P=1.92e-07 · Best GWAS P=7.65e-07 conditioned to 0.0144
100.2M
100.4M
100.6M
100.8M
101M
101.2M
101.4M
0
1
2
3
4
5
6
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Breast Mammary Tissue
AP1S1
0.18
0.14
lasso
4
0.12
1.5e-06
4.4
5.2
1.9e-07
-0.56
0.03
0.92
TRUE
2
The Cancer Genome Atlas
Pancreatic Adenocarcinoma
C7orf52
0.23
0.10
blup
54
0.12
7.0e-06
4.4
-5.1
2.9e-07
0.58
0.07
0.80
FALSE