TWAS
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Traits
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Traits
:
Leg fat mass (left)
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chr17:20,350,968-22,010,013
Best TWAS P=1.06e-08 · Best GWAS P=2.1e-09 conditioned to 0.0197
20.4M
20.6M
20.8M
21M
21.2M
21.4M
21.6M
21.8M
22M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Thyroid
KCNJ12
0.36
0.23
lasso
5
0.25
2.9e-19
-4.5
-5.7
1.1e-08
0.81
0.57
0.42
TRUE
1
GTEx
Thyroid
DHRS7B
0.17
0.02
enet
22
0.11
1.2e-08
-4.7
-5.2
2.6e-07
0.26
0.60
0.30
FALSE