Hub : Genes

C7orf52

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Brain Lower Grade Glioma 0.0326 0.0173 1.3e-03 0.019 0.019 0.008 NA 0.014 2.6e-03 2.7e-03 3.3e-02 NA 8.1e-03
2 TCGA Pancreatic Adenocarcinoma 0.2350 0.1000 1.3e-06 0.095 0.124 0.118 NA 0.105 8.6e-05 7.0e-06 1.3e-05 NA 3.6e-05
3 TCGA Thyroid Carcinoma 0.0860 0.0300 2.7e-11 0.078 0.105 0.117 NA 0.107 5.1e-08 2.3e-10 1.8e-11 NA 1.5e-10

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.6 0.9 1.5 -0.2 1.1 1.2
Bipolar Disorder or Schizophrenia 0.3 0.7 1.1 0.6 -0.8 -1.1
Depressed Affect (Nagel 2018) 0.1 0.2 0.5 -0.7 -0.2 -0.1
Depression (Nagel 2018) 1.1 1.7 3.0 -1.7 1.1 0.9
Intelligence (Savage-Jansen 2018) 1.1 3.4 4.5 -1.1 2.1 2.1
Neuroticism (Nagel 2018) 2.2 5.2 7.2 -2.7 2.1 2.0
Schizophrenia (2018) 1.6 3.4 5.6 1.0 -1.9 -2.4
Schizophrenia vs Biploar Disorder 3.6 4.7 5.1 2.2 -2.0 -2.3
Worry (Nagel 2018) 2.4 5.0 10.3 -3.2 1.7 1.3
Alzheimer’s Disease (in mother) 1.1 1.3 2.9 1.7 -0.8 -0.5
Alzheimer’s Disease (in father) 0.1 0.1 0.1 0.3 -0.2 -0.2
Alzheimer’s Disease (including proxy) 0.2 0.3 0.4 0.6 -0.5 -0.6
Crohns Disease (2017) 0.8 1.8 3.2 -0.3 -1.4 -1.8
Irritable Bowel Disease (IBD) 0.4 0.9 1.6 -1.3 -0.7 -0.9
Ulcerative Colitis (UC) 0.5 0.9 2.4 -1.6 0.4 0.3
Major Depression (MDD) 0.2 0.2 0.4 -0.0 -0.6 -0.6
Reaction Time 0.0 0.0 0.1 0.1 -0.1 -0.3
Verbal and Numeric Reasoning (VNR) 0.4 0.9 1.3 -0.3 1.2 1.1
Breast Cancer 0.1 0.3 0.5 0.4 0.7 0.3
Ovarian Cancer 2.2 2.9 3.5 1.3 -1.8 -1.9
Prostate Cancer 0.1 0.2 0.3 -0.5 -0.5 0.1
Age at First Birth 3.1 4.5 6.1 -1.9 2.5 1.9
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.9 1.2 2.0 0.8 -1.0 -1.4
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 2.1 3.4 4.9 0.7 -2.2 -2.2
Mean Putamen Volume 0.2 0.3 0.4 0.3 0.5 0.7
Fasting Glucose 0.0 0.1 0.1 -0.0 -0.2 -0.4
HbA1C 0.1 0.1 0.3 0.6 0.0 0.1
HDL Cholesterol 2.1 3.6 5.3 -1.4 1.9 2.3
LDL Cholesterol 0.2 0.3 0.5 -0.4 0.7 0.6
Lupus 1.0 1.5 2.7 0.5 -1.6 -1.2
Neuroticism (2016) 1.5 2.2 4.0 -2.0 1.5 0.7
Primary Biliary Cirrhosis 0.3 0.4 0.5 -0.5 0.7 0.7
Rheumatoid Arthritis 3.2 4.4 4.7 2.2 -1.9 -2.2
Schizophrenia (2014) 1.3 2.9 3.9 1.4 -1.7 -2.0
Triglycerides 0.7 1.1 1.6 0.4 -1.3 -1.3
Type 2 Diabetes (T2D) (2012) 0.6 0.7 1.1 -1.1 0.9 0.3
Ulcerative Colitis 0.1 0.2 0.4 0.0 -0.6 -0.5
Blood Eosinophil Count 0.4 3.1 3.8 1.5 -1.8 -1.9
Blood Platelet Count 0.0 0.1 0.3 0.1 -0.6 0.1
Blood Red Count 3.5 34.2 59.1 2.2 -6.2 -7.7
Blood White Count 0.3 2.1 4.5 -0.3 -1.3 -2.1
Heel T-Score 0.6 5.1 9.7 -0.8 2.2 3.1
BMI 4.0 23.2 26.8 5.2 -5.2 -4.0
Height 1.4 26.6 44.1 -1.8 6.6 5.7
Waist Hip Ratio (WHR) 0.1 0.2 0.4 -0.4 -0.6 -0.4
Systolic Blood Pressure 0.1 0.3 0.5 0.7 -0.7 -0.1
Smoking Status 4.5 10.7 13.7 2.5 -3.5 -3.7
Allergy or Eczema 0.2 0.6 0.9 0.2 1.0 0.9
Cardiovascular Disease 0.2 0.5 0.7 -0.8 0.6 0.8
Hypothyroidism (self reported) 0.3 0.7 1.1 0.8 0.4 1.0
Respiratory disease 0.0 0.0 0.0 -0.0 -0.2 -0.0
Type 2 Diabetes (T2D) (2018) 0.9 1.8 2.4 1.5 -1.5 -0.9
Lung FEV1/FVC ratio 1.0 4.9 8.4 2.9 -2.4 -1.0
Lung FVC 0.6 3.0 4.2 -1.3 2.0 1.7
Neuroticism 0.7 1.8 2.9 -1.7 1.1 1.1
Chronotype (morning person) 1.3 3.1 4.9 -1.0 1.8 2.2
Hair Pigment 0.0 0.5 1.2 0.3 0.2 1.1
Tanning 0.3 3.3 5.8 1.0 -1.8 -2.4
Hand grip strength (left) 1.7 4.5 7.4 -0.4 2.7 2.4
Number of treatments/medications taken 0.0 0.1 0.2 0.2 -0.4 0.0
Average weekly spirits intake 5.0 6.3 10.0 3.2 -2.2 -2.0
Sensitivity / hurt feelings 1.8 3.1 3.6 -1.7 1.8 1.9
Frequency of depressed mood in last 2 weeks 1.5 2.1 3.7 -1.9 1.1 1.1
Hearing difficulty/problems: Yes 1.3 1.9 3.9 2.0 -1.1 -0.8
Relative age of first facial hair 0.7 1.5 2.2 -1.5 1.1 1.0
Other serious medical condition/disability diagnosed by doctor 1.4 1.9 3.1 0.5 -1.7 -1.5
Ever used hormone-replacement therapy (HRT) 0.8 1.0 1.8 0.2 -1.4 -1.1
Ever had hysterectomy (womb removed) 0.2 0.2 0.3 -0.6 0.4 -0.3
Systolic blood pressure, automated reading 1.5 4.4 7.7 2.8 -1.9 -1.4
Eye problems/disorders: Diabetes related eye disease 0.4 0.4 0.8 0.4 -0.9 -0.6
Angina 1.0 1.3 1.5 1.1 -1.2 -1.1
Medication for hormone replacement therapy 0.2 0.2 0.4 -0.6 0.4 0.1
Vitamin and mineral supplements 2.3 3.1 5.0 2.2 -1.6 -1.3
Supplements: Zinc 0.1 0.1 0.2 -0.4 -0.3 0.0
Medication: Co-codamol 2.2 2.5 3.1 1.5 -1.5 -1.8
Medication: Metformin 0.3 0.4 0.6 0.5 -0.6 -0.8
Diabetes (father) 0.3 0.4 0.8 -0.9 0.4 0.4
Diabetes (mother) 0.7 0.9 1.7 -0.6 -0.8 -1.3
Severe depression (siblings) 1.5 1.7 2.3 1.1 -1.5 -1.2
Pack years adult smoking proportion 0.8 1.2 1.3 1.1 -1.2 -1.1
Impedance of leg (right) 0.9 4.1 10.3 -3.2 1.3 0.6
Leg fat-free mass (left) 0.2 1.1 2.6 1.6 0.5 0.7
Trunk fat percentage 3.6 14.4 19.1 2.9 -4.4 -4.0
Hand grip strength (right) 4.0 10.9 16.4 -1.3 4.0 3.8
Townsend deprivation index at recruitment 0.2 0.3 0.5 -0.7 0.3 -0.5
Current tobacco smoking 1.3 2.2 4.0 0.6 -1.5 -2.0
Average weekly fortified wine intake 0.4 0.5 0.9 -0.2 0.9 0.7
Maternal smoking around birth 1.4 2.0 3.3 0.3 -1.6 -1.8
Fed-up feelings 0.4 0.6 1.9 -1.4 -0.0 0.0
Frequency of unenthusiasm / disinterest in last 2 weeks 1.3 1.7 3.8 -2.0 1.0 0.6
Relative age voice broke 3.9 6.0 8.3 -2.9 2.6 1.7
Taking other prescription medications 0.1 0.1 0.2 -0.3 -0.5 -0.2
Age when periods started (menarche) 0.6 1.4 3.8 -1.9 0.5 0.4
Bilateral oophorectomy (both ovaries removed) 1.2 1.4 2.6 -1.6 1.2 0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.5 0.7 -0.5 0.7 0.8
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 1.0 -1.0 0.9 -0.0
Qualifications: CSEs or equivalent 0.3 0.4 0.9 -1.0 0.4 0.0
Serious illness, injury or assault to yourself 1.1 1.3 2.6 0.5 -1.1 -1.6
High blood pressure 0.0 0.1 0.2 0.4 -0.3 0.3
Hayfever, allergic rhinitis or eczema 0.0 0.1 0.1 0.1 0.4 0.2
Multivitamins +/- minerals 1.6 2.1 2.3 -1.3 1.5 1.5
Stomach or abdominal pain in last month 2.3 2.9 3.7 1.2 -1.9 -1.9
Supplements: Glucosamine 0.8 1.0 1.4 1.2 -1.0 -0.8
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.2 -0.5 0.4 0.4
Medication: Atenolol 1.1 1.3 2.2 0.9 -1.5 -1.0
Medication: Levothyroxine sodium 0.6 1.0 2.4 1.5 -0.6 -0.4
Sitting height 1.4 9.8 17.1 -1.4 4.1 3.2
Chronic bronchitis/emphysema (father) 0.3 0.3 0.4 0.6 -0.6 -0.4
High blood pressure (mother) 0.0 0.1 0.1 -0.2 -0.1 -0.3
Body mass index (BMI) 4.4 18.9 23.2 4.3 -4.8 -3.9
Impedance of leg (left) 0.6 3.0 8.4 -2.9 0.8 0.0
Leg predicted mass (left) 0.2 1.1 2.4 1.6 0.6 0.7
Trunk fat mass 2.4 10.4 12.2 3.0 -3.5 -3.1
Waist circumference 3.4 12.5 15.2 3.6 -3.9 -3.0
Number of incorrect matches in round 1.5 2.5 3.0 1.7 -1.7 -1.4
Past tobacco smoking 9.2 17.0 19.3 -3.9 4.4 4.1
Alcohol usually taken with meals 0.4 0.6 0.8 -0.8 0.9 0.7
Nervous feelings 3.6 6.6 6.9 -2.6 2.6 2.5
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.5 1.5 -1.2 -0.0 -0.3
Hearing difficulty/problems with background noise 0.1 0.1 0.2 0.4 0.2 0.3
Hair/balding pattern: Pattern 2 0.1 0.1 0.1 -0.3 -0.2 0.4
Had menopause 0.8 1.0 1.7 0.6 -1.3 -1.0
Had other major operations 0.0 0.0 0.0 0.0 0.0 0.0
Forced vital capacity (FVC) 3.7 14.4 20.6 -2.7 4.5 3.9
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 0.7 -0.8 0.5 0.5
Ever unenthusiastic/disinterested for a whole week 0.1 0.1 0.3 -0.1 0.1 -0.5
Qualifications: None of the above 0.5 1.1 1.9 0.3 -1.4 -1.1
Financial difficulties in last 2 years 0.8 1.1 1.2 1.1 -1.0 -1.0
Mouth/teeth dental problems 0.9 1.4 2.9 -1.7 1.0 0.4
Heart attack 0.0 0.0 0.1 -0.0 -0.3 -0.2
Allergy 0.0 0.1 0.3 -0.5 0.1 0.2
Pain all over the body in last month 0.9 0.9 1.5 0.1 -1.2 -1.1
Diabetes (self-reported) 0.5 0.8 0.9 0.9 -1.0 -0.8
Hayfever/allergic rhinitis (self-reported) 3.9 5.2 7.5 -0.8 2.7 2.7
Medication: Ramipril 0.8 1.0 1.6 -1.2 0.9 0.8
Medication: Simvastatin 0.7 1.0 1.6 -0.8 1.2 0.9
Fluid intelligence score 0.4 0.8 1.2 -0.9 1.1 0.6
Illnesses of siblings 0.1 0.1 0.1 0.3 -0.3 -0.3
Neuroticism score 1.5 3.2 4.6 -2.1 1.6 1.6
Weight 0.9 4.4 8.1 2.9 -1.8 -1.3
Impedance of arm (right) 1.0 4.8 11.4 -3.4 1.3 1.1
Arm fat percentage (right) 4.2 16.6 23.8 3.2 -4.9 -4.0
Trunk fat-free mass 0.8 4.3 6.2 0.9 2.5 2.4
Hip circumference 1.8 7.7 10.0 3.2 -2.9 -2.2
Time employed in main current job 0.3 0.4 0.7 -0.6 0.8 -0.1
Alcohol intake versus 10 years previously 0.2 0.3 0.7 -0.9 -0.1 0.1
Father’s age at death 0.6 0.8 0.9 -0.8 0.9 1.0
Worrier / anxious feelings 2.1 3.9 8.9 -3.0 1.3 1.0
Frequency of tiredness / lethargy in last 2 weeks 0.6 0.9 1.7 -0.1 -1.3 -1.0
Falls in the last year 0.1 0.2 0.3 -0.5 0.3 -0.3
Hair/balding pattern: Pattern 3 0.0 0.0 0.0 0.0 -0.1 0.1
Number of live births 2.7 3.9 5.0 1.5 -2.0 -2.2
Forced expiratory volume in 1-second (FEV1) 3.3 11.1 14.6 -2.2 3.8 3.7
Pulse rate 0.4 0.7 1.0 -1.0 1.0 -0.2
Happiness 0.4 0.4 0.8 -0.2 -0.9 -0.7
Noisy workplace 1.1 1.4 2.5 0.5 -1.6 -1.2
Qualifications: A levels/AS levels or equivalent 2.4 5.3 8.6 -0.8 2.6 2.9
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 1.8 -0.7 1.4 0.2
Mouth/teeth dental problems: Dentures 0.2 0.4 0.9 0.9 -0.5 -0.0
Asthma 0.1 0.1 0.3 -0.2 0.2 0.6
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 0.7 0.3 -0.6 -0.9
Medication: Cholesterol lowering 1.3 2.1 2.9 -1.4 1.1 1.7
Depression (self-reported) 1.3 1.6 3.1 -0.7 1.1 1.8
Medication: Lansoprazole 0.1 0.1 0.2 0.4 0.2 0.3
Prospective memory result 1.7 2.0 3.0 1.5 -1.7 -0.9
Lung cancer (father) 0.3 0.3 0.5 0.3 -0.7 -0.6
Illnesses of mother 0.4 0.5 0.8 -0.9 0.7 0.6
Forced expiratory volume in 1-second (FEV1), Best measure 4.2 13.3 17.6 -2.7 4.2 3.9
Pulse wave Arterial Stiffness index 0.2 0.2 0.6 0.7 -0.1 -0.2
Impedance of arm (left) 0.9 3.9 10.5 -3.2 1.0 0.5
Arm fat mass (right) 2.8 11.3 13.9 3.3 -3.7 -3.0
Trunk predicted mass 0.8 4.6 6.7 0.9 2.6 2.5
Standing height 2.4 23.8 37.7 -2.6 6.1 5.2
Length of working week for main job 0.2 0.2 0.3 -0.5 0.3 -0.4
Exposure to tobacco smoke at home 0.4 0.4 0.7 0.3 -0.8 -0.8
Breastfed as a baby 0.2 0.2 0.4 0.6 -0.3 0.2
Tense / ‘highly strung’ 4.1 6.7 8.2 -2.7 2.9 2.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.2 0.7 -0.8 0.2 0.2
Hair/balding pattern: Pattern 4 0.2 0.4 0.6 -0.8 0.7 -0.1
Birth weight of first child 1.2 2.1 2.8 -1.7 1.5 1.2
Peak expiratory flow (PEF) 0.3 0.6 1.0 -0.1 0.8 1.0
Pulse wave reflection index 0.1 0.1 0.3 0.6 0.0 0.0
Ever highly irritable/argumentative for 2 days 1.0 1.2 1.7 0.6 -1.2 -1.3
Loud music exposure frequency 0.1 0.1 0.3 -0.1 0.5 -0.1
Qualifications: O levels/GCSEs or equivalent 2.7 4.3 6.8 -1.1 2.6 2.2
Mouth/teeth dental problems: Bleeding gums 5.2 6.7 9.0 3.0 -2.5 -2.2
Blood clot in the leg (DVT) 0.3 0.4 0.8 -0.0 -0.7 -0.9
Medication: Paracetamol 0.1 0.1 0.3 -0.5 -0.0 -0.1
Headache pain in last month 0.0 0.1 0.2 -0.5 -0.0 0.1
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 0.5 0.7 -0.2 -0.7
Glaucoma (self-reported) 0.4 0.5 0.8 0.7 -0.4 -0.9
Gout (self-reported) 1.4 1.9 2.2 1.3 -1.5 -1.4
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 1.7 1.3 -0.8 -0.2
Medication: Amlodipine 0.1 0.1 0.2 -0.4 -0.2 -0.5
Medication: Ventolin 100micrograms inhaler 0.4 0.5 0.8 -0.4 0.9 0.8
Birth weight 3.1 6.7 8.6 -2.7 2.9 2.1
Chronic bronchitis/emphysema (mother) 0.5 0.6 1.1 0.3 -0.8 -1.1
High blood pressure (siblings) 0.1 0.1 0.4 0.6 0.1 -0.0
Forced vital capacity (FVC), Best measure 5.0 18.2 24.8 -3.4 5.0 4.3
Body fat percentage 4.5 17.9 24.0 3.2 -4.9 -4.4
Leg fat percentage (right) 5.3 19.1 25.0 3.5 -5.0 -4.5
Arm fat-free mass (right) 0.3 1.6 3.6 1.9 0.9 0.7
Exposure to tobacco smoke outside home 0.2 0.3 0.9 -0.9 0.1 0.3
Comparative body size at age 10 0.4 1.0 1.9 1.4 -0.6 -0.8
Number of full brothers 0.7 0.9 1.5 -0.5 -1.2 -0.9
Worry too long after embarrassment 7.0 11.7 13.0 -3.6 3.3 3.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.6 1.0 -0.6 -1.0 -0.7
Wheeze or whistling in the chest in last year 0.7 1.3 1.4 1.1 -1.1 -1.2
Number of children fathered 4.1 4.6 6.8 1.9 -2.6 -1.8
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 1.0 -0.4 0.5 1.0
Age at first live birth 4.8 8.5 13.5 -1.1 3.3 3.7
Pulse wave peak to peak time 0.6 0.7 1.4 -1.2 0.6 0.6
Health satisfaction 4.5 5.9 7.2 1.9 -2.6 -2.7
Shortness of breath walking on level ground 0.3 0.3 0.5 -0.6 0.2 0.7
Qualifications: College or University degree 1.8 5.6 10.4 0.3 2.5 3.2
Eye problems/disorders: None of the above 1.6 1.9 2.5 -1.6 1.1 1.4
Mouth/teeth dental problems: Loose teeth 3.5 4.1 4.7 1.7 -2.2 -2.1
Emphysema/chronic bronchitis 0.3 0.4 0.5 0.7 -0.5 -0.6
Medication for pain relief, constipation, heartburn 0.6 1.0 1.5 -0.8 1.2 1.0
Neck or shoulder pain in last month 2.9 4.1 7.2 0.6 -2.2 -2.7
Medication: Blood pressure 0.4 0.6 1.3 -1.1 0.6 0.5
Angina (self-reported) 1.2 1.6 1.7 1.3 -1.3 -1.2
Migraine (self-reported) 0.4 0.5 1.3 0.4 -1.1 -0.5
Medication: Ibuprofen 0.4 0.5 0.6 0.6 -0.7 -0.8
Medication: Allopurinol 0.7 0.9 1.0 1.0 -1.0 -0.9
Medication: Omeprazole 0.5 0.6 1.0 1.0 -0.9 -0.2
Medication: Seretide 50 evohaler 3.0 3.5 4.2 1.8 -2.0 -1.7
Mean time to correctly identify matches 0.1 0.1 0.4 0.6 -0.2 -0.0
Heart disease (mother) 0.5 0.6 0.7 -0.8 0.5 0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.4 2.1 1.1 -1.4 -0.9
Whole body fat mass 3.1 12.8 15.4 3.4 -3.9 -3.4
Leg fat mass (right) 3.8 14.6 17.6 3.6 -4.2 -3.7
Arm predicted mass (right) 0.3 1.4 2.4 1.6 1.1 0.7
Pulse rate, automated reading 0.3 1.0 2.5 -1.6 0.6 -0.4
Alcohol intake frequency. 0.2 0.4 0.9 -1.0 -0.0 -0.6
Comparative height size at age 10 1.9 10.2 15.8 -1.0 4.0 3.7
Number of full sisters 2.0 2.4 4.8 0.5 -2.2 -1.5
Suffer from ‘nerves’ 1.8 2.8 6.8 -2.6 1.1 0.5
Overall health rating 5.3 11.4 15.6 2.1 -4.0 -3.8
Chest pain or discomfort 0.9 1.3 2.7 0.4 -1.6 -1.1
Had major operations 0.4 0.5 0.9 0.7 -0.4 -0.9
Age at last live birth 4.2 6.2 8.3 -1.9 2.5 2.9
Family relationship satisfaction 0.1 0.1 0.2 -0.3 0.5 0.1
Leg pain on walking 1.7 2.1 2.6 1.5 -1.3 -1.6
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 1.2 -0.3 -1.1 -1.0
Commuting to job workplace: Car/motor vehicle 0.4 0.5 0.9 0.5 -0.4 -1.0
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 2.1 -0.2 0.9 1.5
Medication: Aspirin 0.9 1.1 1.5 0.7 -1.2 -1.2
Supplements: Vitamin C 0.4 0.4 1.3 -1.1 0.2 0.0
Knee pain experienced in last month 0.2 0.2 0.5 0.7 -0.3 0.3
Hypertension (Self-reported) 0.1 0.2 0.4 0.6 -0.5 -0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.3 2.7 3.2 1.8 -1.6 -1.5
Illnesses of father: Heart disease 1.9 2.7 5.2 -0.4 1.6 2.3
Illnesses of siblings: Diabetes 0.2 0.3 0.5 0.2 -0.6 -0.7
Smoking status: Previous 10.8 16.1 18.5 3.9 -4.3 -3.8
Forced expiratory volume in 1-second (FEV1), predicted 6.4 13.2 15.8 -2.9 4.0 3.9
Whole body fat-free mass 0.4 2.4 2.9 1.3 1.7 1.7
Leg fat-free mass (right) 0.2 1.1 2.8 1.7 0.4 0.5
Arm fat percentage (left) 4.4 17.5 24.6 3.2 -5.0 -4.2
Average weekly red wine intake 1.1 1.6 3.8 2.0 -0.9 -0.5
Handedness (chirality/laterality): Left-handed 0.0 0.0 0.0 0.2 0.0 0.2
Mood swings 1.0 1.7 3.2 -1.8 1.0 1.0
Loneliness, isolation 0.1 0.2 0.2 0.5 -0.4 -0.3
Long-standing illness, disability or infirmity 3.4 5.2 6.7 1.7 -2.6 -2.5
Ever had bowel cancer screening 1.3 1.5 3.7 1.9 -0.6 -0.7
Diabetes diagnosed by doctor 1.2 2.0 2.7 1.7 -1.5 -1.1
Ever had stillbirth, spontaneous miscarriage or termination 1.5 1.6 2.1 1.1 -1.5 -1.3
Friendships satisfaction 0.1 0.1 0.2 -0.0 0.5 0.1
Qualifications: nursing, teaching 0.2 0.3 0.6 0.8 -0.1 0.6
Commuting to job workplace: Walk 0.3 0.3 0.8 -0.9 -0.1 0.0
Eye problems/disorders: Cataract 0.4 0.5 0.8 0.5 -0.6 -0.9
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 1.5 -0.0 0.7 1.2
Medication for cholesterol 0.4 0.6 1.0 -0.8 0.3 1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.7 2.0 2.9 -1.7 1.2 1.3
Back pain experienced in last month 1.0 1.5 2.5 -0.1 -1.6 -1.4
Mineral and other dietary supplements 0.6 0.8 1.7 0.6 -0.6 -1.3
Breast cancer (self-reported) 1.3 1.6 2.2 -0.8 1.3 1.5
Asthma (self-reported) 0.1 0.2 0.3 -0.4 0.2 0.5
Osteoporosis (self-reported) 0.0 0.1 0.1 -0.2 0.3 0.3
Osteoarthritis (self-reported) 1.4 1.8 2.6 1.2 -1.6 -1.2
Medication: Aspirin 1.2 1.6 2.3 0.7 -1.5 -1.4
Medication: Gliclazide 2.1 2.4 2.4 1.5 -1.5 -1.6
Illnesses of father: None of the above (group 1) 0.4 0.5 0.9 0.4 -0.8 -0.9
Smoking status: Current 1.4 2.2 4.1 0.6 -1.5 -2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 1.8 2.8 -0.6 1.5 1.7
Whole body water mass 0.4 2.3 2.6 1.4 1.6 1.6
Leg predicted mass (right) 0.2 1.1 2.9 1.7 0.4 0.5
Arm fat mass (left) 2.9 12.0 15.0 3.3 -3.9 -3.2
Number of self-reported non-cancer illnesses 0.9 1.6 2.2 1.2 -1.5 -1.1
Average weekly champagne plus white wine intake 1.3 1.8 4.3 -0.4 1.0 2.1
Miserableness 0.1 0.1 0.2 0.5 -0.2 -0.0
Guilty feelings 0.6 0.9 1.7 -0.7 0.8 1.3
Wears glasses or contact lenses 5.5 6.3 8.4 2.9 -2.4 -2.2
Ever taken oral contraceptive pill 0.4 0.4 0.8 -0.9 -0.1 -0.7
Hearing aid user 1.4 1.6 2.5 0.4 -1.5 -1.6
Mother’s age at death 0.1 0.2 0.3 0.5 0.5 0.0
Financial situation satisfaction 0.1 0.2 0.5 0.7 -0.0 0.0
Tinnitus: Yes, now most or all of the time 0.6 0.7 0.8 -0.9 0.8 0.8
Commuting to job workplace: Public transport 0.2 0.2 0.4 0.4 0.3 0.7
Eye problems/disorders: Glaucoma 0.4 0.5 0.9 0.9 -0.5 -0.7
Medication: Blood pressure 0.8 1.6 2.2 1.5 -1.1 -1.1
Pain type(s) experienced in last month: Hip pain 1.2 1.5 2.2 0.5 -1.4 -1.5
Supplements: Fish oil (including cod liver oil) 0.2 0.2 0.3 -0.6 -0.1 0.5
High cholesterol (Self-reported) 0.2 0.3 0.4 0.3 0.6 0.6
Medication: Bendroflumethiazide 0.1 0.1 0.4 0.6 0.1 -0.0
Medication: Paracetamol 0.1 0.2 0.4 -0.3 -0.6 -0.5
Medication: Lisinopril 2.4 3.1 4.4 -1.0 2.0 2.1
Medication: Atorvastatin 1.9 2.4 3.1 1.6 -1.8 -1.1
Illnesses of father: High blood pressure 0.1 0.1 0.1 -0.4 -0.2 -0.3
Alcohol drinker status: Never 0.0 0.0 0.0 0.2 -0.2 0.1
Ever smoked 3.2 5.7 6.0 2.3 -2.5 -2.4
Basal metabolic rate 0.3 1.4 3.1 1.8 0.7 0.8
Leg fat percentage (left) 5.6 20.4 26.3 3.6 -5.1 -4.6
Arm fat-free mass (left) 0.3 1.6 3.3 1.8 0.8 0.9
Number of operations (self-reported) 1.0 1.4 3.0 -0.0 -1.1 -1.7
Average weekly beer plus cider intake 0.1 0.1 0.2 -0.3 -0.2 -0.4
Irritability 0.3 0.4 0.7 0.4 0.8 0.7
Risk taking 0.9 1.4 1.6 1.1 -1.2 -1.1
Ever had prostate specific antigen (PSA) test 1.4 1.6 2.1 -1.0 1.2 1.4
Fractured/broken bones in last 5 years 1.2 1.6 2.4 1.1 -1.1 -1.5
Age started oral contraceptive pill 0.6 0.7 0.9 1.0 -0.9 -0.6
Diastolic blood pressure, automated reading 0.2 0.7 0.9 0.9 -0.8 -0.7
Ever depressed for a whole week 0.2 0.2 0.4 -0.3 0.6 0.5
Unable to work because of sickness or disability 0.1 0.1 0.2 -0.4 0.1 -0.3
Commuting to job workplace: Cycle 0.2 0.2 0.7 0.8 -0.1 0.1
Myopia 0.1 0.1 0.2 -0.1 0.4 0.2
Vascular/heart problems diagnosed by doctor 0.1 0.2 0.6 -0.0 -0.2 -0.7
Cholesterol lowering medication 1.0 1.5 2.3 1.5 -0.7 -1.3
Medication: Omeprazole (e.g. Zanprol) 0.1 0.2 0.2 0.5 -0.5 0.2
Pain experienced in last month 0.7 1.2 1.9 0.7 1.1 1.4
Supplements: Calcium 1.5 1.7 1.9 -1.4 1.3 1.3
Basal cell carcinoma (self-reported) 1.6 1.9 2.7 -1.6 1.5 0.9
Heart attack/myocardial infarction (self-reported) 0.1 0.1 0.2 -0.1 -0.4 -0.2
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 1.2 0.0 -0.8 -1.1
Heart disease (siblings) 0.2 0.3 0.3 -0.5 0.6 0.5
Alcohol drinker status: Previous 0.0 0.0 0.0 0.0 0.1 0.2
Pack years of smoking 0.7 1.0 1.4 1.2 -1.0 -0.7
Impedance of whole body 0.8 4.2 11.3 -3.4 1.0 0.3
Leg fat mass (left) 3.8 14.8 17.7 3.6 -4.2 -3.7
Arm predicted mass (left) 0.3 1.6 2.8 1.7 1.0 1.0