Best TWAS P=4.13e-10 · Best GWAS P=6.45e-10 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ARFRP1 | 0.07 | 0.07 | lasso | 3 | 0.06 | 5.3e-08 | -5.6 | 5.6 | 2.8e-08 | -0.95 | 0.01 | 0.99 | FALSE |
| 2 | METSIM | Adipose | TPD52L2 | 0.03 | 0.00 | bslmm | 207 | 0.02 | 1.5e-03 | 4.6 | 5.3 | 1.5e-07 | -0.68 | 0.02 | 0.71 | FALSE |
| 3 | YFS | Blood | LIME1 | 0.12 | 0.19 | enet | 15 | 0.19 | 5.3e-59 | -6.2 | -6.2 | 4.1e-10 | 0.99 | 0.00 | 1.00 | TRUE |
| 4 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LIME1 | 0.02 | 0.03 | blup | 47 | 0.02 | 6.2e-03 | -3.8 | -5.3 | 1.4e-07 | 0.82 | 0.03 | 0.62 | FALSE |
| 5 | The Cancer Genome Atlas | Lung Adenocarcinoma | TNFRSF6B | 0.02 | 0.01 | enet | 7 | 0.01 | 6.9e-03 | -4.5 | -5.4 | 6.7e-08 | 0.92 | 0.02 | 0.86 | FALSE |
| 6 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | TNFRSF6B | 0.05 | 0.02 | blup | 44 | 0.03 | 2.9e-03 | -5.8 | -5.5 | 4.4e-08 | 0.92 | 0.01 | 0.69 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ARFRP1 | 0.03 | 0.02 | lasso | 2 | 0.02 | 1.2e-03 | -5.6 | 5.6 | 2.0e-08 | -0.96 | 0.01 | 0.96 | FALSE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LIME1 | 0.04 | 0.05 | blup | 47 | 0.05 | 9.0e-06 | -6.1 | -6.1 | 7.8e-10 | 0.97 | 0.00 | 0.99 | FALSE |
| 9 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | LIME1 | 0.10 | 0.02 | blup | 47 | 0.04 | 1.5e-02 | -5.7 | -5.2 | 2.4e-07 | 0.90 | 0.01 | 0.63 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | ARFRP1 | 0.04 | 0.00 | blup | 51 | 0.00 | 1.3e-01 | -6.2 | 5.3 | 1.2e-07 | -0.80 | 0.01 | 0.67 | FALSE |