TWAS hub - PACS1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0830	0.0270	1.1e-06	0.071	0.059	0.076	0.064	0.068	4.7e-09	1.1e-07	1.5e-09	3.2e-08	1.0e-08
2	GTEx	Adipose Subcutaneous	0.0640	0.0280	1.1e-03	0.038	NA	0.028	NA	0.051	4.0e-04	NA	2.2e-03	NA	5.1e-05
3	GTEx	Artery Aorta	0.1380	0.0510	2.5e-04	0.031	NA	0.095	NA	0.061	8.0e-03	NA	6.3e-06	NA	2.7e-04
4	GTEx	Artery Tibial	0.0612	0.0317	7.5e-03	0.047	NA	0.035	NA	0.026	1.4e-04	NA	9.2e-04	NA	3.4e-03
5	GTEx	Brain Cortex	0.1890	0.0670	5.7e-04	0.113	NA	0.036	NA	0.082	5.1e-04	NA	3.5e-02	NA	2.9e-03
6	GTEx	Brain Frontal Cortex BA9	0.1733	0.0717	2.7e-03	0.145	NA	0.179	NA	0.142	1.2e-04	NA	1.7e-05	NA	1.4e-04
7	GTEx	Breast Mammary Tissue	0.0830	0.0340	1.3e-03	0.096	NA	0.090	NA	0.096	1.2e-05	NA	2.2e-05	NA	1.2e-05
8	GTEx	Breast Mammary Tissue (Male)	0.0577	0.0687	2.3e-01	0.027	NA	-0.012	NA	0.002	8.0e-02	NA	8.2e-01	NA	2.9e-01
9	GTEx	Breast Mammary Tissue (Female)	0.0849	0.0495	3.4e-02	-0.010	NA	0.001	NA	-0.009	8.9e-01	NA	2.9e-01	NA	8.1e-01
10	GTEx	Esophagus Mucosa	0.0770	0.0350	5.0e-03	0.007	NA	0.006	NA	0.009	9.7e-02	NA	1.3e-01	NA	7.9e-02
11	GTEx	Nerve Tibial	0.1527	0.0533	7.3e-06	0.082	NA	0.128	NA	0.081	2.1e-06	NA	2.3e-09	NA	2.4e-06
12	GTEx	Thyroid	0.0880	0.0300	1.4e-05	0.036	NA	0.088	NA	0.049	8.5e-04	NA	2.8e-07	NA	1.1e-04
13	GTEx	Uterus	0.2080	0.0870	4.4e-03	-0.009	NA	0.050	NA	0.038	5.3e-01	NA	3.6e-02	NA	6.0e-02
14	METSIM	Adipose	0.1492	0.0353	0.0e+00	0.172	0.140	0.170	0.161	0.165	5.3e-25	2.1e-20	1.2e-24	2.0e-23	5.6e-24
15	ROSMAP	Brain Pre-frontal Cortex	0.1590	0.0378	6.4e-15	0.137	0.146	0.157	0.153	0.156	3.2e-17	2.8e-18	1.1e-19	3.1e-19	1.7e-19
16	YFS	Blood	0.0423	0.0179	5.7e-07	0.025	0.022	0.022	0.024	0.022	1.3e-08	8.7e-08	5.8e-08	2.5e-08	7.4e-08
17	TCGA	Breast Invasive Carcinoma	0.0222	0.0139	2.6e-04	0.019	0.018	0.015	NA	0.016	6.1e-05	8.5e-05	3.0e-04	NA	2.4e-04
18	TCGA	Prostate Adenocarcinoma	0.2897	0.0829	1.1e-12	0.144	0.125	0.136	NA	0.142	7.2e-15	6.0e-13	4.6e-14	NA	1.1e-14

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Bipolar Disorder (2011)	9.5	9.2	23.4	2.5	3.2	4.8	4.7	2.9	2.8	3.3	0.0	2.6	3.4	2.4	3.6	2.0	2.5	3.4	2.9	3.1	0.8
Bipolar Disorder (2018)	7.1	11.2	21.7	2.8	3.9	4.7	4.4	3.2	3.7	4.1	0.0	1.1	4.1	3.0	2.7	2.6	3.5	3.6	3.6	4.0	1.0
Triglycerides	6.6	10.8	19.6	-3.0	-3.6	-3.5	-3.0	-3.4	-4.4	-3.9	-1.1	-1.4	-4.0	-3.4	-2.6	-3.0	-3.9	-3.4	-3.8	-3.9	-1.3
Maternal smoking around birth	6.4	9.3	17.6	-2.4	-3.7	-3.2	-2.0	-2.8	-3.0	-3.8	-3.4	0.9	-3.8	-3.8	-1.0	-4.1	-3.2	-2.4	-3.0	-4.2	0.0
Chronotype (morning person)	6.3	14.7	29.3	-3.6	-3.9	-5.1	-5.4	-3.9	-4.7	-4.1	0.6	-3.3	-4.2	-4.0	-2.7	-2.5	-3.9	-3.8	-4.3	-4.1	-1.5
Handedness (chirality/laterality): Left-handed	6.1	7.3	12.7	2.5	3.3	3.1	3.2	2.4	3.1	3.3	0.6	0.0	3.6	2.0	2.2	2.6	3.0	2.9	3.0	3.3	0.7
Schizophrenia vs Biploar Disorder	5.5	7.2	13.3	-3.2	-3.3	-3.2	-3.2	-2.8	-2.6	-3.2	0.0	-0.8	-3.1	-1.5	-3.6	-2.2	-2.7	-3.1	-2.5	-2.9	-1.2
Fed-up feelings	5.4	9.8	19.5	-2.6	-4.4	-3.4	-3.7	-3.2	-3.7	-4.0	-0.4	-0.6	-4.2	-2.8	-3.0	-3.8	-3.3	-1.1	-2.5	-3.9	1.4
Qualifications: A levels/AS levels or equivalent	4.9	10.8	18.7	3.9	4.1	2.4	2.2	3.8	4.3	3.8	0.3	0.1	3.6	2.8	3.0	3.6	4.2	3.4	4.1	3.9	1.0
Long-standing illness, disability or infirmity	4.8	7.4	15.1	-3.0	-3.5	-1.7	-1.7	-2.8	-3.2	-3.3	-0.7	0.9	-3.2	-3.0	-2.3	-3.9	-3.8	-2.5	-2.4	-3.0	-0.2
Overall health rating	4.7	10.0	18.9	-3.2	-4.0	-1.8	-1.8	-3.8	-4.0	-3.7	-0.2	2.2	-3.6	-3.5	-3.3	-4.1	-4.3	-1.9	-3.1	-3.8	0.2
Leg fat mass (right)	4.1	15.8	36.7	-4.1	-4.6	-1.5	-0.5	-5.5	-4.1	-4.4	-2.8	2.3	-3.9	-3.4	-6.1	-5.4	-5.0	-3.9	-1.9	-5.2	0.3
Bipolar Disorder or Schizophrenia	4.0	9.7	22.7	2.1	3.2	4.8	4.5	3.1	2.8	3.1	0.0	1.0	3.0	3.7	3.3	2.7	3.3	3.5	3.2	3.7	0.2
Medication: Allopurinol	4.0	5.3	16.2	-1.5	-2.3	-3.1	-3.1	-1.4	-2.3	-2.0	0.2	-2.8	-2.5	-2.6	-0.1	-4.0	-2.0	-2.2	-2.7	-2.3	-0.2
Supplements: Fish oil (including cod liver oil)	4.0	5.2	11.7	3.4	2.3	2.6	3.2	2.6	1.7	1.9	0.8	0.5	1.9	-0.2	2.9	1.3	1.8	2.8	2.9	1.3	3.2
Illness, injury, bereavement, stress in last 2 years	3.9	4.7	9.8	3.1	2.3	1.5	1.5	2.2	2.6	2.2	1.1	2.0	2.1	1.1	0.4	2.2	2.9	2.6	2.6	2.3	2.3
Whole body fat mass	3.8	15.8	37.0	-3.9	-4.6	-1.3	-0.3	-5.2	-4.1	-4.3	-2.7	1.9	-3.9	-4.1	-5.4	-6.1	-5.2	-3.7	-1.8	-5.3	0.9
Pain experienced in last month	3.8	6.3	11.4	2.6	3.2	1.7	1.2	3.4	2.9	3.0	3.2	0.3	2.9	2.2	2.4	2.7	3.1	2.1	1.5	3.3	-0.2
Breast Cancer	3.6	8.7	22.9	3.1	3.3	2.3	2.8	3.6	2.4	3.0	0.2	-2.1	2.7	2.1	4.8	4.1	3.1	3.0	3.2	3.3	0.5
Type 2 Diabetes (T2D) (2018)	3.6	6.8	12.7	-2.3	-3.2	-2.1	-2.4	-2.5	-3.6	-3.1	-2.3	1.6	-3.5	-2.0	-2.1	-2.2	-3.2	-1.7	-3.1	-3.4	0.4
Waist circumference	3.6	13.3	33.0	-4.1	-4.6	-0.8	-0.3	-4.5	-4.1	-4.4	-1.4	2.2	-4.3	-3.1	-3.8	-5.7	-4.8	-3.0	-2.3	-4.8	0.2
Leg fat percentage (right)	3.6	13.0	33.8	-3.6	-4.4	-1.9	-1.0	-4.7	-3.8	-4.1	-1.9	1.9	-3.8	-3.1	-5.8	-4.6	-4.5	-3.2	-2.1	-4.7	0.4
Mood swings	3.6	6.5	13.0	-2.7	-3.6	-2.0	-2.0	-3.1	-3.3	-3.3	-1.3	-0.5	-3.4	-2.6	-2.1	-2.7	-3.1	-1.4	-1.8	-3.1	-0.3
Leg fat mass (left)	3.6	14.3	33.1	-3.8	-4.3	-1.1	-0.2	-5.3	-3.9	-4.1	-2.6	2.6	-3.6	-3.3	-5.8	-5.3	-4.8	-3.7	-1.7	-4.9	0.5
Trunk fat mass	3.5	14.9	36.5	-3.6	-4.5	-1.1	-0.2	-5.0	-4.0	-4.2	-2.8	1.4	-3.8	-4.2	-5.2	-6.0	-5.1	-3.5	-1.5	-5.3	1.6
Average weekly red wine intake	3.5	5.1	14.4	1.3	2.4	2.1	1.3	2.8	2.0	1.7	2.6	-0.5	1.5	3.4	3.8	3.2	1.9	1.8	1.7	2.7	-1.2
Qualifications: College or University degree	3.4	10.7	19.5	2.9	3.9	3.9	4.4	3.5	3.3	3.4	1.5	-0.6	3.3	2.8	4.4	3.9	3.7	2.3	3.3	3.8	-0.9
Back pain experienced in last month	3.4	5.0	10.8	-3.1	-2.8	-1.2	-1.1	-2.5	-2.2	-2.6	-2.2	-0.7	-2.5	-1.7	-1.4	-3.3	-2.7	-2.4	-1.6	-2.6	-1.2
Diabetes diagnosed by doctor	3.3	5.5	11.6	-1.5	-3.1	-2.1	-1.4	-2.0	-3.0	-3.0	-1.2	1.5	-3.3	-2.6	-1.7	-2.3	-3.0	-1.1	-2.4	-3.4	1.3
Cholesterol lowering medication	3.3	4.8	9.8	-2.0	-2.6	-1.9	-1.7	-2.0	-2.5	-2.3	2.2	-0.7	-2.3	-2.5	-2.8	-1.9	-3.1	-1.9	-2.5	-2.5	-0.0
Alcohol usually taken with meals	3.2	5.2	12.5	1.1	2.4	2.9	1.8	2.5	1.9	2.2	0.7	-0.6	2.3	3.5	3.4	3.1	2.4	1.3	1.2	3.0	-1.7
Arm fat mass (right)	3.2	13.4	27.6	-3.5	-4.2	-1.2	-0.2	-5.0	-3.8	-4.0	-1.5	3.5	-3.6	-3.8	-4.5	-5.2	-4.8	-3.3	-2.2	-4.9	0.6
Body fat percentage	3.2	12.6	26.5	-3.0	-4.1	-1.5	-0.4	-4.5	-3.7	-3.8	-2.0	2.0	-3.5	-4.3	-5.2	-5.1	-4.8	-2.9	-1.7	-4.8	1.6
Leg fat percentage (left)	3.2	11.6	30.1	-3.3	-4.1	-1.5	-0.6	-4.6	-3.6	-3.8	-1.6	2.1	-3.5	-3.1	-5.5	-4.4	-4.4	-3.0	-1.8	-4.5	0.7
Diabetes (self-reported)	3.1	4.7	9.9	-1.4	-2.7	-2.3	-1.4	-2.0	-2.5	-2.6	-1.6	0.6	-2.8	-2.6	-2.1	-2.2	-2.8	-1.3	-1.8	-3.2	1.3
Weight	3.1	15.4	38.6	-4.2	-4.5	-0.8	-0.0	-5.3	-4.0	-4.3	-3.1	1.8	-3.9	-3.2	-5.0	-6.2	-5.1	-4.1	-1.8	-5.4	0.2
Frequency of tiredness / lethargy in last 2 weeks	3.1	5.1	11.4	-1.6	-2.7	-2.5	-2.3	-2.3	-2.5	-2.7	0.2	0.9	-2.8	-3.0	-0.9	-3.4	-2.8	-0.9	-1.9	-2.7	1.1
Arm fat mass (left)	3.1	12.8	27.5	-3.4	-4.1	-1.1	-0.1	-4.9	-3.7	-3.9	-1.5	3.4	-3.5	-3.7	-4.5	-5.2	-4.7	-3.2	-2.1	-4.9	0.8
Depressed Affect (Nagel 2018)	3.0	6.2	14.3	-2.2	-3.8	-2.5	-2.0	-2.5	-3.0	-3.5	-0.4	-1.1	-3.6	-2.4	-1.8	-3.1	-3.0	-0.8	-1.6	-3.1	0.5
Trunk fat percentage	3.0	11.9	27.9	-2.6	-3.9	-1.3	-0.4	-4.2	-3.5	-3.6	-2.2	1.4	-3.3	-4.6	-4.7	-5.3	-4.7	-2.7	-1.4	-4.7	2.3
Alcohol intake frequency.	3.0	6.9	16.8	-2.9	-2.8	-1.7	-0.6	-2.8	-2.5	-2.4	-0.9	1.0	-2.2	-3.4	-3.3	-4.1	-3.6	-3.5	-2.0	-3.0	-0.8
Body mass index (BMI)	2.9	12.5	30.5	-3.3	-3.8	-1.2	-0.0	-5.0	-3.4	-3.8	-1.0	5.5	-3.3	-3.1	-4.5	-4.6	-4.2	-2.9	-2.3	-4.5	-0.1
Medication: Blood pressure	2.9	5.5	14.0	-2.1	-2.8	-1.7	-1.5	-1.3	-2.7	-2.5	2.7	-0.0	-3.1	-2.7	0.1	-3.7	-3.1	-1.2	-3.2	-2.5	0.0
Commuting to job workplace: Cycle	2.9	3.5	8.0	0.4	2.3	2.0	1.0	1.1	2.1	1.9	1.6	0.5	2.2	2.8	1.6	2.3	2.0	0.2	1.9	2.7	-2.0
BMI	2.8	16.1	34.1	-4.2	-4.5	-1.6	0.3	-5.8	-3.7	-4.5	-2.0	5.7	-3.6	-3.5	-5.4	-5.0	-4.5	-3.5	-2.2	-5.2	-0.8
Stomach or abdominal pain in last month	2.8	3.5	8.5	-1.0	-1.9	-2.1	-1.6	-2.2	-2.0	-2.2	-1.2	1.9	-2.1	-2.6	-0.7	-2.9	-1.8	-1.0	-1.4	-2.5	0.9
Lung cancer (father)	2.8	3.3	6.7	-2.4	-2.6	-1.9	-1.4	-2.5	-1.1	-2.4	-0.6	1.0	-2.0	-1.2	-2.6	-1.8	-1.3	-1.7	-1.6	-1.9	-0.7
Gout (self-reported)	2.8	3.8	17.5	-1.1	-2.1	-2.4	-2.5	-0.8	-1.6	-1.8	0.7	-2.1	-2.4	-2.2	0.5	-4.2	-1.7	-1.2	-2.2	-1.8	0.2
Number of operations (self-reported)	2.7	4.0	10.9	-1.6	-2.1	-2.6	-1.3	-2.1	-2.1	-2.1	0.7	1.4	-2.1	-3.3	-1.5	-2.2	-2.1	-1.6	-2.0	-2.5	0.7
Pack years adult smoking proportion	2.6	4.0	9.0	-3.0	-2.1	-1.1	-1.7	-2.0	-2.0	-1.9	-1.1	-2.2	-1.8	0.7	-1.8	-1.0	-2.3	-2.9	-2.3	-1.4	-2.8
Qualifications: None of the above	2.6	5.5	11.8	-2.6	-2.9	-2.9	-3.4	-1.9	-2.4	-2.7	-0.1	0.1	-2.9	-1.4	-2.2	-2.8	-2.4	-1.9	-2.9	-2.3	-0.9
Medication: Amlodipine	2.6	3.6	11.6	-1.7	-2.3	-2.0	-2.0	-1.0	-1.5	-2.6	-1.1	-0.1	-2.8	-1.2	1.5	-3.4	-1.6	-1.2	-2.5	-2.1	-0.2
Hypothyroidism (self reported)	2.5	5.8	12.1	-1.9	-2.8	-2.2	-2.0	-1.8	-3.1	-2.6	-1.5	-2.8	-2.9	-2.8	-0.4	-2.7	-3.5	-1.6	-2.3	-3.3	0.0
Arm fat percentage (left)	2.5	9.8	19.3	-2.6	-3.5	-1.2	0.0	-4.2	-3.2	-3.4	-0.4	3.9	-3.0	-3.9	-3.8	-4.4	-4.2	-2.4	-2.0	-4.1	1.1
Mineral and other dietary supplements	2.5	3.4	8.5	-2.7	-2.0	-2.0	-2.4	-2.4	-0.9	-1.7	-0.2	0.3	-1.5	0.3	-2.9	-1.1	-0.7	-2.2	-2.1	-0.7	-2.8
Number of self-reported non-cancer illnesses	2.5	4.4	11.6	-1.1	-2.4	-2.1	-1.4	-0.7	-2.2	-2.5	1.7	1.4	-2.8	-3.4	0.6	-3.0	-2.6	-0.6	-2.3	-2.4	1.7
Medication: Levothyroxine sodium	2.4	4.0	8.6	-1.9	-2.3	-1.9	-1.9	-1.8	-2.2	-2.1	-1.8	-2.9	-2.2	-2.2	-1.0	-2.4	-2.6	-1.4	-1.0	-2.3	-0.4
Arm fat percentage (right)	2.4	9.5	17.3	-2.7	-3.3	-1.3	-0.0	-4.2	-3.1	-3.3	-0.4	3.7	-2.9	-3.9	-3.6	-4.1	-4.2	-2.5	-2.1	-4.0	0.7
Hypothyroidism/myxoedema (self-reported)	2.4	4.6	9.3	-1.4	-2.5	-2.2	-2.0	-1.5	-2.4	-2.3	-0.8	-2.2	-2.6	-2.9	-0.7	-3.0	-3.0	-1.0	-1.5	-3.0	0.7
Health satisfaction	2.4	3.1	6.6	-1.6	-2.1	-1.8	-0.8	-2.0	-1.7	-2.2	-0.4	0.6	-2.1	-2.5	-1.3	-2.2	-2.6	-1.4	-1.3	-2.3	0.0
Waist Hip Ratio (WHR)	2.3	10.4	27.1	-4.1	-4.4	-0.9	-1.4	-2.2	-5.1	-4.4	0.1	-1.7	-5.2	-1.9	0.4	-3.5	-4.6	-1.9	-3.4	-3.7	-1.3
Supplements: Glucosamine	2.3	3.0	6.1	2.3	2.5	2.1	2.2	1.9	1.1	2.2	0.0	0.7	2.1	0.8	1.9	1.6	0.5	1.6	2.2	1.2	1.7
Had other major operations	2.3	2.8	6.3	-1.6	-1.7	-1.9	-1.6	-1.6	-1.3	-1.7	1.9	0.4	-1.8	-2.5	-0.9	-1.8	-2.0	-1.6	-1.9	-1.9	-0.1
Qualifications: O levels/GCSEs or equivalent	2.3	3.7	8.1	2.9	2.4	1.4	1.5	1.9	2.2	2.4	-1.3	1.3	2.3	0.4	1.0	1.5	1.5	2.2	2.6	1.4	2.5
Mother’s age at death	2.3	2.8	6.1	0.9	1.6	2.1	1.9	1.3	1.7	1.6	1.4	-1.6	1.7	2.5	1.3	2.2	1.9	0.9	1.8	2.1	-0.6
Hip circumference	2.2	9.3	30.4	-2.8	-3.1	-0.7	0.1	-4.1	-2.2	-2.9	-3.1	1.6	-2.4	-3.3	-4.5	-5.5	-3.6	-3.1	-0.6	-3.9	1.0
Noisy workplace	2.2	2.7	6.1	-0.6	-1.5	-1.8	-1.4	-1.3	-1.1	-1.5	-2.2	1.5	-1.4	-2.0	-1.5	-2.5	-1.9	-1.2	-1.3	-2.4	1.3
Arm predicted mass (left)	2.2	11.1	26.6	-4.3	-3.8	-0.4	-0.1	-4.7	-3.2	-3.6	-3.8	0.9	-3.3	-1.3	-4.0	-5.2	-3.7	-4.0	-1.4	-4.4	-1.1
Medication: Metformin	2.1	3.0	7.1	-1.0	-2.4	-1.3	-0.5	-1.3	-2.4	-2.2	-0.7	1.0	-2.3	-1.7	-2.1	-0.7	-2.3	-0.8	-1.7	-2.7	1.4
Hearing difficulty/problems with background noise	2.1	3.3	11.8	2.9	1.2	0.7	1.1	2.3	2.1	0.9	0.1	2.0	0.6	0.5	2.1	0.7	1.3	3.4	1.8	0.8	3.4
Depression (self-reported)	2.1	2.5	6.5	2.0	1.3	1.6	2.3	1.5	1.5	1.2	-1.0	-0.2	1.0	0.3	1.9	0.6	1.2	2.6	2.1	1.1	2.6
Arm fat-free mass (right)	2.1	10.9	28.6	-4.2	-3.6	-0.0	0.0	-4.6	-3.2	-3.5	-3.8	0.9	-3.2	-1.0	-4.2	-5.3	-3.6	-4.0	-1.0	-4.3	-0.9
Arm fat-free mass (left)	2.1	10.8	26.5	-4.1	-3.7	-0.3	0.1	-4.6	-3.1	-3.6	-3.6	1.0	-3.3	-1.3	-3.9	-5.2	-3.7	-3.8	-1.3	-4.4	-0.7
Eye problems/disorders: Diabetes related eye disease	2.0	2.2	5.1	-1.4	-1.9	-0.8	-1.0	-1.9	-2.3	-1.9	-0.5	0.3	-1.9	-1.4	-1.4	-1.6	-1.8	-1.1	-0.9	-1.9	0.2
Qualifications: CSEs or equivalent	2.0	2.6	6.7	-0.9	-1.5	-1.6	-2.0	-1.9	-2.2	-1.4	-2.6	-1.6	-1.4	-1.3	-1.6	-1.3	-1.6	-1.3	-1.7	-1.8	0.3
Arm predicted mass (right)	2.0	10.0	27.7	-4.0	-3.4	0.1	0.3	-4.4	-2.9	-3.3	-4.0	0.9	-3.0	-0.9	-4.0	-5.3	-3.5	-3.8	-0.8	-4.1	-0.9
Medication for cholesterol	2.0	3.0	8.8	1.8	2.0	1.0	1.6	0.8	2.1	1.9	-2.4	-0.3	2.3	1.4	-0.0	2.1	2.3	0.9	3.0	1.6	0.4
Blood Eosinophil Count	1.9	14.5	51.0	-0.5	-3.3	-3.3	-1.6	-0.4	-3.0	-3.5	1.6	-7.1	-4.6	-6.3	5.9	-3.9	-4.1	0.4	-3.0	-3.9	3.2
Hearing difficulty/problems: Yes	1.9	2.9	7.2	2.3	1.6	0.8	2.0	1.7	2.7	1.3	-0.3	1.5	1.5	0.2	1.0	0.3	1.5	2.5	2.6	1.2	2.2
Severe depression (siblings)	1.9	2.1	4.0	1.7	1.1	0.9	1.8	1.8	1.7	0.9	-1.6	1.5	0.9	1.8	2.0	0.6	1.8	1.5	1.4	0.8	1.0
Basal metabolic rate	1.9	10.7	29.5	-4.1	-3.6	-0.0	0.3	-4.6	-3.2	-3.5	-3.5	1.2	-3.1	-1.7	-3.4	-5.4	-3.9	-3.9	-1.4	-4.4	-0.9
Pack years of smoking	1.9	2.8	7.0	-2.6	-1.8	-0.7	-1.2	-1.5	-1.6	-1.5	-1.0	-1.9	-1.5	0.9	-1.5	-0.9	-1.8	-2.5	-1.9	-1.1	-2.6
Prostate Cancer	1.8	2.5	5.7	2.0	1.6	0.3	0.4	1.7	1.9	1.4	0.1	0.2	1.8	1.2	-0.1	1.4	2.1	2.2	2.4	1.5	2.4
Serious illness, injury or assault to yourself	1.8	2.2	5.1	-1.7	-1.6	-0.5	-0.9	-1.8	-1.8	-1.5	-0.7	1.2	-1.5	-1.5	-1.8	-2.0	-2.3	-1.7	-1.1	-1.5	-0.1
Father’s age at death	1.8	2.5	6.8	1.6	1.8	1.5	2.6	1.4	2.1	1.7	0.9	-1.1	1.9	0.8	1.6	1.8	1.3	0.8	2.0	1.4	-0.1
Suffer from ‘nerves’	1.8	2.8	6.6	1.8	1.8	0.8	0.4	2.1	1.6	1.8	0.1	-1.3	1.7	1.8	2.2	2.2	1.4	2.6	1.3	1.8	1.4
Leg fat-free mass (left)	1.7	9.0	25.2	-3.8	-3.1	0.1	0.3	-4.4	-2.9	-3.1	-2.9	1.8	-2.6	-2.0	-3.0	-5.0	-3.7	-3.6	-1.3	-4.0	-0.8
Average weekly fortified wine intake	1.7	1.9	6.9	1.0	1.7	1.4	1.2	0.9	0.9	1.6	2.6	0.6	1.8	0.1	0.8	1.8	1.3	0.6	1.6	2.1	-0.1
Taking other prescription medications	1.7	2.7	8.8	-0.5	-1.9	-1.8	-0.5	-0.4	-1.1	-1.9	1.1	1.1	-2.0	-3.0	-0.3	-2.7	-1.8	0.3	-0.4	-1.9	2.4
Leg predicted mass (left)	1.7	8.9	25.0	-3.7	-3.1	0.1	0.3	-4.3	-2.8	-3.1	-2.9	1.8	-2.6	-2.0	-3.0	-5.0	-3.6	-3.5	-1.3	-4.0	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	1.7	3.9	9.1	-0.4	-1.6	-2.0	-2.3	-0.3	-2.6	-2.0	-1.5	0.3	-2.9	-1.9	2.9	-3.0	-1.2	0.8	-2.2	-2.3	1.8
Reason for reducing amount of alcohol drunk: Health precaution	1.7	2.0	4.4	1.0	1.9	1.5	1.9	0.7	1.4	1.5	-1.5	0.5	1.9	0.6	0.5	2.1	1.6	0.4	1.9	1.6	-0.3
Age at last live birth	1.7	2.5	4.9	1.5	1.7	1.7	2.2	1.8	1.8	1.8	1.2	-0.5	1.5	1.0	2.0	2.0	1.6	1.5	1.6	1.3	0.5
Commuting to job workplace: Walk	1.7	1.9	9.1	1.6	1.4	0.4	0.6	1.3	1.9	1.4	3.0	-0.5	1.4	0.1	0.9	1.4	1.1	1.4	1.1	1.4	0.9
Breast cancer (self-reported)	1.7	2.1	8.8	-1.3	-1.5	-1.5	-2.3	-1.7	-0.3	-1.5	1.0	0.3	-1.3	-1.0	-1.3	-3.0	-0.9	-1.2	-1.3	-1.5	0.2
Medication: Ramipril	1.6	2.1	6.8	-0.9	-1.6	-1.4	-1.1	-0.9	-1.3	-1.7	0.0	2.1	-1.9	-1.5	0.0	-2.6	-1.3	-1.1	-1.5	-1.7	0.0
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.1	5.4	1.2	1.7	1.8	1.8	1.1	1.6	1.7	-0.3	1.0	1.9	1.0	1.5	-0.1	1.4	1.0	2.3	1.5	1.0
Medication: Blood pressure	1.6	2.9	15.1	2.3	0.2	-1.0	0.0	1.4	0.6	0.1	-0.1	3.9	-0.4	-1.9	1.5	-2.0	-0.2	1.7	-0.0	-0.6	3.8
Medication: Seretide 50 evohaler	1.6	1.8	4.8	-1.5	-1.8	-1.4	-1.9	-1.1	-1.5	-1.7	0.6	-0.9	-1.7	-1.1	0.1	-1.6	-0.9	-0.4	-2.2	-1.1	0.2
Had major operations	1.6	1.8	6.4	-1.4	-1.7	-1.0	-0.3	-1.5	-1.2	-1.6	0.1	0.3	-1.3	-1.5	-0.6	-2.5	-2.0	-1.5	-1.0	-1.6	-0.6
Whole body fat-free mass	1.6	8.9	25.7	-3.9	-3.2	0.3	0.5	-4.2	-2.7	-3.2	-3.4	1.0	-2.8	-1.1	-2.9	-5.1	-3.4	-3.7	-1.1	-3.9	-1.2
Whole body water mass	1.6	8.9	25.3	-3.9	-3.2	0.2	0.4	-4.2	-2.8	-3.2	-3.4	1.0	-2.8	-1.1	-2.9	-5.0	-3.4	-3.7	-1.1	-4.0	-1.2
Alzheimer’s Disease (in father)	1.5	1.6	3.2	-0.5	-1.5	-1.7	-1.5	-0.6	-1.6	-1.4	0.3	-1.0	-1.8	-1.6	-0.8	-1.5	-1.2	-0.7	-1.5	-1.4	0.3
Cardiovascular Disease	1.5	5.0	15.6	-0.6	-1.9	-1.8	-1.2	-0.8	-2.1	-1.8	1.1	3.2	-2.4	-3.2	0.2	-4.0	-3.2	-0.6	-2.7	-2.7	2.2
Other serious medical condition/disability diagnosed by doctor	1.5	2.0	3.8	-1.7	-1.6	-0.8	-0.4	-1.8	-1.6	-1.6	0.6	1.0	-1.5	-1.7	-0.9	-2.0	-1.9	-1.5	-1.1	-1.7	-0.5
Diabetes (father)	1.5	1.8	7.1	-0.6	-1.4	-0.6	-0.4	-0.9	-2.1	-1.4	-0.4	1.1	-1.8	-1.5	-0.2	-0.9	-2.7	-0.4	-1.5	-2.3	1.0
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.4	8.9	-0.5	-1.4	-1.6	-2.1	-0.5	-2.6	-1.7	-1.4	0.5	-2.6	-1.8	2.3	-3.0	-1.8	0.6	-2.1	-2.3	1.8
Alcohol intake versus 10 years previously	1.5	2.2	7.2	-1.7	-1.3	-0.7	-0.4	-1.7	-2.1	-1.1	-0.8	0.0	-1.3	-2.3	-1.4	-2.7	-1.9	-1.4	-1.2	-1.6	-0.3
Asthma	1.5	2.9	6.2	-1.7	-2.3	-1.8	-1.2	-1.8	-2.1	-2.5	1.2	0.8	-2.5	-1.9	0.4	-0.8	-1.6	-0.5	-2.5	-1.8	-0.6
Hypertension (Self-reported)	1.5	4.1	13.6	0.4	-1.4	-1.2	-0.3	0.2	-1.3	-1.4	2.2	2.9	-1.9	-3.2	0.6	-3.7	-2.7	0.3	-1.5	-2.3	3.3
Illnesses of siblings: Diabetes	1.5	1.8	5.0	-1.5	-1.7	-1.1	-0.5	-1.4	-2.2	-1.7	0.7	0.2	-1.8	-1.4	-0.2	-1.3	-1.4	-0.9	-1.9	-1.5	-0.3
Asthma (self-reported)	1.5	2.9	6.2	-1.7	-2.3	-2.0	-1.3	-1.7	-2.0	-2.5	1.2	0.7	-2.5	-2.2	0.5	-0.9	-1.5	-0.5	-2.4	-1.6	-0.6
Guilty feelings	1.5	2.3	14.7	1.9	-0.4	-1.7	-0.1	0.8	-0.2	-0.5	-0.5	0.4	-0.8	-2.5	1.6	-1.7	-0.7	1.8	0.6	-1.1	3.8
Relative age voice broke	1.4	2.2	5.8	0.3	1.7	1.7	1.3	0.6	1.7	1.7	-0.9	0.6	2.1	1.6	0.1	2.4	2.0	0.5	1.3	2.1	-1.2
Hair/balding pattern: Pattern 3	1.4	2.1	5.9	1.5	1.5	2.1	1.7	1.8	1.1	1.5	0.8	0.3	1.5	1.8	0.8	2.4	0.4	1.1	1.6	1.5	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	8.2	1.0	0.5	1.6	1.7	0.4	1.4	0.4	-2.9	1.4	0.8	-0.3	0.4	-1.1	0.8	1.6	2.1	0.4	2.0
Leg fat-free mass (right)	1.4	7.5	22.0	-3.3	-2.6	0.5	0.7	-4.1	-2.5	-2.6	-2.7	2.0	-2.1	-1.9	-2.6	-4.7	-3.4	-3.4	-1.0	-3.6	-0.7
Leg predicted mass (right)	1.4	7.4	21.7	-3.3	-2.6	0.5	0.8	-4.1	-2.5	-2.6	-2.8	2.0	-2.1	-1.9	-2.5	-4.7	-3.4	-3.4	-1.0	-3.6	-0.7
Miserableness	1.4	2.5	6.0	-1.4	-2.2	-1.5	-1.5	-1.5	-2.5	-2.1	-0.5	-1.4	-2.3	-1.4	-0.7	-1.4	-2.0	-0.3	-0.9	-1.8	0.4
Supplements: Calcium	1.4	1.6	3.1	1.4	1.2	0.2	0.9	1.8	1.4	1.1	-0.8	-1.1	1.1	0.8	1.4	1.2	1.1	1.6	1.7	0.8	1.8
Major Depression (MDD)	1.3	1.5	6.9	0.9	1.0	0.7	0.7	1.9	1.2	0.9	0.0	0.0	0.4	1.8	2.6	1.0	0.8	1.9	0.4	1.2	1.1
Primary Biliary Cirrhosis	1.3	1.8	6.3	-1.7	-1.7	-1.3	-1.3	-1.2	-1.1	-1.6	-0.9	0.3	-1.5	-0.5	-0.4	-2.5	-0.7	-0.8	-2.0	-1.0	-1.3
Allergy or Eczema	1.3	3.4	42.7	1.0	0.4	0.6	0.3	1.1	-0.4	-0.0	2.7	-1.1	-0.8	0.4	6.5	0.7	-0.1	1.6	-1.6	0.8	-0.3
Townsend deprivation index at recruitment	1.3	1.8	5.9	-1.3	-1.7	-0.1	-0.0	-0.8	-1.6	-1.5	-1.5	0.3	-1.9	-0.4	0.0	-2.4	-2.3	-0.7	-1.4	-1.6	-0.6
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	5.4	-1.2	0.7	2.2	0.8	-0.2	0.2	0.8	-1.3	1.0	0.9	2.3	0.1	0.5	0.7	-0.4	0.1	1.3	-2.3
Trunk fat-free mass	1.3	7.6	22.6	-3.8	-3.1	0.3	0.4	-3.7	-2.5	-3.0	-3.3	0.1	-2.8	-0.3	-2.5	-4.8	-2.9	-3.4	-0.9	-3.6	-1.4
Trunk predicted mass	1.3	7.7	22.8	-3.8	-3.1	0.3	0.5	-3.7	-2.5	-3.0	-3.3	0.1	-2.8	-0.4	-2.4	-4.8	-3.0	-3.4	-0.9	-3.6	-1.5
Blood clot in the leg (DVT)	1.3	1.6	3.3	-1.1	-1.6	-1.4	-1.2	-1.2	-1.1	-1.6	1.0	1.8	-1.6	-1.3	-0.8	-0.9	-0.9	-1.1	-1.7	-1.3	-0.2
Family relationship satisfaction	1.3	1.5	6.9	1.6	0.5	0.3	-0.2	1.5	1.6	0.6	0.6	0.5	0.2	1.1	0.3	0.7	1.7	2.6	1.5	0.9	2.1
Medication: Gliclazide	1.3	1.4	7.3	1.7	0.7	0.9	1.6	1.1	1.0	0.7	-0.6	2.7	0.7	-0.0	0.4	-0.1	0.7	1.0	1.4	0.4	2.2
Heel T-Score	1.2	9.8	28.7	0.1	-2.4	-2.9	-2.9	-0.0	-3.6	-2.8	-1.9	0.1	-4.3	-3.6	4.7	-5.4	-2.9	1.4	-4.1	-3.2	3.0
Relative age of first facial hair	1.2	2.4	6.1	0.0	1.6	1.1	1.2	0.3	2.5	1.6	0.6	2.1	2.3	1.1	-1.1	2.2	1.8	0.2	1.8	1.9	-0.9
Hand grip strength (right)	1.2	3.2	9.6	-2.3	-1.3	0.1	-1.0	-2.2	-2.1	-1.1	-3.1	-2.5	-1.1	-0.2	-2.4	-1.1	-1.8	-2.6	-0.9	-1.8	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	3.8	-0.5	-1.6	-1.6	-1.8	-0.6	-0.7	-1.6	0.0	1.6	-1.7	-0.2	-0.1	-1.4	-1.0	1.0	-1.2	-1.3	1.9
High blood pressure	1.2	3.3	10.1	0.5	-1.2	-1.1	-0.2	0.5	-1.0	-1.1	2.0	2.8	-1.6	-2.7	0.4	-3.2	-2.5	0.5	-1.3	-1.9	3.2
Hayfever, allergic rhinitis or eczema	1.2	2.6	21.4	-0.4	-0.4	-0.7	-0.3	-0.5	-1.6	-0.9	1.8	-2.3	-1.3	-1.2	4.6	-0.1	-1.0	-0.2	-2.6	-0.4	-1.4
Mouth/teeth dental problems	1.2	1.8	6.3	-1.4	-0.7	-1.1	-0.9	-0.7	-0.8	-1.1	1.0	-2.5	-0.9	-1.6	1.1	-1.3	-0.9	-1.8	-1.4	-0.8	-2.3
Average weekly beer plus cider intake	1.2	1.7	4.0	-1.1	-1.7	-1.1	-2.0	-0.9	-1.5	-1.3	-0.2	-0.1	-1.6	-1.4	-1.0	-1.4	-1.6	-0.3	-1.3	-1.7	1.0
Age at First Birth	1.1	1.6	7.3	0.7	1.0	1.3	-0.0	1.6	0.8	1.2	1.6	-2.7	0.8	1.1	1.2	1.7	0.9	1.1	0.4	1.5	0.4
HDL Cholesterol	1.1	1.9	5.5	1.2	1.7	0.1	0.5	1.6	2.4	1.5	0.1	-1.8	1.5	1.3	1.7	1.3	1.5	0.6	1.5	1.4	0.2
Lung FVC	1.1	5.8	26.9	-1.4	1.1	2.5	1.9	1.1	-0.2	0.5	0.7	-2.5	0.5	5.2	4.7	0.6	1.1	-0.6	-0.0	2.3	-5.2
Allergy	1.1	2.6	14.0	1.0	1.0	0.6	0.4	0.9	1.9	1.3	-2.8	0.4	1.7	1.2	-3.7	0.1	1.2	0.3	2.8	0.6	1.5
Hayfever/allergic rhinitis (self-reported)	1.1	1.4	7.9	-1.1	-0.0	-0.9	-0.9	-0.2	-0.9	-0.2	-0.6	-2.8	-0.4	0.0	2.2	-0.1	-0.1	-0.9	-1.7	0.3	-2.2
Tense / ‘highly strung’	1.1	1.8	6.2	1.4	1.1	1.6	1.8	0.9	0.9	1.0	-0.5	-0.2	1.2	0.1	1.8	0.9	0.9	2.5	1.6	1.0	2.2
Loud music exposure frequency	1.1	1.2	3.2	-0.2	-0.7	-1.1	-0.7	-0.8	-1.2	-0.7	-1.6	-0.1	-0.9	-1.8	-0.0	-1.2	-1.6	-0.8	-1.1	-1.6	0.9
Medication for cholesterol, blood pressure or diabetes	1.1	1.9	10.5	-1.0	0.6	1.7	0.9	-0.9	0.2	0.5	0.2	-3.2	0.9	1.7	-0.8	1.9	0.9	-0.8	0.9	1.0	-2.4
Number of children fathered	1.1	1.2	3.6	-1.4	-1.0	-0.2	-0.2	-1.9	-1.5	-1.1	-1.3	-0.2	-0.7	-0.7	-1.3	-1.2	-0.9	-1.3	-0.9	-1.1	-1.3
Shortness of breath walking on level ground	1.1	1.3	3.4	-1.5	-1.6	-0.6	-0.8	-1.6	-1.0	-1.6	-0.4	-0.5	-1.3	-0.5	-1.5	-0.4	-1.8	-0.9	-0.8	-1.4	-0.4
Schizophrenia (2018)	1.0	2.0	5.9	0.4	0.9	2.4	2.2	1.4	0.6	0.7	0.0	0.4	0.6	2.4	2.1	1.3	1.4	1.7	1.2	1.5	-0.6
Neuroticism (2016)	1.0	1.4	6.4	0.7	-1.0	-1.3	-0.6	-0.4	-0.9	-1.0	1.1	0.1	-1.3	-1.9	-0.0	-1.7	-1.5	0.5	-0.2	-1.4	2.5
Height	1.0	20.2	104.0	-3.5	-4.2	0.3	-0.2	-3.0	-3.4	-3.5	-6.5	-10.2	-3.6	-2.3	-3.0	-7.6	-4.3	-4.7	1.2	-5.2	1.3
Average weekly spirits intake	1.0	1.3	3.0	-0.9	-0.7	-0.2	0.2	-1.6	-1.3	-1.0	-1.1	1.7	-0.8	-1.4	-1.7	-0.7	-1.5	-1.1	-0.0	-1.5	0.6
Frequency of depressed mood in last 2 weeks	1.0	1.4	3.3	-0.8	-1.6	-1.3	-1.1	-1.0	-1.1	-1.7	-0.9	0.3	-1.5	-1.1	-0.2	-1.8	-1.3	-0.0	-0.7	-1.5	0.9
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	2.9	-1.5	-0.8	-0.5	-0.3	-1.2	-1.1	-0.7	1.5	1.6	-0.4	-0.2	-1.7	-0.5	-0.9	-1.6	-1.1	-0.2	-1.6
Sitting height	1.0	7.0	12.5	-2.3	-2.9	-1.1	-1.7	-3.1	-3.5	-2.7	-2.8	-3.3	-2.8	-1.5	-2.5	-2.9	-3.4	-3.4	-1.4	-3.2	-0.6
Ever highly irritable/argumentative for 2 days	1.0	1.1	2.8	1.6	0.8	0.4	1.1	0.5	1.4	0.9	-0.3	1.6	0.9	0.6	0.2	0.5	1.5	1.7	1.1	1.0	1.2
Headache pain in last month	1.0	1.7	4.4	-1.0	-1.7	-1.2	-1.5	-0.9	-1.5	-1.7	-0.6	-1.1	-1.8	-1.3	0.5	-1.0	-1.9	-0.6	-0.5	-2.1	0.9
Heart disease (mother)	1.0	1.2	3.3	0.3	-1.0	-1.5	-1.4	-0.1	-1.2	-0.9	0.4	-1.0	-1.3	-1.8	0.4	-1.0	-1.1	0.7	-1.0	-1.2	1.3
Qualifications: nursing, teaching	1.0	1.6	7.7	1.2	0.6	0.1	0.9	1.8	1.5	0.2	-0.9	-1.4	-0.0	1.2	2.8	0.9	1.7	1.7	1.2	0.5	0.6
Medication: Aspirin	1.0	1.4	8.8	1.6	-0.3	-0.8	0.0	0.4	-0.0	-0.3	-0.3	1.9	-0.8	-2.1	-0.0	-1.1	-0.1	1.3	0.1	-0.8	3.0
Hearing aid user	1.0	1.1	5.6	1.5	0.7	0.2	1.0	0.7	1.4	0.6	-1.1	0.9	0.7	-0.7	-0.0	-0.8	0.5	1.6	1.3	0.2	2.4
Commuting to job workplace: Public transport	1.0	1.1	3.6	0.6	1.6	1.3	1.4	0.9	0.3	1.3	0.8	-0.6	1.2	0.4	1.5	1.9	0.0	0.5	0.8	1.3	-0.7
High cholesterol (Self-reported)	1.0	1.7	4.8	-0.6	-1.4	-2.2	-2.0	-0.4	-0.9	-1.2	0.7	0.9	-1.4	-1.5	-1.5	-1.3	-1.4	-0.3	-1.5	-1.3	1.3
Vascular/heart problems diagnosed by doctor	1.0	2.6	8.9	-0.4	1.0	0.6	0.0	-0.4	0.8	0.8	-1.9	-2.6	1.4	2.4	-0.5	3.0	2.3	-0.5	1.2	1.5	-2.8
Alzheimer’s Disease (including proxy)	0.9	1.3	9.2	-0.6	-1.0	-1.5	-1.4	0.3	-0.5	-0.9	0.9	-3.0	-1.0	0.0	0.0	-0.5	-1.5	-0.6	-1.1	-0.9	0.7
Body Mass Index (BMI) (2010)	0.9	1.2	4.4	-1.0	-0.8	-0.2	-0.5	-1.4	-2.1	-0.6	1.0	0.7	-0.6	-0.4	-1.8	0.2	-1.2	-1.6	-1.4	-0.7	-1.3
LDL Cholesterol	0.9	1.3	12.3	-0.7	-0.5	-1.1	-0.8	-1.5	-1.0	-0.5	-1.1	0.6	-0.2	-0.6	-3.5	0.6	-0.8	-1.3	-0.4	-0.5	-0.9
Type 2 Diabetes (T2D) (2012)	0.9	1.1	4.4	-1.2	-1.2	-0.2	-0.8	-1.1	-2.1	-1.0	0.0	0.2	-1.3	0.1	-1.4	-0.6	-0.8	-1.1	-1.4	-1.1	-0.6
Hand grip strength (left)	0.9	2.4	12.5	-2.1	-0.7	0.1	-0.7	-1.5	-1.1	-0.9	-3.2	-3.5	-0.6	1.3	-1.1	-0.9	-0.6	-2.0	-0.0	-1.1	-1.3
Number of treatments/medications taken	0.9	1.6	5.9	0.3	-0.7	-0.6	0.3	0.2	-0.4	-0.7	1.5	2.4	-0.9	-2.2	0.9	-2.4	-1.1	0.4	-0.5	-0.6	2.1
Ever had hysterectomy (womb removed)	0.9	1.1	3.6	-1.5	-0.5	-0.5	-0.4	-1.3	-0.4	-0.6	0.4	0.8	-0.1	-1.0	-1.5	-1.4	-0.6	-1.9	-0.4	-0.2	-1.9
Impedance of leg (right)	0.9	4.1	54.8	0.8	-0.6	-1.5	-2.1	1.6	-0.1	-0.1	-1.8	-7.4	-0.8	-0.4	-0.4	0.4	0.2	0.8	0.4	0.2	1.9
Impedance of arm (right)	0.9	4.0	38.5	1.6	1.0	-0.8	-0.9	2.3	0.9	1.2	1.4	-6.2	0.8	-1.7	2.7	1.3	0.4	1.1	0.4	1.3	1.6
Happiness	0.9	1.1	2.9	-0.4	-1.4	-0.4	0.1	-1.1	-0.8	-1.3	-0.4	0.7	-1.5	-1.5	-0.3	-1.7	-1.2	0.4	-0.2	-1.7	1.1
Pulse wave Arterial Stiffness index	0.9	1.0	4.2	-0.6	-1.3	-0.5	0.9	-1.0	-1.3	-1.0	0.3	-0.0	-0.8	-2.0	-0.5	-1.6	-1.5	-0.5	-0.6	-1.4	-0.3
Standing height	0.9	9.1	65.0	-2.5	-2.5	0.6	-0.3	-1.5	-2.1	-1.8	-4.5	-8.1	-2.1	-0.8	-1.6	-4.4	-3.0	-3.2	0.7	-2.9	0.8
Glaucoma (self-reported)	0.9	1.0	5.9	0.2	-0.7	-0.8	-0.4	0.6	0.2	-0.9	1.6	-2.4	-1.2	-0.8	1.9	-0.1	-0.3	0.6	-0.3	-0.5	0.5
Medication: Ibuprofen	0.9	1.1	3.0	0.8	1.3	1.2	1.3	0.6	1.0	1.2	1.0	1.2	1.4	-0.1	0.8	-0.5	0.6	0.7	1.7	1.1	1.1
Pulse rate, automated reading	0.9	3.0	9.5	-0.8	-1.7	-2.3	-1.3	-2.2	-0.9	-1.9	1.4	0.2	-1.7	-3.1	-1.7	-2.0	-1.9	-1.8	-1.3	-2.1	0.2
Medication: Aspirin	0.9	1.2	7.3	1.1	-0.7	-0.8	-0.2	0.2	-0.3	-0.6	-0.2	1.9	-1.1	-1.8	-0.4	-1.0	-0.4	1.1	-0.1	-1.0	2.7
Ever depressed for a whole week	0.9	1.1	2.7	0.9	0.9	1.5	1.1	0.7	0.9	1.0	-0.7	0.8	1.0	1.6	0.7	1.6	0.9	1.3	0.9	1.1	0.4
Neuroticism (Nagel 2018)	0.8	2.0	5.7	-0.0	-1.9	-1.4	-0.7	-0.7	-1.2	-1.7	0.1	-0.3	-1.7	-2.1	-0.1	-1.5	-1.9	1.6	-0.4	-1.7	2.4
Alzheimer’s Disease (in mother)	0.8	0.9	6.0	0.6	0.6	-0.4	0.2	1.3	1.4	0.5	0.9	-2.5	0.6	1.0	1.0	0.1	-0.2	0.4	0.7	0.3	1.3
Coronary Artery Disease (CAD)	0.8	0.9	3.5	-0.4	-1.0	-1.2	-0.9	-0.2	-0.6	-1.0	0.0	1.0	-1.3	-1.2	0.7	-1.9	-0.7	-0.5	-1.2	-0.9	-0.1
Smoking Status	0.8	1.8	6.1	-1.3	-1.4	0.5	-0.3	-1.5	-2.1	-1.4	-1.2	2.5	-1.3	-0.7	-0.9	-1.9	-1.6	-0.4	-1.2	-1.5	0.1
Sensitivity / hurt feelings	0.8	1.3	4.1	-0.4	-1.5	-0.9	-0.1	-1.4	-1.3	-1.5	-0.1	-0.1	-1.3	-2.0	-0.5	-1.3	-1.4	0.4	-0.4	-1.7	1.2
Impedance of leg (left)	0.8	3.9	50.7	1.5	0.0	-0.7	-1.3	1.8	0.3	0.6	-1.8	-7.1	-0.1	-0.1	-0.1	0.9	0.5	1.1	1.1	0.7	2.3
Medication: Simvastatin	0.8	1.2	3.7	0.4	-0.7	-1.7	-0.7	0.3	-0.8	-0.5	0.7	1.7	-0.9	-1.7	-0.3	-1.1	-0.9	0.8	-1.5	-0.9	1.9
Prospective memory result	0.8	1.0	2.4	-1.1	-1.1	-1.3	-0.5	-1.5	-1.0	-1.1	-0.4	-0.1	-0.7	-1.1	-1.2	-1.0	-0.5	-1.5	-0.7	-0.9	-1.1
Impedance of arm (left)	0.8	3.9	36.6	1.9	0.9	-0.7	-1.0	2.4	1.0	1.2	1.1	-6.1	0.7	-1.5	2.4	0.7	0.4	1.3	0.7	1.0	2.2
Length of working week for main job	0.8	0.8	4.8	-0.4	-0.2	0.4	-0.5	-1.1	-0.7	-0.1	-2.2	1.7	-0.0	-0.8	-1.7	-0.0	-0.6	-0.4	0.3	-0.7	0.8
Comparative body size at age 10	0.8	2.3	16.6	0.5	0.6	0.2	-0.1	-1.0	0.9	0.7	-1.3	4.1	1.1	1.3	-3.2	1.5	1.2	0.4	1.0	0.8	0.7
Mouth/teeth dental problems: Loose teeth	0.8	0.9	2.6	-0.9	-1.0	-0.7	-0.1	-0.4	-1.5	-1.3	-0.9	-1.0	-1.6	0.8	0.2	0.5	-0.6	-0.5	-0.9	-0.7	-1.4
Chest pain or discomfort	0.8	1.1	4.3	-0.4	-1.3	-0.9	-1.0	-0.7	-1.2	-1.5	-0.6	0.7	-1.9	-0.6	0.9	-2.1	-0.5	0.6	-0.7	-1.1	0.9
Leg pain on walking	0.8	1.0	3.0	-1.0	-1.3	-1.1	-0.1	-0.9	-1.5	-1.5	-0.2	0.5	-1.7	-0.6	-0.2	-1.1	-1.1	-0.4	-1.2	-1.2	-0.8
Knee pain experienced in last month	0.8	1.2	2.2	-1.3	-1.3	-0.2	0.1	-1.5	-1.2	-1.2	-1.4	0.1	-1.0	-0.5	-1.5	-1.4	-1.5	-1.0	-0.9	-1.5	-0.3
Smoking status: Previous	0.8	1.2	10.0	1.1	0.3	-0.1	0.2	0.6	-0.2	0.2	1.8	3.2	-0.0	-0.8	0.5	-0.5	0.4	1.3	-0.0	-0.1	1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	3.8	-1.4	-0.4	-0.6	-0.4	-1.4	-1.4	-0.6	0.5	-0.9	-0.5	-0.6	0.9	-0.3	-0.8	-0.6	-1.3	-0.2	-1.9
Osteoporosis (self-reported)	0.8	0.9	2.5	-1.6	-1.3	-0.5	-0.8	-1.0	-0.7	-1.2	-0.5	0.9	-1.3	0.5	-0.4	-0.8	-0.6	-0.8	-1.2	-0.8	-1.3
Smoking status: Current	0.8	1.3	3.7	-1.9	-1.1	0.6	-0.7	-1.4	-1.4	-1.0	-1.9	0.6	-0.8	1.0	-1.3	-0.9	-1.1	-0.9	-1.2	-0.6	-1.1
Eye problems/disorders: Glaucoma	0.8	0.9	4.7	-0.3	-0.7	-0.8	-0.1	0.7	-0.1	-0.9	1.8	-2.2	-1.1	-0.8	2.0	-0.3	-0.2	0.5	-0.5	0.0	-0.2
Medication: Atorvastatin	0.8	1.0	3.1	-0.5	-0.8	-1.2	-1.7	0.1	-0.9	-0.7	0.1	-1.2	-1.1	-1.7	0.3	-1.8	-0.9	-0.5	-0.9	-0.6	0.6
Impedance of whole body	0.8	4.2	50.5	1.8	0.4	-1.0	-1.5	2.0	0.4	0.9	-0.3	-7.1	0.3	-1.4	0.8	1.2	0.2	1.1	0.8	0.7	2.6
Mean Putamen Volume	0.7	0.8	3.4	-0.4	-0.7	-0.9	-0.9	-1.1	-1.3	-0.7	-1.8	0.7	-0.8	-0.6	-1.2	-0.6	-0.4	-0.4	-0.5	-0.9	0.1
Diabetes (mother)	0.7	0.9	3.2	-0.7	-1.4	-0.3	-0.3	-0.3	-1.8	-1.3	-0.7	0.8	-1.6	0.3	-0.1	-0.6	-0.9	0.3	-1.1	-1.1	0.7
Current tobacco smoking	0.7	1.1	4.2	-1.7	-0.8	0.8	-0.5	-1.1	-1.1	-0.5	-2.0	0.9	-0.4	1.2	-1.2	-0.9	-1.0	-0.7	-1.2	-0.3	-1.2
Forced vital capacity (FVC)	0.7	2.9	23.4	-1.6	-0.0	1.3	0.6	-0.4	-1.4	-0.0	-1.5	-4.8	-0.2	1.9	1.3	-0.5	-0.7	-2.3	-0.3	0.0	-2.8
Financial difficulties in last 2 years	0.7	1.0	2.2	-1.5	-1.5	-0.6	-0.9	-0.9	-1.4	-1.1	-0.2	-0.2	-1.2	-0.0	-0.8	-0.5	-1.4	-1.0	-1.0	-1.2	-1.0
Medication: Cholesterol lowering	0.7	1.0	4.1	0.9	-0.0	-1.5	-1.1	1.2	-0.0	0.1	-0.4	2.0	-0.4	-1.1	0.8	-1.0	0.1	1.0	-0.7	-0.1	2.0
Illnesses of mother	0.7	0.9	4.6	-0.3	0.6	0.2	0.7	0.1	0.8	0.5	-0.5	0.1	0.8	1.3	-0.2	0.8	1.8	-0.8	0.9	1.2	-2.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.1	8.2	-0.3	1.1	2.1	1.8	0.6	0.2	1.0	-1.7	-2.9	1.0	2.4	1.5	1.0	0.6	-0.8	1.2	1.0	-1.7
Breastfed as a baby	0.7	0.9	2.9	0.7	0.7	-1.0	0.0	1.3	1.7	0.5	1.1	-0.9	0.4	0.2	1.4	1.0	1.5	0.9	0.6	0.7	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	7.6	0.1	0.1	1.4	1.7	-0.5	0.3	0.1	-2.8	1.3	0.5	0.2	-0.2	0.2	-0.5	0.8	1.2	-0.1	1.0
Medication: Paracetamol	0.7	1.2	6.4	0.9	-0.2	-1.0	0.2	-0.4	0.4	-0.3	-0.4	0.2	-0.4	-2.2	0.5	-2.2	-0.1	0.5	0.8	-1.1	2.5
Forced vital capacity (FVC), Best measure	0.7	2.5	20.8	-1.0	0.1	1.4	1.0	0.3	-0.8	0.0	-1.9	-4.6	-0.1	2.5	1.8	-0.1	-0.3	-1.4	0.4	0.2	-1.9
Exposure to tobacco smoke outside home	0.7	1.0	2.5	-0.2	-1.2	-0.1	-1.2	-0.7	-1.3	-0.9	-0.9	0.3	-1.2	-1.0	-0.0	-0.9	-1.6	0.5	-1.5	-1.3	1.1
Age at first live birth	0.7	1.3	2.5	1.3	1.3	0.8	1.3	1.5	1.3	1.3	-0.5	-1.2	1.1	0.3	1.6	0.8	1.5	0.9	1.5	0.8	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	2.8	0.8	1.0	0.9	0.6	1.1	0.8	1.1	-0.0	0.9	0.9	1.7	1.0	0.7	0.6	1.0	0.4	1.2	0.2
Comparative height size at age 10	0.7	4.0	19.4	-1.1	-1.3	0.3	0.0	-0.4	-0.4	-0.8	-4.0	-4.4	-0.9	-0.3	-1.3	-3.7	-1.9	-1.6	1.6	-2.0	2.2
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	7.7	-1.2	-1.3	0.4	-1.1	-0.7	-1.3	-0.8	-2.8	-2.1	-1.1	-0.3	-0.6	-1.0	-1.2	-0.6	-0.8	-1.1	1.0
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	2.9	1.5	1.1	-0.1	-0.2	0.9	0.9	1.4	-0.5	-1.7	1.2	0.6	-0.1	1.7	1.0	0.6	0.9	1.0	1.2
Average weekly champagne plus white wine intake	0.7	0.9	4.9	0.3	-0.2	0.7	1.3	0.7	0.3	0.0	-2.1	-2.2	0.1	-0.3	1.0	0.6	0.7	1.1	1.1	0.3	0.1
Age started oral contraceptive pill	0.7	0.9	7.7	-0.1	0.0	0.4	0.3	-0.0	0.6	0.1	2.8	0.3	0.3	-0.2	-1.8	1.5	0.1	-0.3	1.3	0.2	0.0
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.5	-0.7	-1.2	-1.1	-1.0	-0.7	-0.8	-1.2	0.6	1.6	-1.3	-1.0	-0.5	-0.5	-0.4	-0.5	-1.4	-0.9	0.1
Worry (Nagel 2018)	0.6	1.3	3.6	1.2	1.1	0.9	1.5	0.8	1.1	1.1	-0.2	-1.4	1.4	0.3	1.3	1.2	0.3	1.9	1.2	1.1	1.0
Reaction Time	0.6	1.2	4.7	1.1	0.2	-0.9	-1.6	1.7	-0.1	0.4	0.1	0.1	-0.3	0.7	0.3	1.7	0.9	2.2	-0.2	0.6	2.2
HbA1C	0.6	0.6	1.5	-0.4	-0.6	-0.6	-0.5	-1.2	-1.2	-0.6	-0.9	-0.5	-0.8	-1.2	-0.8	-0.3	-1.1	-0.9	-0.6	-0.9	-0.3
Rheumatoid Arthritis	0.6	0.9	2.6	-0.9	-0.5	-1.3	-1.2	-0.8	-0.8	-0.5	-0.8	-1.0	-0.6	-1.1	-0.3	-1.6	-0.9	-1.1	-1.0	-0.9	-0.2
Respiratory disease	0.6	1.3	4.2	-1.0	-1.4	-0.9	-1.0	-0.8	-1.2	-1.5	1.6	0.9	-1.8	-0.4	1.2	-0.5	-0.6	0.3	-2.0	-0.7	-0.4
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	3.6	0.9	0.4	-0.2	0.4	0.9	1.3	-0.0	0.1	0.6	0.1	0.3	1.2	-0.5	0.6	1.2	0.9	0.1	1.9
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	5.2	0.9	0.0	1.0	0.4	0.1	0.5	0.1	-2.0	0.4	0.3	0.6	0.1	-0.1	-0.1	1.8	1.4	0.2	2.3
Hair/balding pattern: Pattern 2	0.6	0.7	3.2	-1.2	-0.1	-0.7	-0.4	-0.7	0.3	-0.2	0.4	-1.6	0.2	0.9	-0.6	-0.4	0.9	-1.2	0.1	0.6	-1.8
Pain all over the body in last month	0.6	0.7	2.6	-0.9	-0.9	-0.6	-0.5	-0.7	-0.6	-0.9	-1.6	0.4	-0.9	-0.1	-0.7	-1.5	-0.6	-0.5	-0.9	-0.3	-0.1
Neuroticism score	0.6	1.3	2.8	-0.2	-1.6	-1.3	-0.8	-1.0	-1.5	-1.4	-0.7	-0.7	-1.4	-1.7	-0.4	-0.9	-1.4	0.7	-0.3	-1.4	1.5
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	11.5	-0.8	0.9	2.0	1.3	0.1	-0.5	0.8	-1.3	-3.4	0.7	2.0	1.4	0.6	0.3	-1.5	0.5	1.0	-2.5
Hair/balding pattern: Pattern 4	0.6	1.4	3.2	1.8	1.6	0.7	1.4	1.8	1.4	1.6	0.9	-1.1	1.2	0.1	1.1	1.4	0.4	0.9	1.2	0.9	0.5
Peak expiratory flow (PEF)	0.6	1.5	5.3	-0.5	1.1	2.0	1.5	0.1	-0.4	1.0	-0.4	-0.6	1.0	2.1	1.4	0.7	1.0	-1.4	0.3	1.1	-2.3
Wheeze or whistling in the chest in last year	0.6	1.1	2.8	-1.4	-1.3	-0.5	-0.4	-1.7	-1.0	-1.5	-0.5	1.3	-1.3	-0.5	0.0	-1.0	-1.0	-0.8	-1.3	-0.9	-1.0
Pulse wave peak to peak time	0.6	0.7	3.3	0.2	0.9	0.5	-0.9	0.8	1.0	0.7	-0.5	-0.7	0.5	1.8	0.2	1.2	1.2	0.2	0.6	1.0	0.3
Eye problems/disorders: None of the above	0.6	0.7	3.6	0.2	1.3	0.6	-0.0	0.1	0.4	1.2	-1.9	-0.1	1.4	1.1	0.1	0.9	0.4	-0.4	0.4	0.8	-0.6
Angina (self-reported)	0.6	0.8	2.3	-1.0	-0.8	-0.6	-1.2	-0.9	-0.6	-0.7	-1.0	-0.9	-0.9	-1.0	-0.6	-1.5	-0.9	-0.9	-0.4	-0.8	0.4
Mean time to correctly identify matches	0.6	1.1	5.5	1.3	0.2	-1.1	-1.3	1.8	0.2	0.4	1.0	-0.2	-0.2	0.4	-0.4	1.5	0.6	1.6	0.2	0.4	2.3
Supplements: Vitamin C	0.6	0.7	3.9	0.0	0.8	0.7	0.9	0.6	0.1	0.5	-1.6	-2.0	0.6	0.7	0.8	0.4	0.3	-0.7	0.7	0.3	-0.6
Friendships satisfaction	0.6	0.8	2.9	0.8	-0.8	-1.2	-0.3	-0.1	-0.2	-1.1	-0.1	-0.3	-1.3	-1.7	0.6	0.2	-0.2	1.2	-0.0	-0.8	1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	3.3	0.0	1.1	1.0	1.3	1.4	1.0	0.9	0.4	0.3	1.0	1.7	1.8	0.5	1.3	0.2	0.7	1.6	-1.7
Pain type(s) experienced in last month: Hip pain	0.6	0.8	3.5	-0.1	-0.3	1.0	1.6	-0.4	-1.1	-0.1	-1.6	0.3	-0.3	-0.7	-0.8	-0.4	-1.9	-0.8	0.3	-0.9	0.3
Medication: Bendroflumethiazide	0.6	0.9	6.6	0.7	0.1	0.8	1.0	0.7	0.5	0.5	1.8	2.6	0.5	0.5	-0.4	-0.8	-0.0	0.6	0.1	0.3	0.7
Medication: Paracetamol	0.6	1.0	6.3	1.0	0.2	-0.6	0.4	-0.2	0.4	0.0	0.5	0.7	-0.0	-2.0	0.4	-1.6	-0.1	0.8	0.9	-0.6	2.5
Medication: Lisinopril	0.6	0.8	3.3	1.1	0.5	0.4	0.3	0.9	0.3	0.5	-0.5	1.0	0.2	-0.4	1.8	-0.9	-0.5	1.3	-0.2	0.1	1.8
Risk taking	0.6	0.9	6.3	-1.6	-0.6	2.5	1.0	-0.9	-0.6	-0.7	-1.5	-0.2	-0.5	0.8	0.5	0.0	-0.1	-0.3	0.4	-0.0	-1.2
Ever had prostate specific antigen (PSA) test	0.6	0.7	8.8	-0.5	-0.1	-0.6	-0.3	-0.0	-0.1	-0.2	3.0	0.7	0.1	-1.0	-0.2	-0.5	-0.2	-0.5	-0.5	0.1	-0.3
Alcohol drinker status: Previous	0.6	0.6	3.2	-0.6	-0.5	0.1	1.3	0.0	-0.4	-0.5	-0.4	-0.2	-0.4	-1.4	0.0	-0.9	-1.8	-1.0	0.1	-1.1	0.4
Depression (Nagel 2018)	0.5	0.8	2.9	-0.7	-1.3	-0.6	-0.5	-0.5	-0.2	-1.3	-0.1	0.6	-1.3	-0.3	0.6	-1.7	-0.9	0.9	-0.2	-0.9	1.4
Crohns Disease (2017)	0.5	1.1	7.4	0.4	-0.3	-1.0	-0.5	-0.1	1.3	-0.2	-1.4	2.7	0.1	-0.3	-0.8	-1.4	0.7	0.6	0.6	-0.2	1.7
Ulcerative Colitis (UC)	0.5	0.9	3.5	0.6	1.2	-0.1	0.5	-0.1	0.7	1.2	-0.6	1.9	1.2	-0.1	0.5	0.1	1.3	0.3	0.3	1.5	-1.2
Crohns Disease (2012)	0.5	0.9	9.0	0.7	-0.3	-0.4	0.0	-0.0	1.0	-0.3	0.0	3.0	0.0	0.1	0.2	-1.0	1.0	0.9	0.6	0.1	1.3
Schizophrenia (2014)	0.5	1.1	4.9	0.2	0.7	2.2	2.2	0.9	-0.0	0.7	0.0	0.6	0.6	1.3	0.8	1.1	0.8	0.9	1.1	1.1	-0.6
Ulcerative Colitis	0.5	0.7	2.2	0.3	0.9	0.5	1.0	0.0	1.0	1.0	-0.3	0.9	1.0	0.2	1.2	-0.4	1.2	0.1	0.5	1.5	-1.4
Systolic Blood Pressure	0.5	2.7	13.2	0.1	-1.0	-1.0	-2.7	0.3	-1.9	-0.7	2.5	2.2	-1.6	-0.3	0.8	-2.0	-1.7	0.3	-3.6	-0.9	0.4
Angina	0.5	0.7	2.6	-0.9	-0.8	-0.6	-1.1	-0.8	-0.5	-0.7	-0.7	-0.9	-0.9	-0.8	-0.3	-1.6	-0.8	-0.7	-0.4	-0.7	0.5
Medication: Atenolol	0.5	0.7	3.1	0.4	-0.1	-0.2	0.1	0.8	0.4	-0.1	1.0	-0.4	-0.5	-1.1	1.0	-1.7	-0.9	0.2	0.4	-0.5	1.8
Number of incorrect matches in round	0.5	0.8	3.3	0.3	0.9	0.4	1.3	-0.4	0.9	0.4	-1.6	1.8	1.0	-1.2	0.8	-1.1	0.3	-0.3	0.2	0.2	-0.4
Mouth/teeth dental problems: Dentures	0.5	0.9	6.8	-0.2	-0.9	0.5	0.7	-0.3	-0.3	-0.5	-0.1	2.6	-0.5	0.9	-1.8	-1.1	-0.7	-0.0	-0.0	-0.8	0.3
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.5	-1.1	-0.6	-0.2	-0.8	-1.0	-0.9	-0.6	-0.8	0.5	-0.4	-1.0	-0.5	-0.7	-0.8	-0.8	-1.2	-0.8	0.1
Worry too long after embarrassment	0.5	0.8	2.8	0.4	-1.0	-1.5	-1.7	0.2	-0.6	-1.0	0.1	0.6	-1.3	-0.7	-0.2	0.0	-0.6	1.1	-0.7	-0.9	1.2
Medication for pain relief, constipation, heartburn	0.5	0.9	4.5	-0.7	0.1	0.2	-1.1	-0.1	-0.4	0.3	-0.6	-1.0	0.3	1.2	-1.0	1.9	0.3	-0.8	-0.8	0.5	-2.1
Neck or shoulder pain in last month	0.5	0.8	3.9	-0.1	-0.7	0.1	-0.5	-1.4	-0.9	-0.3	0.0	0.7	-0.3	-0.8	-2.0	-0.6	-1.2	-0.1	-0.1	-1.0	1.5
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.6	-0.6	-0.2	0.6	1.2	-0.6	-0.7	-0.2	0.9	-0.6	-0.0	-0.7	0.6	0.2	-1.1	-1.3	-0.2	-0.3	-1.2
Alcohol drinker status: Never	0.5	0.6	1.7	0.8	0.4	-0.3	0.3	0.5	1.1	0.5	-0.3	1.1	0.8	-0.5	-0.9	0.5	1.2	0.6	1.3	0.6	1.1
Irritable Bowel Disease (IBD)	0.4	0.9	6.8	0.7	0.7	-0.5	0.1	-0.1	1.3	0.7	-1.3	2.6	0.9	0.0	-0.2	-0.6	1.3	0.6	0.7	1.0	0.3
Systolic blood pressure, automated reading	0.4	1.1	5.7	1.0	0.6	0.6	-0.6	1.4	-0.1	0.8	2.4	1.7	0.2	1.2	0.9	-0.4	0.0	1.6	-0.7	0.9	0.8
Vitamin and mineral supplements	0.4	0.6	2.7	-0.6	-0.8	-1.1	-1.6	-0.4	0.5	-0.3	0.6	0.2	-0.3	0.6	-1.6	0.0	0.7	0.2	-0.9	0.2	-0.8
Age when periods started (menarche)	0.4	0.9	6.2	0.8	0.6	0.8	1.3	0.5	0.7	0.8	-0.0	-2.5	1.1	-0.9	0.4	1.1	0.4	0.4	1.3	0.5	0.2
Multivitamins +/- minerals	0.4	0.5	2.0	0.4	0.6	1.0	1.0	0.2	-0.9	0.2	-0.3	-0.9	0.1	-0.7	1.4	-0.0	-0.8	-0.3	0.6	-0.3	0.7
High blood pressure (mother)	0.4	0.5	2.3	0.7	-0.1	0.2	-0.1	-0.5	-0.4	-0.2	0.3	1.4	-0.3	-1.1	0.5	-1.0	-0.8	0.6	-0.3	-0.8	1.5
Past tobacco smoking	0.4	0.7	6.8	-0.6	-0.2	-0.2	-0.5	-0.3	0.4	0.1	-1.3	-2.6	0.2	0.3	-0.6	0.4	-0.2	-1.0	-0.1	0.3	-1.2
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.6	0.6	0.5	0.6	0.5	0.2	0.7	0.5	-1.3	0.8	0.4	0.9	0.1	0.2	0.7	1.1	0.6	0.6	1.1
Worrier / anxious feelings	0.4	0.7	5.5	-0.5	-0.9	-0.9	-0.1	-0.8	-0.4	-0.9	-0.3	-2.3	-0.6	-1.5	0.1	-0.4	-1.1	0.0	-0.1	-0.5	0.3
Pulse rate	0.4	0.7	1.9	0.6	1.0	0.6	0.9	-0.2	0.8	0.8	1.4	1.2	1.0	-0.3	1.0	0.8	0.5	0.1	0.6	0.9	-0.7
Pulse wave reflection index	0.4	0.5	1.2	1.1	0.9	0.3	1.1	1.0	0.5	1.0	0.3	-0.3	1.0	0.4	0.2	0.5	0.5	0.8	0.6	0.5	0.5
Mouth/teeth dental problems: Bleeding gums	0.4	0.6	3.2	0.2	-0.3	-0.0	-0.6	-0.4	-0.3	-0.1	-1.1	0.7	-0.2	0.0	-1.5	1.1	0.3	1.0	0.7	0.0	1.8
Birth weight	0.4	0.9	5.6	0.3	0.9	0.7	0.3	-0.3	1.2	1.0	-0.3	2.4	1.4	1.4	-1.1	0.2	0.3	-0.0	1.2	0.8	-0.3
High blood pressure (siblings)	0.4	0.5	3.3	0.4	0.2	0.8	0.5	-0.3	-0.5	0.4	1.2	1.8	0.2	-0.4	-0.5	-0.8	-0.8	0.8	0.2	0.0	1.0
Number of full brothers	0.4	0.5	2.6	0.3	-0.4	0.2	0.4	0.4	0.1	-0.4	-1.4	-1.6	-0.5	0.8	0.9	-0.5	-0.2	0.8	0.4	-0.3	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	3.6	0.2	0.5	0.8	-0.4	-0.5	0.0	0.8	-0.5	1.9	0.9	0.7	-0.9	0.8	0.4	0.5	-0.1	0.7	0.1
Loneliness, isolation	0.4	0.5	1.9	-0.3	-1.4	-0.5	0.3	-0.0	-0.9	-1.2	0.2	-0.2	-1.3	0.1	-0.4	0.1	-1.2	-0.1	-0.2	-1.2	0.4
Wears glasses or contact lenses	0.4	0.4	1.4	-0.4	-0.4	-0.2	0.5	-0.7	-0.1	-0.3	1.2	0.8	-0.1	-1.2	-1.1	-0.0	-1.0	-0.8	-0.3	-0.5	-0.6
Ever taken oral contraceptive pill	0.4	0.4	1.7	-0.3	0.1	-0.0	-0.8	0.4	-0.1	0.1	-1.1	-0.9	-0.1	1.3	1.3	0.7	0.3	0.2	-0.1	0.3	-0.9
Illnesses of father: High blood pressure	0.4	0.5	2.0	-0.6	-0.1	-1.2	-0.3	-0.4	-0.5	-0.4	1.1	-0.4	-0.4	-1.4	0.5	-0.3	-0.9	-1.1	-0.5	-0.3	-0.6
Ever smoked	0.4	0.7	2.1	0.7	1.0	1.0	0.7	0.7	0.1	0.8	0.4	1.4	0.7	0.8	1.2	0.6	1.0	1.1	0.5	0.6	0.4
Diastolic blood pressure, automated reading	0.4	1.3	5.4	-0.7	-0.3	-0.3	-1.4	-0.1	-1.2	-0.3	2.0	1.2	-0.8	-0.1	0.9	-2.3	-1.1	-0.4	-2.3	0.0	-1.1
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.7	-0.8	-0.9	-0.7	-1.0	-0.9	-0.8	-0.7	1.0	-0.4	-0.7	-1.3	-1.2	-0.4	-0.8	-1.1	-0.4	-0.8	-0.3
Blood Platelet Count	0.3	3.5	15.2	0.2	-0.0	-2.4	-0.6	-0.2	2.2	-0.7	1.7	-3.9	-0.2	-2.9	3.7	-2.8	0.4	-1.2	1.3	-0.8	-0.3
Blood White Count	0.3	2.1	12.8	-0.9	-1.4	-0.1	0.5	-0.3	-0.6	-1.4	0.3	-3.6	-1.4	-1.9	1.7	-1.4	-1.2	1.2	0.2	-1.4	1.9
Neuroticism	0.3	0.8	2.8	0.2	-1.2	-0.6	-0.2	-0.6	-1.0	-1.0	-0.0	-0.5	-0.9	-1.6	-0.2	-0.6	-1.2	1.2	-0.0	-1.0	1.7
Hair Pigment	0.3	8.4	29.8	2.1	3.5	1.6	2.0	1.3	5.4	3.0	-1.2	0.2	4.3	3.0	-0.4	2.0	4.2	-0.3	5.5	2.7	0.5
Ever used hormone-replacement therapy (HRT)	0.3	0.3	1.5	-0.8	-0.2	-0.2	-0.2	0.2	0.1	-0.3	1.0	0.3	-0.1	0.1	0.7	-0.8	-0.4	-0.7	-0.6	0.3	-1.2
Medication for hormone replacement therapy	0.3	0.4	2.0	-0.8	0.2	0.6	-0.3	-0.1	-0.6	0.0	0.7	0.4	0.1	0.3	1.3	0.6	-0.0	-0.4	-0.8	0.3	-1.4
Supplements: Zinc	0.3	0.3	1.8	0.4	0.6	1.2	0.7	0.3	0.1	0.6	0.6	0.1	0.6	0.3	-0.1	1.3	-0.3	0.1	0.7	0.3	0.0
Medication: Co-codamol	0.3	0.4	2.0	-0.6	0.0	-0.3	0.3	-0.8	0.3	0.3	-0.8	0.8	0.3	0.3	-1.4	-0.7	0.8	-0.3	0.3	0.5	-0.4
Nervous feelings	0.3	0.6	5.5	0.3	-0.1	-1.3	-0.7	0.3	-0.3	-0.0	-1.2	-2.3	-0.0	-0.7	0.4	0.5	-0.5	0.1	-0.6	-0.4	0.5
Had menopause	0.3	0.3	1.3	0.4	0.3	-0.1	0.2	0.7	0.6	0.3	1.1	-0.8	0.5	0.1	0.9	0.3	0.0	-0.4	0.9	0.5	0.1
Illnesses of siblings	0.3	0.4	1.8	0.6	0.5	-0.0	0.2	0.7	0.6	0.3	-0.3	-1.1	0.4	0.6	0.0	1.3	0.9	0.1	0.9	0.2	0.7
Falls in the last year	0.3	0.4	2.9	-0.8	-0.4	0.5	0.3	0.4	0.3	-0.6	0.2	0.6	-0.5	0.5	1.7	-0.7	-0.4	-0.0	-0.6	-0.2	-1.0
Number of live births	0.3	0.4	2.2	-0.2	-0.0	0.3	1.0	0.2	0.4	-0.1	1.3	0.4	0.0	0.5	1.5	0.9	0.1	-0.1	-0.2	0.3	-0.7
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.5	-0.0	0.1	0.3	0.3	0.5	1.2	0.2	-0.8	-0.6	0.2	1.0	0.9	0.3	0.9	0.7	0.2	0.5	-0.8
Medication: Lansoprazole	0.3	0.4	1.6	0.2	0.2	-0.5	-0.5	0.1	-0.2	0.2	1.2	1.3	0.0	1.1	0.4	0.9	0.6	0.5	-0.7	0.3	-0.1
Exposure to tobacco smoke at home	0.3	0.3	1.5	-0.3	-0.1	-0.6	-0.9	-0.2	0.3	-0.1	-0.0	0.9	-0.1	0.7	-1.2	0.2	0.2	-0.2	-0.7	0.3	-0.3
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.7	-0.3	-0.0	-0.4	-0.2	0.2	0.5	0.0	-0.1	-0.9	-0.0	1.0	1.3	0.5	0.3	0.4	-0.3	0.9	-1.0
Emphysema/chronic bronchitis	0.3	0.3	1.4	-0.4	-0.1	0.6	-0.2	0.1	0.1	0.1	0.7	0.0	0.1	1.1	-0.6	0.8	1.2	0.2	0.3	0.9	-0.4
Migraine (self-reported)	0.3	0.3	1.1	-0.1	-0.6	-1.1	-0.7	-0.1	0.1	-0.7	-0.5	0.6	-0.5	-0.6	-0.4	0.7	0.1	0.6	0.4	-0.6	0.8
Medication: Omeprazole	0.3	0.4	1.8	-0.8	-0.2	0.4	0.8	-0.6	-0.4	-0.3	-0.0	0.6	-0.1	-0.3	-0.6	-0.3	-0.9	-1.4	-0.1	-0.3	-1.2
Illnesses of father: Heart disease	0.3	0.4	1.6	-0.4	0.0	-0.6	-0.8	0.2	-0.6	-0.2	-1.3	-0.8	-0.5	-0.1	1.2	-0.4	-0.3	-0.5	-0.5	0.4	-1.0
Financial situation satisfaction	0.3	0.4	1.3	0.2	-0.7	-0.6	-0.9	-0.5	-0.2	-0.4	-0.8	0.9	-0.7	-0.7	-0.6	-0.7	-0.2	0.5	-0.2	-0.5	1.1
Tinnitus: Yes, now most or all of the time	0.3	0.4	2.7	0.0	0.4	0.3	0.4	0.4	1.6	0.5	1.1	-0.0	0.7	0.6	-0.4	-0.2	0.1	-0.5	1.0	0.3	-0.0
Irritability	0.3	0.5	1.8	0.5	-0.3	0.8	1.3	-0.7	-0.7	-0.2	-0.7	0.2	0.0	-0.9	-0.4	-0.2	-0.9	0.7	0.7	-0.4	1.0
Fractured/broken bones in last 5 years	0.3	0.4	1.8	0.1	0.7	0.5	0.8	0.3	1.4	0.5	0.5	-0.5	0.9	-0.2	-0.4	-0.2	-0.5	-0.2	1.4	-0.0	0.9
Unable to work because of sickness or disability	0.3	0.4	2.8	-0.7	-0.0	-0.5	-1.7	0.3	-0.2	0.2	0.5	-1.3	-0.0	0.6	-0.3	-0.1	-0.4	-0.6	-0.7	0.4	-0.1
Basal cell carcinoma (self-reported)	0.3	0.4	1.8	-0.3	0.1	-0.3	-0.4	-0.6	0.0	0.1	1.3	0.9	0.1	-0.3	-1.3	1.0	0.8	-0.8	-0.1	0.2	0.3
Intelligence (Savage-Jansen 2018)	0.2	0.7	4.3	0.5	0.3	-0.4	-0.8	0.6	0.8	0.4	2.1	-1.8	0.2	0.6	0.2	0.6	1.0	0.5	1.1	0.8	0.3
Ovarian Cancer	0.2	0.3	2.0	0.2	0.1	0.4	0.1	0.2	-0.1	0.2	-0.1	1.1	-0.0	0.1	1.4	-0.9	-0.5	0.2	-0.2	-0.2	-0.6
Fasting Glucose	0.2	0.3	0.8	-0.1	-0.5	-0.4	-0.2	-0.2	-0.7	-0.6	0.9	-0.7	-0.7	0.1	0.2	0.2	-0.2	-0.5	-0.7	-0.3	-0.7
Lupus	0.2	0.2	2.0	-0.3	-0.1	0.2	0.2	0.2	-0.7	-0.3	-0.3	-0.4	-0.8	0.1	0.3	-1.4	-0.1	0.2	0.4	-0.4	0.5
Blood Red Count	0.2	2.1	9.9	-0.7	-0.6	1.0	1.7	-1.0	-1.3	-1.0	2.6	3.1	-0.6	1.2	-0.0	-0.5	-0.9	-0.5	-1.4	-0.4	-2.7
Lung FEV1/FVC ratio	0.2	1.2	8.4	0.1	-0.3	0.2	0.5	-1.2	-1.2	-0.1	-1.0	2.0	0.1	-2.1	-2.9	0.3	0.0	-0.5	0.2	-0.7	0.6
Tanning	0.2	2.6	6.5	-2.3	-1.5	-1.2	-1.6	-2.3	-2.3	-1.7	-0.6	-0.8	-1.6	-1.4	-0.1	0.1	-1.6	-1.8	-2.5	-1.4	-1.8
Fluid intelligence score	0.2	0.4	2.0	0.4	0.3	0.1	-0.1	0.1	0.0	0.5	1.0	-0.6	0.3	-1.4	-0.5	0.5	0.0	0.4	0.8	0.1	1.2
Time employed in main current job	0.2	0.3	1.8	0.4	0.4	0.4	0.1	0.8	0.3	0.4	-0.2	-0.7	0.3	-0.1	-0.1	0.5	0.1	0.4	0.9	0.3	1.3
Birth weight of first child	0.2	0.4	2.7	-0.5	0.1	-0.5	-0.5	-0.8	0.2	-0.2	-1.6	-1.3	0.1	0.0	-0.4	-0.1	0.3	-0.8	0.3	-0.2	-0.7
Number of full sisters	0.2	0.3	1.2	-0.4	0.1	0.6	1.0	0.6	0.4	0.2	-0.6	0.5	0.1	0.4	1.1	-0.7	-0.5	0.3	-0.4	0.3	-0.2
Commuting to job workplace: Car/motor vehicle	0.2	0.3	3.2	-0.1	-0.2	-0.1	-0.1	0.0	0.3	-0.1	-1.8	0.4	0.1	0.5	-0.4	-0.2	0.6	-0.2	0.2	0.1	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	1.7	0.1	0.1	-0.1	0.0	0.4	0.0	0.1	0.8	-0.6	0.1	0.3	-1.3	0.8	0.2	-0.2	0.9	-0.1	0.2
Ever had bowel cancer screening	0.2	0.3	1.4	0.2	0.1	0.3	0.9	0.2	0.5	0.1	0.8	1.2	0.2	-0.2	-0.9	-0.5	0.4	0.2	0.6	0.2	0.2
Osteoarthritis (self-reported)	0.2	0.3	2.8	0.1	-0.1	0.2	-0.3	0.4	-0.0	0.2	-1.7	-0.8	0.0	0.1	0.1	-0.8	-0.2	0.0	-0.0	0.0	0.5
Illnesses of father: None of the above (group 1)	0.2	0.3	1.6	-0.1	-0.3	0.5	0.3	-0.5	0.7	-0.1	0.9	0.4	0.2	0.3	-1.3	0.2	0.4	0.3	0.1	-0.4	0.8
Myopia	0.2	0.3	4.1	-0.1	0.1	-0.4	-0.2	0.6	0.4	-0.0	2.0	0.5	0.0	-0.1	-0.0	0.0	0.2	-0.2	0.4	0.3	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	1.2	-0.3	0.1	0.5	1.1	-0.2	-0.0	-0.1	0.3	1.0	0.0	-0.2	-0.1	-0.2	-0.7	-0.9	0.3	-0.2	-0.6
Heart attack/myocardial infarction (self-reported)	0.2	0.3	1.4	0.1	-0.0	-0.8	-1.1	0.1	-0.4	-0.1	-0.0	0.0	-0.3	-1.2	0.0	-0.5	-0.7	-0.4	-0.5	-0.0	0.5
Heart disease (siblings)	0.2	0.3	0.8	-0.1	0.3	0.0	-0.3	0.6	0.6	0.5	-0.8	-0.6	0.3	0.5	0.9	-0.4	0.3	0.3	-0.1	0.7	-0.7
Chronic bronchitis/emphysema (father)	0.1	0.1	0.6	0.3	0.0	-0.2	0.4	-0.2	0.1	-0.0	0.2	0.5	0.3	-0.4	0.2	-0.0	0.6	0.4	0.8	0.3	0.7
Heart attack	0.1	0.2	0.9	0.4	0.3	-0.5	-0.8	0.4	-0.3	0.3	0.1	-0.3	-0.0	-0.9	0.2	-0.1	-0.5	-0.1	-0.3	0.2	0.6
Eye problems/disorders: Cataract	0.1	0.1	0.5	0.2	-0.2	0.4	0.3	0.6	0.6	0.0	0.2	0.7	-0.2	-0.0	-0.3	-0.3	0.3	0.4	0.4	0.2	0.3

Hub : Genes

PACS1

Models

Trait associations