TWAS
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Usage
Models
Genes
Traits
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Traits
:
Leg fat mass (left)
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chr17:27,222,988-29,547,601
Best TWAS P=9.17e-09 · Best GWAS P=1.95e-09 conditioned to 8.24e-06
27.5M
28M
28.5M
29M
29.5M
0
2
4
6
8
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
The Cancer Genome Atlas
Colon Adenocarcinoma
CCDC55
0.15
0.01
blup
64
0.04
1.9e-03
-5.2
5.7
9.2e-09
0.31
0.02
0.55
TRUE
3
GTEx
Thyroid
ANKRD13B
0.23
0.12
lasso
6
0.18
2.3e-13
-3.3
-5.5
4.5e-08
-0.73
0.04
0.96
FALSE
1
CommonMind
Brain Pre-frontal Cortex
EFCAB5
0.11
0.18
blup
392
0.17
1.7e-20
-4.7
-5.4
8.7e-08
-0.23
0.38
0.62
FALSE
2
GTEx
Brain Cortex
GOSR1
0.20
0.20
enet
7
0.18
1.4e-05
4.6
5.2
1.6e-07
0.16
0.33
0.60
FALSE
5
The Cancer Genome Atlas
Prostate Adenocarcinoma
EFCAB5
0.04
0.03
enet
10
0.02
6.0e-03
-4.7
-5.1
2.7e-07
-0.20
0.04
0.92
FALSE