TWAS hub - CCDC55

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Colon Adenocarcinoma	0.153	0.096	0.0025	0.012	0.042	0.021	NA	0.021	0.065	0.0019	0.021	NA	0.0220
2	TCGA	Esophageal Carcinoma	0.268	0.143	0.0093	-0.005	-0.001	-0.004	NA	-0.004	0.480	0.3500	0.440	NA	0.4400
3	TCGA	Skin Cutaneous Melanoma	0.515	0.140	0.0099	0.000	0.005	-0.011	NA	0.065	0.330	0.2400	0.970	NA	0.0079

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Lung FEV1/FVC ratio	19.6	99.2	156.2	12.5	11.6	2.6
Illnesses of siblings	10.2	14.3	21.4	-4.1	-4.6	-2.1
Leg fat percentage (right)	8.9	32.2	51.7	7.2	6.3	-2.2
Heel T-Score	8.3	65.6	116.6	-10.8	-9.0	0.0
Heart disease (siblings)	7.9	9.7	15.4	3.9	3.7	0.4
High blood pressure (siblings)	7.5	10.8	17.5	3.7	4.2	1.1
Number of incorrect matches in round	7.2	11.9	16.7	-3.3	-4.1	-2.8
Cholesterol lowering medication	7.0	10.3	14.3	3.8	3.8	1.6
Leg fat percentage (left)	6.8	24.7	40.5	6.4	5.4	-2.1
Chest pain or discomfort	6.3	9.1	15.7	3.4	4.0	-0.1
Back pain experienced in last month	6.3	9.2	10.2	3.2	3.1	2.8
Arm fat percentage (right)	6.1	24.2	37.4	6.1	5.5	-2.2
Leg fat mass (right)	6.1	23.6	39.5	6.3	5.3	-1.6
Body fat percentage	6.0	23.7	37.9	6.2	5.4	-2.1
Arm fat percentage (left)	5.7	22.5	36.2	6.0	5.4	-1.6
Stomach or abdominal pain in last month	5.3	6.6	10.2	3.2	3.0	-0.6
Pain type(s) experienced in last month: Hip pain	5.3	6.7	10.5	3.0	3.2	0.7
Medication for cholesterol, blood pressure or diabetes	5.0	8.3	15.9	-2.9	-4.0	0.6
Number of self-reported non-cancer illnesses	4.9	8.5	14.7	3.8	3.3	-0.2
Leg fat mass (left)	4.9	19.0	33.0	5.7	4.7	-1.4
Cardiovascular Disease	4.8	15.7	29.7	4.2	5.5	0.1
Heel bone mineral density (BMD) T-score, automated (left)	4.7	10.7	21.4	-4.6	-3.2	0.4
Forced vital capacity (FVC)	4.7	18.2	30.4	-5.5	-4.9	0.2
Pain experienced in last month	4.7	7.8	11.5	-3.4	-3.3	-1.2
BMI	4.6	26.6	39.6	6.3	6.3	-0.8
Angina	4.5	5.9	11.1	2.6	3.3	-0.1
Trunk fat percentage	4.5	18.2	29.3	5.4	4.7	-1.8
Medication: Blood pressure	4.5	8.0	12.1	3.3	3.5	-0.8
Bipolar Disorder (2011)	4.2	4.0	7.4	-2.7	-2.2	0.0
Forced vital capacity (FVC), Best measure	4.2	15.5	24.8	-5.0	-4.7	-0.2
Hypertension (Self-reported)	4.2	11.7	20.7	3.6	4.6	-1.2
Vascular/heart problems diagnosed by doctor	4.1	11.3	21.1	-3.5	-4.6	0.7
Blood White Count	4.0	29.6	51.3	-7.2	-4.7	-4.0
Body mass index (BMI)	4.0	16.9	28.1	5.3	4.6	-1.0
Angina (self-reported)	4.0	5.3	10.1	2.4	3.2	-0.2
Whole body fat mass	3.9	16.3	27.8	5.3	4.4	-1.5
Fluid intelligence score	3.8	7.9	13.2	3.2	3.6	0.1
Alcohol intake versus 10 years previously	3.8	5.7	10.6	2.3	3.3	-1.2
Intelligence (Savage-Jansen 2018)	3.7	11.2	17.1	4.1	4.1	0.3
High blood pressure	3.7	10.4	19.0	3.3	4.4	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	3.7	8.5	15.3	-3.9	-3.1	0.9
Arm fat mass (right)	3.6	14.9	25.4	5.0	4.2	-1.4
Arm fat mass (left)	3.6	14.8	25.4	5.0	4.2	-1.4
Hypothyroidism (self reported)	3.5	8.0	9.9	2.6	3.1	2.7
Peak expiratory flow (PEF)	3.4	7.9	13.0	3.6	2.8	1.7
Trunk fat mass	3.3	14.3	23.7	4.9	4.1	-1.6
Medication: Allopurinol	3.3	4.4	10.0	1.7	3.2	-0.5
Medication: Aspirin	3.3	4.3	7.8	2.2	2.8	-0.1
Waist circumference	3.1	11.3	17.3	4.2	4.0	-0.8
Prospective memory result	3.1	3.9	7.0	-2.0	-2.6	-0.7
Blood Red Count	3.0	28.5	43.4	6.6	6.5	-0.5
Heart attack	3.0	3.9	6.4	1.9	2.5	1.2
Medication: Aspirin	3.0	3.9	7.5	2.1	2.7	-0.0
Heart attack/myocardial infarction (self-reported)	3.0	3.9	6.2	1.9	2.5	1.3
Knee pain experienced in last month	2.9	4.5	7.7	2.8	2.4	0.4
Hypothyroidism/myxoedema (self-reported)	2.8	5.5	7.2	1.9	2.7	2.3
Alzheimer’s Disease (including proxy)	2.7	4.0	7.0	-2.2	-2.6	0.5
Type 2 Diabetes (T2D) (2012)	2.7	3.1	7.1	0.8	2.7	1.3
Number of operations (self-reported)	2.7	3.9	5.7	2.4	1.6	-1.8
High blood pressure (mother)	2.6	3.6	4.1	1.7	2.0	2.0
Medication: Simvastatin	2.6	3.8	7.5	1.9	2.7	-0.4
Heart disease (mother)	2.6	3.2	5.1	1.7	2.3	-1.3
Verbal and Numeric Reasoning (VNR)	2.5	5.9	9.1	2.9	3.0	-0.2
Taking other prescription medications	2.5	3.9	6.8	2.6	2.2	0.0
Had menopause	2.5	3.2	6.5	2.5	1.6	0.7
Supplements: Zinc	2.4	2.6	4.5	2.1	1.7	0.6
Serious illness, injury or assault to yourself	2.4	2.9	3.2	1.6	1.7	-1.8
Number of full brothers	2.4	3.0	5.4	0.9	1.7	-2.3
HDL Cholesterol	2.3	3.8	9.2	-1.5	-3.0	0.4
Medication: Atenolol	2.3	2.9	4.0	1.3	2.0	-1.7
Illnesses of mother	2.3	2.9	4.4	-2.0	-2.1	-0.6
Alzheimer’s Disease (in mother)	2.2	2.5	3.9	-2.0	-1.9	0.5
Number of treatments/medications taken	2.2	4.0	6.7	2.3	2.6	-0.0
Medication: Bendroflumethiazide	2.2	3.3	4.1	1.3	2.0	-2.0
Bipolar Disorder or Schizophrenia	2.1	5.1	8.7	-3.0	-2.4	-0.9
Chronic bronchitis/emphysema (mother)	2.1	2.4	2.8	1.3	1.7	-1.6
Irritability	2.1	3.5	4.4	2.1	1.8	1.7
Bipolar Disorder (2018)	2.0	3.2	4.7	-2.2	-1.5	-1.6
Ovarian Cancer	2.0	2.7	7.8	-0.5	-0.1	-2.8
Coronary Artery Disease (CAD)	2.0	2.4	4.9	1.3	2.2	-0.8
Medication: Cholesterol lowering	2.0	3.2	8.3	1.1	2.9	-0.1
Illnesses of father: High blood pressure	2.0	2.4	3.8	1.8	1.9	0.7
Ulcerative Colitis	1.9	2.8	4.0	1.4	1.6	-2.0
Lung FVC	1.8	9.4	14.1	-3.6	-3.8	-0.9
Hayfever, allergic rhinitis or eczema	1.8	3.9	6.7	2.1	2.6	0.9
Migraine (self-reported)	1.8	2.2	3.3	-1.6	-1.8	-0.8
Medication: Metformin	1.7	2.4	3.7	1.8	1.9	-0.1
Falls in the last year	1.7	2.3	6.7	-0.2	-0.5	-2.6
Standing height	1.7	17.2	27.9	-4.9	-5.3	0.4
Medication: Amlodipine	1.7	2.4	3.8	2.0	1.8	0.1
Mood swings	1.7	3.0	5.1	2.0	2.3	-0.5
Illnesses of father: None of the above (group 1)	1.7	2.1	3.0	-1.7	-1.3	-1.3
Basal cell carcinoma (self-reported)	1.7	2.0	2.9	-1.1	-1.7	1.4
Allergy or Eczema	1.6	4.1	8.0	2.0	2.8	0.7
Alcohol usually taken with meals	1.6	2.6	4.1	-1.8	-2.0	0.8
Gout (self-reported)	1.6	2.3	5.0	1.3	2.2	-0.3
Mean time to correctly identify matches	1.6	3.0	6.6	1.5	0.2	2.6
Medication: Blood pressure	1.6	3.1	6.8	1.4	2.6	-0.5
Reaction Time	1.5	2.8	7.8	0.6	-0.5	2.8
Average weekly spirits intake	1.5	1.8	3.5	-1.3	-1.9	-0.5
Other serious medical condition/disability diagnosed by doctor	1.5	2.0	2.3	1.4	1.3	1.5
Worry too long after embarrassment	1.5	2.5	5.7	-1.2	-0.6	-2.4
High cholesterol (Self-reported)	1.5	2.6	5.8	1.3	2.4	0.6
Medication: Lisinopril	1.5	2.0	3.9	2.0	1.4	-0.2
Ulcerative Colitis (UC)	1.4	2.5	3.4	1.8	1.8	-1.0
Fasting Glucose	1.4	1.7	2.8	-1.7	-1.4	-0.5
Hearing difficulty/problems: Yes	1.4	2.1	3.6	1.9	1.5	-0.7
Medication for hormone replacement therapy	1.4	1.6	2.6	-1.6	-1.5	0.3
Birth weight of first child	1.4	2.6	4.5	-1.8	-2.1	0.2
Neck or shoulder pain in last month	1.4	2.0	3.7	1.4	1.9	0.6
Forced expiratory volume in 1-second (FEV1), predicted	1.4	2.8	4.2	-1.7	-2.0	1.2
Long-standing illness, disability or infirmity	1.4	2.1	3.6	1.2	1.9	-1.2
Financial situation satisfaction	1.4	1.7	3.3	-1.3	-0.4	1.8
Nervous feelings	1.3	2.3	4.2	-2.1	-1.5	-0.7
Mouth/teeth dental problems	1.3	2.0	3.5	-1.1	-1.9	1.2
Hip circumference	1.3	5.8	8.7	2.9	2.6	-1.4
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	1.9	1.4	1.2	-1.2
Blood clot in the leg (DVT)	1.3	1.6	2.9	1.7	1.4	0.3
Health satisfaction	1.3	1.7	2.7	0.6	1.4	1.7
Overall health rating	1.3	2.8	5.9	1.6	2.4	0.2
Ever depressed for a whole week	1.3	1.6	2.8	-1.7	-0.4	1.3
Schizophrenia (2018)	1.2	2.5	4.1	-2.0	-1.8	0.3
Medication: Ramipril	1.2	1.6	2.6	0.8	1.2	-1.6
Noisy workplace	1.2	1.5	2.2	-1.4	-1.5	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.9	2.2	1.5	1.3	-1.3
Hearing aid user	1.2	1.4	3.4	-0.6	-0.5	-1.9
Deep venous thrombosis (DVT) (self-reported)	1.2	1.6	3.0	1.7	1.3	0.3
Hand grip strength (right)	1.1	3.1	5.4	-1.0	-2.3	1.6
Age when periods started (menarche)	1.1	2.7	4.4	-2.1	-1.8	0.4
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	1.8	1.3	1.3	0.3
Pain all over the body in last month	1.1	1.2	2.3	-1.1	-0.3	1.5
Comparative height size at age 10	1.1	6.0	10.8	-2.7	-3.3	0.1
Family relationship satisfaction	1.1	1.4	2.4	1.2	1.5	0.7
Supplements: Vitamin C	1.1	1.3	2.5	1.6	1.1	0.6
Average weekly red wine intake	1.1	1.6	2.0	-1.3	-1.0	-1.4
Diastolic blood pressure, automated reading	1.1	3.5	5.7	2.1	2.4	0.6
Lupus	1.0	1.5	3.4	-1.8	0.3	1.0
Height	1.0	18.4	33.2	-4.7	-5.8	0.1
Had other major operations	1.0	1.2	2.2	1.5	1.1	0.1
Time employed in main current job	1.0	1.1	2.4	0.9	0.5	-1.5
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.2	2.9	-0.2	-0.9	1.7
Ever had bowel cancer screening	1.0	1.1	1.6	1.2	1.3	-0.5
Eye problems/disorders: Cataract	1.0	1.1	2.2	1.5	1.0	-0.6
Osteoarthritis (self-reported)	1.0	1.4	3.3	-1.8	-0.7	-0.5
Ever used hormone-replacement therapy (HRT)	0.9	1.2	2.0	-1.1	-0.5	-1.4
Average weekly fortified wine intake	0.9	1.1	2.4	-1.0	-1.5	0.1
Qualifications: CSEs or equivalent	0.9	1.2	2.7	-0.6	-1.6	-0.6
Weight	0.9	4.5	8.1	2.9	2.1	-0.9
Medication for cholesterol	0.9	1.3	3.1	-1.0	-1.8	-0.1
Wears glasses or contact lenses	0.9	1.0	1.8	1.3	0.7	-0.9
Fractured/broken bones in last 5 years	0.9	1.2	2.8	1.7	0.9	-0.1
Alcohol drinker status: Previous	0.9	1.0	1.8	0.3	-1.3	-1.1
Irritable Bowel Disease (IBD)	0.8	2.0	2.4	1.5	1.2	-1.5
Body Mass Index (BMI) (2010)	0.8	1.1	1.9	0.9	1.4	0.8
LDL Cholesterol	0.8	1.3	2.6	0.8	1.6	-0.9
Frequency of depressed mood in last 2 weeks	0.8	1.2	3.2	0.1	0.5	1.8
Pulse rate	0.8	1.3	3.8	-0.3	-0.4	-1.9
Medication: Lansoprazole	0.8	0.9	1.7	0.6	0.7	-1.3
Medication: Ventolin 100micrograms inhaler	0.8	1.0	1.9	-1.4	-0.8	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	1.8	0.0	-1.0	1.3
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.7	-0.8	-0.5	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	1.2	1.1	0.6	-1.1
Handedness (chirality/laterality): Left-handed	0.8	1.0	2.2	-0.7	-0.5	1.5
Average weekly champagne plus white wine intake	0.8	1.1	2.6	1.6	0.9	0.2
Guilty feelings	0.8	1.2	2.9	-0.7	-0.6	1.7
Supplements: Calcium	0.8	0.9	2.2	1.5	0.5	0.5
Major Depression (MDD)	0.7	0.9	1.7	-1.3	-0.9	0.0
Diabetes (mother)	0.7	0.9	1.5	1.2	1.1	0.1
Diabetes (self-reported)	0.7	1.1	1.7	1.2	1.3	0.5
Number of live births	0.7	0.9	1.4	-0.2	-1.2	-1.2
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	3.0	-1.7	-1.6	1.2
Breastfed as a baby	0.7	0.8	2.1	1.4	0.6	0.1
Tense / ‘highly strung’	0.7	1.1	2.0	-1.4	-1.0	0.6
Loud music exposure frequency	0.7	0.8	1.5	-1.2	-0.6	0.6
Medication: Ibuprofen	0.7	0.8	1.8	-0.3	-0.8	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	2.5	-1.6	-0.1	0.3
Had major operations	0.7	0.8	1.4	0.9	0.5	-1.2
Loneliness, isolation	0.7	1.0	1.9	0.3	1.0	1.4
Diabetes diagnosed by doctor	0.7	1.1	2.3	0.9	1.5	0.4
Qualifications: nursing, teaching	0.7	1.1	2.6	1.6	0.7	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.8	1.3	0.2	0.8
Mineral and other dietary supplements	0.7	0.9	1.3	-1.2	-1.0	0.6
Osteoporosis (self-reported)	0.7	0.9	1.5	0.3	-1.0	-1.2
Prostate Cancer	0.6	0.8	2.5	-0.2	-1.6	-0.1
Schizophrenia (2014)	0.6	1.2	2.5	-1.6	-0.9	-0.6
Triglycerides	0.6	0.9	2.2	-1.5	0.7	-0.3
Blood Platelet Count	0.6	7.4	16.5	0.2	4.1	2.4
Smoking Status	0.6	1.5	3.3	-1.8	-0.4	-0.9
Sensitivity / hurt feelings	0.6	1.0	1.4	-1.2	-0.6	-1.1
Systolic blood pressure, automated reading	0.6	1.7	2.2	1.4	1.5	-0.9
Multivitamins +/- minerals	0.6	0.8	1.3	1.1	0.3	1.1
Sitting height	0.6	4.3	8.9	-3.0	-1.9	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	2.7	-0.1	0.3	1.6
Allergy	0.6	1.4	2.6	-1.1	-1.6	-0.7
Father’s age at death	0.6	0.8	1.9	-0.6	-1.4	0.2
Happiness	0.6	0.7	1.1	-0.9	0.6	1.1
Exposure to tobacco smoke outside home	0.6	0.7	1.6	1.3	0.8	0.0
Comparative body size at age 10	0.6	1.6	3.3	1.1	0.7	1.8
Illnesses of father: Heart disease	0.6	0.8	1.7	1.3	0.7	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.8	-1.3	-0.5	0.2
Medication: Gliclazide	0.6	0.7	1.0	0.8	0.8	-1.0
Mother’s age at death	0.6	0.7	1.9	1.4	0.1	0.4
Medication: Atorvastatin	0.6	0.7	1.0	0.5	1.0	0.9
Crohns Disease (2017)	0.5	1.1	3.2	0.2	-0.1	-1.8
Systolic Blood Pressure	0.5	2.3	3.1	1.4	1.4	-1.8
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	0.9	-0.9	-0.3	-0.8
Medication: Levothyroxine sodium	0.5	0.9	2.0	0.3	0.8	1.4
Asthma	0.5	1.0	2.2	-1.5	-0.4	-0.8
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.2	1.1	0.2	-1.1
Shortness of breath walking on level ground	0.5	0.6	1.3	-0.3	1.2	0.6
Eye problems/disorders: None of the above	0.5	0.5	1.5	1.2	0.3	0.0
Medication for pain relief, constipation, heartburn	0.5	0.8	1.2	-1.1	-1.1	-0.2
Medication: Omeprazole	0.5	0.5	1.1	0.2	0.7	1.1
Number of full sisters	0.5	0.6	1.6	0.1	-0.3	-1.3
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	0.8	-0.7	-0.8	0.9
Illnesses of siblings: Diabetes	0.5	0.7	1.7	0.5	0.1	1.3
Ever taken oral contraceptive pill	0.5	0.5	1.1	-0.1	0.6	1.1
Age started oral contraceptive pill	0.5	0.7	1.4	1.2	0.5	-0.6
Depressed Affect (Nagel 2018)	0.4	0.8	1.8	0.8	1.3	0.3
Worry (Nagel 2018)	0.4	0.9	1.9	-1.4	-0.9	0.1
Age at First Birth	0.4	0.5	1.3	0.5	1.1	-0.2
Blood Eosinophil Count	0.4	2.9	8.1	0.3	2.9	0.7
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.4	0.6	1.2	0.7
Chronotype (morning person)	0.4	0.9	1.8	-0.6	-0.8	1.3
Hand grip strength (left)	0.4	1.2	1.7	-1.0	-1.3	0.9
Relative age of first facial hair	0.4	0.9	1.9	0.4	1.4	0.8
Vitamin and mineral supplements	0.4	0.5	1.0	-0.4	0.6	-1.0
Diabetes (father)	0.4	0.5	0.8	0.7	0.2	-0.9
Fed-up feelings	0.4	0.8	2.2	-0.0	0.4	1.5
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.8	0.9	0.1	0.8
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.3	0.1	0.2	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.0	1.0	0.6	0.8
Lung cancer (father)	0.4	0.4	1.2	0.0	-0.3	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.1	1.8	-1.1	-1.4	0.5
Pulse wave Arterial Stiffness index	0.4	0.5	0.8	-0.8	-0.1	-0.9
Ever highly irritable/argumentative for 2 days	0.4	0.5	0.8	-0.7	0.3	-0.9
Birth weight	0.4	1.0	2.7	-0.2	-1.6	0.5
Age at first live birth	0.4	0.7	1.1	1.0	1.0	0.4
Mouth/teeth dental problems: Loose teeth	0.4	0.4	0.8	0.6	0.3	-0.9
Emphysema/chronic bronchitis	0.4	0.4	0.7	-0.1	-0.9	-0.7
Friendships satisfaction	0.4	0.5	1.0	0.2	0.7	1.0
Breast cancer (self-reported)	0.4	0.5	1.0	-0.6	-0.3	-1.0
Asthma (self-reported)	0.4	0.7	1.7	-1.3	-0.3	-0.6
Miserableness	0.4	0.7	1.1	0.1	1.0	-1.0
Alcohol drinker status: Never	0.4	0.5	0.7	-0.7	-0.9	-0.6
Schizophrenia vs Biploar Disorder	0.3	0.4	1.0	0.2	1.0	0.5
Alzheimer’s Disease (in father)	0.3	0.3	0.5	0.7	-0.5	-0.5
Breast Cancer	0.3	0.6	1.6	1.3	0.2	0.4
Mean Putamen Volume	0.3	0.4	0.5	0.4	0.6	0.7
Primary Biliary Cirrhosis	0.3	0.4	0.5	-0.6	-0.7	-0.5
Rheumatoid Arthritis	0.3	0.4	0.4	0.7	0.6	-0.7
Respiratory disease	0.3	0.7	1.3	-1.1	-0.6	-0.8
Severe depression (siblings)	0.3	0.3	0.6	-0.5	-0.8	0.3
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.0	-0.2	-0.1	1.0
Past tobacco smoking	0.3	0.5	1.0	0.6	-1.0	0.4
Hearing difficulty/problems with background noise	0.3	0.5	0.9	0.7	1.0	-0.4
Hair/balding pattern: Pattern 3	0.3	0.5	0.9	-0.9	0.1	0.8
Impedance of arm (left)	0.3	1.4	2.8	-1.2	-1.7	-0.2
Exposure to tobacco smoke at home	0.3	0.3	0.7	-0.2	0.3	-0.8
Pulse wave reflection index	0.3	0.4	0.7	0.7	0.8	0.0
Mouth/teeth dental problems: Bleeding gums	0.3	0.5	0.9	-0.1	0.7	-0.9
Medication: Paracetamol	0.3	0.5	1.2	0.6	0.1	-1.1
Glaucoma (self-reported)	0.3	0.3	0.9	0.1	0.9	0.3
Pulse wave peak to peak time	0.3	0.4	0.8	0.5	-0.2	0.9
Pulse rate, automated reading	0.3	1.1	1.8	-1.1	-1.3	-0.6
Alcohol intake frequency.	0.3	0.6	1.2	-0.8	-1.1	0.2
Suffer from ‘nerves’	0.3	0.4	0.7	-0.4	-0.6	-0.9
Smoking status: Previous	0.3	0.4	0.8	-0.9	0.6	-0.2
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.8	-0.2	0.9	0.4
Eye problems/disorders: Glaucoma	0.3	0.4	1.1	-1.0	-0.2	-0.0
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.6	0.8	0.5	-0.6
Medication: Paracetamol	0.3	0.5	1.5	0.2	-0.2	-1.2
Risk taking	0.3	0.5	1.1	0.7	1.0	-0.0
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.5	0.7	0.6	0.2
Myopia	0.3	0.4	0.8	0.5	0.6	-0.9
Neuroticism (2016)	0.2	0.3	0.6	-0.8	0.5	-0.4
Waist Hip Ratio (WHR)	0.2	0.7	1.3	-1.0	0.2	1.1
Hair Pigment	0.2	6.5	15.8	-4.0	-1.9	-0.2
Ever had hysterectomy (womb removed)	0.2	0.3	0.6	0.4	-0.3	0.8
Impedance of leg (right)	0.2	0.8	1.1	0.8	0.9	-1.0
Townsend deprivation index at recruitment	0.2	0.2	0.4	-0.7	-0.4	0.3
Relative age voice broke	0.2	0.3	0.7	-0.9	-0.4	-0.0
Impedance of arm (right)	0.2	1.0	1.4	-0.7	-1.0	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.4	-0.6	-0.4	-0.6
Wheeze or whistling in the chest in last year	0.2	0.4	0.7	0.8	0.8	0.0
Number of children fathered	0.2	0.2	0.4	0.7	0.0	0.3
Qualifications: College or University degree	0.2	0.7	1.4	-1.2	-0.2	0.8
Medication: Seretide 50 evohaler	0.2	0.2	0.4	-0.5	0.2	0.7
Age at last live birth	0.2	0.2	0.7	0.0	0.2	-0.8
Commuting to job workplace: Walk	0.2	0.3	0.6	0.3	0.8	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.8	0.7	-0.1	0.9
Ever smoked	0.2	0.3	0.9	0.4	0.9	0.0
Depression (Nagel 2018)	0.1	0.2	0.4	-0.4	0.6	0.3
Neuroticism (Nagel 2018)	0.1	0.2	0.6	-0.0	0.8	-0.3
HbA1C	0.1	0.1	0.2	0.1	0.4	-0.3
Tanning	0.1	1.1	2.1	-0.5	-1.4	1.0
Medication: Co-codamol	0.1	0.2	0.2	-0.5	0.5	0.1
Pack years adult smoking proportion	0.1	0.2	0.5	-0.7	-0.3	0.2
Current tobacco smoking	0.1	0.2	0.4	0.0	0.4	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.3	-0.6	0.1	0.5
Supplements: Glucosamine	0.1	0.1	0.3	-0.2	0.6	-0.2
Chronic bronchitis/emphysema (father)	0.1	0.1	0.3	0.0	-0.5	-0.1
Impedance of leg (left)	0.1	0.5	1.1	-0.4	-0.4	-1.0
Hair/balding pattern: Pattern 2	0.1	0.2	0.4	0.1	-0.4	-0.6
Qualifications: None of the above	0.1	0.3	0.5	-0.7	-0.2	-0.5
Financial difficulties in last 2 years	0.1	0.2	0.3	-0.5	-0.2	0.5
Neuroticism score	0.1	0.2	0.4	-0.5	0.0	0.6
Trunk fat-free mass	0.1	0.6	1.0	-0.9	-1.0	-0.0
Worrier / anxious feelings	0.1	0.2	0.5	0.1	0.4	-0.7
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.6	0.1	-0.0	0.8
Depression (self-reported)	0.1	0.1	0.2	0.5	0.4	0.0
Trunk predicted mass	0.1	0.5	0.9	-0.7	-1.0	0.1
Length of working week for main job	0.1	0.1	0.3	-0.6	-0.1	0.1
Hair/balding pattern: Pattern 4	0.1	0.2	0.3	0.6	-0.3	-0.5
Headache pain in last month	0.1	0.2	0.4	-0.7	-0.1	0.3
Leg pain on walking	0.1	0.1	0.3	0.6	0.1	-0.1
Leg fat-free mass (right)	0.1	0.6	1.0	-0.7	-1.0	0.5
Smoking status: Current	0.1	0.1	0.2	-0.3	0.1	-0.4
Leg predicted mass (right)	0.1	0.6	1.1	-0.8	-1.1	0.4
Average weekly beer plus cider intake	0.1	0.2	0.5	0.3	0.7	0.1
Unable to work because of sickness or disability	0.1	0.2	0.4	-0.3	-0.1	0.6
Commuting to job workplace: Cycle	0.1	0.1	0.1	0.3	0.2	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	-0.5	0.3	0.0
Pack years of smoking	0.1	0.1	0.2	-0.4	-0.1	0.3
Impedance of whole body	0.1	0.6	0.8	-0.7	-0.9	-0.7
Crohns Disease (2012)	0.0	0.1	0.2	0.1	-0.4	-0.2
Neuroticism	0.0	0.1	0.2	-0.2	0.4	-0.3
Leg fat-free mass (left)	0.0	0.1	0.3	0.6	0.2	0.3
Maternal smoking around birth	0.0	0.1	0.1	-0.3	-0.2	-0.2
Leg predicted mass (left)	0.0	0.1	0.2	0.4	0.1	0.3
Ever unenthusiastic/disinterested for a whole week	0.0	0.0	0.0	-0.1	0.2	0.0
Mouth/teeth dental problems: Dentures	0.0	0.0	0.1	-0.2	0.3	-0.1
Arm fat-free mass (right)	0.0	0.1	0.2	0.2	-0.3	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.1	0.3	0.2	0.1
Arm predicted mass (right)	0.0	0.1	0.2	-0.1	-0.4	0.4
Whole body fat-free mass	0.0	0.2	0.4	-0.4	-0.7	0.1
Mouth/teeth dental problems: Mouth ulcers	0.0	0.0	0.1	-0.0	0.3	0.2
Whole body water mass	0.0	0.2	0.5	-0.4	-0.7	0.2
Commuting to job workplace: Public transport	0.0	0.0	0.1	0.4	0.1	0.0
Basal metabolic rate	0.0	0.1	0.1	0.4	0.1	-0.1
Arm fat-free mass (left)	0.0	0.1	0.2	0.4	0.2	-0.2
Arm predicted mass (left)	0.0	0.1	0.4	0.6	0.2	-0.0

Hub : Genes

CCDC55

Models

Trait associations