TWAS hub - C7orf52

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Brain Lower Grade Glioma	0.0326	0.0173	1.3e-03	0.019	0.019	0.008	NA	0.014	2.6e-03	2.7e-03	3.3e-02	NA	8.1e-03
2	TCGA	Pancreatic Adenocarcinoma	0.2350	0.1000	1.3e-06	0.095	0.124	0.118	NA	0.105	8.6e-05	7.0e-06	1.3e-05	NA	3.6e-05
3	TCGA	Thyroid Carcinoma	0.0860	0.0300	2.7e-11	0.078	0.105	0.117	NA	0.107	5.1e-08	2.3e-10	1.8e-11	NA	1.5e-10

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Smoking status: Previous	10.8	16.1	18.5	3.9	-4.3	-3.8
Past tobacco smoking	9.2	17.0	19.3	-3.9	4.4	4.1
Worry too long after embarrassment	7.0	11.7	13.0	-3.6	3.3	3.3
Forced expiratory volume in 1-second (FEV1), predicted	6.4	13.2	15.8	-2.9	4.0	3.9
Leg fat percentage (left)	5.6	20.4	26.3	3.6	-5.1	-4.6
Wears glasses or contact lenses	5.5	6.3	8.4	2.9	-2.4	-2.2
Leg fat percentage (right)	5.3	19.1	25.0	3.5	-5.0	-4.5
Overall health rating	5.3	11.4	15.6	2.1	-4.0	-3.8
Mouth/teeth dental problems: Bleeding gums	5.2	6.7	9.0	3.0	-2.5	-2.2
Average weekly spirits intake	5.0	6.3	10.0	3.2	-2.2	-2.0
Forced vital capacity (FVC), Best measure	5.0	18.2	24.8	-3.4	5.0	4.3
Age at first live birth	4.8	8.5	13.5	-1.1	3.3	3.7
Smoking Status	4.5	10.7	13.7	2.5	-3.5	-3.7
Body fat percentage	4.5	17.9	24.0	3.2	-4.9	-4.4
Health satisfaction	4.5	5.9	7.2	1.9	-2.6	-2.7
Body mass index (BMI)	4.4	18.9	23.2	4.3	-4.8	-3.9
Arm fat percentage (left)	4.4	17.5	24.6	3.2	-5.0	-4.2
Arm fat percentage (right)	4.2	16.6	23.8	3.2	-4.9	-4.0
Forced expiratory volume in 1-second (FEV1), Best measure	4.2	13.3	17.6	-2.7	4.2	3.9
Age at last live birth	4.2	6.2	8.3	-1.9	2.5	2.9
Tense / ‘highly strung’	4.1	6.7	8.2	-2.7	2.9	2.2
Number of children fathered	4.1	4.6	6.8	1.9	-2.6	-1.8
BMI	4.0	23.2	26.8	5.2	-5.2	-4.0
Hand grip strength (right)	4.0	10.9	16.4	-1.3	4.0	3.8
Relative age voice broke	3.9	6.0	8.3	-2.9	2.6	1.7
Hayfever/allergic rhinitis (self-reported)	3.9	5.2	7.5	-0.8	2.7	2.7
Leg fat mass (right)	3.8	14.6	17.6	3.6	-4.2	-3.7
Leg fat mass (left)	3.8	14.8	17.7	3.6	-4.2	-3.7
Forced vital capacity (FVC)	3.7	14.4	20.6	-2.7	4.5	3.9
Schizophrenia vs Biploar Disorder	3.6	4.7	5.1	2.2	-2.0	-2.3
Trunk fat percentage	3.6	14.4	19.1	2.9	-4.4	-4.0
Nervous feelings	3.6	6.6	6.9	-2.6	2.6	2.5
Blood Red Count	3.5	34.2	59.1	2.2	-6.2	-7.7
Mouth/teeth dental problems: Loose teeth	3.5	4.1	4.7	1.7	-2.2	-2.1
Waist circumference	3.4	12.5	15.2	3.6	-3.9	-3.0
Long-standing illness, disability or infirmity	3.4	5.2	6.7	1.7	-2.6	-2.5
Forced expiratory volume in 1-second (FEV1)	3.3	11.1	14.6	-2.2	3.8	3.7
Rheumatoid Arthritis	3.2	4.4	4.7	2.2	-1.9	-2.2
Ever smoked	3.2	5.7	6.0	2.3	-2.5	-2.4
Age at First Birth	3.1	4.5	6.1	-1.9	2.5	1.9
Birth weight	3.1	6.7	8.6	-2.7	2.9	2.1
Whole body fat mass	3.1	12.8	15.4	3.4	-3.9	-3.4
Medication: Seretide 50 evohaler	3.0	3.5	4.2	1.8	-2.0	-1.7
Neck or shoulder pain in last month	2.9	4.1	7.2	0.6	-2.2	-2.7
Arm fat mass (left)	2.9	12.0	15.0	3.3	-3.9	-3.2
Arm fat mass (right)	2.8	11.3	13.9	3.3	-3.7	-3.0
Number of live births	2.7	3.9	5.0	1.5	-2.0	-2.2
Qualifications: O levels/GCSEs or equivalent	2.7	4.3	6.8	-1.1	2.6	2.2
Worry (Nagel 2018)	2.4	5.0	10.3	-3.2	1.7	1.3
Trunk fat mass	2.4	10.4	12.2	3.0	-3.5	-3.1
Qualifications: A levels/AS levels or equivalent	2.4	5.3	8.6	-0.8	2.6	2.9
Standing height	2.4	23.8	37.7	-2.6	6.1	5.2
Medication: Lisinopril	2.4	3.1	4.4	-1.0	2.0	2.1
Vitamin and mineral supplements	2.3	3.1	5.0	2.2	-1.6	-1.3
Stomach or abdominal pain in last month	2.3	2.9	3.7	1.2	-1.9	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.3	2.7	3.2	1.8	-1.6	-1.5
Neuroticism (Nagel 2018)	2.2	5.2	7.2	-2.7	2.1	2.0
Ovarian Cancer	2.2	2.9	3.5	1.3	-1.8	-1.9
Medication: Co-codamol	2.2	2.5	3.1	1.5	-1.5	-1.8
Crohns Disease (2012)	2.1	3.4	4.9	0.7	-2.2	-2.2
HDL Cholesterol	2.1	3.6	5.3	-1.4	1.9	2.3
Worrier / anxious feelings	2.1	3.9	8.9	-3.0	1.3	1.0
Medication: Gliclazide	2.1	2.4	2.4	1.5	-1.5	-1.6
Number of full sisters	2.0	2.4	4.8	0.5	-2.2	-1.5
Comparative height size at age 10	1.9	10.2	15.8	-1.0	4.0	3.7
Illnesses of father: Heart disease	1.9	2.7	5.2	-0.4	1.6	2.3
Medication: Atorvastatin	1.9	2.4	3.1	1.6	-1.8	-1.1
Sensitivity / hurt feelings	1.8	3.1	3.6	-1.7	1.8	1.9
Hip circumference	1.8	7.7	10.0	3.2	-2.9	-2.2
Qualifications: College or University degree	1.8	5.6	10.4	0.3	2.5	3.2
Suffer from ‘nerves’	1.8	2.8	6.8	-2.6	1.1	0.5
Hand grip strength (left)	1.7	4.5	7.4	-0.4	2.7	2.4
Prospective memory result	1.7	2.0	3.0	1.5	-1.7	-0.9
Leg pain on walking	1.7	2.1	2.6	1.5	-1.3	-1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	2.0	2.9	-1.7	1.2	1.3
Schizophrenia (2018)	1.6	3.4	5.6	1.0	-1.9	-2.4
Multivitamins +/- minerals	1.6	2.1	2.3	-1.3	1.5	1.5
Eye problems/disorders: None of the above	1.6	1.9	2.5	-1.6	1.1	1.4
Basal cell carcinoma (self-reported)	1.6	1.9	2.7	-1.6	1.5	0.9
Neuroticism (2016)	1.5	2.2	4.0	-2.0	1.5	0.7
Frequency of depressed mood in last 2 weeks	1.5	2.1	3.7	-1.9	1.1	1.1
Systolic blood pressure, automated reading	1.5	4.4	7.7	2.8	-1.9	-1.4
Severe depression (siblings)	1.5	1.7	2.3	1.1	-1.5	-1.2
Number of incorrect matches in round	1.5	2.5	3.0	1.7	-1.7	-1.4
Neuroticism score	1.5	3.2	4.6	-2.1	1.6	1.6
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	2.1	1.1	-1.5	-1.3
Supplements: Calcium	1.5	1.7	1.9	-1.4	1.3	1.3
Height	1.4	26.6	44.1	-1.8	6.6	5.7
Other serious medical condition/disability diagnosed by doctor	1.4	1.9	3.1	0.5	-1.7	-1.5
Maternal smoking around birth	1.4	2.0	3.3	0.3	-1.6	-1.8
Sitting height	1.4	9.8	17.1	-1.4	4.1	3.2
Gout (self-reported)	1.4	1.9	2.2	1.3	-1.5	-1.4
Osteoarthritis (self-reported)	1.4	1.8	2.6	1.2	-1.6	-1.2
Smoking status: Current	1.4	2.2	4.1	0.6	-1.5	-2.0
Hearing aid user	1.4	1.6	2.5	0.4	-1.5	-1.6
Ever had prostate specific antigen (PSA) test	1.4	1.6	2.1	-1.0	1.2	1.4
Schizophrenia (2014)	1.3	2.9	3.9	1.4	-1.7	-2.0
Chronotype (morning person)	1.3	3.1	4.9	-1.0	1.8	2.2
Hearing difficulty/problems: Yes	1.3	1.9	3.9	2.0	-1.1	-0.8
Current tobacco smoking	1.3	2.2	4.0	0.6	-1.5	-2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.7	3.8	-2.0	1.0	0.6
Medication: Cholesterol lowering	1.3	2.1	2.9	-1.4	1.1	1.7
Depression (self-reported)	1.3	1.6	3.1	-0.7	1.1	1.8
Ever had bowel cancer screening	1.3	1.5	3.7	1.9	-0.6	-0.7
Breast cancer (self-reported)	1.3	1.6	2.2	-0.8	1.3	1.5
Average weekly champagne plus white wine intake	1.3	1.8	4.3	-0.4	1.0	2.1
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	2.6	-1.6	1.2	0.4
Birth weight of first child	1.2	2.1	2.8	-1.7	1.5	1.2
Angina (self-reported)	1.2	1.6	1.7	1.3	-1.3	-1.2
Diabetes diagnosed by doctor	1.2	2.0	2.7	1.7	-1.5	-1.1
Medication: Aspirin	1.2	1.6	2.3	0.7	-1.5	-1.4
Pain type(s) experienced in last month: Hip pain	1.2	1.5	2.2	0.5	-1.4	-1.5
Fractured/broken bones in last 5 years	1.2	1.6	2.4	1.1	-1.1	-1.5
Depression (Nagel 2018)	1.1	1.7	3.0	-1.7	1.1	0.9
Intelligence (Savage-Jansen 2018)	1.1	3.4	4.5	-1.1	2.1	2.1
Alzheimer’s Disease (in mother)	1.1	1.3	2.9	1.7	-0.8	-0.5
Serious illness, injury or assault to yourself	1.1	1.3	2.6	0.5	-1.1	-1.6
Medication: Atenolol	1.1	1.3	2.2	0.9	-1.5	-1.0
Noisy workplace	1.1	1.4	2.5	0.5	-1.6	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.4	2.1	1.1	-1.4	-0.9
Average weekly red wine intake	1.1	1.6	3.8	2.0	-0.9	-0.5
Lupus	1.0	1.5	2.7	0.5	-1.6	-1.2
Lung FEV1/FVC ratio	1.0	4.9	8.4	2.9	-2.4	-1.0
Angina	1.0	1.3	1.5	1.1	-1.2	-1.1
Impedance of arm (right)	1.0	4.8	11.4	-3.4	1.3	1.1
Ever highly irritable/argumentative for 2 days	1.0	1.2	1.7	0.6	-1.2	-1.3
Mood swings	1.0	1.7	3.2	-1.8	1.0	1.0
Back pain experienced in last month	1.0	1.5	2.5	-0.1	-1.6	-1.4
Number of operations (self-reported)	1.0	1.4	3.0	-0.0	-1.1	-1.7
Cholesterol lowering medication	1.0	1.5	2.3	1.5	-0.7	-1.3
Body Mass Index (BMI) (2010)	0.9	1.2	2.0	0.8	-1.0	-1.4
Type 2 Diabetes (T2D) (2018)	0.9	1.8	2.4	1.5	-1.5	-0.9
Impedance of leg (right)	0.9	4.1	10.3	-3.2	1.3	0.6
Mouth/teeth dental problems	0.9	1.4	2.9	-1.7	1.0	0.4
Pain all over the body in last month	0.9	0.9	1.5	0.1	-1.2	-1.1
Weight	0.9	4.4	8.1	2.9	-1.8	-1.3
Impedance of arm (left)	0.9	3.9	10.5	-3.2	1.0	0.5
Chest pain or discomfort	0.9	1.3	2.7	0.4	-1.6	-1.1
Medication: Aspirin	0.9	1.1	1.5	0.7	-1.2	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.8	2.8	-0.6	1.5	1.7
Number of self-reported non-cancer illnesses	0.9	1.6	2.2	1.2	-1.5	-1.1
Risk taking	0.9	1.4	1.6	1.1	-1.2	-1.1
Crohns Disease (2017)	0.8	1.8	3.2	-0.3	-1.4	-1.8
Ever used hormone-replacement therapy (HRT)	0.8	1.0	1.8	0.2	-1.4	-1.1
Pack years adult smoking proportion	0.8	1.2	1.3	1.1	-1.2	-1.1
Supplements: Glucosamine	0.8	1.0	1.4	1.2	-1.0	-0.8
Had menopause	0.8	1.0	1.7	0.6	-1.3	-1.0
Financial difficulties in last 2 years	0.8	1.1	1.2	1.1	-1.0	-1.0
Medication: Ramipril	0.8	1.0	1.6	-1.2	0.9	0.8
Trunk fat-free mass	0.8	4.3	6.2	0.9	2.5	2.4
Trunk predicted mass	0.8	4.6	6.7	0.9	2.6	2.5
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.1	-0.2	0.9	1.5
Medication: Blood pressure	0.8	1.6	2.2	1.5	-1.1	-1.1
Impedance of whole body	0.8	4.2	11.3	-3.4	1.0	0.3
Triglycerides	0.7	1.1	1.6	0.4	-1.3	-1.3
Neuroticism	0.7	1.8	2.9	-1.7	1.1	1.1
Relative age of first facial hair	0.7	1.5	2.2	-1.5	1.1	1.0
Diabetes (mother)	0.7	0.9	1.7	-0.6	-0.8	-1.3
Medication: Simvastatin	0.7	1.0	1.6	-0.8	1.2	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.8	-0.7	1.4	0.2
Number of full brothers	0.7	0.9	1.5	-0.5	-1.2	-0.9
Wheeze or whistling in the chest in last year	0.7	1.3	1.4	1.1	-1.1	-1.2
Medication: Allopurinol	0.7	0.9	1.0	1.0	-1.0	-0.9
Pain experienced in last month	0.7	1.2	1.9	0.7	1.1	1.4
Pack years of smoking	0.7	1.0	1.4	1.2	-1.0	-0.7
Bipolar Disorder (2018)	0.6	0.9	1.5	-0.2	1.1	1.2
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.1	-1.1	0.9	0.3
Heel T-Score	0.6	5.1	9.7	-0.8	2.2	3.1
Lung FVC	0.6	3.0	4.2	-1.3	2.0	1.7
Age when periods started (menarche)	0.6	1.4	3.8	-1.9	0.5	0.4
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.0	-1.0	0.9	-0.0
Medication: Levothyroxine sodium	0.6	1.0	2.4	1.5	-0.6	-0.4
Impedance of leg (left)	0.6	3.0	8.4	-2.9	0.8	0.0
Father’s age at death	0.6	0.8	0.9	-0.8	0.9	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	1.7	-0.1	-1.3	-1.0
Pulse wave peak to peak time	0.6	0.7	1.4	-1.2	0.6	0.6
Medication for pain relief, constipation, heartburn	0.6	1.0	1.5	-0.8	1.2	1.0
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.2	-0.3	-1.1	-1.0
Mineral and other dietary supplements	0.6	0.8	1.7	0.6	-0.6	-1.3
Guilty feelings	0.6	0.9	1.7	-0.7	0.8	1.3
Tinnitus: Yes, now most or all of the time	0.6	0.7	0.8	-0.9	0.8	0.8
Age started oral contraceptive pill	0.6	0.7	0.9	1.0	-0.9	-0.6
Ulcerative Colitis (UC)	0.5	0.9	2.4	-1.6	0.4	0.3
Qualifications: None of the above	0.5	1.1	1.9	0.3	-1.4	-1.1
Diabetes (self-reported)	0.5	0.8	0.9	0.9	-1.0	-0.8
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.1	0.3	-0.8	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.0	-0.6	-1.0	-0.7
Medication: Omeprazole	0.5	0.6	1.0	1.0	-0.9	-0.2
Heart disease (mother)	0.5	0.6	0.7	-0.8	0.5	0.9
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.2	0.0	-0.8	-1.1
Irritable Bowel Disease (IBD)	0.4	0.9	1.6	-1.3	-0.7	-0.9
Verbal and Numeric Reasoning (VNR)	0.4	0.9	1.3	-0.3	1.2	1.1
Blood Eosinophil Count	0.4	3.1	3.8	1.5	-1.8	-1.9
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.8	0.4	-0.9	-0.6
Average weekly fortified wine intake	0.4	0.5	0.9	-0.2	0.9	0.7
Fed-up feelings	0.4	0.6	1.9	-1.4	-0.0	0.0
Alcohol usually taken with meals	0.4	0.6	0.8	-0.8	0.9	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.5	1.5	-1.2	-0.0	-0.3
Fluid intelligence score	0.4	0.8	1.2	-0.9	1.1	0.6
Pulse rate	0.4	0.7	1.0	-1.0	1.0	-0.2
Happiness	0.4	0.4	0.8	-0.2	-0.9	-0.7
Illnesses of mother	0.4	0.5	0.8	-0.9	0.7	0.6
Exposure to tobacco smoke at home	0.4	0.4	0.7	0.3	-0.8	-0.8
Glaucoma (self-reported)	0.4	0.5	0.8	0.7	-0.4	-0.9
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.7	1.3	-0.8	-0.2
Medication: Ventolin 100micrograms inhaler	0.4	0.5	0.8	-0.4	0.9	0.8
Comparative body size at age 10	0.4	1.0	1.9	1.4	-0.6	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.0	-0.4	0.5	1.0
Medication: Blood pressure	0.4	0.6	1.3	-1.1	0.6	0.5
Migraine (self-reported)	0.4	0.5	1.3	0.4	-1.1	-0.5
Medication: Ibuprofen	0.4	0.5	0.6	0.6	-0.7	-0.8
Had major operations	0.4	0.5	0.9	0.7	-0.4	-0.9
Commuting to job workplace: Car/motor vehicle	0.4	0.5	0.9	0.5	-0.4	-1.0
Supplements: Vitamin C	0.4	0.4	1.3	-1.1	0.2	0.0
Whole body fat-free mass	0.4	2.4	2.9	1.3	1.7	1.7
Eye problems/disorders: Cataract	0.4	0.5	0.8	0.5	-0.6	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.5	-0.0	0.7	1.2
Medication for cholesterol	0.4	0.6	1.0	-0.8	0.3	1.0
Illnesses of father: None of the above (group 1)	0.4	0.5	0.9	0.4	-0.8	-0.9
Whole body water mass	0.4	2.3	2.6	1.4	1.6	1.6
Ever taken oral contraceptive pill	0.4	0.4	0.8	-0.9	-0.1	-0.7
Eye problems/disorders: Glaucoma	0.4	0.5	0.9	0.9	-0.5	-0.7
Bipolar Disorder or Schizophrenia	0.3	0.7	1.1	0.6	-0.8	-1.1
Primary Biliary Cirrhosis	0.3	0.4	0.5	-0.5	0.7	0.7
Blood White Count	0.3	2.1	4.5	-0.3	-1.3	-2.1
Hypothyroidism (self reported)	0.3	0.7	1.1	0.8	0.4	1.0
Tanning	0.3	3.3	5.8	1.0	-1.8	-2.4
Medication: Metformin	0.3	0.4	0.6	0.5	-0.6	-0.8
Diabetes (father)	0.3	0.4	0.8	-0.9	0.4	0.4
Qualifications: CSEs or equivalent	0.3	0.4	0.9	-1.0	0.4	0.0
Chronic bronchitis/emphysema (father)	0.3	0.3	0.4	0.6	-0.6	-0.4
Time employed in main current job	0.3	0.4	0.7	-0.6	0.8	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.7	0.3	-0.6	-0.9
Lung cancer (father)	0.3	0.3	0.5	0.3	-0.7	-0.6
Peak expiratory flow (PEF)	0.3	0.6	1.0	-0.1	0.8	1.0
Blood clot in the leg (DVT)	0.3	0.4	0.8	-0.0	-0.7	-0.9
Arm fat-free mass (right)	0.3	1.6	3.6	1.9	0.9	0.7
Shortness of breath walking on level ground	0.3	0.3	0.5	-0.6	0.2	0.7
Emphysema/chronic bronchitis	0.3	0.4	0.5	0.7	-0.5	-0.6
Arm predicted mass (right)	0.3	1.4	2.4	1.6	1.1	0.7
Pulse rate, automated reading	0.3	1.0	2.5	-1.6	0.6	-0.4
Commuting to job workplace: Walk	0.3	0.3	0.8	-0.9	-0.1	0.0
Basal metabolic rate	0.3	1.4	3.1	1.8	0.7	0.8
Arm fat-free mass (left)	0.3	1.6	3.3	1.8	0.8	0.9
Irritability	0.3	0.4	0.7	0.4	0.8	0.7
Arm predicted mass (left)	0.3	1.6	2.8	1.7	1.0	1.0
Alzheimer’s Disease (including proxy)	0.2	0.3	0.4	0.6	-0.5	-0.6
Major Depression (MDD)	0.2	0.2	0.4	-0.0	-0.6	-0.6
Mean Putamen Volume	0.2	0.3	0.4	0.3	0.5	0.7
LDL Cholesterol	0.2	0.3	0.5	-0.4	0.7	0.6
Allergy or Eczema	0.2	0.6	0.9	0.2	1.0	0.9
Cardiovascular Disease	0.2	0.5	0.7	-0.8	0.6	0.8
Ever had hysterectomy (womb removed)	0.2	0.2	0.3	-0.6	0.4	-0.3
Medication for hormone replacement therapy	0.2	0.2	0.4	-0.6	0.4	0.1
Leg fat-free mass (left)	0.2	1.1	2.6	1.6	0.5	0.7
Townsend deprivation index at recruitment	0.2	0.3	0.5	-0.7	0.3	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	0.7	-0.5	0.7	0.8
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.2	-0.5	0.4	0.4
Leg predicted mass (left)	0.2	1.1	2.4	1.6	0.6	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.7	-0.8	0.5	0.5
Alcohol intake versus 10 years previously	0.2	0.3	0.7	-0.9	-0.1	0.1
Mouth/teeth dental problems: Dentures	0.2	0.4	0.9	0.9	-0.5	-0.0
Pulse wave Arterial Stiffness index	0.2	0.2	0.6	0.7	-0.1	-0.2
Length of working week for main job	0.2	0.2	0.3	-0.5	0.3	-0.4
Breastfed as a baby	0.2	0.2	0.4	0.6	-0.3	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.2	0.7	-0.8	0.2	0.2
Hair/balding pattern: Pattern 4	0.2	0.4	0.6	-0.8	0.7	-0.1
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.5	0.7	-0.2	-0.7
Exposure to tobacco smoke outside home	0.2	0.3	0.9	-0.9	0.1	0.3
Alcohol intake frequency.	0.2	0.4	0.9	-1.0	-0.0	-0.6
Knee pain experienced in last month	0.2	0.2	0.5	0.7	-0.3	0.3
Illnesses of siblings: Diabetes	0.2	0.3	0.5	0.2	-0.6	-0.7
Leg fat-free mass (right)	0.2	1.1	2.8	1.7	0.4	0.5
Qualifications: nursing, teaching	0.2	0.3	0.6	0.8	-0.1	0.6
Leg predicted mass (right)	0.2	1.1	2.9	1.7	0.4	0.5
Commuting to job workplace: Public transport	0.2	0.2	0.4	0.4	0.3	0.7
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.3	-0.6	-0.1	0.5
High cholesterol (Self-reported)	0.2	0.3	0.4	0.3	0.6	0.6
Diastolic blood pressure, automated reading	0.2	0.7	0.9	0.9	-0.8	-0.7
Ever depressed for a whole week	0.2	0.2	0.4	-0.3	0.6	0.5
Commuting to job workplace: Cycle	0.2	0.2	0.7	0.8	-0.1	0.1
Heart disease (siblings)	0.2	0.3	0.3	-0.5	0.6	0.5
Depressed Affect (Nagel 2018)	0.1	0.2	0.5	-0.7	-0.2	-0.1
Alzheimer’s Disease (in father)	0.1	0.1	0.1	0.3	-0.2	-0.2
Breast Cancer	0.1	0.3	0.5	0.4	0.7	0.3
Prostate Cancer	0.1	0.2	0.3	-0.5	-0.5	0.1
HbA1C	0.1	0.1	0.3	0.6	0.0	0.1
Ulcerative Colitis	0.1	0.2	0.4	0.0	-0.6	-0.5
Waist Hip Ratio (WHR)	0.1	0.2	0.4	-0.4	-0.6	-0.4
Systolic Blood Pressure	0.1	0.3	0.5	0.7	-0.7	-0.1
Supplements: Zinc	0.1	0.1	0.2	-0.4	-0.3	0.0
Taking other prescription medications	0.1	0.1	0.2	-0.3	-0.5	-0.2
Hearing difficulty/problems with background noise	0.1	0.1	0.2	0.4	0.2	0.3
Hair/balding pattern: Pattern 2	0.1	0.1	0.1	-0.3	-0.2	0.4
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.3	-0.1	0.1	-0.5
Illnesses of siblings	0.1	0.1	0.1	0.3	-0.3	-0.3
Falls in the last year	0.1	0.2	0.3	-0.5	0.3	-0.3
Asthma	0.1	0.1	0.3	-0.2	0.2	0.6
Medication: Lansoprazole	0.1	0.1	0.2	0.4	0.2	0.3
Pulse wave reflection index	0.1	0.1	0.3	0.6	0.0	0.0
Loud music exposure frequency	0.1	0.1	0.3	-0.1	0.5	-0.1
Medication: Paracetamol	0.1	0.1	0.3	-0.5	-0.0	-0.1
Medication: Amlodipine	0.1	0.1	0.2	-0.4	-0.2	-0.5
High blood pressure (siblings)	0.1	0.1	0.4	0.6	0.1	-0.0
Mean time to correctly identify matches	0.1	0.1	0.4	0.6	-0.2	-0.0
Family relationship satisfaction	0.1	0.1	0.2	-0.3	0.5	0.1
Hypertension (Self-reported)	0.1	0.2	0.4	0.6	-0.5	-0.1
Loneliness, isolation	0.1	0.2	0.2	0.5	-0.4	-0.3
Friendships satisfaction	0.1	0.1	0.2	-0.0	0.5	0.1
Asthma (self-reported)	0.1	0.2	0.3	-0.4	0.2	0.5
Miserableness	0.1	0.1	0.2	0.5	-0.2	-0.0
Mother’s age at death	0.1	0.2	0.3	0.5	0.5	0.0
Financial situation satisfaction	0.1	0.2	0.5	0.7	-0.0	0.0
Medication: Bendroflumethiazide	0.1	0.1	0.4	0.6	0.1	-0.0
Medication: Paracetamol	0.1	0.2	0.4	-0.3	-0.6	-0.5
Illnesses of father: High blood pressure	0.1	0.1	0.1	-0.4	-0.2	-0.3
Average weekly beer plus cider intake	0.1	0.1	0.2	-0.3	-0.2	-0.4
Unable to work because of sickness or disability	0.1	0.1	0.2	-0.4	0.1	-0.3
Myopia	0.1	0.1	0.2	-0.1	0.4	0.2
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.6	-0.0	-0.2	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.2	0.5	-0.5	0.2
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	-0.1	-0.4	-0.2
Reaction Time	0.0	0.0	0.1	0.1	-0.1	-0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
Fasting Glucose	0.0	0.1	0.1	-0.0	-0.2	-0.4
Blood Platelet Count	0.0	0.1	0.3	0.1	-0.6	0.1
Respiratory disease	0.0	0.0	0.0	-0.0	-0.2	-0.0
Hair Pigment	0.0	0.5	1.2	0.3	0.2	1.1
Number of treatments/medications taken	0.0	0.1	0.2	0.2	-0.4	0.0
High blood pressure	0.0	0.1	0.2	0.4	-0.3	0.3
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.1	0.1	0.4	0.2
High blood pressure (mother)	0.0	0.1	0.1	-0.2	-0.1	-0.3
Had other major operations	0.0	0.0	0.0	0.0	0.0	0.0
Heart attack	0.0	0.0	0.1	-0.0	-0.3	-0.2
Allergy	0.0	0.1	0.3	-0.5	0.1	0.2
Hair/balding pattern: Pattern 3	0.0	0.0	0.0	0.0	-0.1	0.1
Headache pain in last month	0.0	0.1	0.2	-0.5	-0.0	0.1
Handedness (chirality/laterality): Left-handed	0.0	0.0	0.0	0.2	0.0	0.2
Osteoporosis (self-reported)	0.0	0.1	0.1	-0.2	0.3	0.3
Alcohol drinker status: Never	0.0	0.0	0.0	0.2	-0.2	0.1
Alcohol drinker status: Previous	0.0	0.0	0.0	0.0	0.1	0.2

Hub : Genes

C7orf52

Models

Trait associations