[Hub]/) : Traits : Leg fat percentage (left) :

chr11:64,501,991-66,919,278

Best TWAS P=1.42e-10 · Best GWAS P=3.79e-13 conditioned to 0.0164

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex FIBP 0.08 0.11 enet 20 0.12 8.1e-14 4.9 6.4 1.4e-10 -0.34 1.00 0.00 TRUE
2 CommonMind Brain Pre-frontal Cortex SNX32 0.46 0.36 lasso 8 0.39 1.9e-50 5.9 5.8 8.2e-09 -0.16 0.96 0.04 FALSE
3 GTEx Adrenal Gland CTSW 0.13 0.08 lasso 12 0.06 3.0e-03 4.6 -5.5 4.8e-08 0.22 0.31 0.17 FALSE
4 GTEx Breast Mammary Tissue CTSW 0.25 0.19 lasso 8 0.16 1.3e-08 4.9 -5.2 2.0e-07 0.13 1.00 0.00 FALSE
5 GTEx Breast Mammary Tissue (Male) LTBP3 0.11 -0.01 enet 26 -0.01 5.8e-01 4.4 5.2 2.4e-07 -0.08 0.03 0.25 FALSE
6 GTEx Breast Mammary Tissue (Male) NEAT1 0.27 0.01 enet 29 0.03 6.3e-02 4.1 5.5 3.6e-08 -0.16 0.04 0.27 FALSE
7 GTEx Cells EBV-transformed lymphocytes FIBP 0.40 0.21 enet 26 0.29 4.3e-10 4.9 5.3 8.8e-08 -0.17 0.99 0.00 FALSE
8 GTEx Colon Transverse CTSW 0.37 0.27 lasso 8 0.26 1.5e-12 4.8 -5.1 3.1e-07 0.17 1.00 0.00 FALSE
9 GTEx Esophagus Muscularis CTD-3074O7.5 0.22 0.02 enet 17 0.09 3.7e-06 -3.0 6.4 1.5e-10 -0.50 0.26 0.52 TRUE
10 GTEx Heart Atrial Appendage RP11-867G23.1 0.19 0.13 lasso 5 0.11 1.6e-05 -5.3 -5.4 6.7e-08 0.66 0.09 0.85 FALSE
11 GTEx Muscle Skeletal FIBP 0.12 0.13 enet 10 0.13 2.6e-12 4.9 5.2 1.7e-07 -0.17 1.00 0.00 FALSE
12 GTEx Skin Sun Exposed Lower leg RP11-867G23.1 0.06 0.06 enet 7 0.02 1.3e-02 5.0 -5.1 3.1e-07 0.69 0.28 0.43 FALSE
13 GTEx Thyroid PACS1 0.09 0.04 enet 16 0.09 2.8e-07 -7.2 -5.5 4.0e-08 0.79 0.01 0.99 FALSE
14 ROSMAP Brain Pre-frontal Cortex SNX32 0.50 0.53 lasso 13 0.54 1.1e-81 5.9 5.5 3.5e-08 -0.13 0.95 0.05 FALSE
15 The Cancer Genome Atlas Breast Invasive Carcinoma CTSW 0.25 0.39 blup 44 0.41 7.3e-91 4.9 -5.2 1.8e-07 0.17 0.17 0.83 FALSE
16 The Cancer Genome Atlas Breast Invasive Carcinoma SNX32 0.15 0.17 blup 60 0.17 2.9e-34 5.9 5.5 5.2e-08 -0.16 0.00 1.00 FALSE
17 The Cancer Genome Atlas Colon Adenocarcinoma SNX32 0.11 0.08 enet 5 0.07 9.7e-05 5.0 5.3 1.1e-07 -0.14 0.00 1.00 FALSE
18 The Cancer Genome Atlas Glioblastoma Multiforme CTSW 0.16 0.18 enet 16 0.19 2.3e-06 4.6 -5.4 5.3e-08 0.23 0.08 0.83 FALSE
19 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma SNX32 0.15 0.14 enet 8 0.15 2.5e-16 3.9 5.1 2.8e-07 -0.16 0.00 0.99 FALSE
20 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma CTSW 0.32 0.26 lasso 1 0.26 4.3e-15 5.1 -5.1 2.7e-07 0.12 0.13 0.86 FALSE
21 The Cancer Genome Atlas Brain Lower Grade Glioma FIBP 0.04 0.04 lasso 3 0.04 1.2e-05 5.9 5.8 7.4e-09 -0.13 0.00 1.00 FALSE
22 The Cancer Genome Atlas Lung Adenocarcinoma FIBP 0.02 0.01 blup 45 0.02 1.3e-03 5.1 5.2 2.1e-07 -0.25 0.06 0.50 FALSE
23 The Cancer Genome Atlas Lung Adenocarcinoma SNX32 0.14 0.09 blup 60 0.13 8.8e-15 5.9 5.6 2.2e-08 -0.16 0.01 0.99 FALSE
24 The Cancer Genome Atlas Lung Squamous Cell Carcinoma SNX32 0.22 0.21 enet 16 0.24 6.2e-27 5.9 5.3 1.4e-07 -0.17 0.00 1.00 FALSE
25 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma SNX32 0.08 0.10 blup 60 0.11 6.0e-08 5.9 5.2 1.7e-07 -0.19 0.01 0.99 FALSE
26 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma SNX32 0.30 0.19 lasso 1 0.14 3.9e-06 5.9 5.9 4.1e-09 -0.12 0.00 1.00 FALSE
27 The Cancer Genome Atlas Stomach Adenocarcinoma SNX32 0.12 0.13 blup 60 0.13 1.2e-09 4.9 5.8 6.8e-09 -0.16 0.04 0.95 FALSE
28 The Cancer Genome Atlas Thyroid Carcinoma SNX32 0.23 0.26 lasso 7 0.25 6.4e-24 5.9 5.6 1.7e-08 -0.14 0.00 1.00 FALSE
29 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma CTSW 0.24 0.21 enet 21 0.24 2.9e-07 4.9 -5.3 1.3e-07 0.17 0.06 0.93 FALSE