Best TWAS P=3.46e-08 · Best GWAS P=2.16e-11 conditioned to 0.000151
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | STK33 | 0.18 | 0.18 | lasso | 9 | 0.20 | 3.8e-24 | -4.8 | 5.5 | 3.5e-08 | -0.83 | 0.90 | 0.10 | TRUE |
| 2 | GTEx | Brain Caudate basal ganglia | RP11-152H18.3 | 0.23 | 0.01 | enet | 1 | 0.06 | 1.1e-02 | -5.1 | -5.2 | 2.7e-07 | 0.69 | 0.04 | 0.70 | FALSE |
| 3 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | STK33 | 0.05 | 0.03 | lasso | 2 | 0.03 | 2.5e-04 | -5.3 | 5.1 | 2.7e-07 | -0.53 | 0.45 | 0.16 | FALSE |
| 4 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | ST5 | 0.41 | 0.02 | blup | 128 | 0.13 | 2.3e-05 | 3.2 | -5.1 | 2.9e-07 | 0.58 | 0.03 | 0.61 | FALSE |
| 5 | The Cancer Genome Atlas | Thyroid Carcinoma | STK33 | 0.14 | 0.08 | lasso | 6 | 0.10 | 1.0e-09 | -5.1 | 5.5 | 3.6e-08 | -0.66 | 0.89 | 0.11 | FALSE |