[Hub]/) : Traits : Leg fat mass (left) : ← →

chr11:26,818,083-29,054,545

Best TWAS P=2.35e-26 · Best GWAS P=8.58e-34 conditioned to 3.43e-07

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	LIN7C	0.08	0.06	lasso	1	0.04	4.1e-04	10.62	10.6	2.3e-26	0.65	0.75	0.13	TRUE
11	The Cancer Genome Atlas	Colon Adenocarcinoma	LIN7C	0.10	0.03	blup	32	0.08	2.8e-05	10.98	8.3	9.4e-17	0.56	0.01	0.96	TRUE
14	The Cancer Genome Atlas	Lung Adenocarcinoma	LIN7C	0.02	0.02	enet	3	0.02	5.6e-03	1.96	5.3	1.3e-07	0.54	0.01	0.73	TRUE
9	ROSMAP	Brain Pre-frontal Cortex	METTL15	0.04	0.03	blup	364	0.03	4.6e-05	-2.95	-5.2	1.5e-07	-0.19	0.72	0.01	TRUE
8	NTR	Blood	LIN7C	0.01	0.00	lasso	3	0.01	2.2e-03	10.84	-10.6	4.4e-26	-0.74	0.11	0.79	FALSE
7	GTEx	Thyroid	LIN7C	0.08	0.04	lasso	4	0.04	6.0e-04	10.62	10.2	2.5e-24	0.71	0.46	0.43	FALSE
12	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LIN7C	0.05	0.02	lasso	3	0.03	2.9e-04	11.04	9.8	7.2e-23	0.65	0.00	0.99	FALSE
3	GTEx	Cells Transformed fibroblasts	LIN7C	0.26	0.22	lasso	6	0.25	1.4e-18	10.62	8.8	2.1e-18	0.64	1.00	0.00	FALSE
2	GTEx	Brain Putamen basal ganglia	BDNF-AS	0.22	0.17	lasso	4	0.13	5.5e-04	-6.71	8.1	5.9e-16	0.33	0.23	0.05	FALSE
5	GTEx	Liver	METTL15	0.18	0.05	lasso	3	0.09	1.9e-03	-0.43	-7.6	2.7e-14	-0.69	0.02	0.83	FALSE
4	GTEx	Esophagus Muscularis	LIN7C	0.14	0.08	enet	11	0.07	5.4e-05	3.44	7.5	7.5e-14	0.62	0.70	0.14	FALSE
10	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	LIN7C	0.04	0.01	lasso	3	0.02	1.0e-02	-1.80	6.3	3.0e-10	0.48	0.02	0.83	FALSE
6	GTEx	Nerve Tibial	LIN7C	0.18	0.08	enet	27	0.12	4.2e-09	10.62	6.2	5.6e-10	0.56	0.67	0.30	FALSE
13	The Cancer Genome Atlas	Brain Lower Grade Glioma	LIN7C	0.09	0.12	lasso	2	0.12	2.6e-13	3.52	5.9	2.9e-09	0.53	0.92	0.08	FALSE
15	The Cancer Genome Atlas	Thyroid Carcinoma	LIN7C	0.09	0.10	enet	7	0.09	8.1e-09	3.52	5.3	1.1e-07	0.49	0.93	0.07	FALSE